Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

作     者：Keitaro Hayashi Naohiko Anzai 

作者机构：Department of Pharmacology and Toxicology Dokkyo Medical University School of Medicine Department of PharmacologyChiba University Graduate School of Medicine 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2017年第9卷第1期

页      面：21-29页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：LAT1 Amino acid transporter Molecular target drug Amino acid starvation response Signal transduction 

摘      要：L-type amino acid transporters(LATs) mainly assist the uptake of neutral amino acids into cells. Four LATs(LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1(SLC7A5) has been attracting much attention in the field of cancer research since it is commonly up-regulated in various cancers. Basic research has made it increasingly clear that LAT1 plays a predominant role in malignancy. The functional significance of LAT1 in cancer and the potential therapeutic application of the features of LAT1 to cancer management are described in this review.