Double-negative T cells:a promising avenue of adoptive cell therapy in transplant oncology

作     者：Zhihang HU Modan YANG Hao CHEN Chiyu HE Zuyuan LIN Xinyu YANG Huigang LI Wei SHEN Di LU Xiao XU Zhihang HU;Modan YANG;Hao CHEN;Chiyu HE;Zuyuan LIN;Xinyu YANG;Huigang LI;Wei SHEN;Di LU;Xiao XU

作者机构：Zhejiang University School of MedicineHangzhou 310058China Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang ProvinceHangzhou 310006China Institute of Organ TransplantationZhejiang UniversityHangzhou 310003China NHC Key Laboratory of Combined Multi-organ TransplantationHangzhou 310003China Department of Hepatobiliary and Pancreatic SurgeryShulan(Hangzhou)HospitalHangzhou 310004China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第5期

页      面：387-396页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Key Research&Development Plan of Zhejiang Province(Nos.2019C03050 and 2021C03118) the National Key Research and Development Program of China(No.2021YFA1100500) the National Natural Science Foundation of China(No.92159202) 

主　　题：Double-negative T cell(DNT) Adoptive cell therapy(ACT) Liver cancer Liver transplantation Oncology 

摘      要：Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver *** addition to the common mechanisms underlying tumor recurrence,another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and *** oncology is an emerging field that addresses oncological challenges in *** this context,a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of ***-negative T cells(DNTs)are a cluster of heterogeneous cells mainly consisting of two subsets stratified by T cell receptor(TCR)*** them,TCRαβ^(+)DNTs are considered to induce immune suppression in immune-mediated diseases,while TCRγδ^(+)DNTs are widely recognized as tumor *** a composite cell therapy,healthy donor-derived DNTs can be propagated to therapeutic numbers in vitro and applied for the treatment of several malignancies without impairing normal tissues or being rejected by the *** this work,we summarized the biological characteristics and functions of DNTs in oncology,immunology,and *** on the multiple roles of DNTs,we propose that a new balance could be achieved in liver transplant oncology using them as an off-the-shelf adoptive cell therapy(ACT).