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Probability of Osteoporotic Vertebral Fractures Assessment Based on DXA Measurements and Finite Element simulation

Advances in Bioscience and Biotechnology 2014年第6期5卷 527-545页

作者： Enrique lópez Elena Ibarz antonio Herrera jesús Mateo antonio lobo-Escolar sergio Puértolas luis Gracia Aragón Health sciences Institute Zaragoza Spain Department of Design and Manufacturing Engineering University of Zaragoza Zaragoza Spain Department of Mechanical Engineering University of Zaragoza Zaragoza Spain Department of Orthopaedic surgery and Traumatology Miguel Servet University Hospital Zaragoza Spain Department of surgery University of Zaragoza Zaragoza Spain

Osteoporotic vertebral fractures represent major cause of disability, loss of quality of life and even mortality among the elderly population. Decisions on drug therapy are based on the assessment of risk factors for fracture, from bone mineral density measurements. The combination of biomechanical models with clinical studies could better estimate bone strength and support the specialists in their decision. A model to assess the probability of fracture, based on the Damage and Fracture Mechanics has been developed, evaluating the mechanical magnitudes involved in the fracture process from clinical bone mineral density measurements. The model is intended for simulating the degenerative process in the skeleton, with the consequent lost of bone mass and hence the decrease of its mechanical resistance which enables the fracture due to different traumatisms. Clinical studies were chosen, both in non-treatment conditions and receiving drug therapy, and fitted to specific patients according their actual bone mineral density measures. The predictive model is applied in a finite element simulation of the lumbar spine. The fracture zone would be determined according loading scenario (fall, impact, accidental loads, etc.), using the mechanical properties of bone obtained from the evolutionary model corresponding to the considered time. Bone mineral density evolution in untreated patients and in those under different treatments was analyzed. Evolutionary curves of fracture probability were obtained from the evolution of mechanical damage. The evolutionary curve of the untreated group of patients presented a marked increase of the fracture probability, while the curves of patients under drug treatment showed variable decreased risks, depending on the therapy type. The finite element model allowed obtaining detailed maps of damage and fracture probability, identifying high-risk local zones at vertebral body, which are the usual localization of osteoporotic vertebral fractures. T

关键词： Osteoporosis Osteoporotic Vertebral Fracture Predictive Model Finite Elements Fracture Risk Fracture Probability

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study of reverse osmosis membranes fouling by inorganic salts and colloidal particles during seawater desalination

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Chinese Journal of Chemical Engineering 2020年第3期28卷 733-742页

作者： santiago Gutiérrez Ruiz Juan antonio lópez-Ramírez Mohammed Hassani Zerrouk Agata Egea-Corbacho lopera JoséMaría Quiroga Alonso Department of Environmental Technologies Faculty of Marine and Environmental SciencesUniversity of Cadiz11510Puerto RealCadizSpain

Fouling phenomenon is considered among the major reasons that cause significant increase of operating cost of desalination plants equipped with reverse osmosis(RO)*** phenomenon is studied in the present work in the case of RO polyamide aromatic membranes using model seawater containing inorganic salts and colloidal *** solubility conditions of CaCO3 and CasO4 were applied to study RO performances with and without colloid *** experiments,the membrane permeate fluxes were continuously ***,studies of chemical composition,structure,and morphology of the materials deposited on the membrane surface were conducted using energy dispersive microanalysis(EDs)X-ray diffraction and scanning electronic microscopy(sEM).Results show that in conditions of calcium carbonate oversaturation there is a reduction in the permeate flow of 11.2%due to fouling of the membrane by the precipitation of this *** in the same conditions of calcium sulphate oversaturation the reduction of the flow is 5%,so we can conclude that in conditions of oversaturation of both salts,calcium carbonate produces a greater fouling of the membrane that in its view causes greater decrease in the flow of *** this based on the results of the test with both salts in oversaturated *** in the formation of calcite and gypsum crystals onto the membranes as XRD analyses *** presence of colloidal silica in those conditions intensifies strongly the fouling,leading until to 24.1%of permeate flux decrease.

