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Powder metallurgy with space holder for porous titanium implants:A review

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Journal of Materials Science & Technology 2021年第17期76卷 129-149页

作者： alejandra Rodriguez-Contreras Miquel Punset JoséA.Calero Francisco Javier Gil Elisa Ruperez JoséMaría Manero Biomaterials Biomechanics and Tissue Engineering Group(BBT)Department of Materials Science and EngineeringUniversitat Politecnica de Catalunya(UPC)Av.Edurad Maristany 1608019BarcelonaSpain Barcelona Research Centre in Multiscale Science and Engineering Technical University of Catalonia(UPC)Av.Eduard Maristany 10-1408019BarcelonaSpain UPC Innovation and Technology Center(CIT-UPC).Technical University of Catalonia(UPC) C.Jordi Girona 3-108034Barcelona.Spain AMES GROUP SA.Carretera Nacional 340 Pol.Ind."Les Fallulles"08620Sant Vicenc dels HortsBarcelonaSpain Bioengineering Institute for Technology Universitat Intemacional de Catalunyac/Josep Trueta s/n08195BarcelonaSpain

One of the biggest challenges in the biocompatibility of implantable metals is the prevention of the stress shielding effect,which is related to the coupling of the bone-metal mechanical *** stress shielding phenomenon provokes bone resorption and the consequent adverse effects on prosthesis ***,it can be inhibited by adapting the stiffness of the implant *** the use of titanium(Ti)porous structures is a great alternative not only to inhibit this effect but also to improve the osteointegration of orthopedic and dental implants,a brief description of the techniques used for their manufacturing and a review of the current commercialized implants produced from porous Ti assemblies are compiled in this *** powder metallurgy(PM)with space holder(SH)is a powerful technology used to produce porous Ti structures,it is here discussed its potential for the fabrication of medical devices from the perspectives of both design and *** most important parameters of the technique such as the size and shape of the initial metallic particles,the SH and binder type of materials,the compaction pressure of the green form,and in the sintering stage,the temperature,atmosphere,and time are reviewed according to the bibliography ***,the importance of the porosity and its types together with the influence of the mentioned parameters in the final porosity and,consequently,in the ultimate mechanical properties of the structure are ***,a few examples of the PM-SH application for the manufacturing of orthopedic implants are presented.

关键词： Powder metallurgy Space holder method Porous titanium structures Medical devices Stress shielding effect Porous materials permeability Interconnected porosity Porous bone substitute materials Open-cell titanium foams Sintering-dissolution technique

COvID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner

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World Journal of Pediatrics 2022年第6期18卷 373-382页

作者： Carolina valderas Gastón Méndez alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval Department of Neurology Hospital Dr.Exequiel González CortésGran Avenida JoséMiguel Carrera 33008900085SantiagoRegión MetropolitanaChile

Background Since December 2019,the SARS-Cov-2 virus has been a global health *** main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been *** this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-Cov-2 infection and the pandemic’s effects in children with neurologic *** sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COvID-19,Neurological COvID-19,coronavirus,SARS-Cov-2,pediatric COvID-19,COvID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA *** studies cited were published between 2004 and 2022,and represent the most relevant articles in the *** World Health Organization COvID-19 online dashboard was assessed to obtain updated epidemiological *** The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle *** can be present during COvID-19 or weeks after recovering from *** who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and *** neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated *** the other hand,the COvID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and *** various neurologic manifestations have been associated with children’s SARS-Cov-2 *** is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting se

关键词： Coronavirus COvID-19 Neurologic Pediatric SARS-Cov-2 MIS-C

The largest dengue outbreak in Argentina and spatial analyses of dengue cases in relation to a control program in a district with sylvan and urban environments

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 227-234页

作者： Aníbal E Carbajo alejandra Rubio María J viani María R Colombo Laboratorio de Eoclogía de Enfermedades Transmitidas por vectores Instituto de Investigación e Ingeniería AmbientalUniversidad Nacional de General San Martín Consejo Nacional de Investigaciones Científicas y Técnicas Secretaria de Política Sanitaria y Desarrollo Humano Municipio de Tigre

Objective: To analyze the largest outbreak of dengue in Argentina in the municipality of Tigre during 2016, through detailed spatial analyses of the occurrence of cases in relation to demographic factors and vector control actions. Methods: Detailed and georreferenced data on dengue cases with laboratory results(NS1 or IgM) were analyzed. The occurrences of imported and autochthonous cases by census tract were modeled using demographic variables(population by age class, proportion of foreigners, proportion with university grade, proportion of males), dwelling variables(number of homes, proportion of dwellings with latrine, number of dwellings, proportion of houses, proportion of flats, proportion of slums) and census tract area as explanatory variables. The probability of occurrence of autochthonous and imported cases was modeled separately. The spatio-temporal occurrence of cases was studied in relation to focal and perifocal control actions(involving education campaigns, removal of Aedes aegypti breeding sites and exhaustive insecticide spraying) to assess the efficiency in stopping autochthonous cases spreading. Results: All autochthonous cases occurred in the urban environment with no sylvan cases. The majority of the imported cases registered came from Paraguay and Northeastern Argentina. The age structure of imported and autochthonous cases did not differ from the age structure of the municipality, while that of the negative cases *** studied spatially, the occurrence of imported cases by census tract was mildly associated with a higher proportion of foreign population and more people at active age, while occurrence of autochthonous cases was not significantly associated with any of the studied *** census tracts with laboratory confirmed results, the models showed higher probability of autochthonous cases related to higher population density and population age structure. The clustering of autochthonous cases was generally mild, with prevailing i

