Tuning the diffusion constant to optimize the readout of positional information of spatial concentration patterns

作     者：江嘉杰 罗春雄 刘峰 Ka Kit Kong;Chunxiong Luo;Feng Liu

作者机构：The State Key Laboratory for Artificial Microstructures and Mesoscopic PhysicsSchool of PhysicsPeking UniversityBeijing 100871China Center for Quantitative BiologyPeking UniversityBeijing 100871China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China Key Laboratory of Hebei Province for Molecular BiophysicsInstitute of BiophysicsSchool of Health Science&Biomedical EngineeringHebei University of TechnologyTianjin 300130China 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2024年第33卷第8期

页      面：579-586页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 070104[理学-应用数学] 0901[农学-作物学] 090102[农学-作物遗传育种] 0701[理学-数学] 0702[理学-物理学] 

基　　金：Project supported by the National Natural Science Foundation of China (Grant Nos.32271293 and 11875076) 

主　　题：pattern formation positional information mutual information diffusion 

摘      要：Positional information encoded in spatial concentration patterns is crucial for the development of multicellular ***,it is still unclear how such information is affected by the physically dissipative diffusion *** we study one-dimensional patterning systems with analytical derivation and numerical *** find that the diffusion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration ***,there exists an optimal diffusion constant that maximizes the positional ***,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.