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Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression

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Acta Pharmaceutica Sinica B 2020年第3期10卷 462-474页

作者： han Saem Son Jiae Lee Hye in Lee Narae Kim You-Jin Jo Gong-Rak Lee Seong-Eun Hong Minjeong Kwon Nam Young Kim Hyun Jin Kim Jin ha Park Soo Young Lee Woojin Jeong Department of Life Science and the Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea

Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity,which is closely associated with ***(Ba.ha. been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that inhibits the production of proinflammatory cytokines or ***,its role in osteoclast differentiation and function remains ***,we explored the role of ba in regulating osteoclast differentiation and elucidated the underlying *** inhibited osteoclast differentiation and strongly suppressed interleukin-1β(iL-1β)*** inhibited osteoclast formation and bone resorption when added to bone marrowderived macrophages and differentiated osteoclasts,and the inhibitory effect was reversed by iL-1β*** reporter assay and the inhibitor study of iL-1βtranscription suggested that ba inhibited nuclear factor-κB and activator protein-1 by regulating iκB kinase,extracellular signal regulated kinase and P38,resulting in the down-regulation of iL-1β*** also promoted osteoblast ***,ba protected lipopolysaccharide-and ovariectomy-induced bone loss in mice,suggesting therapeutic potential against inflammation-induced bone diseases and postmenopausal osteoporosis.

关键词： Benzydamine Osteoclast Bone interleukin-1β Nuclear factor-κB Activator protein-1

The application of artificial intelligence to chest medical image analysis

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intelligent Medicine 2021年第3期1卷 104-117页

作者： Feng Liu Jie Tang Jiechao Ma Cheng Wang Qing ha Yizhou Yu zhen zhou Deepwise Ai Lab Deepwise Inc.No.8 Haidian AvenueBeijing 100080China Department of Computer Science The University of Hong KongPok Fu LamHong KongChina

The aim of this article is to review recent progress in the application of artificial intelligence to chest medical image *** lungs,bone,and mediastinum were included in terms of anatomy,while X-ray and computed tomography(CT),with and without contrast enhancement,were considered regarding imaging *** key components of deep learning were summarized,namely,network architectures,learning strategies,optimiza-tion methods,and vision ***-specific applications were discussed in detail with respect to the dimen-sion of the data input,network architecture,and modality:lung cancer,pneumonia,tuberculosis,pulmonary embolism,chronic obstructive pulmonary disease,and interstitial lung disease for lung;traumatic fractures,os-teoporosis,osteoporotic fractures,and bone metastases for bone;and coronary artery calcification and aortic dissection for vascular ***,five promising research directions and possible solutions were presented for future work.

关键词： Artificial intelligence Deep learning Medical images Chest Lung Fracture Mediastinum

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深沟球轴承的动力学分析及其软件ba

轴承 2009年第8期 14-19页

作者：薛峥汪久根 Rymuza z Kusznierewicz z 马勒投资技术有限公司上海2014002 浙江大学机械系杭州310027 华沙工业大学机电一体化系华沙02525

根据空间坐标变换建立接触和碰撞模型,利用数值方法计算分析,编写了适用于深沟球轴承的拟静力学以及动力学分析的软件包ba。描述了程序的模型,并以一定工况下的球轴承为案例分析了深沟球轴承的动力学,得到了钢球的运动速度、钢球与内外... 详细信息

根据空间坐标变换建立接触和碰撞模型,利用数值方法计算分析,编写了适用于深沟球轴承的拟静力学以及动力学分析的软件包ba。描述了程序的模型,并以一定工况下的球轴承为案例分析了深沟球轴承的动力学,得到了钢球的运动速度、钢球与内外圈间的接触载荷与保持架质心的运动轨迹等,验证了ba的分析能力。

关键词：深沟球轴承拟静力学动力学固体润滑保持架

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圆柱滚子轴承的动力学分析

轴承 2009年第7期 1-6页

作者：薛峥汪久根 Rymuza z Kusznierewicz z 马勒投资技术有限公司上海201400 浙江大学机械系杭州310027 华沙工业大学机电一体化系华沙02525

介绍了圆柱滚子轴承的3自由度模型的建立方法,分析了滚子与套圈、滚子与保持架、套圈与保持架间的接触或碰撞关系。介绍了使用Fortran 90编写的轴承动力学分析软件包ba的程序架构。得到了滚子的运动速度、滚子与内、外圈间的接触载荷与... 详细信息

