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An effective round ball tool in electrochemistry process as novel reuse fabrication technology

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中国有色金属学会会刊：英文版 2012年第S3期22卷 825-830页

作者： P.S.pa Department of Digital Content Design Graduate School of Toy and Game DesignNational Taipei University of Education

A reuse fabrication module using micro electrochemistry (MECM) with a round-ball tool to remove the defective In2O3 SnO2 thin film from the surfaces of digital paper display was *** etching effect improves that the number of the round-balls decreases for promoting the concentration of electric power and increasing discharge *** a small size of the round-ball tool takes less time for the same amount of In2O3 SnO 2 layer removal since the effect of MECM is easily developed for supplying of sufficient electrochemical power.A higher feed rate of the poly ethylene terephthalate (PET) diaphragm combines with enough electric power to drive fast etching rate.A pulsed direct current can improve the effect of dreg discharge and is advantageous to couple this current with the fast feed rate of the *** the ultra-precise etching of In2O 3 SnO2,the optoelectronic semiconductor industry can effectively reuse the defective products,reducing production *** precision etching process is of high efficiency and requires only a short period of time to remove the In2O3 SnO2 nanostructures.

关键词： thin film round-ball tool In2O3SnO2 micro electrochemistry digital paper display

Adenosine A_(2A) receptors in neuronal outgrowth:a target for nerve regeneration?

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Neural Regeneration Research 2016年第5期11卷 706-708页

作者： filipa F.Ribeiro Ana M.Sebastiao Instituto de Farmacologia e Neurociencias Faculdade de MedicinaUniversidade de LisboaLisbonPortugal Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

Axonal and dendritic outgrowth are fundamental processes in the development of the nervous *** this period neurons change their morphology from a simple bipolar shape into a mature complex *** develop dendrites and extend long or short axons that travel through a complex path until reaching target cells and form functional and accurate neuronal circuits.

关键词： receptors in neuronal outgrowth Adenosine A BDNF

Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing

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International Journal of Oral Science 2023年第3期15卷 513-526页

作者： pa Reum Lee Jihoon Kim Heather Lynn Rossi Sena Chung Seung Yub Han Junhyong Kim Seog Bae Oh Department of Neurobiology and Physiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoulRepublic of Korea Genomics and Computational Biology Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of pathobiology University of PennsylvaniaPhiladelphiaPAUSA Department of Biology University of PennsylvaniaPhiladelphiaPAUSA Brain Science Institute Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea

Dental primary afferent(Dpa)neurons and proprioceptive mesencephalic trigeminal nucleus(MTN)neurons,located in the trigeminal ganglion and the brainstem,respectively,are essential for controlling masticatory *** extensive transcriptomic studies on various somatosensory neurons,there is still a lack of knowledge about the molecular identities of these populations due to technical challenges in their circuit-validated ***,we employed high-depth single-cell RNA sequencing(scRNA-seq)in combination with retrograde tracing in mice to identify intrinsic transcriptional features of Dpa and MTN *** transcriptome analysis revealed five major types of Dpa neurons with cell type-specific gene enrichment,some of which exhibit unique mechano-nociceptive properties capable of transmitting nociception in response to innocuous mechanical stimuli in the ***,we discovered cellular heterogeneity within MTN neurons that potentially contribute to their responsiveness to mechanical stretch in the masseter muscle ***,Dpa and MTN neurons represented sensory compartments with distinct molecular profiles characterized by various ion channels,receptors,neuropeptides,and ***,our study provides new biological insights regarding the highly specialized mechanosensory functions of Dpa and MTN neurons in pain and proprioception.

关键词： trigeminal specialized Together

Effective tool design of three-rank form as precision removal-process of ITO thin-films

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中国有色金属学会会刊：英文版 2009年第B9期19卷 232-237页

作者： pai-shan pa Digital Content Design Graduate School of Toy and Game DesignNational Taipei University of Education

A new effective tool design of three-rank form of electroremoval was present using a precision recycle system offering faster performance in removing the indium-tin-oxide(ITO) thin-films on color filter surface of displays. Higher electric power is not required since the three-rank form tool is adopted as a feeding mode to reduce the response area. The low yield of ITO persists throughout the entire semiconductor production process. By establishing a recycle process of ultra-precise removal of the thin-film nanostructure, defective products in the optoelectronic semiconductors industry can be effectively recycled, decreasing both production costs and pollution. A 5th generation TFT-LCD was used. The design features of the removal processes for the thin-films and the tool design of three-rank form were of major interest. For the precision removal processes, a pulsed current can improve the effect of dreg discharge and contributes to the achievement of a fast workpiece (displays' color filter) feed rate, but raises the current rating. High flow velocity of the electrolyte with a high rotational speed of the tool electrodes elevates the ITO removal effect. A displays' color filter with a fast feed rate is combined with enough electric power to provide highly effective removal. A small thickness of the rank and a small arc angle of the negative-electrode correspond to a higher removal rate for ITO-film. An effective three-rank form negative-electrode provides larger discharge mobility and better removal effect. It only needs a short period of time to remove the ITO easily and cleanly.

