检索结果-南通市图书馆

Extrahepatic organs in the development of non-alcoholic fatty liver disease in liver transplant patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2022年第3期11卷 400-411页

作者： Renyi Su Xuyong Wei Qiang Wei Di Lu zuyuan lin Shuo Wang Chuxiao Shao Xiao Xu Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina NHC Key Laboratory of Combined Multi-Organ Transplantation HangzhouChina Department of Hepatobiliary and Pancreatic Surgery Shu Lan HospitalShu Lan International Medical College of Zhejiang Shuren UniversityHangzhouChina Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishuiChina

Background and Objective:Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients who undergo liver transplantation(LT).Whereas there is huge data on NAFLD,little is known about NAFLD in *** this review,we aim to explore extrahepatic organs and their potential mechanisms in the development of NAFLD in LT patients and discuss current limitations in preclinical and clinical scenarios with suggestions for future ***:The following keywords,such as NAFLD,NASH,liver transplant,therapy,pathogenesis and biomarkers,were set for literature *** articles which were published articles in English till 25th June 2020 in PubMed database were included,and there is no limit for the study design *** Content and Findings:Following LT,there are significant shifts in the microbiota and farnesoid X receptor may be a potential therapeutic target for NAFLD in LT *** roles of probiotics and diet on NALFD remain inconclusive in LT ***,the adipokines and cytokines disorder and local insulin resistance of adipose tissue may contribute to NAFLD *** surgeries are promising in controlling de novo and recurrent NAFLD with significant reduction in abdominal adipose tissue,despite the optimal timing is inconclusive in LT ***,circumstantial evidence indicates that miRNA-33a may function as a mediator bridging sarcopenia and NAFLD of post-LT.β-Hydroxy-β-Methyl-Butyrate treatment could improve muscle status in graft recipients and shows protective potential for NAFLD in LT ***:Gut,adipose tissue and muscle are intricately intertwined in promoting NAFLD in LT *** animal studies are needed to deepen our understanding of mechanisms in multi-organ *** quality clinical trials are warrant for making guidelines and developing management strategies on NAFLD after LT.

关键词： Non-alcoholic fatty liver disease(NAFLD) liver transplant sarcopenia lipid gut

FGF21-mediated autophagy:Remodeling the homeostasis in response to stress in liver diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 264-274页

作者： Wei Shen Modan Yang Hao Chen Chiy He Huigang Li Xinyu Yang Jianyong Zhuo zuyuan lin Zhihang Hu Di Lu Xiao Xu Zhejiang University School of Medicine HangzhouZhejiang 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China The Institute for Organ Repair and Regenerative Medicine of Hangzhou HangzhouZhejiang 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhouZhejiang 310003China National Center for Healthcare Quality Management in Liver Transplant HangzhouZhejiang 310003China

Liver diseases are worldwide problems closely associated with various stresses,such as endoplasmic reticulum *** exact interplay between stress and liver diseases remains *** plays an essential role in maintaining homeostasis,and recent studies indicate tight crosstalk between stress and autophagy in liver *** the bal-ance between damage and autophagy is broken,autophagy can no longer resist injury or main-tain *** recent years,FGF21(fibroblast growth factor 21)-induced autophagy has attracted much ***21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to ***,increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal *** review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clinical practice.

关键词： Autophagy Fibroblast growth factor 21 Liver diseases mTOR Stress

Double-negative T cells:a promising avenue of adoptive cell therapy in transplant oncology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 387-396页

作者： Zhihang HU Modan YANG Hao CHEN Chiyu HE zuyuan lin Xinyu YANG Huigang LI Wei SHEN Di LU Xiao XU Zhejiang University School of Medicine Hangzhou 310058China Department of Hepatobiliary and Pancreatic Surgery Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310004China

Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver *** addition to the common mechanisms underlying tumor recurrence,another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and *** oncology is an emerging field that addresses oncological challenges in *** this context,a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of ***-negative T cells(DNTs)are a cluster of heterogeneous cells mainly consisting of two subsets stratified by T cell receptor(TCR)*** them,TCRαβ^(+)DNTs are considered to induce immune suppression in immune-mediated diseases,while TCRγδ^(+)DNTs are widely recognized as tumor *** a composite cell therapy,healthy donor-derived DNTs can be propagated to therapeutic numbers in vitro and applied for the treatment of several malignancies without impairing normal tissues or being rejected by the *** this work,we summarized the biological characteristics and functions of DNTs in oncology,immunology,and *** on the multiple roles of DNTs,we propose that a new balance could be achieved in liver transplant oncology using them as an off-the-shelf adoptive cell therapy(ACT).

关键词： Double-negative T cell(DNT) Adoptive cell therapy(ACT) Liver cancer Liver transplantation Oncology

TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2023年第1期35卷 66-80页

作者： Huigang Li zuyuan lin Jianyong Zhuo Modan Yang Wei Shen Zhihang Hu Yichen Ding Hao Chen Chiyu He Xinyu Yang Siyi Dong Xuyong Wei Beicheng Sun Shusen Zheng Ren Lang Di Lu Xiao Xu Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China The Institute for Organ Repair and Regenerative Medicine of Hangzhou Hangzhou 310006China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China National Center for Healthcare Quality Management in Liver Transplant Hangzhou 310003China Department of Hepatobiliary Surgery the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 311112China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 31003China Department of Hepatobiliary Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical UniversityBeijing 100020China

Objective:Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma(HCC).The precise prediction of post-transplant lung metastasis in the early phase is of great ***:The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling *** enrolled 241 HCC patients who underwent liver transplantation from three *** microarrays were used to evaluate the prognostic capacity of tumor necrosis factor(TNF),tumor necrosis factor receptor 1(TNFR1),and TNFR2,particularly for post-transplant lung ***:Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of *** expression of TNF was degraded in comparison to that in para-tumor tissues(Pling pathway,TNFR1 and TNFR2,was higher in HCC tissues than in para-tumor tissues(P<0.001).TNF and TNFR1 showed no relationship with patients’outcomes,whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival(OS)and increased recurrence risk(5-year OS rate:31.9%vs.62.5%,P<0.001).Notably,elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis(hazard ratio:1.146;P<0.001).Cox regression analysis revealed that TNFR2,Hangzhou criteria,age,and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis,and a novel nomogram was established *** nomogram achieved excellent prognostic efficiency(area under time-dependent receiver operating characteristic=0.755,concordance-index=0.779)and was superior to conventional models,such as the Milan ***:TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC.A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantatio

关键词： Lung metastasis hepatocellular carcinoma liver transplantation nomogram

维普期刊数据库

A NEW TEXTURE IMAGE RETRIEVAL WAY

在线全文

学校读者我要写书评

暂无评论

Journal of Electronics(China) 2001年第4期18卷 306-313页

作者： Wang zuyuan Luo lin Zhuang Zhenquan(Dept. of Electronic Science and Technology, University of Science & Technology of China, Hefei 230026) Dept. of Electronic Science and Technology University of Science & Technology of China Hefei

This paper proposes a new texture image retrieval method for the considering of the population search and random information exchange merits of evolving programming which can be used to optimize image feature vector extraction. The experimental results show that this way can efficiently improve the retrieval accuracy and realize fasttips with the advantage of evolving programming algorithm.

关键词： Texture image Image retrieval Evolving programming

维普期刊数据库

Impact of immunosuppressants on tumor pulmonary metastasis: new insight into transplantation for hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第11期21卷 1033-1049页

作者： Jinyan Chen Huigang Li Jianyong Zhuo zuyuan lin Zhihang Hu Chiyu He Xiang Wu Yiru Jin Zhanyi lin Renyi Su Yiyang Sun Rongsen Wang Jiancai Sun Xuyong Wei Shusen Zheng Di Lu Xiao Xu Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People's Hospital School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical College The Fourth School of Clinical Medicine Zhejiang Chinese Medical University Department of Hepatobiliary and Pancreatic Surgery Shulan (Hangzhou) Hospital Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery Zhejiang Provincial People's Hospital (Affiliated People's Hospital) School of Clinical Medicine Hangzhou Medical College Institute of Translational Medicine Zhejiang University School of Medicine

Pulmonary metastasis is a life-threatening complication for patients with hepatocellular carcinoma(HCC) undergoing liver transplantation(LT). In addition to the common mechanisms underlying tumor metastasis, another inevitable factor is that the application of immunosuppressive agents, including calcineurin inhibitors(CNIs) and rapamycin inhibitors(mTORis), after transplantation could influence tumor recurrence and metastasis. In recent years, several studies have reported that mTORis, unlike CNIs, have the capacity to modulate the tumorigenic landscape post-liver transplantation by targeting metastasis-initiating cells and reshaping the pulmonary microenvironment. Therefore, we focused on the effects of immunosuppressive agents on the lung metastatic microenvironment and how mTORis impact tumor growth in distant organs. This revelation has provided profound insights into transplant oncology, leading to a renewed understanding of the use of immunosuppressants after LT for HCC.

关键词： Liver transplantation hepatocellular carcinoma immunosuppressants lung immune microenvironment lung metastasis

CCL16 inhibits tumor proliferation and metastasis in HCC by impacting CK19 phenotype

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

iLIVER 2024年第2期3卷 43-52页

作者： Huigang Li Jianyong Zhuo Peiru Zhang Jinyan Chen zuyuan lin Xudong Yang Ruijie Zhao Chenghao Cao Wei Shen Chiyu He Hao Chen Ting Lv Xuyong Wei Shusen Zheng Xiao Xu Di Lu Zhejiang University School of Medicine Hangzhou 310058China Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People’s HospitalHangzhou 310006China The Fourth School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310000China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310000China Hangzhou Normal University Hangzhou 310000China Department of Hepatobiliary&Pancreatic Surgery and Minimally Invasive Surgery Zhejiang Provincial People’s HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou 310014China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China Institute of Translational Medicine Zhejiang UniversityHangzhou 310000China

