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Chinese Chemical Letters 2012年第2期23卷 237-240页

作者： ali taherkhani Hassan Karimi-Maleh ali A.Ensafi Hadi Beitollahi Ahmad Hosseini Mohammad A.Khalilzadeh Hassan Bagheri Department of Physics Takestan Branchlslamic Azad UniversityTakestanlran Department of Chemistry Majlesi BranchIslamic Azad UniversityIsfahanIran Environment Department Research Institute of Environmental SciencesInternational Center for ScienceHigh Technology and Environmental SciencesKermanIran Department of Chemistry Qaemshahr BranchIslamic Azad UniversityQaemshahrlran Department of Chemistry Takestan Branchlslamic Azad UniversityTakestanlran

A carbon paste electrode（CPE） chemically modified with multiwall carbon nanotubes and ferrocene（FC） was used as a selective electrochemical sensor for the simultaneous determination of trace amounts of cysteamine（CA） and folic acid（FA）.This modified electrode showed very efficient electrocatalytic activity for the anodic oxidation of *** peak current of differential pulse voltammograms of CA and FA increased linearly with their concentration in the ranges of 0.7-200μmol/L CA and 5.0- 700μmol/L *** detection limits for CA and FA were 0.3μmol/L and 2.0μmoI/L,*** diffusion coefficient（D） and transfer coefficient（α） of CA were also *** conditions are sufficient to allow determination of CA and FA both individually and simultaneously.

关键词： Cysteamine Folic acid Carbon nanotube paste electrode Voltammetry

Dynamics of host immune responses to SARS-CoV-2

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World Journal of Clinical Cases 2021年第18期9卷 4480-4490页

作者： Reza taherkhani Sakineh taherkhani Fatemeh Farshadpour Department of Virology Bushehr University of Medical SciencesBushehr ***Iran Persian Gulf Tropical Medicine Research Center Bushehr University of Medical SciencesBushehr ***Iran School of Medicine Arak University of Medical SciencesArak ***Iran

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the most recent global health threat,is spreading throughout the world with worrisome speed,and the current wave of coronavirus disease 2019(COVID-19)seems to have no *** this mysterious virus challenges our ability to control viral infections,our opportunities to control the COVID-19 pandemic are gradually ***,pandemic management relies on preventive *** prevention is a good strategy to mitigate SARS-CoV-2 transmission,it still cannot be considered an absolute solution to eliminate this ***,developing a potent immunity against this viral infection seems to be the most promising strategy to drive down this ongoing global ***,with the emergence of new challenges in the context of immune responses to COVID-19,the road to control this devastating pandemic seems bumpier;thus,it is pivotal to characterize the dynamics of host immune responses to COVID-19,in order to develop efficient prophylactic and therapeutic *** begs the question of whether the effector mechanisms of the immune system are indeed potent or a possible contributing factor to developing more severe and lethal forms of *** this review,the possible role of the immunopathologic phenomena including antibody-dependent enhancement,cytokine storm,and original antigenic sin in severity and mortality of COVID-19 will be discussed.

关键词： SARS-CoV-2 COVID-19 Immune response Antibody-dependent enhancement Cytokine storm Original antigenic sin

Epidemiology of hepatitis E virus in Iran

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World Journal of Gastroenterology 2016年第22期22卷 5143-5153页

作者： Reza taherkhani Fatemeh Farshadpour Department of Microbiology and Parasitology School of Medicine Bushehr University of Medical Sciences Persian Gulf Biomedical Research Center Bushehr University of Medical Sciences Persian Gulf Tropical Medicine Research Center Bushehr University of Medical Sciences

Iran is known as an endemic country for hepatitis E virus(HEV) infection, while there are variations in the epidemiology of HEV infection throughout the country. The available epidemiological studies in different regions of Iran show HEV seroprevalence of 1.1%-14.2% among general population, 4.5%-14.3% among blood donors, 6.1%-22.8% among injecting drug users, 6.3%-28.3% among hemodialysis patients, 1.6%-11.3% among patients infected with other hepatitis viruses, 27.5% among patients with chronic liver disease, 30.8% among kidney transplant recipient patients, and 10%-16.4% among human immunodeficiency virus-infected patients. These variations reflect differences in the status of public health and hygiene, risk factors, and routes of transmission in different regions and groups. Therefore, it is necessary to review the epidemiology of HEV infection to determine the most prevalent risk factors and routes of transmission, and to evaluate the effectiveness of preventive strategies employed in the public health services of the country. Moreover, the other epidemiological aspects of HEV, including the genotypic pattern, extra hepatic manifestations, and incidence of chronic infection need to be investigated among Iranian population to expand the current knowledge on the epidemiology of HEV and to clarify the real burden of HEV infection. Therefore, this review was performed to provide a general overview regarding the epidemiology of HEV in Iran.