关键词： Reverse osmosis Desalination Fouling seawater scaling

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The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles

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science China Materials 2022年第6期65卷 1662-1670页

作者： Eric Voltà-Durán Julieta M sánchez Hèctor-lópez-laguna Eloi Parladé laura sánchez-García Alejandro sánchez-Chardi Ario de Marco Ugutz Unzueta Esther Vázquez antonio Villaverde Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN) Bellaterra 08193BarcelonaSpain Instituto de Investigaciones Biológicas y Tecnológicas(IIBYT)(CONICET-Universidad Nacional de Córdoba) ICTA&Cátedra de Química BiológicaDepartamento de QuímicaFCEFyNUNC.Av.Velez Sarsfield 1611X 5016GCA CórdobaArgentina servei de Microscòpia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsFacultat de BiologiaUniversitat de Barcelona08028 BarcelonaSpain laboratory for Environmental and life sciences University of Nova GoricaNova Gorica 5000Slovenia Biomedical Research Institute sant Pau(IIB sant Pau) Sant Antoni Ma Claret 16708025 BarcelonaSpain

Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent *** fact allows the cost-effective,large-scale generation of microscopic and macroscopic protein materials with intriguing biomedical *** such materials,resulting from the simple bioproduction of protein building blocks,homomeric nanoparticles are of special value as multivalent interactors and drug ***,we have here identified that the assembly of a given His-tagged protein might render distinguishable categories of self-assembling protein *** fact has been scrutinized through the nanobody-containing fusion proteins EM1-GFP-H6 and A3C8-GFP-H6,whose biosynthesis results in two distinguishable populations of building *** one of them,the assembling and disassembling is controllable by ***,a second population immediately self-assembles upon purification through a non-regulatable pathway,rendering larger nanoparticles with specific biological *** structural analyses of both model proteins and nanoparticles revealed important conformational variability in the building *** fact renders different structural and functional categories of the final soft materials resulting from the participation of energetically unstable intermediates in the oligomerization *** data illustrate the complexity of the Hismediated protein assembling in recombinant proteins but they also offer clues for a better design and refinement of protein-based nanomedicines,which,resulting from biological fabrication,show an architectonic flexibility unusual among biomaterials.

关键词： recombinant proteins self-assembling protein materials nanoparticles biomaterials

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Prevalence of hepatocarcinoma-related hepatitis B virus mutants in patients in grey zone of treatment

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World Journal of Gastroenterology 2019年第38期25卷 5883-5896页

作者： Ana Isabel Gil-García antonio Madejón Irene Francisco-Recuero Ana lópez-lópez Emiliana Villafranca Miriam Romero Araceli García antonio Olveira Rocío Mena Juan Ramón larrubia Javier García-samaniego Hepatology Unit Hospital Universitario La PazMadrid 28046Spain Centro de Investigación Biomédica en Red Instituto de Salud Carlos IIIMadrid 28029Spain Instituto de Investigación del Hospital Universitario la Paz Madrid 28046Spain Biochemistry Department Faculty of MedicineUniversidad Autónoma de MadridMadrid 28029Spain Instituto de Genética Médica y Molecular Hospital Universitario La PazMadrid 28046Spain Translational Hepatology Unit Hospital General Universitario de GuadalajaraGuadalajara 19002Castilla-La ManchaSpain

BACKGROUND Antiviral treatment of patients with chronic hepatitis B(CHB)in the grey zone of treatment comands risk management in order to optimize the health *** this sense,the identification of HBV mutants related with an increased risk of hepatocellular carcinoma(HCC)could be useful to identify subpopulations with potential indication of antiviral *** To analyze the prevalence/persistence of hepatitis B virus(HBV)pres and basal core promoter(BCP)/precore/core variants associated to HCC development in CHB patients in the grey *** Work was designed as a longitudinal retrospective study,including 106 plasma samples from 31 patients with CHB in the grey zone of treatment:Hepatitis B e antigen negative,HBV-DNA levels between 12-20000 IU/ml,normal or discordant transaminase levels during follow up and mild/moderate necroinflammatory activity in liver biopsy or Fibroscan(up to 9.5 kPa).serum HBVDNA was tested using the Abbott Real Time HBV Assay and the BCP/precore/core and the hepatitis B surface antigen(HBsAg)coding regions were analyzed in positive samples by PCR/bulk-sequencing to identify the HCCrelated HBV *** High-risk HCC related mutants were detected in 24(77%)patients:19(61%)in the BCP/precore/core,and 7(23%)in the HBsAg coding region(2 pres1 and 5 pres2 deletions).The prevalence of pres deletions was genotype-dependent:3/5(60%)patients with pres2 deletions and 1/2 with pres1 deletions were infected with the HBV-E *** HBV-E was the most prevalent in sub-saharan patients,a correlation between pres deletions and ethnicity was also found:6/8(75%)sub-saharan vs 1/19(5%)Caucasian patients had pres deletions(P=0.00016).Remarkably,this correlation was maintained in those patients infected with HBV-A,a minor genotype in sub-saharan patients:2/2 patients infected with HBV-A from West Africa vs 0/6 of Caucasian origin had pres *** HCC related variants were the major strains and persisted over time(up to 48 mo).Pa

关键词： Hepatitis B virus Hepatocellular carcinoma Pres deletions Hepatitis B virus treatment Grey zone

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Atmospheric-pressure dielectric barrier discharge generation by a full-bridge flying capacitor multilevel inverter

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Plasma science and Technology 2017年第7期19卷 40-49页

作者： Rosendo PE?A-EGUIlUZ José A lópez-FERNáNDEZ antonio MERCADO-CABRERA Bethsabet JARAMIllO-sIERRA Régulo lópez-CAllEJAs Benjamín RODRíGUEZ-MéNDEZ Raúl VAlENCIA-AlVARADO Allan A FlOREs-FUENTEs Arturo E MU?OZ-CAsTRO Plasma Physics laboratory Instituto Nacional de Investigaciones Nucleares Tecnológico de Estudios superiores de Tianguistenco Universidad Autónoma del Estado de México

A new configuration of a resonant full-bridge flying capacitor multicell inverter has been designed and constructed with the aim of achieving an extended output voltage frequency range with low harmonic distortion and reduced semiconductor commutation losses. This configuration was tested as a power supply for two different coaxial dielectric barrier discharge reactors, one of them employed for electric characterization and the other one for inorganic compound elimination in an aqueous solution. Two different gas mixtures, 90% Ar-10% 02 and 80% Ar-20% 02, were individually supplied during the experiments; the results showed a high- efficiency removal of meta-cresol （m-cresol） to the order of 98%, which was obtained by adding more oxygen to the plasma gas mixture.

关键词： plasma applications water pollution plasma sources power supply circuits electricdischarges

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Cutaneous Dengue Virus Inoculation Triggers strong B Cell Reactions but Contrastingly Poor T Cell Responses

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Virologica sinica 2020年第5期35卷 575-587页

作者： Edith Marcial-Juárez Julio García-Cordero Raúl antonio Maqueda-Alfaro Rafael Eduardo saucedo-lópez luvia Enid sánchez-Torres leticia Cedillo-Barrón leopoldo Flores-Romo Department of Cell Biology Center for Advanced Research(CINVESTAV-IPN)The National Polytechnic Institute07360 Mexico CityMexico Department of Molecular Biomedicine Center for Advanced Research(CINVESTAV-IPN)The National Polytechnic Institute07360 Mexico CityMexico Immunology Department The National School of Biological Sciences(ENCB-IPN)The National Polytechnic Institute11340 Mexico CityMexico