介绍了圆柱滚子轴承的3自由度模型的建立方法,分析了滚子与套圈、滚子与保持架、套圈与保持架间的接触或碰撞关系。介绍了使用Fortran 90编写的轴承动力学分析软件包ba的程序架构。得到了滚子的运动速度、滚子与内、外圈间的接触载荷与保持架质心的运动轨迹等,并通过案例分析了圆柱滚子轴承的动力学性能,验证了ba的分析能力。

关键词：圆柱滚子轴承拟静力学动力学

Polycaprolactone-carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion

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Bio-Design and Manufacturing 2018年第4期1卷 245-253页

作者： M.E.Aleman-Domfnguez z.Ortega A.N.Benitez Mario Monzon L.V.Garzon Sara Ajami Chaozong Liu Departamento de ingenier/a de Procesos Universidad de Las Palmas de Gran CanadaEdificio de Fabricacion integrada Parque Cientifico-Tecnologico de la ULPGC35017Las PalmasSpain Departamento de ingenierfa Mecainica Universidad de Las Palmas de Gran CanadaEdificio de Fabricacion integrada Parque Cientifico-Tecnologico de la ULPGC35017 Las PalmasSpain institute of Orthopaedic and Musculoskeletal Science Royal National Orthopaedic HospitalUniversity College London StanmoreLondon HA74LPUK

Polycaprolactone-carboxymethyl cellulose composites have been obtained and used to print porous structures by material *** materials used contained 0,2 and 5% w/w of the carboxymethyl cellulose *** structures have been analyzed in terms of their morphology (including the evaluation of their porosity),mechanical properties under compression load and cell *** affinity has been evaluated by culturing sheep mesenchymal stem cells and analyzing their viability by the Alamar Blue(R)assay at days 1,3,6 and *** results show that composites samples have similar values of porosity and apparent density than pure polycaprolactone ***,samples containing 5%w/w of carboxymethyl cellulose have micropores on the filaments due to a hindered deposition *** characteristic affects the mechanical properties of the structures,so these ones have a mean compression modulus significantly lower than pure polycaprolactone ***, the samples containing 2%w/w of carboxymethyl cellulose show no significant difference with the pure polycaprolactone ones in terms of their mechanical ***,the presence of 2%w/w of additive improves cell proliferation on the surface of the porous *** complementary information,the flow properties of the composite materials were studied and the power law equations at 210℃ obtained,as this temperature was the 3D printing *** equations can be useful for simulation and designing purposes of other manufacturing processes.

关键词： Additive manufacturing Tissue engineering Viscosity model Biomaterials 3D printing Bone regeneration

Effects of chemical pressure on diluted magneticsemiconductor(ba,K)(zn,Mn)_2As_2

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Chinese Physics B 2019年第5期28卷 288-292页

作者： Y Peng S Yu G Q zhao W M Li J F zhao L P Cao X C Wang Q Q Liu S J zhang R z Yu z Deng X H zhu C Q Jin College of Materials Science & Engineering Sichuan University Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences Collaborative innovation Center of Quantum Matter

Chemical pressure induced by iso-valent doping has been widely employed to tune physical properties of materials. in this work, we report effects of chemical pressure by substitution of Sb or P into As on a recently discovered diluted magnetic semiconductor(ba,K)(zn,Mn)_2 As_2, which has the record of reliable Curie temperature of 230 K due to independent charge and spin doping. Sb and P are substituted into As-site to produce negative and positive chemical pressures, respectively.X-ray diffraction results demonstrate the successful chemical solution of dopants. Magnetic properties of both K-underdoped and K-optimal-doped samples are effectively tuned by Sb-and P-doping. The hall effect measurements do not show decrease in carrier concentrations upon Sb-and P-doping. impressively, magnetoresistance is significantly improved from7% to 27% by only 10% P-doping, successfully extending potential application of(ba,K)(zn,Mn)_2 As_2.