关键词： Hepatitis E virus General population Blood donors Injecting drug users Hemodialysis Immunocompromised patients Chronic liver disease Prevalence Epidemiology Iran

Global elimination of hepatitis C virus infection:Progresses and the remaining challenges

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World Journal of Hepatology 2017年第33期9卷 1239-1252页

作者： Reza taherkhani Fatemeh Farshadpour the Persian Gulf Tropical Medicine Research Center Bushehr University of Medical SciencesBushehr ***Iran

Today, with the introduction of interferon-free direct-acting antivirals and outstanding progresses in the prevention, diagnosis and treatment of hepatitis C virus(HCV) infection, the elimination of HCV infection seems more achievable. A further challenge is continued transmission of HCV infection in high-risk population specially injecting drug users(IDUs) as the major reservoir of HCV infection. Considering the fact that most of these infections remain undiagnosed, unidentified HCVinfected IDUs are potential sources for the rapid spread of HCV in the community. The continuous increase in the number of IDUs along with the rising prevalence of HCV infection among young IDUs is harbinger of a forthcoming public health dilemma, presenting a serious challenge to control transmission of HCV infection. Even the changes in HCV genotype distribution attributed to injecting drug use confirm this issue. These circumstances create a strong demand for timely diagnosis and proper treatment of HCV-infected patients through risk-based screening to mitigate the risk of HCV transmission in the IDUs community and, consequently, in the society. Meanwhile, raising general awareness of HCV infection, diagnosis and treatment through public education should be the core activity of any harm reduction intervention, as the root cause of failure in control of HCV infection has been lack of awareness among young drug takers. In addition, effective prevention, comprehensive screening programs with a specific focus on high-risk population, accessibility to the new anti-HCV treatment regimens and public education should be considered as the top priorities of any health policy decision to eliminate HCV infection.

关键词： Hepatitis C virus Epidemiology Elimination Injecting drug user Prevention Vaccine Diagnosis Treatment

Pediatric case with vaccine-related poliovirus infection: A case report

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World Journal of Clinical Pediatrics 2021年第5期10卷 106-111页

作者： Reza taherkhani Fatemeh Farshadpour Department of Virology School of MedicineBushehr University of Medical SciencesBushehr ***Iran

BACKGROUND As long as oral poliovirus vaccine(OPV)is used,the potential risk for the emergence of vaccine-related polioviruses *** SUMMARY We report a case of Sabin-like type 1 poliovirus infection in an immunocompetent 17-mo-old child after receiving four scheduled doses of ***,the four doses did not confer full protection,possibly because of interference created by other *** The surveillance of vaccine-related polioviruses has important implications for improving health policies and vaccination *** cases of vaccinerelated poliovirus infection might pose a potential risk to global poliovirus ***,the global withdrawal of OPV and a shift to the inclusion of only inactivated poliovirus vaccine in the vaccination schedule is the main objective of the polio eradication program.

关键词： Poliovirus Oral poliovirus vaccine Vaccine-associated paralytic poliomyelitis Case report

Epidemiology of Hepatitis E in Pregnant Women and Children in Iran: A General Overview

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Journal of Clinical and Translational Hepatology 2016年第3期4卷 269-276页

作者： Reza taherkhani Fatemeh Farshadpour Department of Microbiology and Parasitology School of Medicine Bushehr University of Medical Sciences Bushehr Iran Persian Gulf Biomedical Research Center Bushehr University of Medical Sciences Bushehr Iran Department of Microbiology and Parasitology School of Medicine Bushehr University of Medical Sciences Bushehr Iran Persian Gulf Tropical Medicine Research Center Bushehr University of Medical Sciences Bushehr Iran

From an epidemiological point of view,hepatitis E is an old infection in Iran,but only recently has its importance as a public health concern been considered from research and public health *** such,there is still a long road ahead to clarify the real burden of hepatitis E virus (HEV) infection in *** to the available epidemiological studies,the seroprevalence of HEV infection among pregnant women is between 3.6% and 7.4%,and among Iranian children is between 0.9% to 8.5%,varying by geographic regions within the country and directly dependent upon the sanitary status of *** addition to evaluating the sanitation level of a society,community-based seroprevalence studies of HEV infection demonstrate the most prevalent risk factors,the major routes of transmission,and the epidemiological patterns of HEV among that country's *** this review,the current knowledge about the pathogenesis and epidemiology of HEV infection in pregnant women and children in Iran,as well as the recent advances in diagnosis,prevention and treatment of HEV infection have been summarized.

