3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction

作     者：Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang Xingyu Gui;Zhiyu Peng;Ping Song;Li Chen;Xiujuan Xu;Hairui Li;Pei Tang;Yixi Wang;Zixuan Su;Qingquan Kong;Zhenyu Zhang;Zhengyong Li;Ying Cen;Changchun Zhou;Yujiang Fan;Xingdong Zhang

作者机构：National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Department of Thoracic SurgeryWest China HospitalSichuan UniversityChengdu 610041China Analytical and Testing CenterSichuan UniversityChengdu 610064China College of Biomedical EngineeringSichuan UniversityChengdu 610064China Department of Burn and Plastic SurgeryWest China HospitalSichuan UniversityChengdu 610041China Department of OrthopedicsWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2023年第6卷第4期

页      面：451-463页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China(No.81171731) the Project of Chengdu Science and Technology Bureau(Nos.2021-YF05-01619-SN and 2021-RC05-00022-CG) the Science and Technology Project of Tibet Autonomous Region(Nos.XZ202202YD0013C and XZ201901-GB-08) the Sichuan Science and Technology Program(No.2022YFG0066) the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYJC21026,ZYGD21001 and ZYJC21077) 

主　　题：Microtia 3D printing Polylactic acid(PLA)polymer scaffolds Gelatin methacrylamide Cartilage reconstruction 

摘      要：At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal *** method has great trauma to patients,poor plasticity and inaccurate ***-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic *** study explored the combination of 3D printing and tissue engineering to precisely reconstruct the ***,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle *** vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage *** vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle *** results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in *** three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in *** autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction.