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Could ketamine be the answer to treating treatment-resistant major depressive disorder?

General Psychiatry 2020年第5期33卷 296-300页

作者： abdullah mohammed ramadan Islam Ahmed Mansour Psychiatry Mansoura University Faculty of MedicineMansouraEgypt

Major depressive disorder(MDD)is a common,serious,debilitating condition affecting 350 million people worldwide,which remains to be unsatisfactorily treated with 53%of patients still complaining of symptoms after completing their courses with the correct ***,which was approved by the Food and Drug Administration in 2019,is a potential treatment option for those recalcitrant *** mechanism of ketamine is not fully understood,but as type it is classified as an N-methyl-D-aspartate(NMDA)glutamate receptor antagonist,and can be given intravenously,intranasally and *** is used to treat treatment-resistant depression,depression associated with suicidal ideation,mood and anxiety disorders and depressions associated with either type of bipolar *** ketamine is considered relatively safe,several side effects have been reported with the major ones being psychiatric in the form of worsening mood,anxiety and agitation;psychotomimetic in the form of dissociation,perceptual disturbance and abnormal sensations;cardiovascular in the form of increased blood pressure and increased heart rate;and neurological in the form of headache and *** is still not approved worldwide for usage in patients with treatment-resistant MDD,but if it is approved sometime in the future with relatively fewer side effects,it is expected to significantly save millions of dollars spent yearly on patients with treatment-resistant depression and that will lift this major burden off the shoulders of healthcare *** study was designed to measure the effects of ketamine,an NMDA receptor antagonist,on patients with treatment-resistant MDD and to analyse the concept that makes it different and relatively safer than other major antidepressants like selective serotonin reuptake inhibitors,monoamine oxidase inhibitors and TCAs(tricyclic antidepressants).

关键词： ketamine dosage sensation

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Are climate change and mental health correlated?

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General Psychiatry 2021年第6期34卷 49-57页

作者： abdullah mohammed Hassan ramadan Ahmed G Ataallah Department of Psychiatry Mansoura University Faculty of MedicineMansouraEgypt

Climate change is one of the biggest challenges of our time and is likely to affect human beings in substantial ***,researchers started paying more attention to the changes in climate and their subsequent impact on the social,environmental and economic determinants of health,and the role they play in causing or exacerbating mental health *** effects of climate change-related events on mental well-being could be classified into direct and indirect *** direct effects of climate change mostly occur after acute weather events and include post-traumatic stress disorder,anxiety,substance abuse disorder,depression and even suicidal *** indirect effects include economic losses,displacement and forced migration,competition over scarce resources and collective *** risk factors for developing those mental health issues include young age,female gender,low socioeconomic status,loss or injury of a loved one,being a member of immigrant groups or indigenous people,pre-existing mental illness and inadequate social ***,in some individuals,especially those undisturbed by any directly observable effects of climate change,abstract awareness and acknowledgement of the ongoing climate crisis can induce negative emotions that can be intense enough to cause mental health *** strategies should be provided to the affected communities to protect their mental health from collapse in the face of climate *** of the mental health impacts of climate change should be raised,especially in the high-risk *** and global attention to the climate crisis and its detrimental effects on mental health are *** paper was written with the aim of trying to understand the currently,scientifically proven impact of climate change-related disasters on mental health and understanding the different methods of solving the problem at the corporate level,by trying to decrease greenhouse gas emissions to zero,and at the i

关键词： mostly collective likely

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Generalized Truncated Fréchet Generated Family Distributions and Their Applications

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Computer Modeling in Engineering & Sciences 2021年第2期126卷 791-819页

作者： ramadan A.ZeinEldin Christophe Chesneau Farrukh Jamal mohammed Elgarhy abdullah M.Almarashi Sanaa Al-Marzouki Deanship of Scientific Research King AbdulAziz UniversityJeddah21589Saudi Arabia Faculty of Graduate Studies for Statistical Research Cairo UniversityAl OrmanGiza Governorate12613Egypt Universite de Caen LMNOCampus IIScience 3Caen14032France Department of Statistics The Islamia University of BahawalpurPunjab63100Pakistan The Higher Institute of Commercial Sciences Al Mahalla Al KubraAlgarbia31951Egypt Statistics Department Faculty of ScienceKing AbdulAziz UniversityJeddah21551Saudi Arabia

