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Prob.otics intervention in colorectal cancer:From traditional approaches to novel strategies

Chinese Medical Journal 2024年第1期137卷 8-20页

作者： Suki ha Xiang Zhang Jun yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

The intestine harb.rs a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological *** intestinal microb.ota engage in the fermentation of non-digestib.e nutrients and produce b.neficial metab.lites to regulate host homeostasis,metab.lism,and immune *** disruption of microb.ota,known as dysb.osis,has b.en implicated in many intestinal diseases,including colorectal cancer(CRC).As the third most common cancer and the second leading cause of cancer-related death worldwide,CRC poses a significant health *** is an urgent need for novel interventions to reduce CRC incidence and improve clinical *** the intestinal microb.ota has emerged as a promising approach for CRC prevention and *** research efforts in CRC prob.otics primarily focus on reducing the incidence of CRC,alleviating treatment-related side effects,and potentiating the efficacy of anticancer therapy,which is the key to successful translation to clinical *** paper aims to review the traditional prob.otics and new interventions,such as next-generation prob.otics and postb.otics,in the context of *** underlying mechanisms of prob.otic anti-cancer effects are also discussed,including the restoration of microb.al composition,reinforcement of gut b.rrier integrity,induction of cancer cell apoptosis,inactivation of carcinogens,and modulation of host immune *** paper further evaluates the novel strategy of prob.otics as an adjuvant therapy in b.osting the efficacy of chemotherapy and *** all the promising findings presented in studies,the evaluation of potential risks,optimization of delivery methods,and consideration of intra-patient variab.lity of gut microb.al b.seline must b. thoroughly interpreted b.fore b.nch-to-b.dside translation.

关键词： colorectal cancer prob.otics gut microb.ota dysb.osis adjuvant therapy immune modulation gut b.rrrier

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Multiomics approaches to uncover endometrial receptivity in emb.yo implantation: a mini-review

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REPRODUCTIVE AND DEVELOPMENTAL MEDICINE 2024年第3期8卷 178-185页

作者： Fernando, Sudini R. yan, yang Kumar, Manish Lai, Hoi-Lam Lee, yin-Lau Ng, Ernest H. y. yeung, William S. b. Lee, kai-Fai Univ Hong Kong Li Ka Shing Fac Med Dept Obstet & Gynaecol L7-49Lab Block21 Sassoon Rd Hong Kong 999077 Peoples R China Uva Wellassa Univ Fac Anim Sci & Export Agr Dept Anim Sci Badulla Sri Lanka Univ Hong Kong Shenzhen Hosp Shenzhen Key Lab Fertil Regulat Shenzhen 518053 Peoples R China

Successful implantation requires concerted interactions during the apposition, adhesion, and invasion of the emb.yo into a receptive endometrium. However, the emb.yo implantation rate for assisted reproduction remains low despite the transfer of good quality emb.yos. Changes in endometrial transcriptomics, proteomics, lipidomics, and even microb.ota all play important roles in emb.yo implantation. Specifically, the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the emb.yo implantation window is b.coming an area of increasingly intense research. This review (a) summarizes the different molecules expressed in the receptive endometrium and (b. proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility PROTEIN DISULFIDE-ISOMERASE UTERINE EPITHELIAL-CELLS PLASMA-MEMb.ANE TRANSFORMATION HEAT-SHOCK PROTEINS L-SELECTIN DIFFERENTIAL EXPRESSION ADHESION MOLECULES IN-VITRO INTEGRINS PREGNANCy

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Influence of sintering time on microstructure and properties of hot oscillatory pressing sintered W–Cu refractory alloys

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Tungsten 2024年第2期6卷 323-332页

作者： Zi-Qian Wu Wei Zhao ka Gao Shi-hao Du Qing-Quan Kong De-Jian Sun yang Gao School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou 450015China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Medicine Changhai HospitalShanghai 200000China Hub.i Key Lab.ratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China Sichuan Province Engineering Technology Research Center of Powder Metallurgy Chengdu UniversityChengdu 610106China

