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基因治疗递送系统的研究新进展:遗传性视网膜疾病治疗的曙光

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华中科技大学学报（医学版） 2024年第3期53卷 414-419页

作者：翟杨苏子璇王兴华姜发纲华中科技大学同济医学院第一临床学院武汉430030 华中科技大学同济医学院附属协和医院眼科武汉430022

遗传性视网膜疾病是多种先天性视网膜神经退行性疾病的总称,临床上以夜盲、进行性视野缩小、视力下降甚至失明为特点,具有多种遗传形式。由于其病变的根源在于基因突变,通过基因治疗,即利用外源性核苷酸替换或沉默基因缺陷细胞内的致病... 详细信息

遗传性视网膜疾病是多种先天性视网膜神经退行性疾病的总称,临床上以夜盲、进行性视野缩小、视力下降甚至失明为特点,具有多种遗传形式。由于其病变的根源在于基因突变,通过基因治疗,即利用外源性核苷酸替换或沉默基因缺陷细胞内的致病基因,使细胞表达正确的蛋白质,恢复细胞的功能,就有可能治愈疾病。同时,眼睛具有免疫“豁免”特性,是实现基因治疗的理想器官。为了完成遗传物质的修正,治疗性核苷酸需要进入细胞内发挥作用,携带健康基因的载体递送系统是实现这一过程的有利工具。该文重点总结了包括病毒载体和非病毒载体在内的遗传性视网膜疾病基因治疗递送系统的研究进展及面临的问题。

关键词：遗传性视网膜疾病视网膜基因治疗基因递送系统病毒载体非病毒载体

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眼附属器淋巴瘤临床病理的研究进展

华中科技大学学报（医学版） 2024年第1期53卷 123-128页

作者：齐智依王兴华苏子璇杜雅丽叶青姜发纲华中科技大学同济医学院附属协和医院眼科武汉430022

眼附属器淋巴瘤是一种常见的眼眶恶性肿瘤。眼附属器淋巴瘤的发病率呈逐年快速增长趋势,疾病的临床表现以及影像学特点不具有特异性,因此疾病的诊断依赖于病理组织分析。眼附属器淋巴瘤精确诊断依赖于形态学、免疫组化、分子和细胞遗传... 详细信息

眼附属器淋巴瘤是一种常见的眼眶恶性肿瘤。眼附属器淋巴瘤的发病率呈逐年快速增长趋势,疾病的临床表现以及影像学特点不具有特异性,因此疾病的诊断依赖于病理组织分析。眼附属器淋巴瘤精确诊断依赖于形态学、免疫组化、分子和细胞遗传学。随着对疾病的深入研究,发现该肿瘤的临床预后呈现出高复发特征。该文主要综述眼附属器淋巴瘤高复发率与病理组织学特征的相关性。

关键词：眼附属器淋巴瘤组织病理免疫组化分子遗传

Energy-Efficient Driving Strategy for High-Speed Trains with Considering the Checkpoints

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Chinese Journal of Electronics 2024年第3期33卷 847-858页

作者： zixuan ZHANG Yuan CAO Shuai su State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong University School of Electronic and Information Engineering Beijing Jiaotong University National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University Frontiers Science Center for Smart High-speed Railway System Beijing Jiaotong University

With rising energy prices and concerns about environmental issues,energy-efficient driving strategies(EEDS) for high-speed trains have received a substantial amount of *** particular,energy-saving schemes play a huge role in reducing the energy and operating costs of *** article studies the EEDS of high-speed trains at a given time.A well-posed model is formulated,in which the constraints of the checkpoints,in addition to the speed limits,vehicle dynamics,and discrete control throttle,are first *** a given control sequence,the Karush-Kuhn-Tucker(KKT) conditions are used to obtain the necessary conditions for an *** to several key equations of the necessary conditions,the checkpoint constraints are *** case studies are conducted based on the data of the Beijing-Shanghai high-speed line to illustrate the effectiveness of the proposed approach.

