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Nerve growth factor pretreatment against glutamate-induced hippocampal neuronal injury Action mechanism of phosphatase and tensin homologue deleted on chromosome 10

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Neural Regeneration Research 2010年第1期5卷 5-9页

作者： Yae Hu Jiahui Mao Yan zhu ailing Zhou Department of Pathophysiology Medical School of Nantong University Nantong 226001 Jiangsu Province China

BACKGROUND： Nerve growth factor （NGF） attenuates glutamate-induced injury to hippocampal neurons, and the human tumor suppressor gene phosphatase and tensin homologue deleted on chromosome 10 （PTEN） promotes neuronal apoptosis. However, effects of PTEN in NGF-mediated neuroprotection against glutamate excitotoxicity remain poorly understood. OBJECTIVE： To investigate the relationship between NGF inhibition of glutamate-induced injury and PTEN. DESIGN, TIME AND SE＇I＇rlNG： The randomized, controlled, in vitro study was performed at the Department of Pathophysiology, Medical School of Nantong University, China from October 2007 to March 2008. MATERIALS： Glutamate, NGF, 4, 6-diamidino-2-phenyl-indolediacetate, 3-[4, 5-dimethylthiazol-2-yl]- 2, 5-diphenyl tetrazoliumbromide （M-I-F）, and lactate dehydrogenase kit （Sigma, USA）, fluorescence microscope and inverted phase contrast microscope （Olympus, Japan） were used in this study. METHODS： Hippocampal neurons were obtained from newborn （〈 24 hours） Sprague Dawley rats and cultured for 7 days. The control group was not treated with any intervention factor, the glutamate group was treated with glutamate （0.2 mmol/L）, and NGF groups were treated with NGF （10, 50, 100, and 200 μg/L, respectively） prior to glutamate treatment. MAIN OUTCOME MEASURES： The MTT and lactate dehydrogenase assays were applied to evaluate viability of hippocampal neurons. Morphological changes in hippocampal neurons were observed using an inverted phase-contrast microscope, and neuronal apoptosis was detected by 4, 6-diamidino-2- phenyl-indolediacetate staining. PTEN mRNA and protein expression were measured by reverse transcription-polymerase chain reaction and Western blot analysis, respectively. RESULTS： Glutamate （0.2 mmol/L） induced significantly decreased neuronal viability and greater lactate dehydrogenase efflux compared with the control group （P 〈 0.01）. However, compared with the glutamate group, cell viability significantly increased and lac

关键词： nerve growth factor glutamate phosphatase and tensin homologue deleted on chromosome 10 hippocampus neurons nerve factor

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Dithizone-functionalized C18 online solid-phase extraction-HPLC-ICP-MS for speciation of ultra-trace organic and inorganic mercury in cereals and environmental samples

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Journal of Environmental Sciences 2022年第5期34卷 403-410页

作者： Ying Wang ailing zhu Yingying Fang Changjun Fan Yanli Guo Zhiqiang Tan Yongguang Yin Yong Cai Guibin Jiang Laboratory of Environmental Nanotechnology and Health Effect Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Shimadzu China Innovation Center Shimadzu(China)Co.LTDBeijing 100020China Department of Chemistry and Biochemistry Florida International UniversityMiamiFL 33199United States

