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Electron-ion collider in china

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Frontiers of physics 2021年第6期16卷 1-78页

作者： Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu chen Xurong chen Zhuojun chen Zhufang Cui Lingyun Dai {3.tian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang ren Craig Droberts Juan rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang rong Wang ruiru Wang Taofeng Wang {3. Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hong{3. Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou Guangdong Provincial key laboratory of Nuclear science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China IrFU CEAUniversitéParis-SaclayF-91191 Gif-sur-YvetteFrance institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China university of Chinese Academy of sciences Beijing 100049China Nankai university Tianjin 300071China Xinyang normal university Xinyang 464000China School of Physics and Materials science Guangzhou UniversityGuangzhou 510006China Hunan university Changsha 410082China Nanjing university Nanjing 210093China Huazhong university of science and Technology Wuhan 430074China European Centre for Theoretical Studies in Nuclear Physics and related Areas(ECT*)and Fondazione Bruno Kessler Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy School of Physics Peking UniversityBeijing 100871China Hunan normal university Changsha 410081China institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Nanjing normal university Nanjing 210023China Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Southwest Jiaotong university Chengdu 610000China Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.3210000 ZagrebCroatia Bogoliubov laboratory of Theoretical Physics Joint Institute for Nuclear ResearchDubna 141980Russia School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Lanzhou university Lanzhou 730000China key laboratory of Particle Physics and Particle Irradiation(moe) Shandong UniversityQingdao 266237China key laboratory of Quark and Lepton Physics(moe)and {3. of Particle Physics Central China Normal UniversityWuhan 430079China School of Physics Southeast UniversityNanjing 211189China key laboratory of Nuclear Physics and Ion-beam Application(moe) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Depa

Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as *** a future high energy nuclear physics project,an Electron-ion collider in china(EicC)has been *** will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron *** proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3.×103. cm^(−2)·s^(−1).Polarized deuterons and Helium-3.as well as unpolarized ion beams from Carbon to Uranium,will be also available at the *** main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3. tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark *** addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the *** order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge *** document is the result of collective contributions and valuable inputs from experts across the *** EicC physics program complements the ongoing scientific programs at the Jefferson laboratory and the future EIC project in the United *** success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in china.

关键词： electron ion collider nucleon structure nucleon mass exotic hadronic states quantum chromodynamics 3.-tomography helicity transverse momentum dependent parton distribution generalized parton distribution energy recovery linac polarization spin rotator

Advances in nuclear detection and readout techniques

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Nuclear science and Techniques 2023年第12期34卷 281-358页

作者： rui He Xiao‑Yang Niu Yi Wang Hong‑wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang wei‑Jia Han Bei Cao Gang chen Cong Dai Li‑Min Duan rui‑rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin cheng‑Ming Liu Guo‑rui Liu Jun‑Tao Liu Ze Long Meng‑chen Niu Hao Qiu Hu ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑run Yang Hong Yin Hong Yuan Chun‑Hui Zhang rui‑Guang Zhao ran Zheng cheng‑Xin Zhao institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy science and Technology Guangdong laboratory Huizhou 516000China key laboratory of Particle and radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi key laboratory for relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear science and Technology Lanzhou UniversityLanzhou 730000China State key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition radiation Detector,and readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MrPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

基于神经网络的直肠癌CT图像自动分割和分类

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中国医疗设备 2022年第2期37卷 60-64页

作者：肖波朱旭东魏华江魏波陈同生华南师范大学生物光子学研究院教育部激光生命科学重点实验室广东广州510631 华南师范大学生物光子学研究院广东省激光生命科学重点实验室广东广州510631 中山大学第三附属医院胃肠外科广东广州510630 华南师大(清远)科技创新研究院有限公司广东清远511517

目的为准确地定位直肠癌肿瘤位置以及对直肠癌进行术前T分期。方法首先分别采用FCN-8s、U-Net和SegNet模型对直肠癌CT图像进行分割以定位肿瘤位置。在分割基础上分别使用简单CNN、AlexNet和InceptionV3.型对分割后的CT图像进行识别并... 详细信息

