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proteomics of cell-free breast cancer scaffolds identify clinically relevant imprinted proteins and cancer-progressing properties

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Cancer Communications 2024年第6期44卷 695-699页

作者： Anna Gustafsson Emma Jonasson anders Stalberg Goan Landberg Sahlgrenska Center for Cancer Research Department of Laboratory of MedicineInstitute of BiomedicineSahlgrenska Academy at University of GothenburgGothenburgSweden Wallenberg Centre for molecular and Translational medicine University of GothenburgGothenburgSweden Department of Clinical Genetics and Genomics Sahlgrenska University HospitalRegion Vatra GoalandGothenburgSweden Department of Clinical pathology and Genetics Sahlgrenska University HospitalRegion Vatra GoalandGothenburgSweden

The composition of the extracellular tumor microenvironment(TmE)has not been fully delineated,limiting the understanding of general cancer-progressing properties within the cancer *** interplay and dynamics between cancer cells and the surrounding structures and cells clearly differ between various subtypes of cancer,adding to the complexity of precision medicine[1].

关键词： cancer clinically breast

Highly efficient vanadium redox flow batteries enabled by a trilayer polybenzimidazole membrane assembly

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Carbon Energy 2024年第7期6卷 191-204页

作者： Trung Tuyen Bui mingyu Shin mohammad Rahimi anders Bentien Yongchai Kwon Dirk Henkensmeier Hydrogen·Fuel Cell Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Chemical and Biomolecular Engineering Seoul National University of Science and TechnologySeoulRepublic of Korea Department of Biological and Chemical Engineering Aarhus UniversityAarhusDenmark KIST School Division of Energy and Environment TechnologyUniversity of Science and TechnologySeoulRepublic of Korea Graduate School of Energy and Environment Korea UniversitySeoulRepublic of Korea

A novel polybenzimidazole(pBI)-based trilayer membrane assembly is developed for application in vanadium redox flow battery(VRFB).The membrane comprises a 1μm thin cross-linked poly[2,2′-(p-oxydiphenylene)−5,5′-bibenzimidazole](OpBI)sandwiched between two 20μm thick porous OpBI membranes(p-OpBI)without further lamination *** trilayer membrane demonstrates exceptional properties,such as high conductivity and low area-specific resistance(ASR)of 51 mS cm−1 and 81mΩcm^(2),*** with vanadium electrolyte increases the ASR of trilayer membrane only to 158mΩcm^(2),while that of Nafion is 193mΩcm^(2).VO^(2+)permeability is 2.73×10^(-9) cm^(2) min^(−1),about 150 times lower than that of Nafion *** addition,the membrane has high mechanical strength and high chemical stability against VO^(2+).In VRFB,the combination of low resistance and low vanadium permeability results in excellent performance,revealing high Coulombic efficiency(>99%),high energy efficiency(EE;90.8%at current density of 80mA cm^(−2)),and long-term *** EE is one of the best reported to date.

关键词： polybenzimidazole porous membrane proton conductivity trilayer VRFBs

Fashion and out of fashion:appearance and disappearance of a novel nest building innovation

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Avian Research 2017年第2期8卷 71-75页

作者： anders p.møller Ecologie Systematique Evolution Universite Paris‑SudCNRSAgroParisTechUniversite Paris‑Saclay91405 Orsay CedexFrance

Background:Nests are composed of and built with different materials that are handled in specific ways. These mate?rials must initially have been used de novo before commonly being incorporated into nests. plastic and plastic bags were invented in the 1950s, and they are widely distributed in the environment. Birds started picking up.p.astic from plastic used to cover farm produce such as silage, potatoes, beets and other crops for use in their nests in the ***:I recorded the frequency of such plastic use by the Blackbird(Turdus merula) in nests in Denmark, starting in 1966, followed by a peak in use in the 1970s and a subsequent ***:Nests with plastic were initially built earlier in the season than those without plastic, indicating an associa?tion between innovation and early reproduction. plastic use was subsequently selected against because nests with plastic suffered from higher rates of predation than nests without plastic, probably because nests with plastic were easier to locate. However, the elevated risk of nest predation only applied to outdoor nests, but not to nests inside buildings, probably because visually searching nest predators such as corvids do not enter ***:These findings show that the dynamics of nest material use depend on the benefits of innovation and the fitness costs of nest predation.