Dengue is a global health problem without current specific treatment nor safe vaccines *** severe dengue is related to pre-existing non-neutralizing dengue virus(DENV)antibodies,the role of T cells in protection or pathology is *** cutaneous DENV infection in immunocompetent mice we previously showed the generation of PNA+germinal centers(GCs),now we assessed the activation and proliferation of B and T cells in draining lymph nodes(DlNs).We found a drastic remodelling of DlN compartments from 7 to 14 days post-infection(dpi)with greatly enlarged B cell follicles,occupying almost half of the DlN area compared to*24%in na?ve *** clusters of proliferating(Ki-67+)cells inside B follicles were found 14 dpi,representing*33%of B cells in DlNs but only*2%in noninfected *** GCs,we noticed an important recruitment of tingle body macrophages removing apoptotic *** contrast,the percentage of paracortex area and total T cells decreased by 14–16 dpi,compared to *** randomly distributed Ki-67+T cells were found,similar to non-infected ***69 expression by CD4+and CD8+T cells was minor,while it was remarkable in B cells,representing 1764.7%of change from basal levels 3 *** apparent lack of T cell responses cannot be attributed to apoptosis since no significant differences were observed compared to noninfected *** study shows massive B cell activation and proliferation in DlNs upon DENV *** contrast,we found very poor,almost absent CD4+and CD8+T cell responses.

关键词： Dengue virus(DENV) B and T cells proliferation lymphocyte activation lymph nodes In vivo cutaneous infection Immunocompetent mice

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Recent Advances on Early-stage Fire-Warning systems: Mechanism, Performance, and Perspective

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Nano-Micro letters 2022年第12期14卷 106-136页

作者： Xiaolu li antonio Vazquez-lopez Jose sanchez del Rio saez De-Yi Wang IMDEA Materials Institute C/Eric Kandel228906 GetafeMadridSpain E.T.s.de Ingenieros de Caminos Universidad Politecnica de MadridCalle Profesor Aranguren 328040 MadridSpain Departamento de Ingenieria Electrica Electronica Automatica y Fisica AplicadaETSIDIUniversidad Politecnica de MadridRonda de Valencia 328012 MadridSpain

Early-stage fire-warning systems(EFWss)have attracted significant attention owing to their superiority in detecting fire situations occurring in the pre-combustion *** progress on EFWss has been achieved recently,and they have presented a considerable possibility for more evacuation time to control constant unintentional fire hazards in our daily *** review mainly makes a comprehensive summary of the current EFWss,including the working mechanisms and their *** to the different working mechanisms,fire alarms can be classified into graphene oxide-based fire alarms,semiconductor-based fire alarms,thermoelectric-based fire alarms,and fire alarms on other working ***,the challenge and prospect for EFWss are briefly provided by comparing the art of state of fire *** work can propose a more comprehensive understanding of EFWss and a guideline for the cutting-edge development direction of EFWss for readers.

关键词： smart thermosensitive fire sensors Working mechanism Response time signal conversion

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Yearly variation in the structure and diversity of a non-breeding passerine bird community in a Mediterranean wetland

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Avian Research 2020年第3期11卷 238-245页

作者： Juan Arizaga Daniel Alonso ArinCrespo Xabier Esparza Efrén Fernández Iógo lópez David Martín antonio Vilches Department of Ornithology Aranzadi Sciences Society S. Sebastián Spain

Background:The dynamics and structure of many bird communities are changing due to the global warming and changes in the land use and *** Ebro Valley constitutes one of the chief wintering areas for several passerine species in Iberia,and the reed beds spread across this Valley concentrate huge numbers of birds that use them to roost,while the surrounding agricultural areas serve as main foraging *** aims of this work are(1)to quantify how variable a non-breeding passerine bird community associated to a reed bed area in the Ebro Valley is,and,(2)to test for the effect of weather on possible annual fluctuations in species’proportions at a regional/local ***:We used for that ringing data collected at Badina de Escudera lagoon(Navarra)over a 12-year ***:Though,overall,the assemblage did not vary strongly among years(most similarity values were>0.8),we still found a significant linear effect of year on the proportion of captures of Reed Buntings(Emberiza schoeniclus),i.e.,the dominant species detected in our passerine *** increasing loss of weight of Reed Buntings in the community was due to a progressive decrease in its ***:The structure and diversity of passerine community in Badina Escudera was not influenced by meteorological conditions at a local scale,suggesting that local weather would not have an impact on numbers of Reed Buntings in winter.

