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Health hazards related to conidia of Cladosporium—biological air pollutants in Poland, central Europe

Journal of Environmental Sciences 2018年第3期30卷 271-281页

作者： Elzbieta Weryszko-Chmielewska Idalia Kasprzyk Malgorzata Nowak Aneta Sulborska Joanna Kaczmarek agata szymanska Weronika Haratym Miroslaw Gilski Malgorzata Jedryczka Department of Botany Lublin University of Life Sciences Department of Environmental Biology University of Rzeszow Laboratory of Aeropalynology Faculty of Biology Adam Mickiewicz University Department and Clinic of Dermatology University of Medical Sciences Institute of Plant Genetics Polish Academy of Sciences Institute of Bioorganic Chemistry Polish Academy of Sciences Department of Crystallography Faculty of Chemistry Adam Mickiewicz University

The spores of Cladosporium Link. are often present in the air in high quantities and produce many allergenic proteins, which may lead to asthma. An aerobiological spore monitoring program can inform patients about the current spore concentration in air and help their physicians determine the spore dose that is harmful for a given individual. This makes it possible to develop optimized responses and propose personalized therapy for a particular sensitive patient. The aim of this study was to assess the extent of the human health hazard posed by the fungal genus Cladosporium. For the first time, we have determined the number of days on which air samples in Poland exceeded the concentrations linked to allergic responses of sensitive patients, according to thresholds established by three different groups（2800/3000/4000 spores per 1 m^3 of the air）. The survey was conducted over three consecutive growing seasons（April–September, 2010–2012） in three cities located in different climate zones of Poland（Poznan, Lublin and Rzeszow）. The average number of days exceeding 2800 spores per cubic meter（the lowest threshold） ranged from 61（2010） through 76（2011） to 93（2012）, though there was significant variation between cities. In each year the highest concentration of spores in the air was detected in either Poznan or Lublin, both located on large plains with intensive agriculture. We have proposed that an effective, science-based software platform to support policy-making on air quality should incorporate biological air pollutant data,such as allergenic fungal spores and pollen grains.

关键词： Environmental contaminant Biological air pollution Inhalant allergy AsthmaAllergen Conidium

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Role of pituitary adenylate cyclase-activating polypeptide in peripheral nerve regeneration:a cellular and molecular perspective

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Neural Regeneration Research 2024年第7期19卷 1429-1430页

作者： Grazia Maugeri Velia D’agata Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly

Neuro regeneration is a very complex phenomenon characterized by the generation of new neurons and synapses,involving connections between adjacent cells and axonal *** supplies additional longterm resources to replace... 详细信息

关键词： replace functional regeneration

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Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test,proof of acini–islet–acinar interactions

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World Journal of Experimental Medicine 2024年第3期14卷 101-107页

作者： Kateryna Pierzynowska Piotr Wychowański Kamil Zaworski Jarosław Woliński Janine Donaldson Dominika Szkopek Katarzyna Roszkowicz-Ostrowska agata Kondej Stefan G Pierzynowski Department of Biology Lund UniversityLund 22362Sweden Department of Animal Physiology The Kielanowski Institute of Animal Physiology and NutritionPolish Academy of SciencesJabłonna 05110Poland Anara AB Trelleborg 23132Sweden Department of Head and Neck and Sensory Organs Division of Oral Surgery and ImplantologyInstitute of Clinical DentistryGemelli Foundation for the University PoliclinicCatholic University of the“Sacred Heart”Rome 00168Italy Department of Oral Surgery Medical University of GdańskGdańsk 80211Poland Laboratory of Large Animal Models The Kielanowski Institute of Animal Physiology and NutritionPolish Academy of SciencesJabłonna 05110Poland School of Physiology Faculty of Health SciencesUniversity of the Witwatersrand(WITS)Johannesburg 2050South Africa Department of Medical Biology Institute of Rural HealthLublin 20090Poland

BACKGROUND The possible existence of an acini–islet–acinar(AIA)reflex,involving mutual amylase and insulin interactions,was investigated in the current acute experiment on *** To confirm the existence of an AIA reflex and justify the placement of the exocrine and endocrine pancreatic components within the same *** The study was performed on six pigs under general *** intravenous glucose tolerance test was performed,with a bolus infusion of 50%glucose to the jugular vein,while amylase(5000 U/kg)or vehicle intrapancreatic infusions were administered via the pancreaticoduodenalis cranialis artery during 30 min with a 1 mL/min flow *** The amylase infusion to pancreatic arterial circulation inhibited and delayed the insulin release peak which is usually associated with the highest value of blood glucose and is typically observed at 15 min after glucose infusion,for>1 *** intrapancreatic infusion of the vehicle(saline)did not have any effect on the time frame of insulin *** of 1%bovine serum albumin changed the insulin release curve dramatically and prolonged the high range of insulin secretion,far beyond the glucose *** Intrapancreatic arterial infusion of amylase interrupted the integrated glucose–insulin *** confirms an AIA reflex and justifies placement of the exocrine and endocrine pancreatic components within the same organ.

