The landscape of aging

作     者：Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu 

作者机构：State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and RegenerationChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative MedicineBeijing 100101China Frontier Science Center for Immunology and MetabolismMedical Research InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China CAS Key Laboratory of Genomic and Precision MedicineBeijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Tissue Microenvironment and TumorShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking University International Cancer InstitutePeking University Health Science CenterPeking UniversityBeijing 100191China School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China State Key Laboratory of Molecular Developmental BiologyInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Pharmaceutical SciencesBeijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Colorectal Cancer Center/Department of Gastrointestinal SurgeryShanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Department of GeriatricsMedical Center on Aging of Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China International Laboratory in Hematology and CancerShanghai Jiaotong University School of Medicine/Ruijin HospitalShanghai 200025China Shanghai Key Laboratory of Maternal Fetal MedicineClinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan ProvinceKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China CAS Center for Excellence in Animal Evolution and GeneticsChinese Academy of SciencesKunming 650223China Institute on Aging and Brain DisordersThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China State Key Laboratory of Cell BiologyShanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Aging and Vascular DiseasesHuman Aging Research Institute(HARI)and School of Life ScienceNanchang Universityand Jiangxi Key Laboratory of Human AgingNanchang 330031China Center of GrowthMetabolism and AgingKey Laboratory of Bio-Resource and Eco-EnvironmentMinistry of EducationCollege of Life SciencesSichuan UniversityChengdu 610065China Institute of Ageing ResearchHangzhou Normal UniversitySchool of Basic Medical SciencesHangzhou 311121China Advanced Innovation Center for Human Brain ProtectionNational Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine CenterInternational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China The Fifth People’s Hospital of ChongqingChongqing 400062China MOE Key Laboratory of Cellular DynamicsHefei National Research Center for Physical Sciences at the MicroscaleCAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research CenterSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Guangzhou LaboratoryGuangzhou International Bio IslandGuangzhou 510005China Department of Medicine and VAPSHCSUniversity of WashingtonSeattle 98195USA Department of Immunology and PathologyMonash University Faculty of MedicinePrahranVictoria 3181Australia Hudson Institute of Medical Researchand Monash University Department of Molecular and Translational ScienceClaytonVictoria 3168Australia Peking-Tsinghua Center for Life SciencesAcademy for Advanced Interdisciplinary StudiesCenter for Quantitative BiologyPeking UniversityBeijing 100871China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第12期

页      面：2354-2454页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

基　　金：supported by the National Natural Science Foundation of China(31871380,32000500,32070730,32170756,32170804,81330008,81671377,81725010,81725010,81872874,81921006,81922027,81971312,81991512,82030041,82103167,82122024,82125009,82125011,82130044,91749126,91949101,91949207,92049302) the National Key Research and Development Program of China(2017YFA0506400,2018YFA0800200,2018YFA0800700,2018YFA0900200,2018YFC2000100,2018YFC2000400,2018YFE-0203700,20192ACB70002,2019YFA0802202,2020YFA0113400,2020YFA0803401,2020YFA0804000,2020YFC2002800,2020YFC-2002900,2021ZD0202401) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100,XDA16010603,XDA16020400,XDB29020000,XDB39000000,XDB39000000,XDB39030300) the China Association for Science and Technology(2021QNRC001) the Beijing Municipal Science and Technology Commission(Z200022) the Natural Science Foundation of Shanghai(21JC1406400) the Key Programs of the Jiangxi Province China(20192ACB70002) the“Shu Guang”Project supported by the Shanghai Municipal Education Commission and Shanghai Education Development Foundation(19SG18) the Shanghai Sailing Program(22YF1434300) the Research Project of Joint Laboratory of University of Science and Technology of China and Anhui Mental Health Center(2019LH03) the Fundamental Research Funds for the Central Universities(WK2070210004) the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(YESS20210002) the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022083)。 

主　　题：aging mechanism intervention 

摘      要：Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.