关键词： Hepatitis E virus Pregnant women Children Epidemiology Iran

Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第1期25卷 42-58页

作者： Shahab Mahmoudvand Somayeh Shokri Reza taherkhani Fatemeh Farshadpour Department of Virology School of Medicine Ahvaz Jundishapur University of Medical Sciences Department of Medical Virology School of MedicineHamadan University of Medical Sciences The Persian Gulf Tropical Medicine Research Center Bushehr University of Medical Sciences

Hepatocellular carcinoma(HCC) is the fifth most common cancer, and hepatitis C virus(HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β(TGF-β), vascular endothelial growth factor(VEGF), Wnt/β-catenin(WNT), cyclooxygenase-2(COX-2) and peroxisome proliferator-activated receptor α(PPARα) by HCV core protein is implicated in the development of HCC. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of HCC. In addition, considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC.

关键词： Hepatitis C virus Core protein Transforming growth factorβ Vascular endothelial growth factor Wnt/β-catenin Cyclooxygenase-2 Peroxisome proliferatoractivated receptorα Hepatocellular carcinoma

Lurking epidemic of hepatitis C virus infection in Iran: A call to action

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World Journal of Hepatology 2017年第24期9卷 1040-1042页

作者： Reza taherkhani Fatemeh Farshadpour the Persian Gulf Biomedical Research Center Bushehr University of Medical Sciences the Persian Gulf Tropical Medicine Research Center Bushehr University of Medical Sciences

Despite having a relatively low prevalence in the Iranian general population, the burden of hepatitis C virus(HCV) infection is on the rise, and hepatitis C is predicted to be the most important leading cause of viral hepatitis-related mortality in the near future in Iran. The recent population-based epidemiological studies have revealed the predominant role of injecting drug use in increasing prevalence of HCV infection. Undoubtedly, new management paradigm is required to drive down the rising wave of hepatitis C in Iran. Priority should be given to young injecting drug users as the cornerstone of the lurking epidemic of HCV infection in Iran.

关键词： General population Injecting drug user Epidemiology Hepatitis C virus Iran

Surface ligand engineering on the optical properties of atomically precise AuAg nanoclusters

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Chinese Journal of Structural Chemistry 2023年第9期42卷 1-5页

作者： Xiang Liu Yifei Zhang Zhiwen Li Gao Li Farid taherkhani Hunan Drug Inspection Center Hunan Institute for Drug ControlChangsha410013China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang110034China University of Chinese Academy of Sciences Beijing100049China Departments of Production Engineering Universität Bremen Bibliothekstraße 128359Germany

*** In recent decade,atomically precise metal nanoclusters,comprised of metal kernel and surface protecting ligands,have appeared as a new and promising nanomaterial for abundant applications,such as nanocatalysis,sensor,photoluminescence,a few to name,which is attributed to their electron energy quantization arising from quantum size effect[1].And the very recent investigations showed that the configuration of metal kernel and the electronic properties of metal nanoclusters with the same metal core are largely affected by the surface protecting ligands[[2],[3]].For example,the surface ligands can significantly alter the catalytic performance of metal nanocluster catalysts(*** and selectivity)in a positive *** have found that the Au_(25)(SR)_(18)nanocluster with the aromatic ligands can give higher conversions and a markedly increasing selectivity toward the desired product[4].

关键词： precise clusters selectivity

Standardization of the Main Dimensions of Design Container Ships in Ports—A Case Study

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World Journal of Engineering and Technology 2017年第4期5卷 51-61页

作者： Soheil Radfar Amir taherkhani Roozbeh Panahi Department of Marine Structures Tarbiat Modares University Tehran Iran

Ports are crucial element in the export and import chains of each country. Therefore, sufficient and efficient designing of ports is of great importance to increase the safety of operations and to lower the construction costs. Their design procedure is iterative and specifications of the design ship are of the most important inputs in this regard. The design ship is characterized with its length (L), breadth (B), and draft (d). In this research a regression analysis has been carried out in the southern coasts of Iran (Persian Gulf) to obtain these specifications. The results have shown under- and over-estimations of the main dimensions. Hence, this supports the idea that it is worth performing individual regression analysis, especially in restricted waterways and in the regions with specific fleet for the sake of verification of recommended values by standard technical guidelines.

关键词： Length Breadth Draft Dead Weight Tonnage Terminal