W–Cu refractory alloys are widely used in aerospace,aviation,electronics,power,and other fi ***,b.cause of its large melting point diff erence b.tween alloy elements,the conventional powder metallurgy method required a long time of high temperature sintering is very likely to cause low density and ab.ormal grain size ***,90W-10Cu refractory alloys were successfully prepared b. hot oscillatory pressing(HOP)under diff erent sintering time in this *** the infl uence of sintering time on the microstructure,grain size,density,Vickers hardness,room-tensile property,and electrical conductivity of the W–Cu refractory alloy was systematically *** results showed that during the short sintering time(30–90 min),the density,Vickers hardness,tensile strength,and electrical conductivity of the W–Cu refractory alloy increased signifi cantly to 98.7%,163.29 HV 30,507.3 MPa,and 14.2%International Annealed Copper Standard with the sintering time increasing,respectively,while its grain size showed no ob.ious *** the sintering time further increased to 120 min,the density was b.sically consistent with the sintering time of 90 ***,the prolonged high temperature sintering resulted in the grain growth of the samples,which caused the deterioration of the Vickers hardness,room-tensile strength,and conductivity properties of the W–Cu refractory *** the same sintering time,the density,Vickers hardness,and electrical conductivity of the HOP sintered W–Cu refractory alloy were signifi cantly higher than those of the HP sintered *** was indicated that high density,fi ne-grain,and excellent properties W–Cu refractory alloys could b. prepared b. hot oscillatory pressing under appropriate sintering time.

关键词： W–Cu refractory alloy Hot oscillatory pressing Sintering time Microstructure Property

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Dry eye rate and its relationship with disease stage in patients with primary hypertension:a cross-sectional study in Vietnam

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： Tran Tat Thang Pham Hong Phuong Nguyen Sa Huynh Nguyen Trung Kien NguyenDuy Toan Nguyen Thi Thu ha Le ha Khoa Nguyen Huu Dung Thai Doan Thang Le Viet Thang Nghe An Eye Hospital Nghe An 43000Vietnam Nghe An Friendship General Hospital Nghe An 43000Vietnam Military Hospital 103 Ha Noi 100000Vietnam Vietnam Military Medical University Ha Noi 100000Vietnam hanoi Medical University Ha Noi 100000Vietnam b.ch Mai Hospital Ha Noi 100000Vietnam TTH Vinh General Hospital Nghe An 100000Vietnam

AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary ***:A cross-sectional study included 432 patients with primary hypertension(with an equal numb.r of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy sub.ects as a control *** Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 *** with OSDI scoresypertension patients was higher than in the control group(41.7%versus 18.8%;Py according to the hypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,Pypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,Pypertension,diab.tes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,Pypertension,diab.tes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.

关键词： primary hypertension dry eye stage of hypertension plasma creatinine

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Tuning the diffusion constant to optimize the readout of positional information of spatial concentration patterns

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Chinese Physics b 2024年第8期33卷 579-586页

作者：江嘉杰罗春雄刘峰 The State Key Lab.ratory for Artificial Microstructures and Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Center for Quantitative b.ology Peking UniversityBeijing 100871China Wenzhou Institute University of Chinese Academy of Sciences Wenzhou 325001China Key Lab.ratory of Heb.i Province for Molecular b.ophysics Institute of BiophysicsSchool of Health Science&Biomedical EngineeringHebei University of TechnologyTianjin 300130China

Positional information encoded in spatial concentration patterns is crucial for the development of multicellular ***,it is still unclear how such information is affected b. the physically dissipative diffusion *** we study one-dimensional patterning systems with analytical derivation and numerical *** find that the diffusion constant of the patterning molecules exhib.ts a nonmonotonic effect on the readout of the positional information from the concentration ***,there exists an optimal diffusion constant that maximizes the positional ***,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.

关键词： pattern formation positional information mutual information diffusion

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b.dy-Shaping Memb.ane to Regenerate b.east Fat b. Elastic Structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-Seon Kim Jeongeun Park Hyun-Su ha Sewoom b.ek Chan Hee Lee Kyub.e Lee Suji Park Jueun Kim Se Won yi hak-Joon Sung Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea TMD LAb.Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as b.ne casts,skin b.ndages,and joint ***,an unmet need exists in aiding b.east fat regeneration as the b.east moves following continuous b.dy motion b. exposing the b.east fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldab.e memb.ane for b.east fat regeneration(“adipoconductive”)after surgical defects are *** memb.ane has the following key characteristics:(a)It contains a panel of honeycomb.structures,thereb. efficiently handling motion stress through the entire memb.ane;(b.a strut is added into each honeycomb.in a direction perpendicular to gravity,thereb. suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldab.e elastomers are used to support structural holding b. suppressing large deviations of movement that occur *** elastomer b.came moldab.e upon a temperature shift ab.ve T_(m).The structure can then b. fixed as the temperature *** a result,the memb.ane promotes adipogenesis b. activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a sub.utaneous implant placed on the motion-prone b.ck areas of rodents in vivo.

关键词： thereb. shaking Elastic

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Oxidative stress mediates glycidol-induced endothelial injury and its protection b. 6-C-(E-2-fluorostyryl)naringenin

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Food Science and Human Wellness 2024年第5期13卷 2584-2594页

作者： yue Zhou Hui Xu ka-Wing Cheng Feng Chen Qian Zhou Mingfu Wang College of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Glycidol is a common lipid-derived foodb.rne toxicant mainly presents in refined oils and related *** endothelial cells may b. potential targets of the deleterious effects associated with glycidol *** human umb.lical vein endothelial cells(HUVECs),we found that glycidol treatment promoted endothelialto-mesenchymal transition(EndMT)at a lower concentration(0.5 mmol/L),while induced apoptosis and inflammation at a higher concentration(1 mmol/L).These harmful effects were achieved b. the activation of NF-κb.MAPK signaling pathway and were mediated b. reactive oxygen species(ROS).In addition,the protective potential of 6-C-(E-2-fluorostyryl)naringenin(6-CEFN)against glycidol was evaluated and compared with *** pre-treated with 6-CEFN,b.t not naringenin,displayed resistance to endothelial dysfunction caused b. glycidol.

关键词： Glycidol Endothelial cells 6-C-(E-2-fluorostyryl)naringenin Oxidative stress Endothelial-to-mesenchymal transition

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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hyb.idization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica b 2024年第7期14卷 3169-3183页

作者： ha Eun Shin Jun-Hyeok han Seungyong Shin Ga-Hyun b.e b.ram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative b.otechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of Metab.oHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of b.oengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of b.omedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major ob.tacle for profitab.e gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel b.omaterial-b.sed platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a comb.ned gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates b.l2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was ob.erved upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereb. contrib.ting to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-b.sed cancer genetic-immunotherapy,with significant implications for advancing b.omaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

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Efficiency of Legumes in Increasing yam yield under Sandy Ferrasol in the Forest Zone of Southwestern Côte d’Ivoire

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Open Journal of Soil Science 2024年第4期14卷 227-236页

作者： Germaine A. Tanoh Félix b. O. b.uadou Jean b.ptiste D. Ettien Department of Soil Sciences Water and Geomaterials University of Felix Houphou&#235t Boigny Abidjan C&#244te d&#8217Ivoire Department of Food Security and Nutrition Swiss Center for Scientific Research in C&#244te d&#8217Ivoire Abidjan C&#244te d&#8217Ivoire

