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cMat 2024年第2期1卷 80-90页

作者： Jun Di Yi-Ling Liu Yi Zhang sha-sha Guo Su-Wei wang Wei Jiang Hua-Ming Li Jie-Xiang Xia School of Chemistry and Chemical Engineering National Special Superfine Powder Engineering Research CenterNanjing University of Science and TechnologyNanjingChina School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu UniversityZhenjiangChina Department of Chemistry and Chemical Biology Cornell UniversityIthacaNew YorkUSA

Novel N-doped Bi_(3)O_(4)Br/(BiO)_(2)CO_(3) ultrathin nanojunctions have been *** dehalogenation was performed to form Bi_(3)O_(4)Br,surfactant was employed to control the ultrathin thickness,and few-layers of C_(3)N_(4) as a sacrificial agent were used to build the N-doped(BiO)_(2)CO_(3).The photocatalytic behavior of the achieved N-doped Bi_(3)O_(4)Br/(BiO)_(2)CO_(3) ultrathin nanojunctions was evaluated through the degradation of antibiotic agent ciprofloxacin,tetracycline hydro-chloride,and endocrine disrupting chemical bisphenol A as well as typical dye rhodamine B under visible light *** matched energy band structure between Bi_(3)O_(4)Br and(BiO)_(2)CO_(3) could endow the highly efficient interfacial charge separation,thus leading to excellent nonselective photocatalytic *** structure design in this system will open new windows for the reasonable design of other photocatalysts.

关键词： (BiO)_(2)CO_(3) Bi_(3)O_(4)Br heterojunction photocatalytic ultrathin

Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours(HOPE):protocol for a randomised,controlled,multicentre study

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Stroke & Vascular Neurology 2024年第3期9卷 318-323,I0274-I0282页

作者： Zhongyu Luo Ying Zhou Yaode He Shenqiang Yan Zhicai Chen Xuting Zhang Yi Chen Lu-sha Tong wansi Zhong Haitao Hu Kemeng Zhang Jiansheng Yang Bruce C V Campbell Min Lou Department of Neurology Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina Department of Medicine and Neurology Melbourne Brain Centre at Royal Melbourne HospitalParkvilleVictoriaAustralia

Background While intravenous thrombolysis is recommended for patients who had an acute ischaemic stroke(AIS)within 4.5hours of symptom onset,there are few randomised trials investigating the benefits of thrombolysis beyond this therapeutic *** To determine whether patients who had an AIS selected with the presence of potentially salvageable tissue on CT perfusion at 4.5–24hours after stroke onset(for stroke with unknown onset time,the midpoint of the time last known to be well and symptom recognition time;for wake-up stroke,the midpoint of the time last known to be well or sleep onset and wake up time)will benefit from intravenous *** HOPE is a prospective,multicentre,randomised,open-label blinded endpoint trial with the stage of phase *** treatment allocation employs 1:1 *** treatment arm under investigation is alteplase with standard therapy,the control arm is standard *** imaging criteria include ischaemic core volume≤70mL,penumbra≥10mL and mismatch≥20%.Study outcomes The primary outcome is non-disabled functional outcome(assessed as modified Rankin Scale score of 0–1 at 90 days).Discussion HOPE is the first trial to investigate whether intravenous thrombolysis with alteplase offers benefits in patients who had an AIS presenting within 4.5–24hours,which has the potential to extend time window and expand eligible population for thrombolysis therapy.

关键词： patients intravenous centre

Molecular mechanism of hypoxia and alpha-ketoglutaric acid on collagen expression in scleral fibroblasts

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1780-1790页

作者： Yun Sun Zhuo-Zheng Li Jing Yang Ya-Ru sha Xin-Yu Hou Hong Fu Jia-Yin Li Shu-Chang Bai Yong-Fang Xie Guo-Hui wang School of Life Science and Technology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

