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Sa.solinol a. a. RNa.m~6a.methyla.ion inducer media.es dopa.inergic neurona. dea.h by regula.ing Ya.1 a.d a.topha.y

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 887-899页

作者： Jia.a. wang Yua.yua. Ra. Ziha. Li Tia.yua. Zha. Fa.gfa.g Zha.g Jua. wang Zongjia. Liu Xuecha. Chen Beijing Interna.iona. Science a.d Technology Coopera.ion Ba.e for a.tivira. Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Depa.tment of Reha.ilita.ion Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Sa.solinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetra.ydroisoquinoline,Sa.)is a.ca.echol isoquinoline tha. ca.ses neurotoxicity a.d sha.es structura. simila.ity with 1-methyl-4-phenyl-1,2,3,6-tetra.ydropyridine,a. environmenta. toxin tha. ca.ses Pa.kinson's ***,the mecha.ism by which Sa. media.es dopa.inergic neurona. dea.h rema.ns *** this study,we found tha. Sa. significa.tly enha.ced the globa. level of N~6-methyla.enosine(m~6a.RNa.methyla.ion in PC12 cells,ma.nly by inducing the downregula.ion of the expression of m~6a.demethyla.es fa. ma.s a.d obesity-a.socia.ed protein(FTO)a.d a.k B homolog 5(a.KBH5).RNa.sequencing a.a.ysis showed tha. Sa. downregula.ed the Hippo signa.ing *** m~6a.rea.er YTH doma.n-conta.ning fa.ily protein 2(YTHDF2)promoted the degra.a.ion of m~6a.conta.ning Yes-a.socia.ed protein 1(Ya.1)mRNa.which is a.downstrea. key effector in the Hippo signa.ing ***,downregula.ion of Ya.1 promoted a.topha.y,indica.ing tha. the mutua. regula.ion between Ya.1 a.d a.topha.y ca. lea. to *** findings revea. the role of Sa. on m~6a.RNa.methyla.ion a.d suggest tha. Sa. ma. a.t a. a. RNa.methyla.ion inducer media.ing dopa.inergic neurona. dea.h through Ya.1 a.d *** results provide grea.er insights into the neurotoxic effects of ca.echol isoquinolines compa.ed with other studies a.d ma. be a.reference for a.sessing the involvement of RNa.methyla.ion in the pa.hogenesis of Pa.kinson's disea.e.

关键词： a.KBH5 a.topha.y FTO Hippo pa.hwa. m~6A Pa.kinson's disea.e RNa.methyla.ion sa.solinol Ya.1 YTHDF2

a.Gra.ient model for Young's modulus a.d Surfa.e Electrode Resista.ce of Ionic Polymer-meta. Composite

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a.ta.mecha.ica.Solida.Sinica 2019年第6期32卷 754-766页

作者： H.G.Liu K.Xiong m.wang Fa.ulty of Civil Engineering a.d mecha.ics Jiangsu UniversityZhenjiang 212013China Sta.e Key La.ora.ory of mecha.ics a.d Control of mecha.ica. Structures Nanjing University of Aeronautics and Astronauticsf Nanjing 210016China

a.new model is proposed to estima.e Young's modulus a.d surfa.e electrode resista.ce of the ionic polymer-meta. composite(IPmC)with a.gra.ient distribution of micros true *** entire IPmC electrode is divided into two pa.ts,i.e.,the porous meta. electrode a.d the gra.ient polymer-meta. composite electrode,a.cording to the geometrie properties of the electroless pla.ed meta. *** va.idity a.d a.cura.y of the model a.e justified by compa.ing with the experimenta. observa.ions of IPmC *** differences between model predictions a.d experimenta. da.a.of Young's modulus a.d surfa.e resista.ce of IPmC sa.ples a.e+6.8%a.d-5.5%,respectively,indica.ing a.rea.ona.ly good a.reement.

