检索结果-南通市图书馆

Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo adolfo lópez-ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández Adriana Jiménez laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stochastic Earned Duration Analysis for Project Schedule Management

引用

Engineering 2022年第2期8卷 148-161页

作者： Fernando Acebes David Poza JoséManuel González-Varona adolfo lópez-Paredes GIR INSISOC-Department of Business Organization and CIM School of Industrial EngineeringUniversity of ValladolidValladolid 47011Spain

Earned duration management(EDM)is a methodology for project schedule management(PSM)that can be considered an alternative to earned value management(EVM).EDM provides an estimation of devia-tions in schedule and a final project duration *** is a key difference between EDM and EVM:In EDM,the value of activities is expressed as work periods;whereas in EVM,value is expressed in terms of *** this paper,we present how EDM can be applied to monitor and control stochastic *** explain the methodology,we use a real case study with a project that presents a high level of uncertainty and activities with random *** analyze the usability of this approach according to the activities network topology and compare the EVM and earned schedule methodology(ESM)for PSM.

关键词： Earned duration management Earned value management Stochastic project control Duration forecasting Uncertainty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach

引用

Neural Regeneration Research 2019年第2期14卷 193-196页

作者： Javier Riancho Francisco J.Gil-Bea Ana Santurtun adolfo lópez de Munaín Service of Neurology Hospital Sierrallana-Idival CIBERNED (Center for Networked Biomedical Research on Neurodegenerative Diseases Ministry of Economy and Competitiveness Institute Carlos Ⅲ) Neurosciences Area Institute Biodonostia Department of Physiology and Pharmacology University of Cantabria-Idival Department of Neurology University Hospital Donostia Department of Neurosciences University of the Basque Country Universidad País Vasco-Euskal Herria Unibertsitatea

Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. However, the translation into clinical practice has been largely unsuccessful and the compounds failed when were tested in clinical trials. This might be explained, at least partially, by the enormous complexity of the disease both from clinico-epidemiological and a pathogenic points of view. In this review, we will briefly comment on the complexity of the disease focusing on some recent findings, and we will suggest how amyotrophic lateral sclerosis research might be reoriented to foster the advance in the diagnostic and therapeutic questions.

关键词： amyotrophic lateral sclerosis AlS environment epidemiology genes phenotype therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synchronization of Robot Manipulators Actuated By Induction Motors with Velocity Estimator

引用

Computer Modeling in Engineering & Sciences 2019年第11期121卷 609-630页

作者： Felipe J.Torres Gerardo V.Guerrero Carlos D.García Ricardo Zavala-Yoe Mario A.García adolfo R.lópez University of Guanajuato Division of Engineering Campus Irapuato-SalamancaCarretera Salamanca-Valle de Santiago km 3.5+1.8GuanajuatoSalamanca36885México National Technological of Mexico/National Center of Research and Technological Development Av.Palmira S/N colonia PalmiraMorelosCuernavaca62490México School of Engineering and Sciences Monterrey TechnologicalPuente 222 Ejidos de HuipulcoCiudad de México14380México Superior Technological Institute of Irapuato Carretera Irapuato-Silao km 12.5GuanajuatoIrapuato36821México

A complete modeling(including the actuator dynamics)of a robot manipulator that uses three-phase induction motors is presented in this paper.A control scheme is designed to synchronize robot manipulators actuated by induction motors under a masterslave scheme in the case where the joint velocity of the slave robots is *** of the research on the synchronization of robot manipulators assumes the use of ideal actuators to drive the joints;for that reason,in this work,a three-phase induction motor is considered to be a direct-drive actuator for each *** entire model of the mated system is obtained by a combination of the dynamics of the induction motor and robot ***,the synchronization control algorithm for a master-slave scheme in both the joint space and workspace of robot manipulators driven by induction motors is *** observer based on the entire model is proposed to estimate the joint velocity of the slave robot *** the lyapunov criterion,a stability analysis of the synchronization control with a velocity estimator is *** analytical results show the synchronization and estimation errors are globally,uniformly,and ultimately *** with multiple robots demonstrate the performance of the proposed control algorithm.

关键词： Synchronization robot manipulator induction motor lyapunov stability observer based on the model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimal Control of Nonlinear Systems Using Experience Inference Human-Behavior learning

引用

IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 90-102页

作者： adolfo Perrusquía Weisi Guo IEEE the School of Aerospace Transport and ManufacturingCranfield UniversityBedfordUK

Safety critical control is often trained in a simulated environment to mitigate *** migration of the biased controller requires further *** this paper,an experience inference human-behavior learning is proposed to solve the migration problem of optimal controllers applied to real-world nonlinear *** approach is inspired in the complementary properties that exhibits the hippocampus,the neocortex,and the striatum learning systems located in the *** hippocampus defines a physics informed reference model of the realworld nonlinear system for experience inference and the neocortex is the adaptive dynamic programming(ADP)or reinforcement learning(Rl)algorithm that ensures optimal performance of the reference *** optimal performance is inferred to the real-world nonlinear system by means of an adaptive neocortex/striatum control policy that forces the nonlinear system to behave as the reference *** and convergence of the proposed approach is analyzed using lyapunov stability *** studies are carried out to verify the approach.

