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Zoonotic human liver flukes, a type 1 biocarcinogen, in freshwater fishes: genetic analysis and confirmation of molluscan vectors and reservoir hosts in Bangladesh

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贫困所致传染病(英文) 2024年第3期13卷 1-16页

作者： Labony Sharmin Shahid Alim Md. Abdul Hasan Muhammad Mehedi Hossain Md. Shahadat Akter Sharmin Paul Joydeep Farjana Thahsin Ali Md. Haydar alam mohammad zahangir Hatta Takeshi Kawada Hayato Mizutani Keiko Tsuji Naotoshi Anisuzzaman Department of Parasitology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh Department of Fisheries Technology Faculty of Fisheries Bangladesh Agricultural University Mymensingh Bangladesh Department of Biotechnology School of Life Sciences &amp Biotechnology Adamas University Barasat - Barrackpore Rd Jagannathpur Kolkata West Bengal India Department of Pathology and Parasitology Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh Department of Parasitology and Tropical Medicine Kitasato University School of Medicine-15-Kitasato Minami Sagamihara Kanagawa-0374 Japan Department of Molecular and Cellular Parasitology Kitasato University Graduate School of Medical Sciences-15-Kitasato Minami Sagamihara Kanagawa-0373 Japan

Background Opisthorchiid flukes, particularlyOpisthorchis viverrini,Opisthorchis felineus,Clonorchis sinensis, andMetorchis spp. are the most common fish-borne zoonotic human liver flukes (hLFs). Liver fluke infections are more prevalent in resource-deprived and underprivileged areas. We herein estimated the prevalence of the metacercariae (MC) of major hLFs in common large freshwater fishes (lFWF) marketed for human consumption from some selected areas of Bangladesh along with detection of their molluscan vectors and *** The current status of fish-borne zoonotic hLF infections in lFWF was investigated along with their molluscan vectors and mammalian reservoir hosts in Mymensingh and Kishoreganj in Bangladesh from July 2018–June 2022 using conventional and multiple molecular techniques, such as PCR, PCR-restriction fragment length polymorphism (RFLP), sequencing, and bioinformatic analyses. The infection rate of fishes was analyzed using theZ-test and the loads of MC were compared using the chi-squared (χ2) *** The MC ofC. sinensis,Opisthorchis spp., andMetorchis spp. were detected in 11 species of common and popular lFWF. In lFWF, the estimated prevalence was 18.7% and the mean load was 137.4 ± 149.8 MC per 100 g of fish. The prevalence was the highest (P 0.05) distributed between the head and body of fishes. The infection rate was slightly higher in cultured (19.6%) fishes. The MC ofC. sinensis,O. felineus,O. viverrini, andMetorchis orientalis in fishes were confirmed using PCR, PCR-RFLP and bioinformatics. The cercariae of opisthorchiid (Pleurolophocercus cercariae) flukes were only recovered fromBithynia spp. (3.9%, 42 out of 1089). The ova of hLFs from dogs (4.3%, 5 out of 116) and cats (6.0%, 6 out of 100), and adult flukes (***) from ducks

关键词： Human liver fluke Freshwater fish Molluscan vector Reservoir host Bangladesh

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Implications of electrode modifications in aqueous organic redox flow batteries

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Journal of Energy Chemistry 2024年第8期95卷 499-510,I0011页

作者： Zahid Manzoor Bhat mohammad Furquan Muhammad Aurang Zeb Gul Sial Umair alam Atif Saeed Alzahrani mohammad Qamar Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management(IRC-HTCM) King Fahd University of Petroleum&Minerals(KFUPM)Dhahran 31261Saudi Arabia Department of Materials Science and Engineering King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Interdisciplinary Research Center for Sustainable Energy Systems(IRC-SES) King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

Aqueous organic redox flow batteries(RFBs)exhibit favorable characteristics,such as tunability,multielectron transfer capability,and stability of the redox active molecules utilized as anolytes and catholytes,making them very viable contenders for large-scale grid storage *** attention has been paid on the development of efficient redox-active molecules and their performance optimization through chemical substitutions at various places on the backbone as part of the pursuit for high-performance *** the fact that electrodes are vital to optimal performance,they have not garnered significant *** research has been conducted on the effects of electrode modifications to improve the performance of *** primary emphasis has been given on the impact of electrode engineering to augment the efficiency of aqueous organic *** overview of electron transfer at the electrode-electrolyte interface is *** implications of electrode modification on the performance of redox flow batteries,with a particular focus on the anodic and cathodic half-cells separately,are then *** each section,significant discrepancies surrounding the effects of electrode engineering are thoroughly examined and ***,we have presented a comprehensive assessment along with our perspectives on the future trajectory.

