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QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

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Horticulture Research 2023年第3期10卷 136-150页

作者： Pilar Muñoz Cristina Castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe Chartier annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya Centro IFAPA de Málaga Instituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140MálagaSpain PhD program in Advanced Biotechnology Universidad de Málaga29071MálagaSpain Finca el Cebollar Centro IFAPA las Torres04745HuelvaSpain Hansabred GmbH&Co.KG 01108DresdenGermany INVENIO 33800BordeauxFrance Biotechnology of Natural Products Technische Universität München85354FreisingGermany Dipartimento di Scienze Agrarie Alimentari e AmbientaliUniversitàPolitecnica delle Marche60131AnconaItaly Department of Horticultural Crop Breeding the National Institute of Horticultural ResearchKonstytucji 3 Maja 1/396-100SkierniewicePoland Institute of Bio-and Geosciences Bioinformatics(IBG-4)Forschungszentrum Jülich GmbH52428JülichGermany Univ.Bordeaux INRAEBiologie du Fruit et PathologieUMR 1332F-33140France Departamento de Biología Molecular y Bioquímica Instituto de Hortofruticultura Subtropical y Mediterránea"La Mayora"Universidad de Málaga-Consejo Superior de Investigaciones CientíficasCampus de Teatinos29071 MálagaSpain Unidad Asociada de I+D+i IFAPA-CSIC Biotecnología y Mejora en Fresa 29010MálagaSpain.

strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and *** the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional ***,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European *** account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and *** content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)*** stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG *** genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,*** show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA ***,expression of FaGGP(3A)was two-fold higher in lines with high *** here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.

关键词： straw cultivar content

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微量矿物元素来源对肉鸡生物学利用率参数影响的研究

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中国饲料添加剂 2020年第5期 34-38页

作者：解玉怀王丽雪杨维仁(译) 山东农业大学动物科技学院山东省动物生物工程与疾病防治重点试验室山东泰安271018

本研究旨在调查两种来源的铜、铁、锰和锌对肉鸡畜牧学性能的影响,以及通过消耗-补充研究设计来研究对表观总肠道消化率(ATTD),以及此微量元素在肝脏、胫骨(TB)、胸肌和皮肤中的沉积。将72只1日龄雄性肉鸡(CoW)500)分为3组。14天的消耗... 详细信息

本研究旨在调查两种来源的铜、铁、锰和锌对肉鸡畜牧学性能的影响,以及通过消耗-补充研究设计来研究对表观总肠道消化率(ATTD),以及此微量元素在肝脏、胫骨(TB)、胸肌和皮肤中的沉积。将72只1日龄雄性肉鸡(CoW)500)分为3组。14天的消耗期仅饲喂日粮天然成分中的微量元素,随后的14天,其中两组补充甘氨酸结合的(Gly)或硫酸盐结合的(Sul)微量元素。第三组补充充足的日粮,但不添加微量矿物质(对照组)。相比于基础日粮组,补充微量矿物质可改善体重(P<0.05)和饲料转化率(P<0.05)。Gly组中所有微量矿物元素的ATTD均较高,而Sul组中的Mn的ATTD高于对照组(P<0.05)。Gly组和Sul组之间,锌和铜的ATTD有显著差异(P<0.05)。与对照组相比,补充Gly型矿物元素组的鸡的肝脏,以及Gly和Sul组胫骨中Mn和Fe的沉积率显著升高(P<0.05)。相比于对照组,Gly组的肝脏和胫骨中的Cu、胫骨中的Zn的沉积率有提高的趋势(P<0.1)。本研究证实,在矿物元素补充不足缺乏的情况下,添加Gly结合型的矿物元素相比于硫酸盐型矿物元素,肉鸡对微量矿物质Fe、Mn、Zn和Cu利用率较高。结果表明,比较不同来源的矿物元素,其所测定的指标显示可影响生物利用率。

关键词：微量元素肉鸡性能消化率沉积率

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Realization of T_(e0)>10 keV long pulse operation over 100 s on EAst

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Plasma Science and Technology 2023年第2期25卷 6-10页

作者：龚先祖徐立清钱金平黄娟丁锐 A M GAROFALO annika EKEDAhl 曾龙李二众张斌林士耀沈飙王茂徐旵东张新军李妙辉左桂忠臧庆刘海庆吕波王亮孙有文徐国盛胡建生姚达毛武玉胡立群肖炳甲项农陆坤宋云涛万宝年李建刚 the EAst Team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China General Atomics San Diego 92186-5608United States of America CEA Institute for Magnetic Fusion Research(IRFM)Saint-Paul-lez-Durance F-13108France

In 2021,EAst realized a steady-state long pulse with a duration over 100 s and a core electron temperature over 10 *** is an integrated operation that resolves several key issues,including active control of wall conditioning,long-lasting fully noninductive current and divertor heat/particle *** fully noninductive current is driven by pure radio frequency(RF)waves with a lower hybrid current drive power of 2.5 MW and electron cyclotron resonance heating of 1.4 *** is an excellent experimental platform on the timescale of hundreds of seconds for studying multiscale instabilities,electron-dominant transport and particle recycling(plasma-wall interactions)under weak collisionality.

关键词： EAst tokamak high T_(e) integrated operation scenario

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消费者对食品包装的认知会促进还是阻碍环境的可持续发展？

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绿色包装 2016年第2期 76-76页

作者： Helena Lindh annika Olsson Helen Williams

【摘要】货物在经过供应链到终端消费者的过程中,包装有着确保状态良好的货物安全交货的基础作用。包装在可持续发展的贡献上有着巨大的潜能。本文根据在瑞典开展的一个消费者调查提出了一项研究，探讨并提供了关于瑞典消费者在食品包... 详细信息

【摘要】货物在经过供应链到终端消费者的过程中,包装有着确保状态良好的货物安全交货的基础作用。包装在可持续发展的贡献上有着巨大的潜能。本文根据在瑞典开展的一个消费者调查提出了一项研究，探讨并提供了关于瑞典消费者在食品包装环保方面的认知和知识的见解，并详尽阐述了这些认识将会如伺促进或阻碍环境可持续的发展。

关键词：可持续发展食品包装消费者环境货物安全供应链瑞典环保

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哥本哈根在2025年实现碳中和?2006—2020年哥本哈根城市气候治理的多中心分析

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全球城市研究（中英文） 2023年第1期4卷 114-132,193页

作者：卡斯滕·布鲁恩·汉森安妮卡·艾格胡维(译) 丹麦罗斯基勒大学社会科学与商学系不详

2009年,哥本哈根市宣布其宏伟目标:通过协作性的气候治理方法,在2025年前成为世界上第一个碳中和的城市。然而,根据2020年的状况,要达到这一目标,还需要至少33%的脱碳。本文应用一个“综合的多中心”概念,辅以“参与式气候治理”研究,... 详细信息

2009年,哥本哈根市宣布其宏伟目标:通过协作性的气候治理方法,在2025年前成为世界上第一个碳中和的城市。然而,根据2020年的状况,要达到这一目标,还需要至少33%的脱碳。本文应用一个“综合的多中心”概念,辅以“参与式气候治理”研究,分析了哥本哈根2006—2020年合作式气候治理的不足之处。实证分析显示,2010年气候问题的政治优先性发生了变化,其中的重要原因是,公民社会行为者动员不足,部门合作减弱。本文结论是,自2010年以来,哥本哈根主要采用了一种相当“单中心”的治理方法,并依赖于技术创新,而不是通过公民社会的动员来改变行为,因此没有足够促进碳减排进程使得在2025年实现碳中和。最后,我们讨论了综合的多中心理念为城市气候治理辩论的贡献,以及如何进一步发展这一理念。在经验上,我们使用了文献分析和对哥本哈根32个关键参与者的采访。

关键词：社会动员参与性气候治理多中心理论城市气候治理

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生鲜食品供应链中可持续包装的发展

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绿色包装 2016年第2期 77-77页

作者： Helena Lindhl annika Olssonl Helen Williams

【摘要】生鲜食品行业对于发展能保证食品质量和运输效率的高效、创新解决方案越来越感兴趣；包装就是影响这些重要方面的一个主要因素。本文目的在于对两个现有的包装解决方案进行分析——从经济效益和环境保护两个方面对瓦楞纸箱和可... 详细信息

【摘要】生鲜食品行业对于发展能保证食品质量和运输效率的高效、创新解决方案越来越感兴趣；包装就是影响这些重要方面的一个主要因素。本文目的在于对两个现有的包装解决方案进行分析——从经济效益和环境保护两个方面对瓦楞纸箱和可重复使用塑料容器进行分析，

关键词：食品供应链包装可重复使用运输效率食品质量食品行业塑料容器瓦楞纸箱

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FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

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Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

Assessment of Lung Cancer Risk on the Basis of a Biomarker P...