关键词： Aedes aegypti vector-borne diseases vector control Dengue epidemic

Proposed Strategies to Prevent High Solid Waste Generation,In the Urban Area of Panama

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Proposed Strategies to Prevent High Solid Waste Generation,I...

作者： Idalesky alejandra Nunez Peralta 上海交通大学

学位级别：硕士

The high waste generation in contrast to the limited capacity and infrastructure for its handling,the cultural patterns that exist,is a serious problem in Latin America,and Panama is not exempt from *** collects only the 65% of their total *** the total waste that they generate represents 1.22 *** person per *** does not have an integral system of waste management and treatment,not with the capacity,infrastructure,administration and economic flow for the amount of garbage *** activity in Panama and Latin America is basically done *** by the street workers who are exposed to diseases and pollution every *** contribution represents approximately 98% of the total activity of *** it is estimated that is only 2% of total solid waste ***,it is estimated that 70% of the solid waste of Panama,it is considered *** objectives of this research aims to cover a diagnosis of these factors influencing on the high generation of solid waste in Panama,explore the level of environmental and recycling culture of the citizens,analyze the development of the recycling industry,to evaluate strategies from model countries on waste management to analyze which of these strategies the Panamanian society would be more willing to *** methodology of this study included review of documents from previous studies,interview with the CO Founder of a Panamanian Foundation which helps to collect materials for recycling（Fundacion Costa Recicla）,and a survey for the evaluation of strategies,additional reports from the Government of Panama,at the same time official organizations of Latin America,The World Bank and *** results it was obtained,that in effect it is true the formulated by Forbes,about the five challenges in Latin America,that it is necessary: green politicians,education,fighting poverty,reuse of products and less *** have a good perception of the current and future eco

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Nest composition and worker relatedness in three slave-making ants of the genus Rossomyrmex Arnoldi and their Proformica Ruzsky hosts （Hymenoptera, Formicidae）

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Insect Science 2010年第4期17卷 361-368页

作者： Alberto Tinaut Francisca Ruano Olivia Sanllorente alejandra Fernandez-Zambrano Celal Karaman Yelimbek Kaz Department of Animal Biology Faculty of Sciences University of Granada Granada Spain Department of Biology Faculty of Arts and Sciences Trakya University Edirne Turkey Department of Biology Faculty of Sciences L.N. Gumilev Eurasian National University Astana Kazakhstan

In this paper, we analyze and compare nest composition and architecture as well as worker relatedness in three related species of slave-making ants： Rossomyrmex anatolicus, R. minuchae, and R. quandratinodum. Colony structure within nests is an important trait in ants, especially in the case of mixed societies, when host and parasite coexist in the same nest. Data for their respective free-living hosts, Proformica korbi, P.. longiseta and P. sp., are also provided. For our study, we integrated a meticulous excava- tion procedure with a genetic method. We conclude that the average number of parasites, as well as of slaves, is species-specific, whereas nest depth depends on the nest archi- tecture of the host. The genus Rossomyrmex seems to be monogynous and monandrous, whereas Proformica shows differences in the number of queens and mating frequency. R. quandratinodum shows different traits in nest composition （host/parasite ratio： P/R） and architecture. The difference in traits may account for some differences in parasitism： raid process or avoidance of parasitism.

关键词： nest architecture nest composition Proformica relatedness Rossomyrmex,slave-making ants

G2/M inhibitors as pharmacotherapeutic opportunities for glioblastoma:the old,the new,and the future

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Cancer Biology & Medicine 2018年第4期15卷 354-374页

作者： Angel Mauricio Castro-Gamero Julia alejandra Pezuk Maria Sol Brassesco Luiz Gonzaga Tone Human Genetics Laboratory Institute of Natural SciencesFederal University of Alfenas(UNIFAL-MG)Alfenas 37130-001Brazil Biotechnology and Innovation in Health Program and Pharmacy Program Anhanguera University Sao Paulo(UNIANSP)Sao Paulo 05145-200Brazil Department of Biology Faculty of PhilosophySciences and Letters at Ribeirao PretoUniversity of Sao PauloRibeirao Preto 14040-901Brazil Department of Pediatrics Department of Genetics Ribeirao Preto School of MedicineUniversity of Sao PauloRibeirao Preto 14049-900Brazil

Glioblastoma(GBM) is one of the deadliest tumors and has a median survival of 3 months if left untreated. Despite advances in rationally targeted pharmacological approaches, the clinical care of GBM remains palliative in intent. Since the majority of altered signaling cascades involved in cancer establishment and progression eventually affect cell cycle progression, an alternative approach for cancer therapy is to develop innovative compounds that block the activity of crucial molecules needed by tumor cells to complete cell division. In this context, we review promising ongoing and future strategies for GBM therapeutics aimed towards G2/M inhibition such as anti-microtubule agents and targeted therapy against G2/M regulators like cyclin-dependent kinases,Aurora inhibitors, PLK1, BUB, 1, and BUBR1, and survivin. Moreover, we also include investigational agents in the preclinical and early clinical settings. Although several drugs were shown to be gliotoxic, most of them have not yet entered therapeutic trials. The use of either single exposure or a combination with novel compounds may lead to treatment alternatives for GBM patients in the near future.