关键词： Redox flow batteries Electrode modification Organic redox molecules Outer sphere and inner sphere

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Are gender inclusiveness and rural transformation interlinked?The case of Bangladesh

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Journal of Integrative Agriculture 2024年第6期23卷 2112-2126页

作者： Maria Fay Rola-Rubzen mohammad Jahangir alam Jon Marx Sarmiento Ismat Ara Begum Al Amin Al Abbasi Subrata Saha UWA School of Agriculture and Environment The University of Western AustraliaPerth 6009Australia Department of Agribusiness and Marketing Bangladesh Agricultural UniversityMymensingh-2202Bangladesh Department of Agricultural Economics Bangladesh Agricultural UniversityMymensingh-2202Bangladesh

Gender inclusiveness is important in the rural transformation process of Bangladesh as rural women play key roles in both agricultural and non-agricultural *** inclusiveness also leads to gender *** empirically evaluate relationships between rural transformation and gender inclusiveness in *** consider three rural transformation indicators:high-value commodities’share in agricultural output values,non-farm employment’s share in rural labor employment,and non-agricultural GDP’s share in total *** capturing gender inclusiveness include the per capita rural income of males and females,ratio of investments into gender programs,female access to education,access to healthcare,employment participation,land ownership,and asset *** test the effect of the difference in per capita rural income of males and females and the ratio of their incomes and check for the robustness of the gender variables across different model *** 128 district-level observations from 32 districts of Bangladesh across four time periods(2000,2005,2010 and 2016),we use both ordinary least squares and fixed effects panel regression *** find that female land and asset ownership and access to education and healthcare are robust determinants of various stages of rural ***,our results suggest that improving women’s ownership of land and assets and investing in women’s education and healthcare will likely contribute to a more inclusive rural transformation.

关键词： rural transformation Bangladesh gender inclusiveness investments on women

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Neural network study of the nuclear ground-state spin distribution within a random interaction ensemble

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Nuclear Science and Techniques 2024年第3期35卷 216-227页

作者： Deng Liu alam Noor A Zhen-Zhen Qin Yang Lei School of Mathematics and Physics Southwest University of Science and TechnologyMianyang 621010China School of Nuclear Science and Technology Southwest University of Science and TechnologyMianyang 621010China

The distribution of the nuclear ground-state spin in a two-body random ensemble(TBRE)was studied using a general classification neural network(NN)model with two-body interaction matrix elements as input features and the corresponding ground-state spins as labels or output *** quantum many-body system problem exceeds the capability of our optimized NNs in terms of accurately predicting the ground-state spin of each sample within the ***,our NN model effectively captured the statistical properties of the ground-state spin because it learned the empirical regularity of the ground-state spin distribution in TBRE,as discovered by physicists.

关键词： Neural network Two-body random ensemble Spin distribution of nuclear ground state

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Auto-tuning PVT data using multi-objective optimization: Application of NSGA-Ⅱ algorithm

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Petroleum 2024年第1期10卷 135-149页

作者： Abdolhadi Zarifi mohammad Madani mohammad Jafarzadegan Reservoir Engineering Systems Petroleum Engineering Department Main Office Building of National Iranian South Oil Company (NISOC) Combined Planning Management National Iranian Oil Company (NIOC) Reservoir Engineering Division Petroleum Engineering Department Petroleum Engineering and Development Company (PEDEC)

Reservoir simulation is known as perhaps the most widely used, accurate, and reliable method for field development in the petroleum industry. An integral part of a reliable reservoir simulation process is to consider robust and rigorous tuned EOS models. Traditionally, EOS models are tuned iteratively through arduous workflows against experimental PVT data. However, this comes with a number of drawbacks such as forcingly using weight factors, which upon alteration adversely affects the optimization *** objective of the current work is thus to introduce an auto-tune PVT matching tool using NSGA-II multi-objective optimization. In order to illustrate the robustness of the presented technique, three different PVT samples are used, including two black-oil and one gas condensate sample. We utilize PengRobinson EOS during all the manual and auto-tuning processes. Comparison of auto-tuned EOS-generated results with those of experimental and computed statistical error values for these samples clearly show that the proposed method is robust. In addition, the proposed method, contrary to the manual matching process, provides the engineer with several matched solutions, which allows them to select a match based on the engineering background to be best amenable to the problem at hand. In addition, the proposed technique is fast, and can output several solutions within less time compared to the traditional manual matching method.

关键词： Auto-tuning PVT Equation of state NSGA-II Multi-objective optimization

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The Influence of Rice Husk Ash on Mechanical Properties of the Mortar and Concrete: A Critical Review

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Open Journal of Civil Engineering 2024年第1期14卷 65-81页

作者： Md Jahangir alam Mithun Biswas mohammad Biplab Mia Shahin alam Md Mosabber Hossain College of Civil and Transportation Engineering Hohai University Nanjing China School of Civil Engineering Chang’an University Xi’an China

Increasing the population and infrastructure in both emerging and developed countries requires a considerable amount of cement, which significantly affects the environment. The primary materials of concrete (‘cement’) production emit a large quantity of CO2 into the environment. Also, the cost of conventional building materials like cement gives motivation to find geopolymer waste materials for concrete. To reduce harmful effects on the environment and cost of traditional concrete substance, alternative waste materials like rice husk ash (RHA), ground granulated blast-furnace (GGBS), fly ash (FA), and metakaolin (MK) can be used due to their pozzolanic behavior. RHA waste material with a high silica concentration obtained from burning rice husks can possibly be used as a supplementary cementitious material (SCM) in the manufacturing of concrete, and its strong pozzolanic properties can contribute to the strength and impermeability of concrete. This review paper highlights a summary of the positive effect of using RHA as a partial substitute for cement in building construction, as well as its optimal inclusion of enhanced mechanical properties like compressive strength, flexural strength, and split tensile strength of mortar and concrete.