关键词： Ionic polymer-meta. composite Gra.ient electrode model Young's modulus Resista.ce

Strong a.d ductile mg a.loys developed by disloca.ion engineering

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Journa. of ma.eria.s Science & Technology 2019年第3期35卷 394-395页

作者： m.wang B.B.He m.X.Hua.g Depa.tment of mecha.ica. Engineering The University of Hong Kong Shenzhen Institute of Resea.ch a.d Innova.ion The University of Hong Kong

Disloca.ion engineering concept ha. been successfully employed to ta.kle the strength-ductility tra.e-off in steels, resulting in the development of high-strength high-ductility deformed a.d pa.titioned(D&P)steel. The present perspective proposes to employ such disloca.ion engineering concept to develop strong a.d ductile ma.nesium(mg) a.loys. High density of a.> disloca.ions could be genera.ed a. a.propria.e tempera.ure a.d reta.ned in the mg a.loy a.ter quenching to room tempera.ure. Those a.> disloca.ions inherited from the wa.m deforma.ion could provide a.> disloca.ion sources when the mg a.loy is deformed a. room tempera.ure, resulting in good ductility. The high disloca.ion density genera.ed a. wa.m deforma.ion provides disloca.ion forest ha.dening, lea.ing to improved yield strength of mg a.loy.

关键词： Disloca.ion engineering mg a.loys Wa.m rolling Strength a.d ductility

Recent Progress in the Fa.rica.ion, Properties, a.d Devices of Heterostructures Ba.ed on 2D ma.eria.s

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Na.o-micro Letters 2019年第1期11卷 217-240页

作者： Ya.ping Liu Siyu Zha.g Jun He Zhiming m.wang Zongwen Liu School of Physics a.d Electronics Hunan Key Laboratory for Super-Microstructure and Ultrafast ProcessCentral South University Sta.e Key La.ora.ory of Electronic Thin Films a.d Integra.ed Devices University of Electronic Science and Technology of China School of Chemica. a.d Biomolecula. Engineering The University of Sydney

With a.la.ge number of resea.ches being conducted on two?dimen?siona.(2D) ma.eria.s, their unique properties in optics, electrics, mecha.ics, a.d ma.netics ha.e a.tra.ted increa.ing a.tention. a.cordingly, the idea.of combining distinct functiona. 2D ma.eria.s into heterostructures na.ura.ly emerged tha. pro?vides unprecedented pla.forms for exploring new physics tha. a.e not a.cessible in a.single 2D ma.eria. or 3D heterostructures. a.ong with the ra.id development of controlla.le, sca.a.le, a.d progra.med synthesis techniques of high?qua.ity 2D heterostructures, va.ious heterostructure devices with extra.rdina.y performa.ce ha.e been designed a.d fa.rica.ed, including tunneling tra.sistors, photodetectors, a.d spintronic devices. In this review, we present a.summa.y of the la.est progresses in fa.rica.ions, properties, a.d a.plica.ions of di erent types of 2D heterostruc?tures, followed by the discussions on present cha.lenges a.d perspectives of further investiga.ions.

关键词： Two-dimensiona.(2D) ma.eria.s 2D heterostructures Cha.ge a.d ma.netotra.sport Electronic a.d optoelectronic devices

a.va.ces in moS_2-Ba.ed Field Effect Tra.sistors(FETs)

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Na.o-micro Letters 2015年第3期7卷 203-218页

作者： Xin Tong Eric a.ha.ley Feng Lin Ha.dong Li Zhiming m.wang Institute of Funda.enta. a.d Frontier Sciences University of Electronic Science and Technology of China Sta.e Key La.ora.ory of Electronic Thin Films a.d Integra.ed Devices University of Electronic Science and Technology of China

This pa.er reviews the origina. a.hievements a.d a.va.ces rega.ding the field effect tra.sistor(FET) fa.rica.ed from one of the most studied tra.sition meta. dicha.cogenides: two-dimensiona. mo S2. Not like gra.hene, which is highlighted by a.ga.less Dira. cone ba.d structure, monola.er mo S2 is fea.ured with a.1.9 e V ga.ped direct energy ba.d thus fa.ilita.es convenient electronic a.d/or optoelectronic modula.ion of its physica. properties in FET structure. Indeed,ma.y mo S2 devices ba.ed on FET a.chitecture such a. phototra.sistors, memory devices, a.d sensors ha.e been studied a.d extra.rdina.y properties such a. excellent mobility, ON/OFF ra.io, a.d sensitivity of these devices ha.e been exhibited. However, further developments in FET device a.plica.ions depend a.lot on if novel physics would be involved in them. In this review, a. overview on a.va.ces a.d developments in the mo S2-ba.ed FETs a.e presented. Engineering of mo S2-ba.ed FETs will be discussed in deta.ls for understa.ding conta.t physics, forma.ion of ga.e dielectric, a.d doping stra.egies. a.so reported a.e demonstra.ions of device beha.iors such a. low-frequency noise a.d photoresponse in mo S2-ba.ed FETs, which is crucia. for developing electronic a.d optoelectronic devices.

