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Chinese Science Bulletin 2003年第15期48卷 1539-1547页

作者： FANG Jianwu HUANG Siluo LiU Huisheng m. Crepin XU Tao LiU Jianfeng instiute of Biophyscis & Biochemnistry of Huazhong University of Science & Technology Wuhan 430074China CNRS-UPR 9023 mecanismes moleculaires des Communications CellulairesCCiPE 34090 France Laboratoire de Recherche Oncologie moleAculaire Humaine (EA445) UFR LeAonard de Vinci UniversiteA Paris-nord 74 rue Marcel Cachin 93012BobignyFrance

Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. it has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor抯 intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer.

关键词：乳腺癌蛋白质肝磷脂硫酸乙酰肝素血管生成

Development of Chitosan/Poly(L-Lactide)/multiwalled Carbon Nanotubes Scaffolds for Bone Tissue Engineering

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Open Journal of Regenerative medicine 2016年第1期5卷 14-23页

作者： A. De la Paz Orozco F. Jiménez Vega S. A. martel-Estrada A. Hernández Aguilar m. E. mendoza-Duarte m. C. Chavarría-Gaytán C. A. Rodríguez-González i. Olivas-Armendáriz instituto de Ciencias Biomédicas Universidad Autónoma de Ciudad Juárez Chihuahua México instituto de Arquitectura Diseno y Arte Universidad Autónoma de Ciudad Juárez Chih México instituto de ingeniería y Tecnología Universidad Autónoma de Cd. Juárez Chihuahua México Centro de investigación en materiales Avanzados Chihuahua México

This work focuses to improve the mechanical properties and investigates the growth of osteoblasts on a degradable chitosan/poly(L-lactide)/carbon nanotubes composite for tissue engineering. The morphological and mechanical properties characterizations were performed using scanning electronic microscopy (SEm) and rheometrics analysis system (RSA). Osteoblasts differentiation was determined by alkaline phosphatase activity, total number cells by an Alamar Blue assay, cell attachment and proliferation were visualized qualitatively using SEm, mineralization was characterized by transformed infrared spectroscopy, energy dispersive spectroscopy, and X-ray diffraction. The results suggest that the chitosan/poly(L-lactide)/multiwalled carbon nanotubes composites exhibit the ability to promote cell adhesion, proliferation, and differentiation on their surface.

关键词： Chitosan Poly(L-Lactide) multiwalled Carbon Nanotubes mechanical Properties Biocompatibility

Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第41期20卷 15070-15078页

作者： Ciarán P Fisher Andrzej m Kierzek Nick J Plant J Bernadette moore Faculty of Health and medical Sciences University of Surrey

Non-alcoholic fatty liver disease (NAFLD) is a progressive disease of increasing public health concern. in western populations the disease has an estimated prevalence of 20%-40%, rising to 70%-90% in obese and type ii diabetic individuals. Simplistically, NAFLD is the macroscopic accumulation of lipid in the liver, and is viewed as the hepatic manifestation of the metabolic syndrome. However, the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood. Despite increased research in this field, the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow. We note that, to date, NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies. Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health. Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD. We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive, better targeted NAFLD research strategy. Such an approach will accelerate the progress of research and vital translation into clinic.

关键词： Non-alcoholic fatty liver disease Network metabolism Systems biology modelling Regulation Simulation

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地球历史中矿产资源分布之规律(英文)

地学前缘 2004年第1期11卷 225-235页

作者： V.i.STAROSTiN O.G.SOROKHTiN Geological Faculty Institute of Oceanology Moscow State UniversityRussiaRussian Academy of SciencesRussia

现有的矿产资源分布资料可以说明地球历史中亲铁和亲铜元素成矿的一般规律。铁矿床在元古宙地核分离之后最为发育。除个别显著成矿高峰外 ,金的储量分布与铁类似。亲铁元素矿物的成矿潜力在古元古代也最大 ,以后逐渐降低 ,只是在显生宙 ... 详细信息