关键词： Amylase Glucose-insulin-amylase interaction Intravenous glucose tolerance test Acini-islet-acinar axis Insulin

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Effect of 5-HT1 agonist (sumatriptan) on anorectal function in irritable bowel syndrome patients

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World Journal of Gastroenterology 2006年第10期12卷 1591-1596页

作者： agata Mulak Leszek Paradowski Department of Gastroenterology and Hepatology Wroclaw Medical University WroclawPoland

AIM： To evaluate the effect of sumatriptan, a selective 5-HT1 agonist, on anorectal function in irritable bowel syndrome （IBS） patients. METHODS： Twenty-two IBS patients selected according to the Rome II criteria （F 15, M 7; mean age 29.3±6.8, range 22-44 years） were examined. The study was blind, randomized and placebo-controlled with a crossover design. Anorectal manometry and rectal balloon distension test were performed before and after the administration of placebo and sumatriptan. RESULTS： The administration of sumatriptan caused a significant increase in the resting anal canal pressure from 9.2±2.0 kPa to 13.1±3.3 kPa （P〈0.0001） connected with the increase in the anal sphincter length and high pressure zone. After sumatriptan injection a remarkable increase in the threshold for the first sensation from 27±9 mL to 34±12 mL （P〈0.05） and urge sensation from 61±19 mL to 68±18 mL （P〈0.01） was observed. Sumatriptan did not affect either the volume evoking the rectoanal inhibitory reflex or the results of the straining test. CONCLUSION： 5-HT1 receptors participate in the regulation of anorectal function. Elucidation of the role of 5-HT1 receptors in the pathophysiological mechanisms of IBS may have some therapeutic implications.

关键词： Sumatriptan 5-HT receptors Irritable bowel syndrome, Anorectal function

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What is attractive rural landscape?Differences in the social and expert assessment of the changes in the rural landscape of the Carpathian region in Poland with regard to the need of its protection

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Journal of Mountain Science 2023年第2期20卷 501-515页

作者： agata GAJDEK Barbara KRUPA Anna NOWAK Department of Landscape Architecture Institute of Agricultural SciencesEnvironmental Protection and DevelopmentCollege of Natural SciencesUniversity of Rzeszowul.Ćwiklińskiej 2PL-35-601 RzeszówPoland

Contemporary villages of the mountain region are subject to uncontrolled structural and spatial transformations,which cause deformation of centuries-old spatial systems of high cultural and natural *** aim of the study is to confront the opinions of the inhabitants and experts regarding the condition of the cultural landscape of the villages in south-eastern *** area belongs to the Carpathian region of Central *** historical and economic conditions of the studied region,related to the functioning in the post-war period,and then its breakdown and the development of the free market economy,constitute an interesting background for the proposed *** communities still remembering the period of difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,many difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,which is also expressed in a completely new,previously unknown way of managing the *** implemented in villages are associated by the inhabitants with the improvement of the standards and quality of *** assess them rather *** expert assessment of these landscape transformations indicates their negative dimension and the risk of losing timeless *** discrepancy in the assessment of experts and local residents creates difficulties in the protection of the rural ***,high-quality visual landscape features among rural residents is necessary from the point of view of its multi-faceted and effective *** initiatives and actions in the field of industry policy should play a significant role in this respect by consolidating the images of a harmonious landscape in the public awareness.

关键词： Polish village Landscape attractiveness Cultural landscape Spatial systems

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The role of gut micorbiome in obesity and diabetes

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World Journal of Pediatrics 2019年第4期15卷 332-340页

作者： Katarzyna Górowska-Kowolik agata Chobot Department of Pediatric Gastroenterology and Hepatology Clinical Hospital No 1ul.3-go Maja 13-1541-800 ZabrzePoland Department of Pediatrics Institute of MedicineUniversity of Opole45-418 OpolePoland

Background Obesity and diabetes became a grooving problem in both adults and *** hypotheses concerned agents involved in the excessive weight gain process and it's *** only genetic or environmental factors,but also intestinal microbiome seems to play a role in the pathophysiology of this *** sources A systematic review was conducted using Pubmed as the medical database *** concerning connection between microbiome and metabolic disorders such as obesity and diabetes from last 10 years were *** Intestinal bacteria may be involved both in the development of obesity,and its further *** pro-inflammatory and immunomodulating effect of dysbiosis are possible triggers of insulin resistance and *** interventions aimed at the microbiome,as well as attempts to modify the microbiome at later stages may become new opportunities in the prevention and treatment of obesity and carbohydrate metabolism *** The gut microbiome has been shown to be an important part of the metabolic *** use of probiotic,prebiotics and symbiotics is promising,but requires further investigations to determine the specific metabolic effects of each bacteria strain and substance.

