Dynamics of host immune responses to SARS-CoV-2

作     者：Reza Taherkhani Sakineh Taherkhani Fatemeh Farshadpour 

作者机构：Department of VirologyBushehr University of Medical SciencesBushehr ***Iran Persian Gulf Tropical Medicine Research CenterBushehr University of Medical SciencesBushehr ***Iran School of MedicineArak University of Medical SciencesArak ***Iran 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第18期

页      面：4480-4490页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：SARS-CoV-2 COVID-19 Immune response Antibody-dependent enhancement Cytokine storm Original antigenic sin 

摘      要：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the most recent global health threat,is spreading throughout the world with worrisome speed,and the current wave of coronavirus disease 2019(COVID-19)seems to have no *** this mysterious virus challenges our ability to control viral infections,our opportunities to control the COVID-19 pandemic are gradually ***,pandemic management relies on preventive *** prevention is a good strategy to mitigate SARS-CoV-2 transmission,it still cannot be considered an absolute solution to eliminate this ***,developing a potent immunity against this viral infection seems to be the most promising strategy to drive down this ongoing global ***,with the emergence of new challenges in the context of immune responses to COVID-19,the road to control this devastating pandemic seems bumpier;thus,it is pivotal to characterize the dynamics of host immune responses to COVID-19,in order to develop efficient prophylactic and therapeutic *** begs the question of whether the effector mechanisms of the immune system are indeed potent or a possible contributing factor to developing more severe and lethal forms of *** this review,the possible role of the immunopathologic phenomena including antibody-dependent enhancement,cytokine storm,and original antigenic sin in severity and mortality of COVID-19 will be discussed.