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High Magnetic Property and Toxicity of Particulate Matter Generated during Welding and Cutting Processes

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Environment & Health 2024年第6期2卷 381-389页

作者： Wei Cui zizhen Ma Yuanzheng Chen Shuya Li Di wu Xiu Chen Yuankai Shao Yuzhe Liu Qing Li Jianmin Chen Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266520China Shanghai Institute of Eco-Chongming(SIEC) Shanghai 200062China National Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.LtdTianjin 300300China

Magnetic particulate matter(PM)has raised increasing concern due to its abundant presence in ambient air and negative health ***,there is still a lack of comprehensive understanding of their emission sources and *** here report the observation of high magnetic property and toxicity of PM generated during typical welding and cutting ***,formed during high-temperature operation with less oxygen pressure,was revealed to be the major magnetic *** averaged saturation magnetization and magnetic susceptibility values of fine PM(PM_(2.5))from welding processes are 1.4−4.2 times greater than those of PM emitted from other unintended emission sources,including iron and steel plants and brake wear,while they are 2.0−5.7 times greater for the cutting ***,PM_(2.5)from welding and cutting processes are nearly 3.5−4.5 times more neurovirulent and 2.1−7.0 times more likely to induce oxidative stress than those from other magnetic sources in the nerve cells ***,all of these magnetic PM_(2.5)exhibit greater negative health effects than typical atmospheric PM_(2.5)collected in Shanghai urban *** new findings suggest that appropriate occupational protection measures should be implemented for the welding and cutting process to reduce adverse health impacts.

关键词： pollutant emission magnetic property particulate matters magnetite welding and cutting

Band modification towards high thermoelectric performance of SnSb_(2)Te_(4) with strong anharmonicity driven by cation disorder

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Journal of Materials Science & Technology 2023年第23期154卷 140-148页

作者： Hong wu Peng Chen zizhen Zhou De Zhang Xiangnan Gong Bin Zhang Yang Zhou Kunling Peng Yanci Yan Guiwen Wang Jun Liu Dengfeng Li Guang Han Guoyu Wang Xu Lu Xiaoyuan Zhou School of Science Chongqing University of Posts and Telecommunications Chongqing 400065 China College of Physics and Center for Quantum Materials & Devices Chongqing University Chongqing 401331 China College of Materials Science and Engineering Chongqing University Chongqing 400044 China Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China Analytical and Testing Center of Chongqing University Chongqing 401331 China Interdisciplinary Center for Fundamental and Frontier Sciences Nanjing University of Science and Technology Jiangyin 214443 China

As a typical (IV–VI)_(x)(V_(2)VI_(3))_(y) compound, the tetradymite-like layered SnSb_(2)Te_(4) -based compounds have attracted increasing attention in the thermoelectric community owing to the intrinsically low lattice thermal conductivity. Nevertheless, the effect of cations disorder on the inherent physical characteristics remains puzzling, and its inferior Seebeck coefficient is the bottleneck to achieving high thermoelectric performance. In this work, the thermoelectric properties of polycrystalline In_(x)Sn_(1−x)Sb_(2)(Te_(1−y)Se_(y))_(4) (0≤x≤0.1,0≤y≤0.15) samples are comprehensively investigated. In conjunction with the calculated band structure and experimental results, the Seebeck coefficient and power factor are markedly improved after the introduction of indium and selenium, which originates from the combined effects of the emergent resonant states and converged valence bands along with optimal carrier concentration. Additionally, compared with the ordered lattice structure, the disordered cations occupancy in SnSb_(2)Te_(4) further strengthens lattice anharmonicity and reduces phonon group velocity verified by first-principles calculations, securing intrinsically low lattice thermal conductivity. Finally, a record zT value of ∼0.6 at 670 K and an average zT of ∼0.4 between 320 and 720 K are obtained in the In0.1 Sn0.9 Sb2 Te3.4 Se0.6 sample, being one of the highest zT values among SnSb2 Te4 -based materials. This work not only demonstrates that SnSb2 Te4 -based compounds are promising thermoelectric candidates, but also provides guidance for the promotion of thermoelectric performance in a broad temperature range.