A simple and efficient dithizone-functionalized solid-phase extraction(SPE)procedure,online coupled with high-performance liquid chromatography(HPLC)-inductively coupled plasma mass spectrometry,was developed for the first time for enrichment and determination of ultra-trace mercury(Hg)species(inorganic divalent Hg(Hg(Ⅱ)),methylmercury(CH_(3)Hg(Ⅱ))and ethylmercury(C_(2)H_(5)Hg(Ⅱ))in cereals and environmental *** the proposed method,functionalization of the commercial C_(18) column with dithizone,enrichment,and elution of the above Hg species can be completed online with the developed SPE device.A simple solution of 2-mercaptoethanol(1%(V/V))could be used as an eluent for both the SPE and HPLC separation of Hg species,significantly simplifying the method and *** online SPE method was optimized by varying dithizone dose,2-mercaptoethanol concentration,and sample *** addition,the effect of pH,coexisting interfering ions,and salt effect on the enrichment was also *** the optimized conditions,the detection limits of Hg species for 5 mL water sample were 0.15 ng/L for Hg(Ⅱ),0.07 ng/L for CH_(3)Hg(Ⅱ),and 0.04 ng/L for C_(2)H_(5)Hg(Ⅱ)with recoveries in the range of 85%-100%.The developed dithizone-functionalized C_(18) SPE column can be reused after a single function-alization,which significantly simplifies the enrichment ***,the stability of Hg species enriched on the SPE column demonstrated its suitability for field sampling of Hg species for later laboratory *** environment-friendly method offers a robust tool to detect ultra-trace Hg species in cereals and environmental samples.

关键词： Mercury speciation Online solid-phase extraction HPLC-ICP-MS Dithizone Cereals Natural water

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Hydroxyl radical formation upon dark oxidation of reduced iron minerals: Effects of iron species and environmental factors

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Chinese Chemical Letters 2019年第12期30卷 2241-2244页

作者： ailing zhu Yingying Guo Guangliang Liu Maoyong Song Yong Liang Yong Cai Yongguang Yin Institute of Environment and Health Jianghan UniversityWuhan 430056China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Laboratory of Environmental Nanotechnology and Health Effect Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Chemistry and Biochemistry Florida International UniversityMiamiFL 33199United States

Dark formation of hydroxyl radical upon oxidation of reduced iron minerals plays an important role in the degradation and transformation of organic and inorganic ***,we compared the hydroxyl radical formation from various reduced iron minerals at different redox conditions.·OH production was generally observed from the oxidation of reduced iron minerals,following the order:mackinawite(FeS)>reduced nontronite(iron-bearing smectite clay)> pyrite(FeS2)> side rite(FeCO3).Structural Fe^2+ and dissolved O2 play critical roles in ·OH production from reduced iron minerals.·OH production increases with decreasing pH,and Cl^-has little effect on this *** importantly,dissolved organic matter significantly enhances ·OH production,especially under O2 purging,highlighting the importance of this process in ambient *** sunlight-independent pathway in which ’OH forms during oxidation of reduced iron minerals is helpful for understanding the degradation and transformation of various inorganic and organic pollutants in the redox-fluctuation environments.

关键词： Reduced iron minerals Hydroxyl radical Dark oxidation Mackinawite Dissolved organic matter

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Corrigendum to“Dithizone-functionalized C18 online solid-phase extraction-HPLC-ICP-MS for speciation of ultra-trace organic and inorganic mercury in cereals and environmental samples”Journal of Environmental Science 115(2022)403-410

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Journal of Environmental Sciences 2023年第2期124卷 963-964页

The authors regretThe authors would like to apologize for any inconvenience caused.

关键词： Figure mercury phase

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A Compact Difference Method for Viscoelastic Plate Vibration Equation

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Engineering（科研） 2021年第11期13卷 631-645页

作者： Cailian Wu Congcong Wei ailing zhu School of Mathematics and Statistics Shandong Normal University Jinan China

In this paper, a fourth-order viscoelastic plate vibration equation is transformed into a set of two second-order differential equations by introducing an intermediate variable. A three-layer compact difference scheme for the initial-boundary value problem of the viscoelastic plate vibration equation is established. Then the stability and convergence of the difference scheme are analyzed by the energy method, and the convergence order is . Finally, some numerical examples are given of which results verify the accuracy and validity of the scheme.

关键词： Viscoelastic Plate Vibration Equation Compact Difference Method Stability Convergence

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均匀棒纯纵向运动方程初边值问题的有限体积法

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系统科学与数学 2008年第7期28卷 867-885页

作者：姜子文朱爱玲山东师范大学数学科学学院济南250014

提出了均匀棒纯纵向运动方程初边值问题的有限体积格式,给出了有限体积解的误差分析,得到了有限体积解的最优阶L^2和H^1误差估计及超收敛H^1误差估计,提供了一个数值算例.