关键词： Energy consumption Costs Simulation Mathematical models Energy efficiency Vehicle dynamics Optimization

Experimental investigation of the electromagnetic effect and improvement of the plasma radial uniformity in a large-area,very-high frequency capacitive argon discharge

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Plasma Science and Technology 2021年第5期23卷 66-74页

作者： Daoman HAN zixuan su Kai ZHAO Yongxin LIU Fei GAO Younian WANG Lab of Advanced Space Propulsion and Beijing Engineering Research Center of Efficient and Green Aerospace Propulsion Technology Beijing Institute of Control EngineeringBeijing 100190People’s Republic of China Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024People’s Republic of China

We performed an experimental investigation on the electromagnetic effect and the plasma radial uniformity in a larger-area, cylindrical capacitively coupled plasma reactor. By utilizing a floating hairpin probe, dependences of the plasma radial density on the driving frequency and the radio-frequency power over a wide pressure range of 5-40 Pa were presented. At a relatively low frequency(LF, e.g. 27 MHz), an evident peak generally appears near the electrode edge for all pressures investigated here due to the edge field effect, while at a very high frequency(VHF, e.g.60 or 100 MHz), the plasma density shows a sharp peak at the discharge center at lower pressures, indicating a strong standing wave effect. As the RF power increases, the center-peak structure of plasma density becomes more evident. With increasing the pressure, the standing wave effect is gradually overwhelmed by the ‘stop band’ effect, resulting in a transition in the plasma density profile from a central peak to an edge peak. To improve the plasma radial uniformity, a LF source is introduced into the VHF plasma by balancing the standing wave effect with the edge effect. A much better plasma uniformity can be obtained if one chooses appropriate LF powers, pressures and other corresponding discharge parameters.

关键词： electromagnetic effect plasma radial uniformity very-high-frequency capacitively coupled plasmas

Characteristics of super drought in Southwest China and the associated compounding effect of multiscalar anomalies

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Science China Earth Sciences 2024年第7期67卷 2084-2102页

作者： Lin WANG Wen CHEN Gang HAUNG Ting WANG Qiulin WANG Xiaoyun su zixuan REN Chakrit CHOTAMONSAK Atsamon LIMSAKUL Kritanai TORSRI CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province Chengdu 610072China Department of Atmospheric Science Yunnan UniversityKunming 650500China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Carbon Neutrality Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Hangzhou Meteorological Bureau Hangzhou 310051China Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Geography Faculty of Social SciencesChiang Mai UniversityChiang Mai 50200Thailand Environmental Science Research Center Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Climate Change and Environmental Research Center TechnopolisKlong 5Klong LuangPathumthani 12120Thailand Hydro-Informatics Innovation Division Hydro-Informatics InstituteMinistry of Higher EducationScienceResearch and InnovationBangkok 10900Thailand

In recent decades,Southwest China(SWC)has suffered from frequent super droughts,leading to severe economic losses and ecological *** study investigates the characteristics of super droughts in SWC during 1961-2022,reveals the compounding effect of multiscalar anomalies,and explores the plausible atmospheric circulation mechanisms *** nature of super drought is a compound drought caused by the superposition of extreme drought events across multiple time *** contrasting the typical drought cases in 2006 and 2022,the decisive role of multiscalar drought compounding is *** on the Comprehensive Multiscalar Index(CMI),multiple super drought events in SWC were identified to be temporally clustered during *** them,the decadal background of enhanced evaporation and precipitation deficit at long time scales is a necessary condition for shaping the overall pattern of super droughts,while the precipitation and evaporation anomalies at short time scales trigger the outbreak of super droughts,determining the exact timing of *** events include August-September 2006,November 2009 to May 2010,July-October 2011,April-May 2012,January-April 2013,*** results suggest that the contribution of superposed precipitation anomalies to super drought is 2.4 times that of *** regards the circulation mechanisms affecting multiscalar precipitation,the anomalous spatial patterns at short-term and long-term scales are similar,featuring the cyclonic circulation over the South China Sea and the northeasterly wind anomalies together with the subsidence center over *** 2006-2014,the possible causes for the cross-seasonal persistent precipitation reduction in SWC are the extreme negative phase of the Pacific Decadal Oscillation(PDO)in the North Pacific as well as the pronounced warming of the warm pool in the western *** key dynamic processes are outlined as *** the one hand,the negative PDO p

关键词： super drought Multiscalar Compounding effect Mechanism analysis Southwest China

3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction

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Bio-Design and Manufacturing 2023年第4期6卷 451-463页

作者： Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang zixuan su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Thoracic surgery West China HospitalSichuan UniversityChengdu 610041China Analytical and Testing Center Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China Department of Burn and Plastic surgery West China HospitalSichuan UniversityChengdu 610041China Department of Orthopedics West China HospitalSichuan UniversityChengdu 610041China

At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal *** method has great trauma to patients,poor plasticity and inaccurate ***-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic *** study explored the combination of 3D printing and tissue engineering to precisely reconstruct the ***,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle *** vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage *** vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle *** results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in *** three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in *** autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction.