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2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： sun,nan Florence,Guida Bantis,LeonidasE. Muller,DavidC. Li,Peng Taguchi,Ayumu Dhillon,Dilsher Kundnani,DeepaliL. Patel,NikulJ. Yan,Qingxiang Byrnes,Graham Moons,KarelG.M. Tj?nneland,Anne Panico,Salvatore Claudia ,Agnoli Vineis,Paolo Palli,Domenico Bueno-de-Mesquita,Bas Peeters,PetraH. Agudo,Antonio Huerta,JoseM. Dorronsoro,Miren Barranco,MiguelRodriguez Ardanaz,Eva Travis,RuthC. Byrne,KarlSmith Boeing,Heiner steffen,annika Kaaks,Rudolf Hüsing,Anika Trichopoulou,Antonia Lagiou,Pagona LaVecchia,Carlo Severi,Gianluca Boutron-Ruault,Marie-Christine Sandanger,TorkjelM. Weiderpass,Elisabete N?st,ThereseH. Tsilidis,Kostas Riboli,Elio Grankvist,Kjell Johansson,Mikael Goodman,GaryE. Feng,Ziding Brennan,Paul Johansson,Mattias Hanash,Samir M. The University of Texas MD Anderson Cancer Center Genetic Epidemiology Group International Agency for Research on Cancer Department of Biostatistics The University of Texas MD Anderson Cancer Center Department of Epidemiology and Biostatistics Imperial College London School of Public Health Laboratory of Population Health Max Planck Institute for Demographic Research Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Environment and Radiation Section International Agency for Research on Cancer Department of Epidemiology Julius Center for Health Sciences and Primary CareUniversity Medical Center Unit of Diet Genesand EnvironmentDanish Cancer Society Research Center Department of Clinical Medicine and Surgery Federico Ⅱ University Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Molecular and Genetic Epidemiology Unit Human Genetics Foundation Cancer Risk Factors and Life-style Epidemiology Unit Cancer Research and Prevention Institute-Istituto per lo Studio ela Prevenzione Oncologica Department for Determinants of Chronic Diseases National Institute for Public Health and the Environment Unit of Nutirition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of OncologyBellvitge Institute for Biomedical Research (IDIBELL)L’Hospitalet de Llobregat Department of Epidemiology Murcia Regional Health Council Biomedical Research Institute of Murcia(IMIB-Arrixaca) Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP) Public Health Direction and Biodonostia Research Institute-CIBERESP Escuela Andaluza de Salud Pública Instituto de Investigación Biosanitaria Hospitales Universitarios de Granada/Universidad de Granada Epidemiology Preventionand Promotion Health ServiceNavarra Public Health Institute Instituto de Investigación Sanitaria de Navarra (IdiSNA) Navarra Institute for Health Research Cancer Epidemiology Unit Nuffield Department of Population HealthUniversity of Oxford Department of Epidemi

IMPORTANCE:There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of ***:To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.

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越南河内国家会议中心(NCC)

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建筑技艺 2010年第7期16卷 40-47页

作者：曼哈德.冯.格康 Susi Winter Tuyen Tran Viet Robert Wildegger Hito Ueda Marcus Tanzen Udo Meyer Birgit Fllmer Jens Reichert Uli Rsler Frederik Heisel annika Schrder Elena Melnikova Markus Carlsen Nicole Flores Schlotfeldt Licht Müller BBM Breimann Bruun Christian Gahl 德国gmp建筑师事务所越南国家建设咨询公司

会议中心、酒店和博物馆镶嵌在一片以越南文化和传统作为特色主题和象征的开阔的景观园林内。会议中心作为主导建筑坐落于南北轴线上,几乎占据了以大湖、小池和假山为特色的整个景观公园的中心地带。与园林景观的有机形状形成鲜明对比... 详细信息

会议中心、酒店和博物馆镶嵌在一片以越南文化和传统作为特色主题和象征的开阔的景观园林内。会议中心作为主导建筑坐落于南北轴线上,几乎占据了以大湖、小池和假山为特色的整个景观公园的中心地带。与园林景观的有机形状形成鲜明对比的是：道路和步道系统规划为一个严密的线性网格。

关键词：南河景观园林中心地带园林景观博物馆酒店建筑公园

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No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner stefanie HMüller Dagmar steppat Joanna Miller Nele Schmidt Klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe Jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz annika Spottke Alexander storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

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