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Aggregate 2022年第4期3卷 131-140页

作者： Christine D.Fasana Fabiola G.Gonzalez Jonathan W.Wade Ashley M.weeks B.Dulani Dhanapala Mary E.Anderson Department of Chemistry Furman UniversityGreenvilleSouth CarolinaUSA

Surface-anchored metal-organic frameworks(surMOFs)integrate nanoporous supramolecular MOF materials directly into architectures for applications such as gas storage,chemical sensing,and energy ***-by-layer solution-phase deposition of the MOF-14 components(1,3,5-tris(4-carboxyphenyl)benzene and copper(II)dimers,respectively)produces a porous and conformal film on carboxylterminated self-assembled monolayers(SAMs).In this research,the formation of ultrathin(less than 25 nm)surMOF films on codeposited bicomponent SAMs and microcontact printed SAMs is investigated by atomic force microscopy,ellipsometry,infrared spectroscopy,and contact angle *** composed of methyl-terminated alkanethiols assembled on gold substrates inhibit surMOF formation,whereas carboxyl-terminated alkanethiols promote MOF-14-based film *** tune the density of carboxyl groups that anchor the film,methyl-and carboxylterminated alkanethiols of varying concentrations are codeposited on *** systematic study demonstrates how surMOF film formation and morphology are impacted by these SAMs with mixed surface *** patterning methods for SAMs,such as microcontact printing(μCP),commonly have mixed chemical functionalities within certain regions of the *** gained regarding how mixed surface functionalities affect surMOF film formation are applied herein to optimize theμCP method to produce chemically patterned SAMs that selectively direct surMOF assembly to produce high-quality surMOF film features.

关键词： atomic force microscopy microcontact printing MOF-14 self-assembled monolayers surface-anchored metal-organic frameworks

孤啡肽、内吗啡肽-1和-2与无脊椎动物免疫和神经系统的μ3阿片受体无相互作用（英文）

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Acta Pharmacologica Sinica 2000年第6期21卷 38-42页

作者： Christos M RIALAS,Benjamin weeks,Patrick CADET,Yannick GOUMON,George B STEFANO Neuroscience Research Institute State University of New York at Old Westbury Old Westbury NY 11568-0210 USA Biology Department Adelphi University Garden City New York 11530 USA Neuroscience Research Institute State University of New York at Old Westbury Old Westbury NY 11568-0210 USA Neuroscience Research Institute State University of New York at Old Westbury Old Westbury NY 11568-0210 USA Biology Department Adelphi University Garden City New York 11530 USA Neuroscience Research Institute NY 11568-0210 USA

AIM: To determine if endomorphin-1,-2 and nociceptin (orphanin FQ) bind to the μ3 opiate receptor subtype or release nitric oxide as μ3 selective ligands do. METHODS: These opioid peptides were examined for their ability to displace [3H]dihydromorphine (DHM) binding from the invertebrate (immunocytes and pedal ganglia)μ3 opiate receptor in membrane homogenates. The ligands were also tested for their ability to release nitric oxide from the same intact tissues utilizing an amperometric probe that measures nitric oxide in real-time. RESULTS: Endomorphin-1,-2 and nociceptin do not displace [3H]DHM binding from immunocyte or pedal ganglia membrane homogenates nor do they release nitric oxide from these tissues. CONCLUSION: Since these newly discovered opioid peptides do not interact with the μ3 opiate receptor subtype, endogenous morphine' s significance is enhanced because it appears to be the only naturally occurring opiate ligand for the receptor. Furthermore, since this study involves invertebrate t

关键词：阿片样肽类吗啡一氧化氮贻贝免疫细胞 mu阿片受体

Initial therapeutic evidence of a borosilicate bioactive glass(BSG)and Fe_(3)O_(4)magnetic nanoparticle scaffold on implant-associated Staphylococcal aureus bone infection

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Bioactive Materials 2024年第10期40卷 148-167页

作者： Ying Jin Hang Liu Lei Chu Jin Yang Xiuyang Li Hang Zhou Haitao Jiang Lei Shi Jason weeks Joshua Rainbolt Changjiang Yang Thomas Xue Haobo Pan Zhongliang Deng Chao Xie Xu Cui Youliang Ren Department of Orthopaedics Second Affiliated Hospital of Chongqing Medical University76 Linjiang RoadYuzhong DistinctChongqing400010PR China Department of Orthopaedics Zunyi Medical UniversityZunyiGuizhouPR China Department of Orthopedics The Seventh People’s Hospital of ChongqingThe Central Hospital Affiliated to Chongqing University of TechnologyChongqing400054PR China Center for Musculoskeletal Research Department of Orthopaedics&Physical Performance CenterUniversity of Rochester Medical CenterRochesterNY 14642USA Shenzhen Key Laboratory of Marine Biomedical Materials CAS-HK Joint Lab of BiomaterialsThe Key Laboratory of Biomedical Imaging Science and SystemShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China

