Targeting tumor microenvironment as a treatment strategy for hepatocellular carcinoma
作者机构：Department of Hepatobiliary and Pancreatic SurgeryFirst Affiliated HospitalZhejiang University School of MedicineHangzhouChina National Clinical Research Center for Infectious DiseasesHangzhouChina
出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)
年 卷 期：2020年第9卷第6期
页 面：794-796页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by fundings from National Natural Science Foundation of China(No.81930016) National Major Scientific and Technological Special Project(2017ZX10203205) ey Research&Development Plan of Zhejiang Province(2019C3050)
主 题：hepatocellular mortality treatment
摘 要：Liver cancer was ranked the sixth most commonly diagnosed cancer with the fourth leading cause of cancer-related deaths worldwide in 2018(1).Notably,hepatocellular carcinoma(HCC)constitutes 75-85%among all the liver cancer cases,and ranks first morbidity and mortality of malignancies in Chinese males under *** to hypervascularity in liver and high heterogeneity,HCC was regarded as an aggressive *** clinical trials focusing on resection and transplantation after targeted therapy for advanced HCC show encouraging ***,the adjuvant therapy for patients with high risk of recurrence after surgery still raises ***,emerging evidence suggested that the crosstalk between tumor cells and the microenvironment plays a pivotal role in tumorigenesis and metastasis.
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