关键词： Thermoelectric SnSb_(2)Te_(4) Lattice anharmonicity Resonant level Band Convergence

一种2.25Cr1MoV钢加氢反应设备蠕变疲劳寿命设计方法

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机械工程学报 2015年第6期51卷 51-57页

作者：武欣宇赵姿贞陈旭天津大学化工学院天津300072

加氢反应器在服役过程中会受到高温高压和循环载荷的共同作用,设计时必须同时考虑蠕变和疲劳的影响。ASME规范案例2605提供一种针对2.25Cr1MoV钢的蠕变疲劳寿命设计方法。借助有限元分析软件ANSYS,采用案例2605中的方法对加氢反应设备... 详细信息

加氢反应器在服役过程中会受到高温高压和循环载荷的共同作用,设计时必须同时考虑蠕变和疲劳的影响。ASME规范案例2605提供一种针对2.25Cr1MoV钢的蠕变疲劳寿命设计方法。借助有限元分析软件ANSYS,采用案例2605中的方法对加氢反应设备圆柱筒体直接管结构进行蠕变疲劳寿命校核,详细阐述该案例的设计思想和具体步骤,并讨论操作温度和压力对于设计寿命的影响。结果表明,接管结构蠕变疲劳寿命校核满足要求,筒体与直接管连接处出现应力集中,由于蠕变应变的产生,应力集中处的应力值随蠕变时间的增加不断下降,蠕变损伤累积速度也随之下降。同时,提高操作温度和操作压力均会造成蠕变损伤的增加,疲劳应力幅对蠕变疲劳的寿命影响较大。针对模拟结果,提出一些提高结构蠕变疲劳寿命的措施。

关键词：加氢设备 2.25Cr1MoV 蠕变疲劳

Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

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Curcumin suppresses NLRP3 inflammasome activation and protec...

适合航行的变体水柱系统波浪转换特性实验研究

第十届全国免疫学学术大会

作者： Jin wu zizhen Gong Jiefei Zhou Shengnan Zhao Yingwei Chen Wei Cai Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai Institute for Pediatric Research

Objective: The NLRP3 inflammasome responds to various pathogen-derived factors and danger-associated molecules, mediating IL-1β maturation, therefore is involved in multiple inflammatory diseases, including septic shock. Strategies aimed at modulation of its activation may represent an appealing treatment for inflammatory diseases it contributes to. Curcumin has been shown to possess strong anti-inflammatory activity, but the underlying mechanism is not fully understood. In this study, we sought to investigate the role and mechanism of curcumin on the inhibition of mature IL-1β production via the regulation of NLRP3 inflammasome as well as its effect on the prevention of LPS- induced septic ***: The secretion of IL-1β and HMGB-1 was detected by western blot and ELISA. Intracellular K+ level was determined by ICP-OES assay. Lysosomal disruption and ROS formation were measured by fluorescent ***: Curcumin dramatically inhibited the production of mature IL-1β in LPS-primed macrophages triggered by mul-tiple NLRP3 inflammasome activators, and also reduced the level of cleaved caspase-1. Curcumin prevented K+ efflux and attenuated lysosomes disruption and intracellular ROS formation as well. The inhibition of NLRP3 inflammasome by curcumin was in part mediated via the suppression of extracellular regulated protein kinases phosphorylation. Furthermore, administration of curcumin significantly reduced peritoneal IL-1β and HMGB-1 concentration induced by LPS and improved the survival of mice suffering from lethal endotoxic ***: Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity. Our finding offers a mechanistic basis for the therapeutic potential of curcumin in septic shock and other NLRP3 inflammasome-driven diseases.

关键词： inflammasome curcumin anti-inflammation

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哈尔滨工程大学学报 2023年第3期44卷 353-360页

作者：吴必军张芙铭覃梓真吴亨宇中国科学院广州能源研究所广东广州510640 中国科学院可再生能源重点实验室广东广州510640 南方海洋科学与工程广东省实验室(广州) 广东广州510640 中国科学院大学北京100049 华南师范大学环境学院广东广州510631

针对现有波浪能技术存在成本高、生存性差等问题,本文研究一种具有航行潜质的变体水柱波浪能转换系统,它由浮力舱、垂直管、水平管、闸门等组成,通过闸门改变振荡水柱的长度和形状,改变航行阻力,实验研究了水柱的长度和形状变化、气流... 详细信息