关键词： Microtia 3D printing Polylactic acid(PLA)polymer scaffolds Gelatin methacrylamide Cartilage reconstruction

蓝莓花色苷生理活性、提取纯化及稳态化研究进展

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中国食品学报 2024年第2期24卷 407-417页

作者：李梓旋郭佳婧苏东林单杨湖南大学生物学院隆平分院长沙410125 湖南省农业科学院农产品加工研究所、果蔬贮藏加工与质量安全湖南省重点实验室长沙410125

花色苷是蓝莓中的主要酚类活性成分,因其良好的抗氧化、抗炎、抗肿瘤、护眼等活性而备受关注,然而花色苷容易受到光照、氧气、pH值、金属离子等因素的影响,且人体吸收利用率低,限制了其应用。本文综述了蓝莓花色苷的功能活性、提取纯化... 详细信息

花色苷是蓝莓中的主要酚类活性成分,因其良好的抗氧化、抗炎、抗肿瘤、护眼等活性而备受关注,然而花色苷容易受到光照、氧气、pH值、金属离子等因素的影响,且人体吸收利用率低,限制了其应用。本文综述了蓝莓花色苷的功能活性、提取纯化方法及稳态化技术,为蓝莓花色苷在食品领域的应用提供参考。

关键词：蓝莓花色苷功能活性提取纯化稳态化

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基于HA算法的舰载机出动作业调度方法

系统工程与电子技术 2024年第5期46卷 1691-1702页

作者：刘子玄万兵苏析超郭放刘玉杰海军航空大学航空基础学院山东烟台264001 海军航空大学岸防兵学院山东烟台264001 海军航空大学航空作战勤务学院山东烟台264001

出动离场是舰载机作战效能发挥的基础环节,本文研究其出动作业优化调度,将作业过程抽象为柔性车间调度问题,考虑优先序、资源及空间约束建立了混合整数规划模型,提出了一种基于种群进化搜索与邻域改进能力的混合遗传模拟退火算法,并给... 详细信息

出动离场是舰载机作战效能发挥的基础环节,本文研究其出动作业优化调度,将作业过程抽象为柔性车间调度问题,考虑优先序、资源及空间约束建立了混合整数规划模型,提出了一种基于种群进化搜索与邻域改进能力的混合遗传模拟退火算法,并给出了作业扰动时的重调度策略,通过引入任务表的生成构建了实际作业调度仿真架构。该架构融合了问题输入、动态扰动与算法,实用推广性强。仿真结果表明,所提算法收敛性快、解的准确性好、效率高,可有效解决任务表驱动下的出动调度问题;灵敏度分析发现,保障点军械加工对全局调度影响最为显著。

关键词：舰载机出动作业柔性车间调度混合整数规划混合算法

境外区域资源三号DEM与SRTM1 DEM质量对比分析

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遥感信息 2021年第6期36卷 94-102页

作者：何维灿苏梓璇武文娇赵尚民王馨爽自然资源部陕西基础地理信息中心西安710054 中煤航测遥感集团有限公司西安710054 太原理工大学矿业工程学院太原030024

将资源三号DEM和全球开放DEM进行全面的精度评估和对比分析,能有效促进其改进、推广和应用。文章以孟中印缅经济走廊典型区域为例,基于ICESat/GLA 14测高数据,利用平均误差、绝对平均误差、均方根误差和标准偏差四项统计指标,对资源三... 详细信息

将资源三号DEM和全球开放DEM进行全面的精度评估和对比分析,能有效促进其改进、推广和应用。文章以孟中印缅经济走廊典型区域为例,基于ICESat/GLA 14测高数据,利用平均误差、绝对平均误差、均方根误差和标准偏差四项统计指标,对资源三号卫星影像生产的DEM(ZY3-DEM)与SRTM1 DEM的质量进行对比,并分析不同坡度等级和土地覆盖类型下的绝对垂直误差和相对误差分布。结果表明:1)ZY3-DEM的质量较好,绝对垂直精度和相对精度均优于SRTM1 DEM。2)两种DEM数据的绝对垂直误差和点对坡度误差统计指标随着坡度的增长都呈现出逐渐增大;而错误的坡度方向比率与坡度等级的变化规律相反。除SRTM1 DEM的绝对垂直精度在坡度小于3°的平坦地区高于ZY3-DEM之外,在其他坡度区域ZY3-DEM的精度均高于SRTM1 DEM。3)除耕地区域外,ZY3-DEM的绝对垂直精度在不同地表覆盖类型均高于SRTM1 DEM;除人造地表区域外,ZY3-DEM的相对精度在不同地表覆盖类型均高于SRTM1 DEM。

关键词：资源三号DEM SRTM1 绝对垂直精度相对精度孟中印缅经济走廊