关键词： Navarra Emberiza schoeniclus Ringing long-term monitoring

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Insights into myelin dysfunction in schizophrenia and bipolar disorder

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World Journal of Psychiatry 2022年第2期12卷 264-285页

作者： Marcela Valdés-Tovar Alejandra Monserrat Rodríguez-Ramírez leslye Rodríguez-Cárdenas Carlo E sotelo-Ramírez Beatriz Camarena Marco antonio sanabrais-Jiménez Héctor solís-Chagoyán jesús Argueta Germán Octavio lópez-Riquelme Departamento de Farmacogenética Subdirección de Investigaciones ClínicasInstituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico Departamento de Farmacogenética Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico Doctorado en Biología Experimental Universidad Autónoma Metropolitana-IztapalapaMexico City 09340Mexico laboratorio de Neurofarmacología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico laboratorio de socioneurobiología Centro de Investigación en Ciencias CognitivasUniversidad del Estado de MorelosCuernavaca 62209MorelosMexico

schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide prevalence of approximately 1%.Both disorders present chronic and deteriorating prognoses that impose a large burden,not only on patients but also on society and health *** mental illnesses share several clinical and neurobiological traits;of these traits,oligodendroglial dysfunction and alterations to white matter(WM)tracts could underlie the disconnection between brain regions related to their symptomatic *** is mainly composed of heavily myelinated axons and glial *** internodes are discrete axon-wrapping membrane sheaths formed by oligodendrocyte *** ensheathment allows fast and efficient conduction of nerve impulses through the nodes of Ranvier,improving the overall function of neuronal *** and precisely synchronized nerve impulse conduction through fibers that connect distant brain structures is crucial for higher-level functions,such as cognition,memory,mood,and *** cellular and subcellular anomalies related to myelin and oligodendrocytes have been found in postmortem samples from patients with schizophrenia or bipolar disorder,and neuroimaging techniques have revealed consistent alterations at the macroscale connectomic level in both *** this work,evidence regarding these multilevel alterations in oligodendrocytes and myelinated tracts is discussed,and the involvement of proteins in key functions of the oligodendroglial lineage,such as oligodendrogenesis and myelination,is *** molecular components of the axo-myelin unit could be important targets for novel therapeutic approaches to schizophrenia and bipolar disorder.

关键词： Myelin sheath Oligodendroglia schizophrenia Bipolar disorder White matter

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Renal function and choroidal thickness using swept-source optical coherence tomography in diabetic patients

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 985-989页

作者： antonio Manuel Garrido-Hermosilla Mariola Méndez-Muros Estanislao Gutiérrez-sánchez Cristóbal Morales-Portillo María jesús Díaz-GrANDa Eduardo Esteban-González Isabel Relimpio-lópez María Asunción Martínez-Brocca Enrique Rodríguez-de-la-Rúa-Franch Department of Ophthalmology Virgen Macarena University HospitalSeville 41009Spain OftaRed Institute of Health Carlos IIIMadridSpain Department of Endocrinology and Nutrition Virgen Macarena University HospitalSeville 41009Spain

AIM: To assess the relationship between choroidal thickness and renal function in diabetic patients. METHODs: Cross-sectional retrospective clinical study of 42 eyes of 21 ocular treatment-na?ve diabetic patients. Demographic data included: age, sex, type and course of diabetes. Ocular data included: severity of diabetic retinopathy;retinal thickness at the central macular region, as well as choroidal thickness at the central and paracentral quadrants, using automatically generated maps by swept-source optical coherence tomography;presence of cystic macular edema;and ocular axial length(AXl). lab-test parameters included: glycated hemoglobin(HbA1c), albuminuria, albumin/creatinine ratio in urine, and glomerular filtration rate. REsUlTs: A significant negative correlation was mainly observed between several choroidal thicknesses, age(Plar AXl(Psignificant positive correlation was found between all choroidal thicknesses, HbA1 c(Plbuminuria(PlUsION: Choroidal thickness can represent an additional tool to help clinicians predicting the renal status in ocular treatment-na?ve diabetic patients.

关键词： choroidal thickness renal function swept-source optical coherence tomography spectral-domain optical coherence tomography diabetes mellitus

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