针对现有波浪能技术存在成本高、生存性差等问题,本文研究一种具有航行潜质的变体水柱波浪能转换系统,它由浮力舱、垂直管、水平管、闸门等组成,通过闸门改变振荡水柱的长度和形状,改变航行阻力,实验研究了水柱的长度和形状变化、气流做功方式对系统转换特性的影响,并提出一套量化标准对系统的转换特性进行评价。水槽实验表明:模型规则波下最高俘获宽度比达到了154.6%,随机波下最高俘获宽度比达到了97.0%;规则下闸门打开的模型的俘获宽度比大概是闸门关闭模型俘获宽度比的1/2,随机波下闸门打开模型的俘获宽度比大概是闸门关闭模型俘获宽度比的3/4。

关键词：波浪能振荡水柱俘获宽度比后弯管垂直管规则波随机波适合航行

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不等截面串联双管浮体模型波浪能量转换特性研究

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太阳能学报 2022年第12期43卷 476-481页

作者：覃梓真吴必军张芙铭中国科学院广州能源研究所广州510640 南方海洋科学与工程广东省实验室(广州) 广州510640 中国科学院可再生能源重点实验室广州510640 中国科学院大学北京100049

提出一种具有后弯管和直通管2种工作模式的新型振荡水柱装置,并通过水槽实验来探讨做功方式、波周期、波高及质量等因素对该装置从波浪能到气动能量转换的影响。水槽实验表明,当模型工作在后弯管模式下,气室中气流双向做功时,规则波中... 详细信息

提出一种具有后弯管和直通管2种工作模式的新型振荡水柱装置,并通过水槽实验来探讨做功方式、波周期、波高及质量等因素对该装置从波浪能到气动能量转换的影响。水槽实验表明,当模型工作在后弯管模式下,气室中气流双向做功时,规则波中的俘获宽度比(CWR)最高可达138.6%,随机波中的CWR最高可达94%;气流单向做功时,规则波中CWR最高可达113.7%,随机波中CWR最高可达81.9%。当模型工作在直通管模式下,气流双向做功时,规则波中CWR最高可达81.1%,随机波中CWR最高可达66.2%;气流单向做功时,规则波中CWR最高可达53.9%,随机波中CWR最高可达42.1%。模型在随机波实验中后弯管、直通管工作模式的CWR峰值分别能达到“巨鲸号”的3倍、2倍,显然模型的后弯管工作模式具有更高的能量转换特性。

关键词：波浪能振荡水柱技术俘获宽度比后弯管直通管

Mendelian Randomization Study of Causal Relationship between Inflammatory Factors and Vascular Dementia and Chinese Herbal Medicines Screening for Prevention and Treatment

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Journal of Biosciences and Medicines 2024年第10期12卷 270-284页

作者： Jinzhi Zhang Wei Chen Guifeng Zhuo Chun Yao Mingyang Su Bingmao Yuan Xiaomin Zhu zizhen Zhou Fengyi Lei Yulan Fu Lin wu Department of Neurology The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning China The First Clinical College of Medicine Guangxi University of Chinese Medicine Nanning China Graduate School Guangxi University of Chinese Medicine Nanning China

Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine prediction method, and to screen potential Chinese herbal medicines for the prevention and treatment of VD. Methods: Single nucleotide polymorphisms (SNPs) that exhibit a strong association with vascular dementia (VD) were identified as instrumental variables from the summary statistics of genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighting (IVW), while auxiliary analyses included the MR-Egger method, weighted median method, simple model, and weighted model. A two-way Mendelian randomization analysis was conducted to assess the causal relationship between inflammatory factors and the risk of VD, thereby identifying the key inflammatory factors involved. The MR-Egger intercept test and Cochran’s Q test were employed to assess the horizontal polymorphism and heterogeneity of instrumental variables. A sensitivity analysis was conducted by excluding one method at a time. Ultimately, based on key inflammatory factors, predictions for the prevention and treatment using traditional Chinese medicine were made, along with the screening of homologous herbal remedies. Results: Based on the results of the forward MR, the probability of developing VD was elevated when the inflammatory factors CXCL10 and CXCL5 were expressed at higher levels, whereas the probability of developing VD decreased as the expression levels of IL-13 and IL-20RA increased. These findings were supported by the assessment of pleiotropy, heterogeneity, and sensitivity. The results of the reverse MR analysis showed that there was no causal relationship between VD, as an exposure dataset, and these four inflammatory factors. According to the key inflammatory factors, 37 Chinese herbal medicines such as Siraitia grosvenorii were selected. Their c