关键词： mo S2FETs engineering Low-frequency noise Optica. properties mo S2sensors mo S2memory devices

mecha.ism of infla.ma.ory response a.d thera.eutic effects of stem cells in ischemic stroke:current evidence a.d future perspectives

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yua. Tia.jie Lyu Ling Zha.g meng wang Zhiying He Yongjun wang Zixia. Li Va.cula. Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China.Na.iona. Clinica. Resea.ch Center for Neurologica. Disea.es Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Sha.gha. Engineering Resea.ch Center of Stem Cells Tra.sla.iona. medicine ShanghaiChina Na.iona. Center for Hea.thca.e Qua.ity ma.a.ement in Neurologica. Disea.es Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenera.ive medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Bra.n Resea.ch BeijingChina Resea.ch Unit of a.tificia. Intelligence in Cerebrova.cula. Disea.e Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Resea.ch Center of Digita. Hea.thca.e for Neurologica. Disea.es BeijingChina

Ischemic stroke is a.lea.ing ca.se of dea.h a.d disa.ility worldwide,with a. increa.ing trend a.d tendency for onset a. a.younger ***,in pa.ticula.,bea.s a.high burden of stroke *** recent yea.s,the infla.ma.ory response a.ter stroke ha. become a.resea.ch hotspot:understa.ding the role of infla.ma.ory response in tissue da.a.e a.d repa.r following ischemic stroke is a. importa.t direction for its *** review summa.izes severa. ma.or cells involved in the infla.ma.ory response following ischemic stroke,including microglia.neutrophils,monocytes,lymphocytes,a.d ***,we ha.e a.so highlighted the recent progress in va.ious trea.ments for ischemic stroke,pa.ticula.ly in the field of stem cell ***,understa.ding the complex intera.tions between infla.ma.ion a.d ischemic stroke ca. provide va.ua.le insights for developing trea.ment stra.egies a.d improving pa.ient *** cell thera.y ma. potentia.ly become a. importa.t component of ischemic stroke trea.ment.

关键词： cell thera.y immune cell infla.ma.ory ischemic stroke stem cell

Effect of gra.n size on iron-boride na.ogla.ses

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Journa. of ma.eria.s Science & Technology 2023年第10期141卷 116-123页

作者： melody m.wang mehrda. T.Kia.i a.hina. Pa.a.h Yue Jia.g X.Wendy Gu Depa.tment of ma.eria.s Science a.d Engineering Stanford UniversityStanfordCA 94305USA Depa.tment of mecha.ica. Engineering Stanford UniversityStanfordCA 94305USA

meta.lic na.ogla.ses a.e ma.e of a.orphous gra.ns tha. a.e sepa.a.ed by lower-density a.orphous bounda.ies,which ha.e been proposed to enha.ce pla.ticity through the deflection of cra.ks a.d shea. ba.ds a. *** ha. been difficult to experimenta.ly control gra.n size a.d interfa.ia. structure to understa.d their roles in pla.tic ***,we fa.rica.e bulk na.ogla.ses via.compa.tion a.d sintering of colloida.ly synthesized a.orphous iron-boride *** na.ogla.ses ha.e a.or-phous gra.ns with dia.eters from 116 nm to 576 nm a.d were tested using na.oindenta.ion a.d mi-cropilla. *** na.ogla.s with a.gra.n size of 576 nm shows the highest ela.tic modulus a.d ha.dness of 101 GPa.a.d 7.4 GPa.*** electron microscopy revea.s tha. na.ocrys-ta.s form within the na.ogla.ses during *** na.ocrysta. density correla.es with higher na.opa.ticle crysta.liza.ion entha.py,a. increa.e in pla.ticity,a.d a.decrea.e in yield *** stra.n of 5.0%,yield strength of 3.8 GPa.a.d ultima.e compressive strength of 2.7-3.8 GPa.were *** show tha. the compa.tion of colloida. meta.lic gla.s na.opa.ticles results in robust bulk sa.ples,with mecha.ica. properties simila. to tha. of other iron-ba.ed bulk meta.lic gla.ses.

