Pomegranate peel extract lessens histopathologic changes and restores antioxidant homeostasis in the hippocampus of rats with aluminium chloride-induced Alzheimer’s disease
作者机构：Special Infectious Agent UnitKing Fahd Medical Research CenterKing Abdulaziz UniversityKingdom of Saudi Arabia Department of AnatomyFaculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Department of AnatomyFaculty of MedicineAin Shams UniversityCairoEgypt Department of Medical Microbiology/Parasitology and Molecular Microbiology LaboratoryKAUHKing Abdulaziz UniversityKingdom of Saudi Arabia Department of Hematology/Pediatric OncologyKing Abdulaziz University Hospital(KAUH)Faculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Yousef Abdul Latif Jameel Scientific Chair of Prophetic Medicine ApplicationFaculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Pharmaceutical Research InstituteAlbany College of Pharmacy and Health SciencesRensselaerNYUSA Department of Biological SciencesFaculty of SciencesKing Abdulaziz UniversityJeddahSaudi Arabia
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2020年第13卷第10期
页 面：456-463页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：funded by Deanship of Scientific Research(DSR),King Abdulaziz University,Jeddah,under grant No.DF-658-2481441 DSR technical and financial support
主 题：Pomegranate Peel extract Ellagic acid Antioxidants Hippocampus Behavioural test
摘 要：Objective:To investigate the neuroprotective efficacy of pomegranate and ellagic acid on the histopathological changes in the hippocampus of an aluminium chloride(AlCl3)induced rat model of Alzheimer’s ***:Sprague Dawley rats were divided into 4 groups(n=10each):GroupⅠ:serving as negative control;GroupⅡ,Alzheimer model,induced by administration of 17 mg/kg bw AlCl3;GroupⅢ,administered the same dose of AlCl3 with 50 mg/kg of pomegranate peel extract and GroupⅣ:administered ellagic acid(50 mg/kg)in addition to the same dose of *** medication given to all groups continued for 28 *** were given the compounds by gastric *** arm maze test,hippocampus antioxidant markers,histopathology of the dentate gyrus,and CA3 of the hippocampus were ***:Rats treated with pomegranate peel extract exposed to radial arm maze test showed less number of errors and reduced time needed to reach the *** was an increase in the levels of glutathione,catalase,and total antioxidant capacity and decreased lipid peroxidation *** features in dentate gyrus and CA3 as apoptosis and chromatolysis of pyramidal cells and granular layer,respectively,were *** characteristic neurofibrillary tangles and senile plaques were *** with ellagic acid ameliorated the pathological results but to a statistically lower ***:Pomegranate peel extract alleviates memory deficit and restores antioxidant homeostasis following degenerative changes in the hippocampus induced by aluminium chloride in rats.
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