Background and aims:Cytokeratin 19-positive(CK19t)hepatocellular carcinoma(HCC)is an aggressive subtype with poor *** initiation and development of CK19t HCC in the background of liver cirrhosis remains *** study investigated the role of the cirrhosis-related gene C-C motif chemokine ligand 16(CCL16)in the development of CK19t ***:Datasets from Gene Expression Omnibus(GEO),The Cancer Genome Atlas(TCGA)and International Cancer Genome Consortium(ICGC)were analyzed to screen and validate the genes associated with CK19t HCC.A total of 102 HCC patients were included for tissue microarray ***-of-function experiments were conducted to investigate the biological functions of *** was used to investigate the correlation of CCL16 and immune ***:GEO dataset analysis showed that CK19t HCC had lower expression of *** both TCGA dataset and our HCC cohort,CCL16 expression was negatively correlated with CK19 expression(P<0.05)and its expression was higher in para-tumor than tumor tissues(P<0.001).Moreover,low CCL16 expression was related to advanced stage and poor overall survival(P<0.05).CCL16 overexpression downregulated CK19 expression and impacted the sphere formation ability of HCC *** of CCL16 inhibited the cell proliferation,migration,and invasion of HCC cell *** analysis showed HCC with high CCL16 expression had more infiltration of mast *** patients with both low CCL16 expression and low mast cells had the worst prognosis(P<0.001).Conclusion:Our data indicated that CCL16 downregulated the expression of CK19 and inhibited the malignant phenotype of HCC.

关键词： Hepatocellular carcinoma Cytokeratin 19 C-C motif chemokine ligand 16 Mast cells Prognosis

Integrated sensing and communication in an optical fibre

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第5期12卷 729-742页

作者： Haijun He lin Jiang Yan Pan Anlin Yi Xihua Zou Wei Pan Alan E.Willner Xinyu Fan zuyuan He Lianshan Yan Center for Information Photonics&Communications School of Information Science and TechnologySouthwest Jiaotong University611756 ChengduSichuanChina Peng Cheng Laboratory 518052 ShenzhenChina Optical Fiber Communications Laboratory University of Southern CaliforniaLos AngelesCA 90089USA State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong University200240 ShanghaiChina

The integration of high-speed optical communication and distributed sensing could bring intelligent functionalities to ubiquitous optical fibre networks,such as urban structure imaging,ocean seismic detection,and safety monitoring of underground embedded *** work demonstrates a scheme of integrated sensing and communication in an optical fibre(ISAC-OF)using the same wavelength channel for simultaneous data transmission and distributed vibration *** scheme not only extends the intelligent functionality for optical fibre communication system,but also improves its transmission performance.A periodic linear frequency modulation(LFM)light is generated to act as the optical carrier and sensing probe in PAM4 signal transmission and phase-sensitive optical time-domain reflectometry(Φ-OTDR),*** a 24.5 km fibre transmission,the forward PAM4 signal and the carriercorrespondence Rayleigh backscattering signal are detected and *** results show that the integrated solution achieves better transmission performance(~1.3 dB improvement)and a larger launching power(7 dB enhancement)at a 56 Gbit/s bit rate compared to a conventional PAM4 signal ***,a 4m spatial resolution,4.32-nε/√Hz strain resolution,and over 21 kHz frequency response for the vibration sensing are *** proposed solution offers a new path to further explore the potential of existing or future fibre-optic networks by the convergence of data transmission and status *** addition,such a scheme of using shared spectrum in communication and distributed optical fibre sensing may be used to measure non-linear parameters in coherent optical communications,offering possible benefits for data transmission.

关键词： communication optical fibre

Ultra-high NA graphene oxide flat lens on a fiber facet with near diffraction-limited focusing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第7期12卷 1457-1463页

作者： XIAOKE CHEN lin MA zuyuan HE GUIYUAN CAO HAN lin BAOHUA JIA State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China Nanophotonics Research Center Shenzhen Key Laboratory of Micro-Scale Optical Information TechnologyShenzhen UniversityShenzhen 518060China School of Science RMIT UniversityMelbourne VIC 3000Australia The Australian Research Council(ARC)Industrial Transformation Training Centre in Surface Engineering for Advanced Materials(SEAM) RMIT UniversityMelbourne VIC 3000Australia

The realization of a high numerical aperture(NA) fiber lens is critical for achieving high imaging resolution in endoscopes, enabling subwavelength operation in optical tweezers and high efficiency coupling between optical fibers and photonic chips. However, it remains challenging with conventional design and fabrication. Here we propose an ultrathin(400 nm) graphene oxide(GO) film lens fabricated in situ on a standard single-mode fiber facet using the femtosecond laser direct writing technique. An extremely high NA of 0.89 is achieved with a near diffraction-limited focal spot(FWHM = 0.68λ), which is verified theoretically and experimentally. The diameter of the fabricated fiber GO lens is as small as 12 μm with no beam expansion structure. The proposed fiber GO lens is promising for applications such as super-resolution imaging, compact optical tweezers, medical endoscopes,and on-chip integration.

关键词： fiber high oxide

维普期刊数据库