关键词： Chemotherapy PLK1 AURK survivin BUB BUR1

Multi-Sectoral Reflections and Efforts in Strengthening Partnerships to Reduce Disaster Risk in Mexico:The First MuSe-IDRiM Conference

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International Journal of Disaster Risk Science 2020年第5期11卷 686-691页

作者： Irasema Alcantara-Ayala Daniel Rodriguez-velazquez Ricardo J Garnica-Pena alejandra Maldonado-Martinez Institute of Geography National Autonomous University of Mexico(UNAM)04510 Mexico CityMexico National School of Social Work.National Autonomous University of Mexico(UNAM) 04510 Mexico CityMexico Disaster Risk Reduction Consultant 04700 Mexico CityMexico

Notwithstanding the high societal impact of disasters in Mexico,there is a lack of integrated efforts to establish a sound policy for reducing disaster risk to counterbalance the existing concentrated endeavors in disaster *** the face of such segmentation,the science and technology community has advocated for a change of perspective,from civil protection to integrated disaster risk *** first Multi-Sectoral Conference towards Integrated Disaster Risk Management in Mexico:Building a National Public Policy(MuSe-IDRiM Conference)was held in Mexico City at National Autonomous University of Mexico,21-24 October *** support of the implementation of the Sendai Framework for Disaster Risk Reduction 2015-2030,the conference aimed at enhancing the dialogue between the scienee and technology community,citizens,civil society organizations,private and public sectors,and the federtil,state,and municipal governments to foster the process of transforming the current National Civil Protection System into a national public policy oriented towards integrated disaster risk management(DRM).Barriers and challenges to the implementation of integrated DRM were *** of integrated DRM challenges current socioeconomic structures and encourages all releva nt stakeholders to think,decide,and act from a different perspective and within and across spatial,temporal,jurisdictional,and institutional *** disaster risk from an integrated approach,learning skills that authorities have not learned or used,and hence,strengthening disaster risk governance are prerequisites to effectively manage disaster risk.

关键词： Disaster risk reduction Integrated disaster risk management Mexico Science-based policy making SINAPROC

Production of Camphene by Isomerization Reaction on Sulfated ZrO_2

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Chinese Journal of Chemical Engineering 2000年第1期8卷 64-67页

作者： Nora alejandra Comelli Omar Masini Alfredo Lzaro Carrascull Esther Natalia Ponzi Marta Isabel Ponzi INTEQUI(CONICET-UNSL) Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaCINDECA(CONICET-UNLP)Calle 47 N°2571900 La PlataArgentina

The kinetics of camphene production in liquid phase from α-pinene was experimentally determined in an isothermal batch reactor. To this end, a sulfated ZrO2 catalyst was used and the reaction studied in the temperature range of 370-403 K. By analyzing the experimental data, second reaction order for α-pinene was found. A kinetic model is presented which includes term for the catalyst load used. The specific rate constant at 393K was 2.19×10^-3 mol·L^-1·min^-1, the activation energy being 93kJ·mo1·^-1. Both values are within the range of literature results.

关键词：生产工艺莰烯异构化反应硫酸盐催化剂 ZrO2 反应动力学 α-蒎烯

Microengineering double layer hydrogel structures towards the recapitulation of the hematopoietic stem cell niche

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Science Bulletin 2018年第20期63卷 1319-1323页

作者： Pilar Carreras Rodrigo Cortrim Chaves Miguel Gallardo alejandra Ortiz Joaquin Martinez Lopez Samuel K.Sia Department of Biomedical Engineering Columbia UniversityNew YorkNY 10032USA Hematology Department Research Institute i+12Hospital 12 OctubreMadrid 2804Spain Hematological Malignancies Clinical Research Unit H120 CNIOMadrid 28029Spain

Adult stem cells,especially from bone marrow,have a tremendous therapeutic potential,and its application in regenerative medicine has been increasingly studied [1,2].It is well known that three-dimensional (3D)cell culture matrix promotes many biological relevant functions not observed in two-dimensional (2D) monolayer cell culture [3]and therefore,engineering 3D cell culture platforms to mimic the native in vivo biological systems represents a realistic approach for studies of bone marrow stem cells. High-throughput microfluidics constitutes a promising technology to generate hydrogel three dimensional constructs [4,5],however, its application to host adult stem cells remains still a challenge.

关键词： hydrogel hematopoietic stem cell