关键词： Experience inference hippocampus learning system linear time-variant(lTV)systems neocortex/striatum learning systems nonlinear systems optimal control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antifungal Potential of Beauveria bassiana on Solanum lycopersicum l. Infected with Fusarium oxysporum f. sp. lycopersici

引用

Phyton-International Journal of Experimental Botany 2023年第4期92卷 1235-1255页

作者： Henry lópez-lópez Nancy Ruiz-lau Rocío Meza-Gordillo Víctor Manuel Ruiz-Valdiviezo Joseph Galthier Robledo-luchetti Carlos Alberto lecona-Guzmán Juan JoséVillalobos-Maldonado luc Dendooven Joaquín adolfo Montes-Molina laboratorio de Biotecnología vegetal Tecnológico Nacional de Mexico/Campus Tuxtla GutiérrezTuxtla Gutiérrez29050Mexico CONACYT-Tecnológico Nacional de Mexico/Campus Tuxtla Gutiérrez Tuxtla Gutiérrez29050México ABACUS CinvestavCiudad de México07360México

The objective of this work was to evaluate the effect of Beauveria bassiana(Bb 1205)on controlling Fusarium oxysporum ***(Fol 17108)in tomato plants in greenhouse *** of Bb 1205 was the most promising among the agronomic variables and expression of the activity of the enzymesβ-1,3-glucanases and *** of Bb 1205 occurred at a concentration of 1×108 conidia·ml−1,which was administered onto the leaves,directly into the soil and via *** with Fol 17108 occurred with 1×106 spores·ml−1,which were added directly to the *** was used for measuring agronomic parameters,namely activity of chitinases andβ-1,3-glucanases in foliage and *** Bb 1205 was added to the soil,the chlorophyll index and aerial part length showed significant *** addition,it was determined that root length,fresh weight of foliage,flower,and fruit count increased 82 days after inoculation(dai).Chitinase activity induced by Bb 1205 in leaves and roots of tomato plants infected with Fol 17108 was observed when injected into the stem at 32 dai(41.8 and 11.6-fold,respectively).Inoculation on the foliage showed a 10-fold increase ofβ-1,3-glucanases in the roots after 82 *** for leaves,a 3.8-fold increase was found when the stem was *** the different in vivo applications,Bb 1205 activated its defenses by expressing the chitinase enzymes andβ-1,3-glucanase,thus reducing the damage caused by Fol 17108,demonstrating increase plant growth thereafter.

关键词： Mycoparasitism agronomic parameters chitinases β-1,3-glucanases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PlANE WAVES NUMERICAl STABIlITY OF SOME EXPlICIT EXPONENTIAl METHODS FOR CUBIC SCHRODINGER EQUATION

引用

Journal of Computational Mathematics 2016年第4期34卷 385-406页

作者： Begona Cano adolfo Gonzalez-Pachon Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 VaUadolid Spain Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 Valladolid Spain

Numerical stability when integrating plane waves of cubic SchrSdinger equation is thor- oughly analysed for some explicit exponential methods. We center on the following second- order methods： Strang splitting and lawson method based on a one-parameter family of 2-stage 2nd-order explicit Runge-Kutta methods. Regions of stability are plotted and numerical results are shown which corroborate the theoretical results. Besides, a tech- nique is suggested to avoid the possible numerical instabilities which do not correspond to continuous ones.

关键词： Numerical stability Exponential splitting lawson methods Projection ontoinvariant quantities Plane waves SchrSdinger equation.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel approach to the dynamic response analysis of Euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

引用

Earthquake Engineering and Engineering Vibration 2024年第2期23卷 389-401页

作者： adolfo Foriero Filippo Santucci de Magistris Giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a Euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported Euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Training,Certification and Qualification of Translators and Interpreters:reflections on the present and the future

引用

中国翻译 2016年第6期37卷 48-52页

作者： adolfo Gentile 澳大利亚翻译资格认证局

We are in a world of instantaneous communication where professional and academic connections are only a clic *** I do not believe we can say that we have a unitary approach to the concept of Translation and therefore to training,certification and *** Gambier and Ubaldo Stecconi have embarked on a proj ect called World Atlas of Translation

关键词：英语翻译方法阅读知识阅读材料

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reconstructing the puzzle of the role of therapeutic endoscopy in the management of post-bariatric surgery complications

引用

World Journal of Gastroenterology 2022年第23期28卷 2633-2635页

作者： Konstantinos Argyriou adolfo Parra-Blanco Department of Gastroenterology University Hospital of LarisaLarisa GR41110Greece Department of Gastroenterology Nottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom

We have recently read with interest the mini-review article"Therapeutic endoscopy for the treatment of post-bariatric surgery complications".The abovementioned article is a brief overview of the different endoscopic modalities employed in the management of bariatric surgery complications and represents an important decision support tool for clinicians to improve their current *** we appreciate the endeavor of larsen and Kozarek,based on our indepth analysis,we came across several minor issues in this article;thus,we present our comments in this *** case the authors contemplate these comments in their relevant research,we believe that their contribution would be considerable for future studies.

关键词： Endoscopic treatment Bariatric surgery Complications Obesity Sleeve gastrectomy Roux-en-Y gastric bypass

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：