Understanding a phenomenon from observed data requires contextual and efficient statistical *** models are based on probability distributions having sufficiently flexible statistical properties to adapt to a maximum of *** examples include the distributions of the truncated Fréchet generated *** this paper,we go even further by introducing a more general family,based on a truncated version of the generalized Fréchet *** generalization involves a new shape parameter modulating to the extreme some central and dispersion parameters,as well as the skewness and weight of the *** also investigate the main functions of the new family,stress-strength parameter,diverse functional series expansions,incomplete moments,various entropy measures,theoretical and practical parameters estimation,bivariate extensions through the use of copulas,and the estimation of the model *** considering a special member of the family having the Weibull distribution as the parent,we fit two data sets of interest,one about waiting times and the other about *** statistical criteria attest that the proposed model is superior over other extended Weibull models,including the one derived to the former truncated Fréchet generated family.

关键词： Truncated distribution general family of distributions incomplete moments entropy copula data analysis

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Premature ejaculation:an update on definition and pathophysiology

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Asian Journal of Andrology 2019年第5期21卷 425-432页

作者： mohammed Abu El-Hamd ramadan Saleh Ahmad Majzoub department of Dermatology Venereology and AndrologyFaculty of MedicineSohag UniversitySohag 82749Egypt Department of Urology Hamad Medical Corporation and Weill Cornell Medicine-QatarDoha 00974Qatar

Premature ejaculation(PE)is the most comm on male sexual dysfunction,which represents a diag no stic as well as a therapeutic challenge for ***,no universally accepted definition is currently available for *** a result,physicians continue to diagnose patients with PE according to major guidelines set by the professional *** guidelines either recommend the use of validated questionnaires or patient-reported *** efforts directed toward classifying PE may help provide a better understanding of the prevalence and risk factors of this *** the exact etiology of PE has not been clearly elucidated,several risk factors have been strongly reported in the ***,to understand the revised definition of PE,its etiology and pathophysiology is necessary to improve the clinical management of this medical condition and form the basis of future research in this *** this review,we highlight the past and current definitions of PE and present an appraisal on the classifications and theories suggested for the etiopathogenesis of PE.

关键词： ejaculatory disorders male sexual dysfunction premature ejaculation

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Diagnosis of Various Skin Cancer Lesions Based on Fine-Tuned ResNet50 Deep Network

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Computers, Materials & Continua 2021年第7期68卷 117-135页

作者： Sameh Abd ElGhany Mai ramadan Ibraheem Madallah Alruwaili mohammed Elmogy Department of Information Systems College of Computers and Information SciencesJouf UniversitySakakaSaudi Arabia Department of Information Systems Faculty of Computers and InformationMansoura UniversityEgypt Department of Information Technology Faculty of Computers and InformationKafrelsheikh UniversityEgypt Department of Computer Engineering and Networks College of Computers and Information SciencesJouf UniversitySaudi Arabia Department of Information Technology Faculty of Computers and InformationMansoura UniversityMansoura35516Egypt

With the massive success of deep networks,there have been signi-cant efforts to analyze cancer diseases,especially skin *** this purpose,this work investigates the capability of deep networks in diagnosing a variety of dermoscopic lesion *** paper aims to develop and ne-tune a deep learning architecture to diagnose different skin cancer grades based on dermatoscopic ***-tuning is a powerful method to obtain enhanced classication results by the customized pre-trained ***,batch normalization,and hyperparameter optimization are performed for ne-tuning the proposed deep *** proposed ne-tuned ResNet50 model successfully classied 7-respective classes of dermoscopic lesions using the publicly available HAM10000 *** developed deep model was compared against two powerful models,i.e.,InceptionV3 and VGG16,using the Dice similarity coefcient(DSC)and the area under the curve(AUC).The evaluation results show that the proposed model achieved higher results than some recent and robust models.