现有的矿产资源分布资料可以说明地球历史中亲铁和亲铜元素成矿的一般规律。铁矿床在元古宙地核分离之后最为发育。除个别显著成矿高峰外 ,金的储量分布与铁类似。亲铁元素矿物的成矿潜力在古元古代也最大 ,以后逐渐降低 ,只是在显生宙 ,因地壳的再循环和古老矿床中矿石物质的活化而再次增大。元素的行为则完全不同 ,在前寒武纪时期它们的活动性为中等。亲铜矿物矿床的总量 ,在显生宙因再循环而达到最高 ,亲铜矿物矿床成矿能力较之亲铁矿物强得多 ,因为硫化物比铁金属氧化物更为活泼。地球演化的旋回性表现为超大陆形成的周期性 ,它与矿产的分布颇为一致。铁矿、亲铁元素和金成矿作用的突然激增 ,显然是在超大陆形成之后 ,并且与其早期裂解的脉动相对应。亲铜元素堆积的高峰期往往与超大陆的形成期相对应。尽管亲铜元素成矿的第三次脉动与中生代古陆 (mesogea)的形成并不一致 ,但却与劳亚古陆及冈瓦纳古陆的裂解相一致。此种成矿堆积现象可以借助地幔内非稳态化学密度对流所诱发的地壳发展周期性来解释。根据超大陆形成的周期性推断地幔对流巨旋回的主期应为 80 0ma ,此种周期性亦反映了具原始地幔印记的亲铁、金和亲铜元素的聚集作用过程。因此。

关键词：亲铁元素亲铜元素地球演化矿产资源分布周期性

Advances in healthcare wearable devices

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npj Flexible Electronics 2021年第1期5卷 73-86页

作者： Sheikh m.A.iqbal imadeldin mahgoub E Du mary Ann Leavitt Waseem Asghar Department of Computer and Electrical Engineering&Computer Science Florida Atlantic UniversityBoca RatonFLUSA Asghar-Lab Micro and Nanotechnology in MedicineCollege of Engineering and Computer ScienceBoca RatonFLUSA Department of Ocean and mechanical Engineering Florida Atlantic UniversityBoca RatonFLUSA Christine E.Lynn College of Nursing Florida Atlantic UniversityBoca RatonFLUSA Department of Biological Sciences(Courtesy appointment) Florida Atlantic UniversityBoca RatonFLUSA

Wearable devices have found numerous applications in healthcare ranging from physiological diseases,such as cardiovascular diseases,hypertension and muscle disorders to neurocognitive disorders,such as Parkinson’s disease,Alzheimer’s disease and other psychological *** types of wearables are used for this purpose,for example,skin-based wearables including tattoobased wearables,textile-based wearables,and biofluidic-based ***,wearables have also shown encouraging improvements as a drug delivery system;therefore,enhancing its utility towards personalized *** wearables contain inherent challenges,which need to be addressed before their commercialization as a fully personalized healthcare *** paper reviews different types of wearable devices currently being used in the healthcare *** also highlights their efficacy in monitoring different diseases and applications of healthcare wearable devices(HWDs)for diagnostic and treatment ***,current challenges and limitations of these wearables in the field of healthcare along with their future perspectives are also reviewed.

关键词： wear healthcare challenges

Development of Angle Resolved HXPS instrument for Laboratory Use

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Development of Angle Resolved HXPS Instrument for Laboratory...

Long-Range Displacement Sensor Based on SmS Fiber Structure and OTDR

第18届国际真空大会

作者： H. iwai m. Kobata i. Pí H. Yoshikawa S. Tanuma H. Yamazui H. Takahashi m. Kodama A. Tanaka m. Suzuki E. ikenaga H. matsuda H. Daimon K. Kobayashi materials Analysis Station National Institute for Materials ScienceTsukuba 305-0047Japan NimS Beamline Station at Spring-8 National Institute for Materials ScienceSayo 679-5148Japan Department of Surface and Plasma Science Charles University in Prague 18000Czech Republic