关键词：工具设计薄膜材料 ITO

符合收缩压干预试验标准的美国成人强化收缩压治疗的人群健康获益估计

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中华高血压杂志(中英文) 2024年第8期 800-800页

作者： Derington CG Bress pa Berchie RO Herrick JS Shen JC Ying J Greene T Tajeu GS Sakhuja S Ruiz-Negrón N Zhang YY Howard G Levitan EB Muntner P Safford MM Whelton PK Weintraub WS Moran AE Bellows BK 袁源练桂丽

收缩压干预试验(systolic blood pressure inter-vention trial,SPRINT)表明,与标准目标收缩压(<140 mm Hg)相比,强化收缩压目标(<120 mm Hg)可降低心血管疾病(cardiovascular disease,CVD)风险。对最有可能获益的符合SPRINT标准的成年患者进行强化降压效果的评估可用于指导临床实践。方法:研究者评估SPRINT参与者及在脑卒中的地理和种族差异原因(reasons for geographic and racial differ-ences in stroke,REGARDS)研究及美国国家健康和营养调查(national health and nutrition examination surveys,NHANES)中符合SPRINT标准的参与者。

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Improving toughness of medium-Mn steels after friction stir welding through grain morphology tuning

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Journal of Materials Science & Technology 2022年第23期118卷 243-254页

作者： Mun Sik Jeong Tak Min park Dong-Il Kim Hidetoshi Fujii Hye Ji Im Pyuck-pa Choi Seung-Joon Lee Jeongho Han Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung 15073Republic of Korea Joining and Welding Research Institute Osaka UniversityOsaka 567-0047Japan Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA

This work demonstrated the viability of friction stir welding for the welding of medium-Mn steels when used as cryogenic vessel materials for liquefied gas *** used an intercritically annealed Fe-7 Mn-0.2 C-3 Al(wt.%)steel with a dual-phase(α'martensite andγ_(R) retained austenite)nanolaminate structure as a base material and systematically compared its microstructure and impact toughness after friction stir and tungsten inert gas *** friction stir welded specimen exhibited a large amount ofγ_(R) phase owing to a relatively low temperature during welding,whereas the tungsten inert gas welded specimen comprised only theα'***,the friction stir welded steel exhibited a tuned morphology of nanoscale globular microstructure at the weld zone and did not exhibit any prior austenite grain boundary due to active recrystallization caused by deformation during *** preserved fraction ofγ_(R) and morphological tuning in the weldment improved the impact toughness of the friction stir welded steel at low *** the steel processed by tungsten inert gas welding,the notch crack propagated rapidly along the prior austenite grain boundaries-weakened by Mn and P segregations-resulting in poor impact ***,the friction stir welded steel exhibited a higher resistance against notch crack propagation due to the slow crack propagation along the ultrafine ferrite/ferrite(α/α)interfaces,damage tolerance by the active transformation-induced plasticity from the large amount ofγR,and enhanced boundary cohesion by suppressed Mn and P segregations.

关键词： Charpy impact test Transformation-induced plasticity Friction stir welding Phase stability Medium-Mn steel

The significance of cherts as markers of Ocean Plate Stratigraphy and paleoenvironmental conditions:New insights from the Neoproterozoic-Cambrian Blovice accretionary wedge,Bohemian Massif

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Geoscience Frontiers 2023年第1期14卷 162-180页

作者： LukášAckerman Jirízák Václav Kachlík Jan pašava KarelZák Andreas pack František Veselovsky Ladislav Strnad Institute of Geology of the Czech Academy of Sciences Rozvojová269CZ-16500 Prague 6Czech Republic Czech Geological Survey Klárov3CZ-11821 Prague 1Czech Republic Institute of Geology and paleontology Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic Geowissenschaftliches Zentrum Universität GöttingenGoldschmidtstraβe 1D-37077 GöttingenGermany Laboratories of the Geological Institutes Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic

The Ediacaran to early Cambrian Blovice accretionary complex,Bohemian Massif,hosts abundant chert bodies that formed on an oceanic plate and were involved in subduction beneath the northern margin of *** relationships of cherts to their host,their microstructure and elemental as well as isotopic compositions revealed diverse processes of chert petrogenesis reflecting depositional environment and position on the oceanic *** deep-water cherts formed through a hydrothermal precipitation of silica-rich gels on outer trench swell of the subducted slab with none or only minor addition of terrigenous *** the contrary,the shallow-water cherts formed in lagoons on seamount slopes,and at least some of them represent a product of hydrothermal replacement of former carbonate and/or evaporite *** both chert types,the hydrothermal fluids were of low temperature and continuous pervasive hydrothermal alteration of oceanic crust,together with an elevated Si content in Neoproterozoic seawater,served as the major source of *** the other hand,minor carbon enrichment in chert is mostly linked to variable incorporation of organic matter that was deposited on the *** earth element(REE)systematics of the cherts indicate predominantly oxygenated environment for the shallow-water cherts whereas the deep-water cherts were deposited in diverse redox conditions,depending on their distance from hydrothermal *** these data,we demonstrate that the cherts once formed a part of Ocean Plate Stratigraphy(OPS)now dismembered and mixed with terrigenous siliciclastic material to form OPS mé*** our data with those from the existing literature,we show that cherts can serve as significant markers of OPS since the Archean,recording a complex interplay between seafloor-related volcanic(production of MORB-and OIB-like magmas)and sedimentary processes,hydrothermal activity at mid-ocean ridges and seamount chains as well as at outer slopes o

关键词： Chert Accretionary wedge Ediacaran Triple oxygen isotopes Strontium isotopes Ocean Plate Stratigraphy

骨性Ⅰ类不同垂直骨面型成人腭中缝融合程度的CBCT研究

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实用口腔医学杂志 2024年第2期40卷 263-269页

作者：李彦苏比努尔·依力哈木帕合登夏尔古丽·木合塔尔古力巴哈·买买提力新疆医科大学第二附属医院口腔科乌鲁木齐830063

目的:探究骨性Ⅰ类成人腭中缝的融合程度在不同性别、部位及垂直骨面型的差异性。方法:纳入骨性Ⅰ类错畸形患者173例,根据GoGn-SN角与性别分6组:GoGn-SN>37.7°为高角组(男22,女24);27.2°≤GoGn-SN≤37.7°为均角组(男30,女33);GoGn-... 详细信息

目的:探究骨性Ⅰ类成人腭中缝的融合程度在不同性别、部位及垂直骨面型的差异性。方法:纳入骨性Ⅰ类错畸形患者173例,根据GoGn-SN角与性别分6组:GoGn-SN>37.7°为高角组(男22,女24);27.2°≤GoGn-SN≤37.7°为均角组(男30,女33);GoGn-SN<27.2°为低角组(男33,女31)。Mimics 21.0软件测量并计算腭中缝前区、中区和后区的融合程度,记录前区鼻腭管与测量部位重叠的情况。结果:腭中缝融合程度在不同性别的比较中,低角前区男女间差异有统计学意义(P<0.001);在不同部位的比较中,除低角女性的前区与中区和后区差异无统计学意义外,其余不同部位腭中缝融合程度均有统计学差异(P<0.05),且由后区至前区逐渐减小。在不同垂直骨面型的比较中,除男性中区均角与低角和高角,女性前区低角与高角和均角差异有统计学意义(P<0.05),余无统计学差异。前区鼻腭管影响测量的比率在男性高角和低角、男性低角和女性低角的比较中有统计学意义(P<0.05),余无统计学意义。结论:成年患者的腭中缝并非完全融合,建议腭部微种植体支抗避免放置于腭中缝处。

关键词：腭中缝融合程度垂直骨面型骨性Ⅰ类错[牙合] CBCT 微种植体支抗

Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice

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Neuroscience Bulletin 2022年第4期38卷 373-385页

作者： Seong-Ah Kim Jun Ho Jang Wheedong Kim pa Reum Lee Yong Ho Kim Hue Vang Kihwan Lee Seog Bae Oh Department of Neurobiology and Physiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 03080Republic of Korea Department of Brain and Cognitive Sciences College of Natural SciencesSeoul National UniversitySeoul 08826Republic of Korea Gachon pain Center and Department of Physiology College of MedicineGachon UniversityIncheon 21999Republic of Korea Tooth-Periodontium Complex Medical Research Center School of DentistrySeoul National UniversitySeoul 03080Republic of Korea

Mitochondrial reactive oxygen species(mROS)that are overproduced by mitochondrial dysfunction are linked to pathological conditions including sensory ***,we explored whether mROS overproduction induces itch through transient receptor potential canonical 3(TRPC3),which is sensitive to *** injection of antimycin A(AA),a selective inhibitor of mitochondrial electron transport chain complex III for mROS overproduction,produced robust scratching behavior in naïve mice,which was suppressed by MitoTEMPO,a mitochondria-selective ROS scavenger,and Pyr10,a TRPC3-specific blocker,but not by blockers of TRpa1 or *** activated subsets of trigeminal ganglion neurons and also induced inward currents,which were blocked by MitoTEMPO and ***,dry skin-induced chronic scratching was relieved by MitoTEMPO and Pyr10,and also by resveratrol,an *** together,our results suggest that mROS elicit itch through TRPC3,which may underlie chronic itch,representing a potential therapeutic target for chronic itch.

关键词： Mitochondria Reactive oxygen species TRPC3 Itch Dry skin Trigeminal ganglia