关键词： Diabetes Microbiome Obesity

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Synthesis, structural and spectroscopic studies on GdBO_3:Yb^(3+)/Tb^(3+)@SiO_2 core-shell nanostructures

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Journal of Rare Earths 2015年第11期33卷 1148-1154页

作者： Konrad Kubasiewicz Marcin Runowski Stefan Lis agata Szczeszak Department of Rare Earths Faculty of Chemistry Adam Mickiewicz University

The presented study concerned up-converting core/shell type nanomaterials based on lanthanide（Ⅲ） ions, Ln（Ⅲ）, doped orthoborates. The system studied composed of the GdBO3 doped with Yb^3＋/Tb^3＋ luminescent core ensured an effective cooperative sensitization up-conversion, resulting in a bright green luminescence. The silica coating process was performed by a modified St？ber method, which resulted in the formation of core-shell nanostructures, making them suitable for bioapplications. The nanophosphors and nanocomposites were obtained by various methods, such as co-precipitation in the presence of Triton X-100 and micelle synthesis with ethylenediaminetetraacetic acid（EDTA） as organic modifiers/surfactants. The synthesized nanomaterials were characterized with the use of powder X-ray diffraction（XRD）, infrared light absorption with Fourier transform FT-IR spectra, transmission electron microscopy（TEM）, up-conversion emission spectra under IR light, as well as excitation spectra, emission spectra and fluorescence lifetimes under UV light, and their photophysical properties were compared.

关键词： Ln(Ⅲ) ions GdB O3 silica coating core-shell nanocomposites up-conversion cooperative sensitization rare earths

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Liver injury in the era of COVID-19

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World Journal of Gastroenterology 2021年第5期27卷 377-390页

作者： Halina Cichoż-Lach agata Michalak Department of Gastroenterology with Endoscopy Unit Medical University of LublinJaczewskiego 8Lublin 20-954Poland

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has undoubtedly revolutionized the whole globe and given a new point of view on respiratory tract ***,coronavirus disease 2019(COVID-19)cannot be perceived as a disease limited only to pneumonia with diverse *** and more reports have demonstrated a wide range of possible systemic symptoms,including hepatic *** injury has been observed in a significant proportion of patients,especially in those with a severe or critical ***-19 might provoke a deterioration of liver function in patients with already diagnosed chronic liver diseases and without pre-existing liver *** deterioration of liver function worsens the prognosis,increases the risk of a severe course of SARS-CoV-2 infection and prolongs the hospital *** general,patients who develop liver dysfunction in COVID-19 are mainly males,elderly people,and those with higher body mass *** underlying mechanisms for hepatic failure in patients infected with SARS-CoV-2 are still unclear,nevertheless liver damage appears to be directly connected with virus-induced cytopathic effects.A liver injury observed during hospitalization might be simultaneously caused by the use of potentially hepatotoxic drugs,mainly antiviral *** minireview focuses on a possible relationship between COVID-19 and the liver,potential molecular mechanisms of liver damage,the characteristics of liver injury and suggested factors predisposing to hepatic manifestations in COVID-19 patients.

关键词： SARS-CoV-2 infection COVID-19 Acute liver failure Chronic liver diseases Inflammation

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Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy

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World Journal of Gastroenterology 2013年第1期19卷 26-34页

作者： Halina Cichoz-Lach agata Michalak Department of Gastroenterology Medical University of Lublin20094 LublinPoland 2nd Faculty of Medicine Medical University of Lublin20059 LublinPoland

Hepatic encephalopathy is a medical phenomenon that is described as a neuropsychiatric manifestation of chronic or acute liver disease that is characterized by psychomotor,intellectual and cognitive abnormalities with emotional/affective and behavioral *** article focuses on the underlying mechanisms of the condition and the differences between hepatic encephalopathy and noncirrhotic hyperammonemic *** encephalopathy is a serious condition that can cause neurological death with brain edema and intracranial *** is assumed that approximately 60%-80% of patients with liver cirrhosis develop hepatic encephalopathy This review explores the complex mechanisms that lead to hepatic ***,noncirrhotic hyperammonemic encephalopathy is not associated with hepatic diseases and has a completely different *** hyperammonemic encephalopathy is a severe occurrence that is connected with multiple pathogeneses.

关键词： Hepatic encephalopathy Noncirrhotic hyperammonemic encephalopathy Pathogeneses Ammonia Astrocyte Oxidative stress

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Role of exercise in the brain:focus on oligodendrocytes and remyelination

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Neural Regeneration Research 2023年第12期18卷 2645-2646页

作者： Grazia Maugeri Velia D'agata Giuseppe Musumeci Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly Research Center on Motor Activities(CRAM) University of CataniaCataniaItaly Department of Biology Sbarro Institute for Cancer Research and Molecular MedicineCollege of Science and TechnologyTemple UniversityPhiladelphiaPAUSA

The phrase“Mens sana in corpore sano”taken from Juvenal's Satires(127 a.C.)represents one of the best-known and most used sentences of all time,whose meaning in the modern age refers to the importance of physical activity for mental health and *** literature demonstrated the positive role of exercise in counteracting several diseases,such as diabetes,cardiovascular diseases,neurodegenerative diseases,cancers and age-related disorders including muscle atrophy,the reduction of aerobic capacity,bone and cartilage loss.

关键词： meaning such exercise

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