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Engineering 2021年第12期7卷 1653-1654页

作者： Hailing Tu xingdong zhang General Research Institute for Nonferrous Metals Beijing 100088China GRINM Group Corporation Ltd. Beijing 100088China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China

Biomedical engineering is a relatively new and exciting branch of life sciences that combines materials,devices,design,and problem-solving engineering with medical and biological sciences in order to improve healthcare treatments,including diagnosis,implantation,monitoring,and *** interdisciplinary field of biomedical engineering is changing the ways in which people interact with the *** prosthetic limbs to medicine-delivery technology,the pioneering work by biomedical scientists and engineers has been shaking the very foundations of traditional medicines and healthcare ***,the miniaturization of medical equipment has been a major breakthrough,facilitating the development of more advanced wearable devices.

关键词： breakthrough shaking implantation

Bioactive titanium metal surfaces with antimicrobial properties prepared by anodic oxidation treatment

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Science China(Technological Sciences) 2009年第8期52卷 2269-2274页

作者： YUE ChongXia YANG BangCheng zhang xingdong Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China National Engineering Research Center in Biomaterials Chengdu 610064China

In order to endow titanium metals with bioactivity and antimicrobial properties, titanium plates were subjected to anodic oxidation treatment in NaCl solutions in this study. The treated titanium metals could induce apatite formation in the fast calcification solution, and osteoblasts on the treated titanium surfaces proliferated well as those on the untreated titanium metal surfaces. The treated metals could inhibit S. aureus growth in the microbial culture experiments. It was assumed that Ti-OH groups and Ti-Cl groups formed on the treated titanium surface were responsible for the bioactivity and antimicrobial properties of the metals. The anodic oxidation treatment was an effective way to prepare bioactive titanium surfaces with antimicrobial properties.

关键词： titanium anodic oxidation bioactivity antimicrobial property

Vascular restoration therapy and bioresorbable vascular scaffold

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Regenerative Biomaterials 2014年第1期1卷 49-55页

作者： Yunbing Wang xingdong zhang National Engineering Research Center For Biomaterials Sichuan UniversityChengdu 610064China

This article describes the evolution of minimally invasive intervention technologies for vascular restoration therapy from early-stage balloon angioplasty in 1970s,metallic bare metal stent and metallic drug-eluting stent technologies in 1990s and 2000s,to bioresorbable vascular scaffold(BVS)technology in large-scale development in recent *** history,the current stage,the challenges and the future of BVS development are discussed in detail as the best available approach for vascular restoration *** criteria of materials selection,design and processing principles of BVS,and the corresponding clinical trial results are also summarized in this article.

关键词： bioresorbable vascular scaffold vascular restoration therapy vascular reparative therapy vascular disease bioresorbable/biodegradable material drug-eluting stent drug-eluting biodegradable stent drug-eluting bioresorbable scaffold

Functionalize d 3D-printe d porous titanium scaffold induces in situ vascularized bone regeneration by orchestrating bone microenvironment

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Journal of Materials Science & Technology 2023年第22期153卷 92-105页

作者： Bo Yuan Pin Liu Rui Zhao Xiao Yang Zhanwen Xiao Kai zhang Xiangdong Zhu xingdong zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China

Titanium(Ti)and its alloys have been extensively explored for treating load-bearing bone ***-ever,high-stress shielding,weak osteogenic activity,and insufficient vascularization remain key chal-lenges for the long-term clinical outcomes of Ti-based ***,inspired by structural and func-tional cues of bone regeneration,a silicon-doped nano-hydroxyapatite(nSiHA)/titanium dioxide(TiO_(2))composite coating with a hierarchical micro/nano-network structure is constructed on the surface of a 3D-printed porous Ti scaffold via a combined strategy of acid-alkali(AA)treatment and electrochemi-cal deposition technique,which not only endows the scaffold with excellent osteoinduction ability but can also effectively immobilize and release vascular endothelial growth factor(VEGF).The results of the in vitro cell experiments show that the functionalized Ti scaffold significantly promotes osteogenesis in bone marrow mesenchymal stem cells(BMSCs)and angiogenesis in human umbilical vein endothelial cells(HUVECs)by activating the extracellular signal-regulated protein kinase(ERK)and HIF-1αsignaling *** being implanted into a rat femoral condyle defect model,the functionalized Ti scaffold can induce in situ vascularized bone regeneration by orchestrating the two coupled processes of angio-genesis and *** findings indicate that the functionalized Ti scaffold has great potential in bone tissue regeneration and is a promising candidate for load-bearing bone defect repair.