目的为准确地定位直肠癌肿瘤位置以及对直肠癌进行术前T分期。方法首先分别采用FCN-8s、U-Net和SegNet模型对直肠癌CT图像进行分割以定位肿瘤位置。在分割基础上分别使用简单CNN、AlexNet和InceptionV3.型对分割后的CT图像进行识别并以此确定直肠癌T分期。选用240名患者的直肠癌CT图像进行训练和测试,分割结果评价指标采用Dice系数、精确率和召回率,分类结果评价指标采用准确率、特异性和灵敏度。结果分割中U-Net模型分割效果最佳且其分割肿瘤的平均Dice系数、精确率和召回率分别为84.6%、84.1%和85.2%。分割后使用InceptionV3.型分类效果最好且其分类直肠癌T2和T3.图像的准确率、特异性和灵敏度分别为95.4%、94.3.和96.1%。实验结果表明U-Net模型和InceptionV3.型可以获得更好的分割结果以及更高的分类准确率。结论神经网络模型在直肠癌CT图像上进行肿瘤分割和术前T分期都能达到很好的效果,可作为临床辅助诊断工具帮助医生制定直肠癌临床治疗方案。

关键词： CT图像神经网络图像分割图像分类术前T分期直肠癌

Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin H.r.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.chen S.M.chen Y.chen Y.X.chen J.cheng Z.K.cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo r.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu J.r.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji r.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee r.T.Lei r.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.r.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald r.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-ricoux A.OIshevskiy H.-r.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.raper J.ren C.Morales reveco r.rosero B.roskovec X.C.ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang r.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.wei L.H.wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.r.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 university of Wisconsin MadisonWisconsin 53706 Wright laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei institute of High Energy Physics Beijing 100049 National United university Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen university Shenzhen 518060 Sun Yat-Sen(Zhongshan)university Guangzhou North china Electric Power university Bejjing 102206 Chinese university of Hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 university of science and Technology of china Hefei 230026 Charles university Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence Berkeley National laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Joint institute for Nuclear research DubnaMoscow Region Beijing normal university Beijing 100875 Department of Nuclear science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 china institute of Atomic Energy Beijing 102413 Shandong university Jinan 250100 Guangxi university Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan university of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13.2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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基于单波长激发的定量FrET成像

激光生物学报 2018年第4期27卷 326-331页

作者：魏丽春苏文华陈同生华南师范大学生物光子学研究院激光生命科学研究所暨激光生命科学教育部重点实验室广东广州510631

本文发展了一种针对于固定FrET质粒的单波长激发的E-FrET方法(SDW-E-FrET)。相比于EFrET方法,SDW-E-FrET只需要测量供体激发时供体通道的荧光强度(IDD)和FrET通道的荧光强度(IDA),因此该方法可以实现活细胞的快速定量FrET成像。结合双... 详细信息

本文发展了一种针对于固定FrET质粒的单波长激发的E-FrET方法(SDW-E-FrET)。相比于EFrET方法,SDW-E-FrET只需要测量供体激发时供体通道的荧光强度(IDD)和FrET通道的荧光强度(IDA),因此该方法可以实现活细胞的快速定量FrET成像。结合双通道荧光显微成像系统,该方法无需任何机械切换,定量FrET成像的速度只取决于CCD相机的成像速度,因而特别适合活细胞实时动态定量FrET成像。在本研究小组发展的双通道荧光显微镜平台上,应用SDW-E-FrET方法测量了C5V和C17V的FrET效率,得到了与其它方法测量的一致的结果。

关键词：定量FrET成像 FrET探针单波长激发实时测量活细胞

大公差宽容度矩形孔准周期阵列实现对高阶衍射的有效抑制

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强激光与粒子束 2020年第7期32卷 60-65页

作者：魏来陈勇王少义范全平张强强张众王占山曹磊峰同济大学物理科学与工程学院精密光学工程研究所先进微结构材料教育部重点实验室上海200092 中国工程物理研究院激光聚变研究中心等离子体物理重点实验室四川绵阳621900

传统光栅的基础研究和应用研究进展一直备受关注。然而,高阶衍射污染使传统光栅获得的光谱纯度受到严重影响。为了抑制高阶衍射贡献,人们提出了许多单级或准单级光栅的设计方案,但它们对高阶衍射的抑制效果不可避免地受到加工精度的限... 详细信息

传统光栅的基础研究和应用研究进展一直备受关注。然而,高阶衍射污染使传统光栅获得的光谱纯度受到严重影响。为了抑制高阶衍射贡献,人们提出了许多单级或准单级光栅的设计方案,但它们对高阶衍射的抑制效果不可避免地受到加工精度的限制。提出了一种准周期矩形孔阵列光栅,通过优化矩形孔的概率密度分布函数,获得了比以往设计更大的加工误差宽容度。对这种光栅的衍射特性进行了分析研究。理论计算表明,即使孔径相对误差超过20%,光栅也可以完全抑制二阶、三阶和四阶衍射,五阶衍射效率与一阶衍射效率之比小于0.01%,大大降低了对加工精度的要求。