AIM:To investigate the molecular mechanisms underlying the influence of hypoxia and alpha-ketoglutaric acid(α-KG)on scleral collagen ***:Meta-analysis and clinical statistics were used to prove the changes in choroidal thickness(ChT)during *** establishment of a hypoxic myopia model(HYP)for rabbit scleral fibroblasts through hypoxic culture and the effects of hypoxia andα-KG on collagen expression were demonstrated by Sirius red *** analysis was used to verify the genes and pathways that hypoxia andα-KG affect collagen ***,real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)was used for reverse ***:Meta-analysis results aligned with clinical statistics,revealing a thinning of ChT,leading to scleral *** red staining indicated lower collagen expression in the HYP group and higher collagen expression in the HYP+α-KG group,showed that hypoxia reduced collagen expression in scleral fibroblasts,whileα-KG can elevated collagen expression under HYP *** analysis unveiled the related genes and signaling pathways of hypoxia andα-KG affect scleral collagen expression and the results were verified by ***:The potential molecular mechanisms through which hypoxia andα-KG influencing myopia is unraveled and three novel genes TLCD4,TBC1D4,and EPHX3 are *** findings provide a new perspective on the prevention and treatment of myopia via regulating collagen expression.

关键词： sclera scleral collagen expression hypoxia alpha-ketoglutaric acid myopia

Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage

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Stroke & Vascular Neurology 2024年第4期9卷 429-438,I0131-I0146页

作者： Yujia Jin Yu-hui Huang Yu-ping Chen Yao-dan Zhang Jiawen Li Kai-cheng Yang Xianghua Ye Lu-hang Jin Jian Wu Chang-zheng Yuan Feng Gao Lu-sha Tong Neurology Department The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina School of Public Health Zhejiang UniversityHangzhouChina Department of Neurology Tiantai People's Hospital of Zhejiang ProvinceTaizhouChina

Background and purpose Cortical superficial siderosis(cSS)and cerebral microbleed(CMB)have distinct effects on intracerebral haemorrhage(ICH).We aim to investigate the combined effect of cSS and CMB on outcomes after *** Based on a single-centre stroke registry database,patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were *** patients were divided into four groups(cSS-CMB−,cSS-CMB+,cSS+CMB−,cSS+CMB+)according to cSS and CMB on susceptibility-weighted image of *** outcomes were haematoma volume on admission and unfavourable outcome defined as modified Rankin Scale scores≥3 at 3 *** outcomes were all-cause death,recurrence of stroke and ICH during follow-up(median follow-up 2.0 years,IQR 1.0-3.0 years).Results A total of 673 patients were identified from 1044 patients with spontaneous ICH.131(19.5%)had cSS and 468(69.5%)had *** with cSS+CMB+had the highest rate of poor outcome at 3 months,as well as all-cause death,recurrent stroke and ICH during *** cSS−patients,CMB was associated with smaller haematoma(β−0.13;95%CI−0.22 to−0.03;p=0.009),but it still increased risks of recurrent ICH(OR 4.6;95%CI 1.3 to 15.6;p=0.015)and stroke(OR 2.0;95%CI 1.0 to 4.0;p=0.049).These effects of CMB became unremarkable in the context of cSS+.Conclusions Patients with different combinations of cSS and CMB have distinct patterns of short-term and long-term *** CMB is related to restrained haematoma,it does not improve long-term outcomes.

关键词： superficial cerebral effect

Germ cell-specific deletion of Pex3 reveals essential roles of PEX3-dependent peroxisomes in spermiogenesis

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The Journal of Biomedical Research 2024年第1期38卷 24-36页

作者： Yejin Yao Baolu Shi Xiangzheng Zhang Xin wang Shuangyue Li Ying Yao Yueshuai Guo Dingdong Chen Bing wang Yan Yuan Jiahao sha Xuejiang Guo State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical UniversityNanjingJiangsu 211166China Reproductive and Genetic Branch the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China State Key Laboratory of Reproductive Medicine and Offspring Health Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjing Medical UniversityNanjingJiangsu 211166China.

Peroxisomes are organelles enclosed by a single membrane and are present in various *** abruption of peroxisomes is correlated with peroxisome biogenesis disorders and single peroxisomal enzyme deficiencies that induce diverse diseases in different ***,little is known about the protein compositions and corresponding roles of heterogeneous peroxisomes in various *** transcriptomic and proteomic analyses,we observed heterogenous peroxisomal components among different organs,as well as between testicular somatic cells and different developmental stages of germ *** Pex3 is expressed in both germ cells and Sertoli cells,we generated Pex3 germ cell-and Sertoli cell-specific knockout *** Pex3 deletion in Sertoli cells did not affect spermatogenesis,the deletion in germ cells resulted in male sterility,manifested as the destruction of intercellular bridges between spermatids and the formation of multinucleated giant *** analysis of the Pex3-deleted spermatids revealed defective expressions of peroxisomal proteins and spermiogenesis-related *** findings provide new insights that PEX3-dependent peroxisomes are essential for germ cells undergoing spermiogenesis,but not for Sertoli cells.