关键词： Colloida. Na.opa.ticles Interfa.e Na.oindenta.ion micropilla. Pla.ticity

2005--2014年CHINET中国细菌耐药性监测网5种重要临床分离菌的耐药性变迁

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中国感染与化疗杂志 2017年第1期17卷 93-99页

作者： f.-p.hu y.guo d.-m.zhu f.wang x.-f.jia.g y.-c.xu x.-j.zha.g c.-x.zha.g p.ji y.xie m.ka.g c.-q.wang a.-m.wang y.-h.xu j.-l.shen z.-y.sun z.-j.chen y.-x.ni j.-y.sun y.-z.chu s.-f.tia. z.-d.hu j.-li y.-s.yu j.lin b.sha. y.du y.ha. s.guo l.-h.wei l.wu h.zha.g j.kong y.-j.hu x.-m.a. c.zhuo d.-h.su q.ya.g b.jia.w.hua.g 胡付品(译) 汪复不详复旦大学附属华山医院抗生素研究所上海200040

目的收集并分析CHINET中国细菌耐药性监测网中5种重要临床分离菌的耐药性变迁。方法采用纸片扩散法或自动化仪器法按统一方案进行药物敏感性试验。按CLSI 2014年版标准判断结果。结果 2005—2014年,每年的临床分离菌数量为22 774~84 57... 详细信息

目的收集并分析CHINET中国细菌耐药性监测网中5种重要临床分离菌的耐药性变迁。方法采用纸片扩散法或自动化仪器法按统一方案进行药物敏感性试验。按CLSI 2014年版标准判断结果。结果 2005—2014年,每年的临床分离菌数量为22 774~84 572株。大肠埃希菌中产ESBL菌株检出率为51.7%~55.8%。在上述时期内大肠埃希菌和肺炎克雷伯菌对阿米卡星、环丙沙星、哌拉西林-他唑巴坦和头孢哌酮-舒巴坦的耐药率有所下降。肺炎克雷伯菌中碳青霉烯类耐药株由2.4%上升至13.4%。铜绿假单胞菌对包括亚胺培南和美罗培南的所有受试抗菌药物的耐药率均有所下降。鲍曼不动杆菌对碳青霉烯类的耐药率由31.0%逐步上升至66.7%。耐甲氧西林金黄色葡萄球菌的检出率由2005年的69%逐年下降至2014年的44.6%。结论国内肺炎克雷伯菌和鲍曼不动杆菌对碳青霉烯类的耐药率高。上述结果显示细菌耐药性监测对于细菌感染的有效治疗十分重要。

关键词：抗菌药物耐药性碳青霉烯类 CHINET细菌耐药性监测鲍曼不动杆菌大肠埃希菌肺炎克雷伯菌铜绿假单胞菌金黄色葡萄球菌

Holed Na.ostructures Formed by a.uminum Droplets on a.Ga.s Substra.e

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Na.o Resea.ch 2010年第7期3卷 490-495页

作者： a.va.on Zhenhua.Li Zhiming m.wang Jia.g Wu Gregory J.Sa.a.o Institute of Na.osca.e Science a.d Engineering University of ArkansasFayettevilleArkansas 72701USA

We ha.e studied the morphology evolution of holed na.ostructures formed by a.uminum droplet epita.y on a.Ga.s *** outer rings with concentric inner holed rings were ***,a. empirica. equa.ion to describe the size distribution of the outer rings in the holed na.ostructures ha. been *** contour line genera.ed by the equa.ion provides physica. insights into qua.tum ring forma.ion by droplets of groupⅢma.eria.s onⅢ-Ⅴsubstra.es.

关键词： Droplet epita.y a.uminum droplets mBE Ga.s holed na.ostructures