关键词： Porous titanium 3D-printing Hierarchical micro/nano-structure Bone microenvironment Vascularization Bone regeneration

The material and biological characteristics of osteoinductive calcium phosphate ceramics

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Regenerative Biomaterials 2018年第1期5卷 43-59页

作者： Zhurong Tang Xiangfeng Li Yanfei Tan Hongsong Fan xingdong zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064P.R.China

The discovery of osteoinductivity of calcium phosphate(Ca-P)ceramics has set an enduring paradigm of conferring biological regenerative activity to materials with carefully designed structural *** unique phase composition and porous structural features of osteoinductive Ca-P ceramics allow it to interact with signaling molecules and extracellular matrices in the host system,creating a local environment conducive to new bone *** evidence now indicate that the osteoinductive activity of Ca-P ceramics is linked to their physicochemical and three-dimensional structural *** by this conceptual breakthrough,many laboratories have shown that other materials can be also enticed to join the rank of tissue-inducing biomaterials,and besides the bones,other tissues such as cartilage,nerves and blood vessels were also regenerated with the assistance of ***,we give a brief historical recount about the discovery of the osteoinductivity of Ca-P ceramics,summarize the underlying material factors and biological characteristics,and discuss the mechanism of osteoinduction concerning protein adsorption,and the interaction with different types of cells,and the involvement of the vascular and immune systems.

关键词： calcium phosphate ceramics porous structure osteoinduction tissue regeneration

The morphology of hydroxyapatite nanoparticles regulates clathrinmediated endocytosis in melanoma cells and resultant anti-tumor efficiency

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Nano Research 2022年第7期15卷 6256-6265页

作者： Hongfeng Wu Yuchen Hua Jinjie Wu Qin Zeng Xiao Yang Xiangdong Zhu xingdong zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterials&Institute of Regulatory Science for Medical Devices&NMPA Research Base of Regulatory Science for Medical Devices Sichuan UniversityChengdu 610064China Research Center for Materials Genome Engineering Sichuan UniversityChengdu 610064China

Clathrin-mediated endocytosis plays a critical role for hydroxyapatite nanoparticles(HANPs)to enter tumor cells,induce mitochondrial apoptosis,and inhibit tumor *** study was aimed to investigate how the morphology of HANPs impacts the endocytosis of the particles in melanoma cells,and their anti-tumor effect by using in vitro cell experiments and in vivo tumor animal *** shapes of HANPs,including granular HANPs(G-HANPs),rod-like HANPs(R-HANPs),and needle-like HANPs(N-HANPs),were successfully prepared by wet chemical *** the three HANPs could be internalized into A375 melanoma cells as indicated by cellular transmission electron microscopy *** these HANPs,only G-HANPs induced morphological change of mitochondria and loss of mitochondrial membrane potential(Δψm),and exhibited the greatest intracellular internalization efficiency in the tumor ***,the results of immunofluorescence staining and western blotting indicated that the level of adaptin-2(AP2)protein was up-regulated by all the HANPs,and highest in G-HANPs treated A375 ***,in the tumor-bearing mouse model,we found that tumor growth was delayed by all the three HANPs,of which,G-HANPs delayed tumor growth most efficiently and presented a highest expression level of AP2 protein in tumor ***,this study suggested that the morphology of HANPs regulated their endocytosis efficiency and their effect to inhibit tumor *** work facilitates to direct the rational design of nano-materials for tumor therapy.

关键词： hydroxyapatite nanoparticles adaptin-2 protein morphology endocytosis anti-tumor effect

Whisker of biphasic calcium phosphate ceramics: Osteoimmunomodulatory behaviors

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Nano Research 2022年第10期15卷 9169-9182页

作者： Jinjie Wu Cong Feng Menglu Wang Hongfeng Wu Xiangdong Zhu Xiangfeng Li Xuening Chen xingdong zhang National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China

Immune systems play a critical role in the regulation of bone formation and homeostasis,which arouses a growing interest in the development of biomaterials that can modulate both immune response and *** this study,biphasic calcium phosphate(BCP)ceramics were modified with different whiskered surface,and their effects on macrophage polarization and functional status were *** results showed that compared to BCP-W ceramics with long and solid whiskers,BCPHW ceramics with short and hollow whiskers surface were conducive to protein adsorption and macrophage ***,BCP-HW ceramics down-regulated the expression of M1 macrophage markers(Il1β,Tnfα,and iNos),promoted the expression of M2 macrophage markers(Il10 and Arg)and growth factors(Tgfβ1 and Bmp2),which might be attributed to the differential integrin expression regulated by different whisker *** conditioned medium derived from the supernatant of macrophage/whiskered ceramic co-culture was further used to culture MC3T3-E1 pre-osteoblasts to evaluate the effects of whiskered ceramic-mediated macrophage secretion on osteogenesis in *** with BCP-W ones,the secretion pattern induced by BCP-HW ceramics could promote the expression of bone markers in pre-osteoblasts,which might due to the activation of intracellular signaling cascades like BMP/Smad and TGF-β/Smad signaling pathways.A murine intramuscular implantation model suggested that after implantation for 1,2,and 3 weeks,BCP-HW ceramics drove the switch of macrophages to ARG+wound-healing M2 phenotype,while BCP-W ceramics increased the proportion of iNOS+M1 inflammatory *** 2 months,only BCP-HW could induce ectopic bone *** together,these results indicated that BCP ceramics with hollow whiskers were capable of creating a proper inflammatory microenvironment to induce bone *** whiskered BCP ceramics with good osteo-immunomodulatory capacity hold promise in serving as bone gra