关键词： male infertility spermiogenesis peroxisome oxidative stress PEX3

Research Progress in Integrated Chinese and Western Medicine Health Management for School-Age Children with Asthma

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Journal of Clinical and Nursing Research 2024年第7期8卷 85-90页

作者： Hanlu Zhang Le wang sha wang Nannan Ma Li Mei shaanxi Provincial People’s Hospital Children’s Hospital Xi’an 710000Shaanxi ProvinceChina

Objective:The purpose of this study is to investigate the application of Chinese and Western medicine in the health management of school-age children with asthma and its research progress,with a view to providing a more comprehensive and effective management strategy for the ***:Using the method of literature review,this study systematically searched and analyzed the relevant studies on the combination of Chinese and Western medicine in the health management of school-aged children with asthma in recent years,focusing on Chinese medicine treatment,Western medicine treatment,and the combined health management of Chinese and Western ***:Chinese medicine treatment,Western medicine treatment,and the health management mode of combining Chinese and Western medicine showed unique advantages in school-age asthmatic *** the comprehensive use of Chinese medicine’s diagnosis and treatment,Chinese medicine conditioning,Chinese medicine characteristic therapy,and Western medicine’s modern medical methods,it not only effectively relieved asthma symptoms but also significantly improved the quality of life of the *** the same time,this management mode also focuses on the psychological guidance and family care of the children,forming an all-round and multi-level health management ***:The health management strategy of combining Chinese and Western medicine has a broad application prospect in school-age asthmatic children,and its specific interventions and mechanisms of action should be further studied to provide more scientific and systematic guidance for clinical practice.

关键词： School-age children with asthma Chinese medicine treatment Western medicine treatment Health management

鼻泪管阻塞患者内镜下泪囊鼻腔吻合术前后视觉质量变化

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中华眼视光学与视觉科学杂志 2024年第5期26卷 347-352页

作者：张咏李沙武汉爱尔眼科医院汉口医院武汉430024

目的:探讨内镜下泪囊鼻腔吻合术前后视觉质量的变化。方法:回顾性临床研究。连续收集2021年5月至2023年3月于武汉爱尔眼科医院汉口医院行内镜下泪囊鼻腔吻合术的鼻泪管阻塞患者67例(101眼)。分析患者术前,术后3周、2个月、3个月的泪河高... 详细信息

目的:探讨内镜下泪囊鼻腔吻合术前后视觉质量的变化。方法:回顾性临床研究。连续收集2021年5月至2023年3月于武汉爱尔眼科医院汉口医院行内镜下泪囊鼻腔吻合术的鼻泪管阻塞患者67例(101眼)。分析患者术前,术后3周、2个月、3个月的泪河高度(TMH)、斯特列尔比(SR)、人眼调制传递函数(MTF)曲线中4 mm面积比(AR)以及角膜高阶像差的变化,包括角膜总高阶像差、球差、彗差、三叶草像差。TMH、SR、AR及各类角膜高阶像差分析采用混合模型Ⅲ类固定效应检验,组间两两比较采用Bofferoni校正法;手术前后TMH与SR、AR及各类角膜高阶像差的相关性分析采用Spearman分析法。结果:术前,术后3周、2个月、3个月的TMH、SR、AR、角膜总高阶像差、球差、彗差、三叶草像差比较总体差异均有统计学意义(均P0.05)。手术前后各时间点TMH与SR、AR、角膜总高阶像差、球差、彗差及三叶草像差均无相关性(均P>0.05)。结论:内镜下泪囊鼻腔吻合术后患者的TMH逐渐降低,泪膜形态发生变化,患者的视觉质量明显提升。

关键词：鼻泪管阻塞内镜泪囊鼻腔吻合术泪膜视觉质量

“遇邪”与清代假命案的形成与处理——以《巴县档案》为中心的讨论

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史学集刊 2024年第3期 35-46页

作者：陈廷湘白莎莎四川大学历史文化学院四川成都610065

有清一代,凡最终确定并不构成关系人犯罪的命案称为假命案。在对假命案的处理过程中,涉案人及州县官员均有借用“遇邪”之类理据来促成案件和解的行为。虽然百姓以死者“遇邪”为由和解命案的背后多隐含金钱因素的推动,但知县为了顺利结... 详细信息