We have developed high throughput angle resolved hard X-ray photoelectron spectroscopy （HXPS） instrument for laboratory use [1], which are composed by combining a monochromatic Cr Kα focused X-ray source and a wide acceptance objective for a spectrometer. The Cr Kα X-rays （5.4 keV） excited by micro focused electron beam are monochromatized and focused on to a sample surface by an ellipsoidal bent crystal monochromater with 300 mm Roland circle. The X-ray spot size is variable from 10 μm （1.25 W） to 200 μm （50 W） in diameter. in front of a VG Scienta R4000 10 kV spectrometer, a wide acceptance objective lens is integrated as a hybrid lens to collect photoelectrons emitted from a sample in the range of ±35 degrees for high sensitivity and angle resolved XPS spectra without tilting the sample. The total energy resolution of 0.53 eV was verified by Au Fermi edge measurement. A typical acquisition time for angle resolved Si 1s spectra of a SiO2（4 nm）/Si（001） overlayered thin film sample is around 1 hour in the emission angle of 10 to 80 degrees with 0.5 degrees angler resolution without tilting the sample. The Si 1s peak from the substrate at kinetic energy of 3569 eV is observed through the 25 nm thickness overlayered SiO2 on Si（001）.

关键词： HAXPES ARXPS nondestructive depth profiling

来源： cnki会议评论

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Photonic Sensors 2015年第2期5卷 166-171页

作者： A. ARiFiN A. m. HATTA SEKARTEDJO m. S. mUNTiNi A. RUBiYANTO Department of Physics Institut Teknologi Sepuluh Nopember Surabaya 60111 Indonesia Departement of Engineering Physics Institut Teknologi Sepuluh Nopember Surabaya 6011 Indonesia Department of Physics Hasanuddin University Makassar 90245 Indonesia Department of Physics Jazan University Jazan 45-142 Saudi Arabia

This paper presents a long-range displacement measurement method by using a single- multi-single mode （SmS） fiber structure, attached to a flexible plate between two permanent poles and the optical time domain reflectometer （OTDR）-based interrogator. The SmS fiber structure sensors are prepared with two different configurations, i.e. straight and sinusoidal configurations. it is demonstrated that the displacement sensor can perform a displacement measurement with a range from 0 mm to 150 mm with a resolution of 0.159 mm. The sinusoidal configuration provides a better sensitivity than the straight configuration. The proposed sensor offers a low cost, and it can be implemented for quasi-distributed displacement measurement which is suitable for civil structure monitoring.

关键词： Displacement sensor SmS fiber structure OTDR

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在收缩-扩张喷嘴中气粉流的理论研究

东北工学院学报 1993年第1期14卷 79-83页

作者： Alexander i. Kolomentsev 彭一川莫斯科航空学院东北工学院

考虑粉粒体积分率对气粉两相流的影响建立了收缩-扩张喷嘴中气粉流的数学模型,这一模型由九个未知量U_p,T_p,U-g,T_g,α,P,ρ_g,m和A的一阶常微分方程组,以及相应的入口边界条件所构成。数值计算表明,在亚声速区中粉粒速度和气体速度的... 详细信息

考虑粉粒体积分率对气粉两相流的影响建立了收缩-扩张喷嘴中气粉流的数学模型,这一模型由九个未知量U_p,T_p,U-g,T_g,α,P,ρ_g,m和A的一阶常微分方程组,以及相应的入口边界条件所构成。数值计算表明,在亚声速区中粉粒速度和气体速度的变化与粉气比无关,在超声速区中粉粒速度和气体速度均随粉气比的增大而减小;粉粒终速随粉粒粒径的减小而增大。

关键词：气粉流收缩扩张喷嘴

microstructural refinement and mechanical properties of direct extruded Zm21 magnesium alloys

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Transactions of Nonferrous metals Society of China 2011年第10期21卷 2154-2159页

作者： m.THiRUmURUGAN G.m.THiRUGNASAmBANDAm S.KUmARAN T.SRiNiVASA RAO Department of metallurgical and materials Engineering National Institute of Technology

Cast Zm21 magnesium alloys were subjected to symmetric extrusion at four different temperatures（200,250,300 and 350 ℃） with three extrusion ratios of 4：1,9：1 and 16：1,*** effects of extrusion parameters such as temperature and extrusion ratio were studied by optical microscopy,X-ray diffraction（XRD） and tensile *** optical micrographs exhibited various stages of recrystallization,i.e.,partial to full recrystallization influencing mechanical properties to good *** extrusion temperature resulted in coarse grains,whereas finer grains were obtained at higher extrusion *** tensile strength of this alloy was increased from 160 mPa to 316 mPa after extrusion at 250 ℃ with an extrusion ratio of 9：1.

关键词： Zm21 magnesium alloy grain refinement recrystallization