关键词： Fashion Indoor breeding Innovation Nest predation Turdus merula

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural Regeneration Research 2025年第9期20卷 2591-2593页

作者： Alena Salasova anders Nykjær Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EmBL partnership for molecular medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Eco-evolutionary evidence for the global diversity pattern of Cycas(Cycadaceae)

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Journal of Integrative plant Biology 2024年第6期66卷 1170-1191页

作者： Jian Liu anders JLindstrom Yiqing Gong Shanshan Dong Yusheng(Chris)Liu Shouzhou Zhang Xun Gong CAS Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Department of Economic plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Global Biodiversity Conservancy 144/124 Moo3Soi Bua ThongBangsalaeSattahipChonburi 20250Thailand Key Laboratory of Southern Subtropical plant Diversity Fairy Lake Botanical GardenShenzhen&Chinese Academy of SciencesShenzhen 518004China Department of Earth and Environmental Sciences Indiana University-IndianapolisIndianapolisIN 46202USA

The evolution of the latitudinal diversity gradient(LDG),characterized by a peak in diversity toward the tropics,has captured significant attention in evolutionary biology and ***,the inverse LDG(i-LDG)mechanism,wherein species richness increases toward the poles,remains inadequately *** are among one of the oldest lineages of extant seed plants and have undergone extensive diversification in the ***,the extant cycad abundance exhibits an i-LDG pattern,and the underlying causes for this phenomenon remain largely ***,using 1,843 nuclear genes from a nearly complete sampling,we conducted comprehensive phylogenomic analyses to establish a robust species-level phylogeny for Cycas,the largest genus within *** then reconstructed the spatial-temporal dynamics and integrated global environmental data to evaluate the roles of species ages,diversification rates,contemporary environment,and conservatism to ancestral niches in shaping the i-LDG *** found Cycas experienced decreased diversification rates,coupled with the cooling temperature since its origin in the Eocene from continental *** regions have distinctively contributed to the formation of i-LDG for Cycas,with the northern hemisphere acting as evolutionary museums and the southern hemisphere serving as ***,water-related climate variables,specifically precipitation seasonality and potential evapotranspiration,were identified as paramount factors constraining Cycas species richness in the rainforest biome near the ***,the adherence to ancestral monsoonal climates emerges as a critical factor in sustaining the diversity *** study underscores the imperative of integrating both evolutionary and ecological approaches to comprehensively unravel the mechanisms underpinning global biodiversity patterns.

关键词： cycads latitudinal diversity gradient niche conservatism spatiotemporal diversification species richness

Influence of railway wheel tread damage on wheel-rail impact loads and the durability of wheelsets

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Railway Engineering Science 2024年第1期32卷 20-35页

作者： michele maglio Tore Vernersson Jens C.O.Nielsen anders Ekberg Elena Kabo CHARmEC Department of Mechanical and Maritime SciencesChalmers University of TechnologySE‑41296 GothenburgSweden

Dynamic wheel-rail contact forces induced by a severe form of wheel tread damage have been measured by a wheel impact load detector during full-scale field tests at different vehicle *** on laser scanning,the measured three-dimensional damage geometry is employed in simulations of dynamic vehicle-track interaction to calibrate and verify a simulation *** relation between the magnitude of the impact load and various operational parameters,such as vehicle speed,lateral position of wheel-rail contact,track stiffness and position of impact within a sleeper bay,is *** calibrated model is later employed in simulations featuring other forms of tread damage;their effects on impact load and subsequent fatigue impact on bearings,wheel webs and subsurface initiated rolling contact fatigue of the wheel tread are *** results quantify the effects of wheel tread defects and are valuable in a shift towards condition-based maintenance of running gear,and for general assessment of the severity of different types of railway wheel tread damage.

关键词： Wheel tread damage Rolling contact fatigue cluster Field measurements Dynamic vehicle-track interaction Wheel-rail impact load Wheelset durability

metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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The Innovation 2024年第2期5卷 107-114页

作者： Johan Gustafsson Fariba Roshanzamir anders Hagnestål Sagar m.patel Oseeyi I.Daudu Donald F.Becker Jonathan L.Robinson Jens Nielsen Department of Life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen Simone margaard Offersen anders Brunse mattia pirolo Soumya Kanti Kar Luca Guadabassi Thomas Thymann Department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CmT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GmT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all pprevalence on d 27(pmT showed a higher alpha diversity and a difference in beta diversity compared to CON(pparaclinical endpoints were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota mucosa Neonatal post-weaning diarrhea

Biological consequences of global change for birds

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Integrative Zoology 2013年第2期8卷 136-144页

作者： anders p.p. møller Department of Ecology Systematics and EvolutionUniversity Paris-SouthOrsay CedexFrance

Climate is currently changing at an unprecedented rate;so also human exploitation is rapidly changing the Earth for agriculture,forestry,fisheries and *** addition,pollution has affected even the most remote ecosystems,as has the omnipresence of humans,with consequences in particular for animals that keep a safe distance from potential predators,including human ***,all of these changes are occurring simultaneously,with increasing intensity,and further deterioration in both the short and the long-term is *** the consequences of these components of global change are relatively well studied on their own,the effects of their interactions,such as the combined effects of climate change and agriculture,or the combined effects of agriculture through nutrient leakage to freshwater and marine ecosystems and fisheries,and the effects of climate change and urbanization,are poorly ***,I provide a brief overview of the effects of climate change on phenology,diversity,abundance,interspecific interactions and p.p.lation dynamics of birds.I address whether these effects of changing temperatures are direct,or indirect through effects of climate change on the phenology,distribution or abundance of food,parasites and ***,I review interactions between different components of global change.

关键词： climate change direct effects global change indirect effects interactions