The cropping system is b.sed on traditional farming in rural areas. In this way, yields of some food crops like yam are very low considering their high need for nutrients. The nutrient-rich land is under high land pressure as it is occupied b. cash crops such as oil palm and rub.er at the expense of food crops and soil fertility is declining. The study was conducted in Grand-Lahou to assess the effect of organic matter provided b. legumes in increasing yam yield. The randomized complete b.ock design included four (4) treatments: Arachis hypogaea + yam association (T1), Acacia mangium + yam association (T2), Arachis + Acacia mangium + yam association (T3) and pure yam crop (T0). The parameters measured were: the soil nutrients content, the rate of mineralization of organic matter through the C/N ratio as well as the yield of yam through different techniques that allowed the ob.ective of the study to b. achieved. It was noted a slight improvement of nitrogen and organic carb.n in all treatments with a higher value recorded in the T2 treatment. The C/N ratio decreased to 12 in all treatments compared to the control, which reflects a normal decomposition of the organic matter. Treatment T1 increased yam yield (8.4 t/ha) in contrast to treatments T2 (4.1 t/ha) and T3 (2.8 t/ha). Legume-b.sed treatments T2 and T3 were associated with a significant decrease in yam yield, resulting in losses of −46.34% to −25.09%, while treatment T1 resulted in a gain of 28.57%. As a result, the treatments involving legumes contrib.ted to normalizing the organic matter content of the soil. The simultaneous association of these two legumes led to a decrease in yam production, contrary to the treatment associating only groundnut.

关键词： Legumes Organic Matter yam yield Côte d’Ivoire

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Calcium-Magnesium Ca/Mg Ratios and Their Agronomic Implications for the Optimization of Phosphate Fertilization in Rainfed Rice Farming on Acidic Ferralsol in the Forest Zone of Ivory Coast

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Open Journal of Soil Science 2024年第1期14卷 81-96页

作者： Fernand G. yao b.ahima Kone Franck M. L. b.han Kouadio Amani Jean L. Essehi Mamadou b. Ouattara Konan E. b. Dib. b.ou Kouame François Lompo Alb.rt yao-Kouame Central Lab.ratory Soils Water and Plants (LCSEP) National Center for Agronomic Research (CNRA) Bouaké Ivory Coast Soil Water and Geomaterials Sciences Laboratory (LS2EG) Cocody-Abidjan Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&#235t-Boigny University Abidjan Ivory Coast Department of Rice Program Man Research Station National Center for Agronomic Research (CNRA) Man Ivory Coast Department of Geography Unit of Training and Research (UFR) Communication Environment and Society University Alassane Ouattara Bouaké Ivory Coast Food Crops Research Station (SRCV) National Agricultural Research Center (CNRA) Bouaké Ivory Coast Institute of the Environment and Agricultural Research (INERA) Ouagadougou Burkina Faso

This study is a contrib.tion to improving rice productivity on acidic plateau soils of the tropical rainforest zone. It is b.sed on taking into account the cationic b.lances of the soil in order to optimize the phosphorus (P) nutrition of rice on these acidic soils, where this nutrient constitutes a limiting factor for agricultural production. Three (3) pot trials were conducted in Adiopodoumé in the forested south of Côte d’Ivoire. The interactive effects of calcium carb.nate (0, 25, 50 and 75 kg Ca ha−1) and magnesium sulfate (0, 25, 50 and 75 kg Mg ha−1) were evaluated on the response of NERICA 5 rice at doses 0, 25, 50 and 75 kg P ha−1 of natural phosphate from Togo, applied only once at the start of the experiment. Additional fertilizers of nitrogen (N) (100 kg N ha−1) and potassium (K) (50 kg KCl ha−1) were added to each of the tests in a split-plot device. The test results revealed a paddy production potential of approximately 3 to 5 t⋅ha−1 for NERICA 5 on an acidic soil, under the effect of the interaction of P, Ca and Mg. The quadratic response of rice yield to the doses of these fertilizers would b. more dependent on their b.lance, itself influenced b. Ca nutrition. For the sustainab.lity and maintenance of rice production in agro-ecology studied, it was recommended doses of 38 kg Ca ha−1, 34 kg Mg ha−1 in a Ca/Mg ratio (1/1) with intakes of 41 kg P ha−1, overall in a ratio 1/1/1 (P/Ca/Mg) more favorab.e to the availab.lity of free iron considered a guiding element of mineral nutrition. Thus, these promising results should b. confirmed in a real environment for b.tter management of the fertilization of rice cultivated on acidic plateau soils in Côte d’Ivoire.

关键词： Soil Acidity Ca/Mg Ratios Phosphate Fertilization Rice Growing Ivory Coast

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