关键词： whisker macrophage polariztion osteoinduction biphasic calcium phosphate surface structure

The directional migration and differentiation of mesenchymal stem cells toward vascular endothelial cells stimulated by biphasic calcium phosphate ceramic

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Regenerative Biomaterials 2018年第3期5卷 129-139页

作者： Ying Chen Jing Wang Xiangdong Zhu Xuening Chen Xiao Yang Kai zhang Yujiang Fan xingdong zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China

Osteoinductivity of porous calcium phosphate(CaP)ceramics has been widely investigated and confirmed,and it might be attributed to the rapid formation of the vascular networks after in vivo implantation of the *** this study,to explore the vascularization mechanism within the CaP ceramics,the migration and differentiation of bone marrow-derived mesenchymal stem cells(BMSCs)under the stimulation of porous biphasic calcium phosphate(BCP)ceramic with excellent osteoinductivity were systematically *** results indicated that the directional migration of BMSCs toward BCP ceramic occurred when evaluated by using a transwell model,and the BMSCs migration was enhanced by the seeded macrophages on the ceramic in ***,by directly culturing BMSCs on BCP ceramic discs under both in vitro and in vivo physiological environment,it was found that the differentiation of BMSCs toward vascular endothelial cells(VECs)happened under the stimulation of BCP ceramic,as was confirmed by the up-regulated gene expressions and protein secretions of VECs-related characteristic factors,including kinase insert domain receptor,von willebrand factor,vascular cell adhesion molecule-1 and cadherin 5 in the *** study offered a possibility for explaining the origin of VECs during the rapid vascularization process after in vivo implantation of porous CaP ceramics and could give some useful guidance to reveal the vascularization mechanism of the ceramics.

关键词： BCP ceramic vascularization BMSCs VECs migration differentiation

3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction

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Bio-Design and Manufacturing 2019年第3期2卷 161-171页

作者： Boqing zhang Huan Sun Lina Wu Liang Ma Fei Xing Qingquan Kong Yujiang Fan Changchun Zhou xingdong zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Orthopedics West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China

The bone regenerative scaffold with the tailored degradation rate matching with the growth rate of the new bone is essential for adolescent bone *** satisfy these requirement,we proposed bone tissue scaffolds with controlled degradation rate using osteoinductive materials(Ca-P bioceramics),which is expected to present a controllable biodegradation rate for patients who need bone *** properties,porosity,compressive strength and degradation properties of the scaffolds were studied.3D printed Ca-P scaffold(3DS),gas foaming Ca-P scaffold(FS)and autogenous bone(AB)were used in vivo for personalized beagle skull defect *** results indicated that the 3DS was highly vascularized and well combined with surrounding *** showed obvious newly formed bone *** showed the best repair effect,but it was found that AB scaffolds were partially absorbed and *** study indicated that the 3D printed Ca-P bioceramics with tailored biodegradation rate is a promising candidate for personalized skull bone tissue reconstruction.

关键词： 3D printing Skull repair Calcium phosphate ceramics Tailored biodegradation rate Bone reconstruction

Electrospun silk fibroin/poly(L-lactide-ecaplacton)graft with platelet-rich growth factor for inducing smooth muscle cell growth and infiltration

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Regenerative Biomaterials 2016年第4期3卷 239-245页

作者： Anlin Yin Gary L.Bowlin Rifang Luo xingdong zhang Yunbing Wang Xiumei Mo National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Biomedical Engineering University of MemphisMemphisTN 38152USA College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

The construction of a smooth muscle layer for blood vessel through electrospinning method plays a key role in vascular tissue ***,smooth muscle cells(SMCs)penetration into the electrospun graft to form a smooth muscle layer is limited due to the dense packing of fibers and lack of inducing *** this paper,silk fibroin/poly(L-lactide-e-caplacton)(SF/PLLA-CL)vascular graft loaded with platelet-rich growth factor(PRGF)was fabricated by *** in vitro results showed that SMCs cultured in the graft grew fast,and the incorporation of PRGF could induce deeper SMCs infiltrating compared to the SF/PLLA-CL graft *** properties measurement showed that PRGF-incorporated graft had proper tensile stress,suture retention strength,burst pressure and compliance which could match the demand of native blood *** success in the fabrication of PRGF-incorporated SF/PLLA-CL graft to induce fast SMCs growth and their strong penetration into graft has important application for tissue-engineered blood vessels.

关键词： vascular graft PRGF smooth muscle cell infiltration electrospinning