COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner

作     者：Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval Carolina Valderas;Gastón Méndez;Alejandra Echeverría;Nelson Suarez;Katherin Julio;Francisca Sandoval

作者机构：Department of NeurologyHospital Dr.Exequiel González CortésGran Avenida JoséMiguel Carrera 33008900085SantiagoRegión MetropolitanaChile 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2022年第18卷第6期

页      面：373-382页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Coronavirus COVID-19 Neurologic Pediatric SARS-CoV-2 MIS-C 

摘      要：Background Since December 2019,the SARS-CoV-2 virus has been a global health *** main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been *** this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic *** sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA *** studies cited were published between 2004 and 2022,and represent the most relevant articles in the *** World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological *** The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle *** can be present during COVID-19 or weeks after recovering from *** who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and *** neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated *** the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and *** Various neurologic manifestations have been associated with children’s SARS-CoV-2 *** is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting se