孤啡肽、内吗啡肽-1和-2与无脊椎动物免疫和神经系统的μ3阿片受体无相互作用（英文）
Nociceptin, endomorphin-1 and -2 do not interact with invertebrate immune and neural μ3 opiate receptor作者机构：Neuroscience Research Institute State University of New York at Old Westbury Old Westbury NY 11568-0210 USA Biology Department Adelphi University Garden City New York 11530 USA Neuroscience Research Institute State University of New York at Old Westbury Old Westbury NY 11568-0210 USA Neuroscience Research Institute State University of New York at Old Westbury Old Westbury NY 11568-0210 USA Biology Department Adelphi University Garden City New York 11530 USA Neuroscience Research Institute NY 11568-0210 USA
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2000年第21卷第6期
页 面：38-42页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：National Institute on Drug Abuse NIDA (R24DA009010)
主 题：阿片样肽类 吗啡 一氧化氮 贻贝 免疫细胞 mu阿片受体
摘 要：AIM: To determine if endomorphin-1,-2 and nociceptin (orphanin FQ) bind to the μ3 opiate receptor subtype or release nitric oxide as μ3 selective ligands do. METHODS: These opioid peptides were examined for their ability to displace [3H]dihydromorphine (DHM) binding from the invertebrate (immunocytes and pedal ganglia)μ3 opiate receptor in membrane homogenates. The ligands were also tested for their ability to release nitric oxide from the same intact tissues utilizing an amperometric probe that measures nitric oxide in real-time. RESULTS: Endomorphin-1,-2 and nociceptin do not displace [3H]DHM binding from immunocyte or pedal ganglia membrane homogenates nor do they release nitric oxide from these tissues. CONCLUSION: Since these newly discovered opioid peptides do not interact with the μ3 opiate receptor subtype, endogenous morphine s significance is enhanced because it appears to be the only naturally occurring opiate ligand for the receptor. Furthermore, since this study involves invertebrate t
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