关键词：单级衍射光栅 X射线光谱仪加工误差宽容度

The Solar Upper Transition region Imager(SUTrI)Onboard the SATech-01 Satellite

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research in Astronomy and Astrophysics 2023年第6期23卷 153-171页

作者： Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie chen weidong Qiao wei Ge Fu Li Lei Jin Jiawei He Xiaobo chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu rui Liu Taijie Li Zhenggong Feng Yamin Wang chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space science University of Chinese Academy of SciencesBeijing 101408China School of Earth and Space sciences Peking UniversityBeijing 100871China key laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Tongji university Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringKey Laboratory of Advanced Micro-Structured Materials MOEShanghaiChina Xi'an institute of Optics and Precision Mechanics Chinese Academy of SciencesXi'an 710119China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201304China Yunnan Observatories Chinese Academy of SciencesKunming650011China

The Solar Upper Transition region Imager(SUTrI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3.*** employs a ritchey-Chrétien optical system with an aperture of 18 *** on-orbit observations show that SUTrI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization *** normal cadence of SUTrI images is 3. s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3.of SATech-01's orbit ***15 GB data is acquired each day and made available online after *** images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar *** observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.

关键词： Sun:transition region Sun:UV radiation Sun:activity space vehicles:instruments

The landscape of aging

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science china(life sciences) 2022年第12期65卷 2354-2454页

作者： Yusheng Cai wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu chen Fu-Hui Xiao Dingfeng Li ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie ren Liang Zhang Jun Wang weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu State key laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China institute for Stem Cell and regeneration Chinese Academy of SciencesBeijing 100101China Beijing institute for Stem Cell and regenerative Medicine Beijing 100101China Frontier science Center for Immunology and Metabolism Medical Research InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China university of Chinese Academy of sciences Beijing 100049China State key laboratory of Stem Cell and reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS key laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS key laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking university International Cancer institute Peking University Health Science CenterPeking UniversityBeijing 100191China School of Pharmaceutical sciences Tsinghua UniversityBeijing 100084China State key laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Pharmaceutical sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Colorectal Cancer Center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Department of Geriatrics Medical Center on Aging of Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China International laboratory in Hematology and Cancer Shanghai Jiaotong University School of Med

Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to *** is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and ***,the growing emphasis on “healthy aging” raises a series of important questions in life and social *** recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological *** an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.

关键词： aging mechanism intervention

飞行时间质谱即用型金黄色葡萄球菌质控样品研究

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食品安全质量检测学报 2020年第9期11卷 2952-2957页

作者：张涛张雅伦刘广鹏陈晨郭楠楠李献周巍河北省食品检验研究院河北省食品安全重点实验室石家庄050000 河北师范大学生命科学学院石家庄050000

目的评估即用型金黄色葡萄球菌质控样品在飞行时间质谱技术中的应用价值。方法将金黄色葡萄球菌质控样品分别在3.℃和室温环境25℃进行运输稳定性实验,在4及-20℃条件下进行储藏稳定性实验,并评价其稳定性。对保存在-20℃条件下不同时... 详细信息

目的评估即用型金黄色葡萄球菌质控样品在飞行时间质谱技术中的应用价值。方法将金黄色葡萄球菌质控样品分别在3.℃和室温环境25℃进行运输稳定性实验,在4及-20℃条件下进行储藏稳定性实验,并评价其稳定性。对保存在-20℃条件下不同时间的金黄色葡萄球菌质控样品进行质谱鉴定,并做VITEK全自动微生物分析系统鉴定及血浆凝固酶试验鉴定。结果即用型金黄色葡萄球菌质控样品稳定,质谱图相近,所得蛋白峰信息仅存微小差异,匹配度良好。VITEK全自动微生物分析系统及血浆凝固酶实验结果均为金黄色葡萄球菌,满足飞行时间质谱技术所需质控样品条件。结论基质辅助激光解析电离飞行时间质谱技术直接检测金黄色葡萄球菌具有简单快速、准确性高等优点,相较传统方法操作简单,检验结果更加直观,为飞行时间质谱技术鉴定金黄色葡萄球菌提供及时、准确的依据。

关键词：金黄色葡萄球菌质控样品基质辅助激光解析电离飞行时间质谱