有清一代,凡最终确定并不构成关系人犯罪的命案称为假命案。在对假命案的处理过程中,涉案人及州县官员均有借用“遇邪”之类理据来促成案件和解的行为。虽然百姓以死者“遇邪”为由和解命案的背后多隐含金钱因素的推动,但知县为了顺利结案,对于这一结果往往乐见其成,甚至在审案过程中还存在一些主动引导涉案人确认死者遇邪身亡之举。然而,由于朝廷以儒家思想规范社会,总体上不容妖邪鬼怪之说,州县在上呈详文中又往往隐去“遇邪”的死因记录,以致档案记载的司法状况多呈混乱。在当时社会环境下,此类司法实践存在一定的合理性,但同时也必须看到,这种司法实践会造成案情中许多对社会生活史和法制史研究有重要意义的真实细节的遗失。

关键词：巴县档案遇邪假命案

The Efficacy of Electromyographic Biofeedback Combined with Swallowing Training on Post- Stroke Dysphagia

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Journal of Clinical and Nursing Research 2024年第5期8卷 309-314页

作者： Le wang Yu Zhang Xiaohui wang Zhi Li sha Chang Department of Neurology Shaanxi Provincial People’s HospitalXi’an 710068ShaanxiChina Department of Gynecology Shaanxi Provincial People’s HospitalXi’an 710068ShaanxiChina

Objective:This paper focuses on the research and discussion of the efficacy of electromyographic biofeedback combined with swallowing training on post-stroke ***:This study randomly sampled and analyzed 68 patients with post-stroke dysphagia from January 2023 to December 2023,34 cases of swallowing training intervention were grouped as the control group,and 34 cases of electromyography biofeedback combined with swallowing training intervention were grouped as the study group,and the clinical therapeutic effects of the two groups of patients after receiving the two different modes of intervention were ***:The swallowing function of patients in both groups improved,and the VFSS score of patients in the seminar group was significantly higher than that of the control group,indicating that the clinical efficacy of the seminar group was more *** nasal feeding tube extraction rate,extraction time,and quality of life scores of the seminar group were better than those of the control group(Pwallowing training mode can significantly improve their swallowing *** effective intervention can not only shorten the time for patients to remove the nasal feeding tube but also help to improve the quality of life of patients,which is worth using.

关键词： Electromyographic biofeedback Stroke Swallowing training

Climate change drives flooding risk increases in the Yellow River Basin

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Geography and Sustainability 2024年第2期5卷 193-199页

作者： Hengxing Lan Zheng Zhao Langping Li Junhua Li Bojie Fu Naiman Tian Ruixun Lai sha Zhou Yanbo Zhu Fanyu Zhang Jianbing Peng John J.Clague State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710064China University of Chinese Academy of Sciences Beijing 10049China Yellow River Institute of Hydraulic Research Yellow River Conservancy CommissionZhengzhou 450003China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Earth Surface Processes and Resources Ecology Beijing Normal UniversityBeijing 100875China Key Laboratory of Mechanics on Disaster and Environment in Western China The Ministry of Education of ChinaSchool of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China Department of Earth Sciences Simon Fraser UniversityBurnabyCanada

The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout *** climate change has been suggested to be driving a worldwide increase in flooding ***,owing to insufficient evidence,the quantitative correlation between flooding and climate change remains *** present a long time series of maximum flood discharge in the YRB dating back to 1843 compiled from historical documents and instrument *** in yearly maximum flood discharge show distinct periods:a dramatic decreasing period from 1843 to 1950,and an oscillating gentle decreasing from 1950 to 2021,with the latter period also showing increasing more extreme floods.A Mann-Kendall test analysis suggests that the latter period can be further split into two distinct sub-periods:an oscillating gentle decreasing period from 1950 to 2000,and a clear recent increasing period from 2000 to *** further predict that climate change will cause an ongoing remarkable increase in future flooding risk and an∼44.4 billion US dollars loss of floods in the YRB in 2100.

关键词： Flooding risk Risk management Climate change Flood discharge Extreme precipitation