关键词： Deep learning model multiclass diagnosis dermatoscopic images analysis ResNet50 network

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Gut virome:New key players in the pathogenesis of inflammatory bowel disease

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World Journal of Methodology 2025年第2期15卷 27-43页

作者： Helal F Hetta Rehab Ahmed Yasmin N ramadan Hayam Fathy mohammed Khorshid Mohamed M Mabrouk Mai Hashem Department of Medical Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of Microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of Microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Internal Medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Department of Internal Medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Department of Tropical Medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

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Timing and Classication of Patellofemoral Osteoarthritis Patients Using Fast Large Margin Classifier

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Computers, Materials & Continua 2021年第4期67卷 393-409页

作者： Mai ramadan Ibraheem Jilan Adel Alaa Eldin Balbaa Shaker El-Sappagh Tamer Abuhmed mohammed Elmogy Faculty of Computers and Information Kafrelsheikh UniversityEgypt Faculty of Physical Therapy Kafrelsheikh UniversityEgypt Faculty of Physical Therapy Nahda UniversityNUBEgypt Universidade de Santiago de Compostela Santiago de CompostelaSpain College of Computing Sungkyunkwan UniversitySeoul06351Korea Faculty of Computers and Information Mansoura UniversityMansoura35516Egy

:Surface electromyogram(sEMG)processing and classication can assist neurophysiological standardization and evaluation and provide habitational *** timing of muscle activation is critical in determining various medical conditions when looking at sEMG *** muscle activation timing allows identication of muscle locations and feature validation for precise *** work aims to develop a predictive model to investigate and interpret Patellofemoral(PF)osteoarthritis based on features extracted from the sEMG signal using pattern *** this end,sEMG signals were acquired from ve core muscles over about 200 reads from healthy adult patients while they were going ***,offset,and time duration for the Transversus Abdominus(TrA),Vastus Medialis Obliquus(VMO),Gluteus Medius(GM),Vastus Lateralis(VL),and Multidus Muscles(ML)were acquired to construct a classication *** proposed classication model investigates function mapping from real-time space to a PF osteoarthritis discriminative feature *** activation feature space of muscle timing is used to train several large margin classiers to modulate muscle activations and account for such activation *** fast large margin classier achieved higher performance and faster convergence than support vector machines(SVMs)and other state-of-the-art *** proposed sEMG classication framework achieved an average accuracy of 98.8%after 7 s training time,improving other classication techniques in previous literature.

关键词： literature.Keywords:Muscle activation onset time LS-SVM surface electromyogram patellofemoral osteoarthritis the timing of core muscles

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Omicron: Egyptian nurses’ knowledge and attitudes

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Journal of Integrative Nursing 2022年第1期4卷 15-19页

作者： Mostafa SHABAN Marwa Mamdouh SHABAN Osama ramadan Huda Hamdy mohammed Department of Nursing College of Applied Medical SciencesJouf UniversitySakakaSaudi Arabia Department of Community Health Nursing Faculty of NursingCairo UniversityCairoEgypt Department of Maternal and New-born Health Nursing Faculty of NursingHelwan UniversityHelwanEgypt

Objective:The current study aimed to assess the knowledge and attitudes of nurses toward the current COVID-19 pandemic and Omicron *** and Methods:A cross-sectional online survey was *** 277 Egyptian nurses completed an electronic questionnaire comprising demographics with 5 items,nurses’knowledge on Omicron with 18 questions,and nurses’attitudes on Omicron with 5 *** data collected were expressed using numbers,percentages,and mean and standard ***:The mean age of nurses was 27±5 years,nearly 50%of the nurses were bachelor *** total score of correct answers related to knowledge was 75%,showing the different degrees of knowledge about *** majority of nurses showed positive attitudes toward controlling and managing the COVID-19 ***:Egyptian nurses have average knowledge about Omicron and a positive attitude toward controlling the COVID-19 *** should be scope for further assessment to enhance understanding about ***,health education programs should be developed for nursing staff to improve information,beliefs,behaviors,and attitudes towards the Omicron variant in particular and the COVID-19 pandemic in general.

关键词： Attitude COVID-19 Egypt knowledge Omicron pandemic

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Pomegranate peel extract lessens histopathologic changes and restores antioxidant homeostasis in the hippocampus of rats with aluminium chloride-induced Alzheimer’s disease

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Asian Pacific Journal of Tropical Medicine 2020年第10期13卷 456-463页