关键词： Inflammatory Factors Vascular Dementia Mendelian Randomization Study Causal Association Chinese Medicine Prediction Medicine and Food Homology

中药麻黄干预下炎症因子LTB_4的UPLC-MS/MS法测定的不确定度评定

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中华中医药学刊 2017年第10期35卷 2670-2675页

作者：杨瑞邸子真吴怡陶弘武辽宁省中医药研究院辽宁沈阳10034

目的:建立中药麻黄提取物干预下,人血浆替代基质中炎症因子花生四烯酸代谢产物LTB_4的UPLC-MS/MS法测定的不确定度评定方法。方法:建立不确定度评定的数学模型,寻找不确定度的来源,确定影响不确定度的因素。用A类评定程序评价分析过程... 详细信息

目的:建立中药麻黄提取物干预下,人血浆替代基质中炎症因子花生四烯酸代谢产物LTB_4的UPLC-MS/MS法测定的不确定度评定方法。方法:建立不确定度评定的数学模型,寻找不确定度的来源,确定影响不确定度的因素。用A类评定程序评价分析过程中随机效应引起的不确定度,用B类评定程序评价分析过程的其他因素引起的不确定度,包括:对照品纯度、量瓶允差、称量、移液管允差、移液器允差、回收率及标准曲线的拟合等,计算合成不确定度及扩展不确定度。结果:人血浆替代基质低(2.00μg/L)、中(25.00μg/L)、高(80.00μg/L)浓度LTB_4的扩展不确定度分别为1.46μg/L、3.00μg/L及8.66μg/L(P=95%,k=2)。结论:本方法绿色环保,样品回收率高,数据准确、可靠,适用于UPLC-MS/MS法测定人血浆替代基质中LTB_4浓度的不确定度评定,低浓度质控样品不确定度主要由线性回归过程引入,其次是含药血浆替代基质样品的配制及样品的提取,中、高浓度质控样品的不确定度主要由含药血浆替代基质样品的配制引入,其次是标准曲线的拟合,其他分量影响较小。本方法能够满足检测标准的要求,确保数据的国际互认。

关键词：白三烯B4 UPLC-MS/MS法人血浆替代基质不确定度扩展不确定度

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受酸腐蚀砂岩力学特性及其统计损伤本构模型

铁道学报 2023年第1期45卷 141-149页

作者：苗子臻李曙光霍润科任少强吴应明杨星智西安建筑科技大学土木工程学院陕西西安710055 中铁二十局集团有限公司博士后科研工作站陕西西安710016

酸性侵蚀环境使得隧道、桥梁、房屋等结构劣化,耐久性和承载性能降低,服役时间缩短,最终导致各种灾害事故发生。为深入探究酸性溶液对岩石力学性能的影响,采用室内长期加速腐蚀试验,对pH=1、3、5的盐酸HCl以及pH=7的蒸馏水(H 2O)腐蚀作... 详细信息

酸性侵蚀环境使得隧道、桥梁、房屋等结构劣化,耐久性和承载性能降低,服役时间缩短,最终导致各种灾害事故发生。为深入探究酸性溶液对岩石力学性能的影响,采用室内长期加速腐蚀试验,对pH=1、3、5的盐酸HCl以及pH=7的蒸馏水(H 2O)腐蚀作用下砂岩的单轴力学劣化特性进行系统研究。基于连续损伤力学和统计理论,借助CT扫描试验分析结果,引入化学-荷载共同作用损伤变量,建立考虑受酸腐蚀砂岩应力-应变曲线压密段的统计损伤本构模型,基于单轴压缩试验结果对模型进行验证。研究结果表明,腐蚀岩样单轴压缩应力-应变曲线的压密段变长,弹性段变短,轴向峰值应力、弹性模量和泊松比减小,轴向、径向峰值点应变增大;腐蚀岩样的裂隙闭合点应变增大、裂隙压缩段变长、裂纹扩展段延长,其脆性特征减弱,柔性特征增强,岩样越来越表现出柔性材料的特征;浸泡溶液pH值越小,浸泡时间越长,岩样损伤软化效应越明显。试验曲线与理论曲线的对比结果表明,所建立的统计损伤本构模型能够较好地反映受酸腐蚀砂岩在荷载作用下的变形特性。研究结果可为受酸腐蚀岩体的稳定性及减防灾分析提供理论基础。

关键词：砂岩酸腐蚀力学特性损伤本构模型

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