关键词：均匀棒纯纵向运动方程有限体积法误差估计

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线性抛物型积分微分方程的扩展混合体积元方法

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高等学校计算数学学报 2009年第3期31卷 193-205页

作者：朱爱玲姜子文徐强山东师范大学数学科学学院

1引言考虑线性抛物型积分微分方程初边值问题:这里x=（x,y）,Ω=（a,b）×（c,d）,（?）Ω是区域Ω的边界,p为未知函数,A=(a;);为已知的对称正定矩阵,B=(b;);为已知矩阵,而且a;,b;,(a;);（i,j=1,2）光滑有界,f∈L;（Ω）。

关键词： linear integro-differential equation of parabolic type expanded mixed covolume method error estimate

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南平市稻田土壤养分变化趋势分析

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中国农学通报 2023年第29期39卷 52-58页

作者：朱爱玲福建省南平市农田建设与土壤肥料技术推广站福建南平354200

了解和掌握南平市稻田土壤肥力状况和变化趋势,为合理施肥提供依据。对南平市2017—2021年每年543个稻田土壤定点取样的养分检测数据进行分析,结果表明:稻田土壤为酸性,pH总体有所提升;有机质含量属中等水平,总体呈下降趋势,但含量较缺... 详细信息

了解和掌握南平市稻田土壤肥力状况和变化趋势,为合理施肥提供依据。对南平市2017—2021年每年543个稻田土壤定点取样的养分检测数据进行分析,结果表明:稻田土壤为酸性,pH总体有所提升;有机质含量属中等水平,总体呈下降趋势,但含量较缺乏、中等水平的比例提高,较丰富、丰富水平的比例减少;碱解氮含量属中等水平,但总体呈降低趋势;速效磷含量属丰富水平,缺乏与中等水平的比例下降,丰富水平比例上升;速效钾含量属于中等水平,缺乏水平的比例下降,较丰富、丰富水平的比例上升。稻田土壤有机肥和无机肥的合理配施是维持农业可持续发展的关键土壤培肥措施,在化肥施用上应根据不同区域采取平衡施肥,控氮、稳钾、因地施磷,大配方、小调整的施肥原则。

关键词：水田土壤养分变化趋势分析

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美国发展教师领导力的路径与方法探析

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教师教育学报 2019年第1期6卷 92-99页

作者：朱爱玲西南大学教育学部重庆400715

美国对教师领导力(teacher leadership)的研究发展至今已将近四十年,在教师发展领域仍是一个热点话题。一方面,美国通过提供发展教师领导力的教育培训、建立发展教师领导力的平台、实施发展教师领导力的计划等多种途径来促进教师领导力... 详细信息

美国对教师领导力(teacher leadership)的研究发展至今已将近四十年,在教师发展领域仍是一个热点话题。一方面,美国通过提供发展教师领导力的教育培训、建立发展教师领导力的平台、实施发展教师领导力的计划等多种途径来促进教师领导力的发展;另一方面,美国又通过提高教师个人专业能力、发展有效的学校领导力、实施增加教师领导机会的政策和手段等多种方法来全方位地发展教师领导力。美国这种多途径、全方位地发展教师领导力的做法,为我国教师发展提供了重要的参考。

关键词：美国教师领导力路径方法

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区县图书馆少儿服务如何体现少儿本位意识

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科技情报开发与经济 2014年第7期24卷 73-75页

作者：朱爱玲南京栖霞区图书馆江苏南京210038

阐述了少儿本位意识的概念,从把握少儿读者的阅读生理和心理特点、以少儿视角观察社会和学习知识、让孩子与图书馆互动及图书馆服务创新等方面,探讨了区县图书馆少儿服务如何体现少儿本位意识的问题。

关键词：区县图书馆少儿本位意识少儿服务寓教于乐

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