关键词： Cement Rice Husk Ash RHA Properties Mechanical Properties Carbon Di-oxide Emission and Greenhouse Gas

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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： Md Rakibul alam Md Mizanur Rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

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Investigation of material composition,design,and performance of open-graded asphalt mixtures for semi-flexible pavement:A comprehensive experimental study

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 92-116页

作者： mohammad Taghipoor Abolfazl Hassani mohammad M.Karimi Department of Civil and Environmental Engineering Tarbiat Modares UniversityTehranIran

The primary goal of this study is the design and construction of semi-flexible pavement(SFP)mixture in accordance with the engineering and mechanical *** study involves the use of a range of gradation curves,air void contents,cellulose and synthesized fibers,and neat and modified asphalt binders to prepare the open-graded asphalt(OGA)*** analyze the characteristics of these mixtures,a variety of test,namely binder drainage,semi-circular bending(SCB),Cantabro,wheel tracking,indirect tensile strength(ITS),and permeability tests were ***,to analyze the prepared grouting material,flexural strength,compressive strength,and fluidity tests were *** the final stage,SFP was compared to HMA in terms of engineering characteristics and *** to the results,SFP was more resistant to skid,rutting,fire,and moisture damage,while HMA had a better performance in fracture tests,including SCB *** to the results of the mechanical performance tests conducted on OGA mixtures,the highest and lowest values for air void content to achieve the highest mechanical performance level were 30%-35%and 25%,***,based on the laboratory results,it was determined that the required void ratio for constructing OGA mixtures was 24%-26%based on the bitumen type and fibers amount in the ***,SFP mixture can be regarded as a viable alternative to common pavements thanks to its high resistance to rutting and moisture damage,long freezing-thawing fatigue life,and adequate fire and skid resistance.

关键词： Semi-flexible pavement mixture Open-graded asphalt mixture Engineering properties Cantabro test Hot mix asphalt

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Recent Progress in Bionic Hydrogels for Articular Cartilage:Tribological and Mechanical Characteristics

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Journal of Bionic Engineering 2024年第2期21卷 653-673页

作者： mohammad Javan Almasi Dangsheng Xiong School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

Cartilage regeneration and repair are considered clinical challenges since cartilage has limited capability for *** tissue-engineered materials have the ability to repair cartilage,they have weak mechanical characteristics and cannot resist long-term *** the other hand,surgery to replace the joint is frequently done to treat significant cartilage deterioration these ***,the materials that are being used for replacement have high friction coefficients,lack shock absorption functions,and lack *** research on natural articular cartilage structure and function may lead to bionic hydrogels,which have suitable physicochemical and biological characteristics(e.g.,tribological and mechanical properties and the ability to support loadbearing capability),but need *** on their tribological and mechanical characteristics,the current review highlights the most recent advancements of bionic hydrogels used for articular cartilage,highlighting both the field's recent progress and its potential for future *** this reason,firstly,some important property improvement methods of bionic hydrogels are discussed and then,the recent findings of various research on the making of those bionic materials are provided and *** seems that by using some modifications such as product design,surface treatments,animal tests,controlling the isoelectric point of hydrogels,and computer simulation,the intended mechanical and tribological characteristics of natural articular cartilage may be attained by the bionic hydrogels.

关键词： Bionic hydrogel Articular cartilage Mechanical property Tribological property Lubrication

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Ultrasensitive plasmonic sensor based on MDM waveguide containing Persian Orsi window cavities for refractive index and blood plasma sensing

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Optoelectronics Letters 2024年第7期20卷 406-411页

作者： mohammad Ghanavati mohammad Azim Karami School of Electrical Engineering Iran University of Science and Technology

We developed a plasmonic refractive index（RI） with a metal-dielectric-metal（MDM） structure that utilizes two Persian Orsi windows-like separated cavities with a high figure of merit（FoM） and ultrasensitivity. The simulated and optimized Ag-air-Ag MDM sensor for surface plasmon resonance（SPR） offers high RI sensitivity（SRI） and the ability to detect blood plasma concentration（BPC）. The results verified that structural parameters have an effect on S;RI;, full width at half maximum（FWHM）, FoM, sensitivity of blood plasma（S;p;） for right and left peaks, whose values are 1 345.45 nm·RIU;-1;, 32 nm, 42.04 RIU;-1;, 0.26 and 0.19 nm·L·g;-1;, respectively. The proposed design opens a new horizon in sensor development.

关键词： A

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