Electrospun silk fibroin/poly(L-lactide-ecaplacton)graft with platelet-rich growth factor for inducing smooth muscle cell growth and infiltration

作     者：Anlin Yin Gary L.Bowlin Rifang Luo Xingdong Zhang Yunbing Wang Xiumei Mo 

作者机构：National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Department of Biomedical EngineeringUniversity of MemphisMemphisTN 38152USA College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2016年第3卷第4期

页      面：239-245页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by National Natural Science Foundation of China(31500784) China Postdoctoral Science Foundation Funded Project(2015M580790) Program of Introducing Talents of Discipline to Universities(B16033) 

主　　题：vascular graft PRGF smooth muscle cell infiltration electrospinning 

摘      要：The construction of a smooth muscle layer for blood vessel through electrospinning method plays a key role in vascular tissue ***,smooth muscle cells(SMCs)penetration into the electrospun graft to form a smooth muscle layer is limited due to the dense packing of fibers and lack of inducing *** this paper,silk fibroin/poly(L-lactide-e-caplacton)(SF/PLLA-CL)vascular graft loaded with platelet-rich growth factor(PRGF)was fabricated by *** in vitro results showed that SMCs cultured in the graft grew fast,and the incorporation of PRGF could induce deeper SMCs infiltrating compared to the SF/PLLA-CL graft *** properties measurement showed that PRGF-incorporated graft had proper tensile stress,suture retention strength,burst pressure and compliance which could match the demand of native blood *** success in the fabrication of PRGF-incorporated SF/PLLA-CL graft to induce fast SMCs growth and their strong penetration into graft has important application for tissue-engineered blood vessels.