Implant-associated Staphylococcus aureus(***)osteomyelitis is a severe challenge in *** antibiotic-loaded bone cement is a standardized therapeutic approach for *** osteomyelitis,it falls short in eradicating Staphylococcus abscess communities(SACs)and bacteria within osteocyte-lacuna canalicular network(OLCN)and repairing bone *** address limitations,we developed a borosilicate bioactive glass(BSG)combined with ferroferric oxide(Fe_(3)O_(4))magnetic scaffold to enhance antibacterial efficacy and bone repair *** conducted comprehensive assessments of the osteoinductive,immunomodulatory,antibacterial properties,and thermal response of this scaffold,with or without an alternating magnetic field(AMF).Utilizing a well-established implant-related *** tibial infection rabbit model,we evaluated its antibacterial performance in *** transcriptome sequencing demonstrated that BSG+5%Fe_(3)O_(4)enhanced the immune response to bacteria and promoted osteogenic differentiation and mineralization of ***,BSG+5%Fe_(3)O_(4)upregulated gene expression of NOD-like receptor and TNF pathway in MSCs,alongside increased the expression of osteogenic factors(RUNX2,ALP and OCN)in *** cytometry on macrophage exhibited a polarization effect towards M2,accompanied by upregulation of anti-inflammatory genes(TGF-β1 and IL-1Ra)and downregulation of pro-inflammatory genes(IL-6 and IL-1β)among *** vivo CT imaging revealed the absence of osteolysis and periosteal response in rabbits treated with BSG+5%Fe_(3)O_(4)+AMF at 42 *** analysis indicated complete controls of SACs and bacteria within OLCN by day 42,along with new bone formation,signifying effective control of *** *** investigations will focus on the in vivo biosafety and biological mechanism of this scaffold within infectious microenvironment.

关键词： Osteomyelitis Staphylococcus aureus Biofilm Borosilicate bioactive glass Magnetic nanoparticles

注入过渡金属离子的二氧化硅的光学和磁学特性

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上海建材学院学报 1989年第2期 110-117页

作者： G.Whichard R.A.weeks 何丰来美国范德比尔特大学

通过在160 keV,4μA/cm~2的条件下,注入剂量为0.5×1016～6×1016ions/cm~2的过渡金属离子(Cr~+,Mn~+和Fe~+),以改变高纯二氧化硅的表面和近表面区域的光学和磁学特性。由背散射技术测得注入离子的分布呈高斯型,其峰值出现在距表面0.12... 详细信息

通过在160 keV,4μA/cm~2的条件下,注入剂量为0.5×1016～6×1016ions/cm~2的过渡金属离子(Cr~+,Mn~+和Fe~+),以改变高纯二氧化硅的表面和近表面区域的光学和磁学特性。由背散射技术测得注入离子的分布呈高斯型,其峰值出现在距表面0.12μm处,半高宽(FWHM)为0.14μm。在5.0 eV和5.8 eV处,能分辨出由辐照损伤所引起并迭加到光学吸收带低能尾部的吸收带。离子改性区的折射率用椭率测量技术测定,它随注入剂量的增加而增大。对于注入剂量为6×1016ions/cm~2的试样,其折射率随注入离子的原子量的增加而增大。离子注入试样的电子顺磁共振(EPR)谱与温度及方向的关系表明,它们的磁特性差别很大,而且是过渡金属离子种类的函数。室温下,注入剂量为6×1016ions/cm~2的试样的EPR谱表明,注入的Fe离子引起的信号比Mn离子的信号大约强40倍,但没有观察到注入的Cr离子的信号。EPR谱说明离子改性的表面区包含混合磁相。综述的数据说明,将过渡金属离子注入非晶二氧化硅制成的是新型材料。离子改性区的特性是现有数据和理论所没有预见到的。

关键词：磁学特性 Fe Mn 离子改性二氧化硅过渡金属离子光学

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地下开采作业的电气短路问题

世界煤炭技术 1991年第8期 18-23页

作者： weeks,A 洪源

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吻别

长喜欢乐英语

长喜欢乐英语 2004年第8期 10-11页

作者： Fred weeks

董事会结束了。鲍勃站了起来,撞在桌子上,却把咖啡洒在了笔记本上,“真让人尴尬,我老了,变得这么笨拙。”所有人都笑了。很快我们都讲起自己最尴尬的时刻来。轮到弗兰克时,他正安静地坐着听他人讲。有人说:“说吧,弗兰克。给我们讲讲最... 详细信息

董事会结束了。鲍勃站了起来,撞在桌子上,却把咖啡洒在了笔记本上,“真让人尴尬,我老了,变得这么笨拙。”所有人都笑了。很快我们都讲起自己最尴尬的时刻来。轮到弗兰克时,他正安静地坐着听他人讲。有人说:“说吧,弗兰克。给我们讲讲最令你尴尬的时刻。”

关键词：弗兰克粗帆布

如何选择执行机构——正确的执行机构选型可减少停工时间

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流程工业 2010年第10期 22-25页

作者： Donald weeks

要保证生产率最大化，最重要的因素之一就是正确地选择执行机构和阀门的设计能力。不正确地选择阀门和执行机构会导致设备的过早毁损，造成高昂的维修成本和生产损耗。执行机构的尺寸确定与选择如不符合规范，会导致各种方式下底线成本... 详细信息

要保证生产率最大化，最重要的因素之一就是正确地选择执行机构和阀门的设计能力。不正确地选择阀门和执行机构会导致设备的过早毁损，造成高昂的维修成本和生产损耗。执行机构的尺寸确定与选择如不符合规范，会导致各种方式下底线成本的剧增。如果所采购的设备型号过大，购置成本就会增多，所以价格也更贵。维修费用也会更多，因为阀门和执行机构总像是要出问题。另外，工厂的安全性也会降低，因为设备紧急停机功能与设备的应用并不十分匹配。根据卫生与安全行政部门（一家英国的机构）的调查所得出的结论，2／3的执行机构的故障在实际使用之前就发生了，而初次故障产生的原因就是设备不符合规范要求。

关键词：执行机构机构选型停工时间设备型号维修成本设计能力尺寸确定维修费用

Impact of Relaxation and Group Psycho-Education on Health Outcomes Using Integrated Care Models and Quality Improvement

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