关键词： chemical pressure (ba,K)(zn,Mn)2As2 diluted magnetic semiconductor iso-valent doping

Assessment of Unmet Transfusion Needs in the Management of immediate Postpartum haemorrhage at the Kalaban Coro Reference Health Centre (MALi)

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Open Journal of Obstetrics and Gynecology 2023年第9期13卷 1645-1657页

作者： Bocary Sidi Kone Kalifa Traore Mahamoudou Coulibaly Cheickna Sylla Sema Keita Yacouba Sylla Mamadou haïdara Mahamadou Keita Sékou bakary Keita bamba Brehima Mamadou Kampo Dramane Fomba Yacouba Aba Coulibaly Seydou z. Dao Modibo Dicko Department of Gynecology and Obstetrics Polyclinique Mère Enfant Mohamed VI Bamako Mali Department of Gynecology and Obstetrics National Centre for Scientific and Technological Research Bamako Mali Department of Gynecology and Obstetrics Kalaban Coro Reference Health Centre Bamako Mali Department of Gynecology and Obstetrics Centre Hospitalo-Universitaire Gabriel Touré de Bamako Bamako Mali Department of Gynecology and Obstetrics Fana Reference Health Centre Koulikoro Mali Department of Gynecology and Obstetrics Reference Health Centre of Commune II of the District of Bamako Bamako Mali Department of Gynecology and Obstetrics Reference Health Centre of Commune I of the District of Bamako Bamako Mali Department of Gynecology and Obstetrics Timbuktu Hospital Timbuktu Mali Department of gynecology and Obstetrics Reference Health Centre of Commune VI of the District of Bamako Bamako Mali

The aim was to assess transfusion needs in the management of immediate postpartum haemorrhage. Materials and Methods: this was a prospective, descriptive, analytical study from 01 January 2018 to 31 October 2018 in the gynecology and obstetrics department of the reference health center of Kalaban-Coro (Mali). Results: During the study period we recorded 32 cases of transfusion of the immediate postpartum out of 109 cases of hemorrhage or 29.35%;for a total of 2425 deliveries or a frequency of 1.31%. The main indications for blood transfusion were: postpartum haemorrhage due to tearing of the soft parts in 21.9%;retroplacental hematoma in 18.6%;uterine rupture in 12.5%;and placenta previa covering hemorrhagic in 12.5%. More than half of the transfused were evacuees, or 62.5%. Unmet transfusion requirements were 59.4%. The blood products requested were: whole blood in 99% of cases and fresh frozen plasma in only 1% of cases. Conclusion: the need for labile blood products remains a reality in obstetrics. The permanent availability of labile blood products improves the prognosis of immediate postpartum haemorrhages.

关键词： Blood Transfusion Postpartum Hemorrhage

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冲击压实技术在公路路基施工中的应用

交通标准化 2011年第11期39卷 62-64页

作者：白卫生郝海飞陕西省榆林公路管理局陕西榆林719000

从冲击压实技术的原理着手,对其适用范围进行介绍,给出冲击压实技术在施工过程中的注意事项。通过对试验路段主要技术指标如压实度、弯沉以及平整度的检测,证明冲击压实技术在确保工程质量方面具有较好的效果。

关键词：冲击压实适用范围注意事项

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突发灾难事件引发创伤后应激障碍特点的研究

社会心理科学 2010年第5期25卷 45-50页

作者：王贞贞麦尔合巴新疆医科大学人文社科部大学生心理健康咨询中心

目的:探讨新疆地区突发灾难事件后医学院大学生创伤后应激障碍发生的特点,为高校学生心理健康指导及民族团结教育提供科学依据。方法:采用PTSD筛查问卷及开放式访谈调查方法对750名医学本科生进行研究。结果:在7.5暴力事件突发后,医学生... 详细信息

目的:探讨新疆地区突发灾难事件后医学院大学生创伤后应激障碍发生的特点,为高校学生心理健康指导及民族团结教育提供科学依据。方法:采用PTSD筛查问卷及开放式访谈调查方法对750名医学本科生进行研究。结果:在7.5暴力事件突发后,医学生PTSD的发生率达到12.8%。总体来看,以学生的PTSD症状中,回避维度平均分高于警觉维度的平均分。在性别、民族、学院、年级以及被试的性质上,被试的PTSD存在显著差异。医学生在7.5事件中充当的角色性质、所处学院、所处年级三个变量能联合预测PTSD症状2.7%的变异量。结论:高校学生工作者及高校教师应该根据医学生的特点,及时有效地采取危机干预措施,减少和避免创伤后应激障碍的发生,促进学生心理健康,引导学生建立积极的民族团结意识。

关键词：医学生创伤后应激障碍特点