作者： Steve Harakeh Wafaa S.ramadan mohammed S.Al Muhayawi Soad Al Jaouni Shaker Mousa Khalid Rehman Hakeem Special Infectious Agent Unit King Fahd Medical Research CenterKing Abdulaziz UniversityKingdom of Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Department of Anatomy Faculty of MedicineAin Shams UniversityCairoEgypt Department of Medical Microbiology/Parasitology and Molecular Microbiology Laboratory KAUHKing Abdulaziz UniversityKingdom of Saudi Arabia Department of Hematology/Pediatric Oncology King Abdulaziz University Hospital(KAUH)Faculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Yousef Abdul Latif Jameel Scientific Chair of Prophetic Medicine Application Faculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Pharmaceutical Research Institute Albany College of Pharmacy and Health SciencesRensselaerNYUSA Department of Biological Sciences Faculty of SciencesKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To investigate the neuroprotective efficacy of pomegranate and ellagic acid on the histopathological changes in the hippocampus of an aluminium chloride(AlCl3)induced rat model of Alzheimer’s ***:Sprague Dawley rats were divided into 4 groups(n=10each):GroupⅠ:serving as negative control;GroupⅡ,Alzheimer model,induced by administration of 17 mg/kg bw AlCl3;GroupⅢ,administered the same dose of AlCl3 with 50 mg/kg of pomegranate peel extract and GroupⅣ:administered ellagic acid(50 mg/kg)in addition to the same dose of *** medication given to all groups continued for 28 *** were given the compounds by gastric *** arm maze test,hippocampus antioxidant markers,histopathology of the dentate gyrus,and CA3 of the hippocampus were ***:Rats treated with pomegranate peel extract exposed to radial arm maze test showed less number of errors and reduced time needed to reach the *** was an increase in the levels of glutathione,catalase,and total antioxidant capacity and decreased lipid peroxidation *** features in dentate gyrus and CA3 as apoptosis and chromatolysis of pyramidal cells and granular layer,respectively,were *** characteristic neurofibrillary tangles and senile plaques were *** with ellagic acid ameliorated the pathological results but to a statistically lower ***:Pomegranate peel extract alleviates memory deficit and restores antioxidant homeostasis following degenerative changes in the hippocampus induced by aluminium chloride in rats.

关键词： Pomegranate Peel extract Ellagic acid Antioxidants Hippocampus Behavioural test

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Evaluating the influence of a structured nursing protocol on targeted outcomes in rheumatoid arthritis patients

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Journal of Integrative Nursing 2024年第1期6卷 22-28页

作者： mohammed Elsayed ZAKY Shimaa Magdi FARGHALY Osama Mohamed Elsayed ramadan Rehab M.ABDELKADER Mostafa SHABAN Department of Medical Surgical Nursing Faculty of Nursing Cairo UniversityCairoEgypt Department of Medical Surgical Nursing College of NursingJouf UniversitySakakaAljawfSaudi Arabia Faculty of Nursing Cairo University CairoEgypt Department of Geriatric Nursing Faculty of Nursing Cairo UniversityCairoEgypt

Objective:Rheumatoid arthritis(RA)requires comprehensive *** nursing protocols may enhance outcomes,but evidence is *** study evaluated the effect of a structured nursing protocol on RA *** and Methods:In this one-group pre-post study,30 Egyptian RA patients completed assessments before and after a 12-week nursing protocol comprising education,psychosocial support,and self-management *** included clinical evaluation of joint counts,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)and patient-reported Arthritis Self-Efficacy Scale(ASES),Health Assessment Questionnaire(HAQ),Visual Analog Scale(VAS)for pain,and Hospital Anxiety and Depression Scale(HADS).Results:The study demonstrated significant improvements in both clinical-and patient-reported *** count decreased from 18.4±4.2 to 14.2±3.8(P<0.001),ESR from 30.1±6.8 mm/h to 25.5±6.8 mm/h(P<0.01),and CRP levels from 15.2±3.6 mg/L to 11.8±2.9 mg/L(P<0.01)***-reported outcomes showed a marked increase in ASES score from 140±25 to 170±30(P<0.001)and reductions in HAQ from 1.6±0.4 to 1.3±0.3(P<0.01),VAS pain score from 7.8±1.7 to 6.2±1.2(P<0.001),and HADS anxiety and depression scores from 11±3 to 8±2(P<0.05)and 10±2 to 7±1(P<0.05),***:A structured nursing protocol significantly improved clinical disease activity,physical functioning,pain,self-efficacy,and emotional well-being in RA patients.A multifaceted nursing intervention appears beneficial for optimizing RA outcomes.

关键词： Nursing care patient education quality of life rheumatoid arthritis self‑management

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