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Drosophila Studies on Autism Spectrum Disorders

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Neuroscience Bulletin 2017年第6期33卷 737-746页

作者： Yao Tian zi chao zhang Junhai Han Institute of Life Sciences The Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China

In the past decade, numerous genes associated with autism spectrum disorders（ASDs） have been identified. These genes encode key regulators of synaptogenesis,synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.

关键词： Autism spectrum disorders Drosophila Chromatin remodeling Synaptic scaffolding Synaptic transmission

Novel regulation of the eEF2K/eEF2 pathway:prospects of'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'

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Journal of Molecular Cell Biology 2021年第5期13卷 392-394页

作者： Yuqian Shen Junhai Han zi chao zhang School of Life Science and Technology Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accuracy of protein *** the elongation process,eukaryotic elongation factor 2(eEF2)binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate,which then allows the next AA-tRNA to enter the A site for translation *** activity of eEF2 is negatively regulated by its kinase eEF2K that phosphorylates eEF2 at threonine-56(Thr56).

关键词： synthesis EF2 translational

Direct synthesis and dehydrogenation properties of NaAlH_4 catalyzed with ball-milled Ti–B

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Rare Metals 2017年第6期36卷 517-522页

作者： Li Li zi-chao zhang Yi-Jing Wang Li-Fang Jiao Hua-Tang Yuan Laboratory of Inorganic Functional Materials School of Materials Science and Engineering University of Jinan Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Key Laboratory of Advanced Energy Materials Chemistry (MOE) College of University Nankai University

Ball-milled Ti-B-doped sodium aluminum hydride was directly synthesized via mechanical ball-milling of a NaH/Al mixture. The mixture was completely hydrogenated to NaAlH4 after 70 h under hydrogen pressure of 1 MPa. And higher hydrogen pressure is beneficial for the conversion from NaH/Al mixture to NaAlH4. The dehydrogenation properties of the as-synthesized Ti-Bdoped sodium aluminum were systematically *** result shows that ball-milled Ti-B has a remarkable catalytic effect on the enhanced dehydrogenation properties of NaAlH4. As-synthesized Ti-B-doped NaAlH_4 sample releases hydrogen at the temperature of about 100 ℃. Approximately 4.15 wt% H2 is released from ballmilled Ti-B-doped NaAlH_4 at 233.7 ℃. Even at 110 ℃, it also releases about 2.83 wt% hydrogen. The apparent activation energy（E_a） for the first step is estimated to be 83.97 k J·mol^-1 using Arrhenius equation. Thus, utilization of ball-milled Ti-B as catalyst would substantially enhance the practical applications of NaAlH_4 for hydrogen storage.

关键词： Hydrogen storage material NaAlH4 Ti-B Dehydrogenation

Minimally invasive surgery for glycogen storage disease combined with inflammatory bowel disease:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4342-4347页

作者： Jian Wan zi-chao zhang Mu-Qing Yang Xiao-Min Sun Lu Yin Chun-Qiu Chen Center for Difficult and Complicated Abdominal Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Gastroenterology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKGROUND Inflammatory bowel disease(IBD)is rare in patients with glycogen storage disease(GSD).In GSD patients,a decrease in the number of neutrophils leads to prolonged intestinal infection,leading to the formation of chronic inflammation and eventually the development of *** invasive surgery for patients with IBD has been proven to reduce inflammatory responses and postoperative risks and ultimately promote rapid *** we discuss minimally invasive surgery and the perioperative management in a patient with GSD and *** SUMMARY A 23-year-old male had GSD Ib associated with IBD-like disease for 10 *** standard treatments,such as mesalazine,prednisone and adalimumab,the patient eventually developed colonic stenosis with incomplete *** adequate assessment,the patient was treated with minimally invasive surgery and discharged in stable *** Minimally invasive surgery for patients with IBD and GSD is safe,feasible and effective.

关键词： Minimally invasive surgery Glycogen storage disease Inflammatory bowel disease Perioperative Rapid recovery Case report

Effects of Ca^(2+) channel blockers on store-operated Ca^(2+) channel currents of Kupffer cells after hepatic ischemia/reperfusion injury in rats

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World Journal of Gastroenterology 2006年第29期12卷 4694-4698页

作者： Nan Jiang Zong-Ming zhang Liang Liu Chi zhang Yan-Lu zhang zi-chao zhang Department of General Surgery Digestive Medical Center First Affiliated Hospital of TsinghuaUniversity Beijing 100016 China Department of 1st General Surgery of Tongji Hospital Tongji University Shanghai 200065 China

AIM： To study the effects of hepatic ischemia/ reperfusion （I/R） injury on store-operated calcium channel （SOC） currents （Isoc） in freshly isolated rat Kupffer cells, and the effects of Ca^2＋ channel blockers, 2-aminoethoxydiphenyl borate （2-APB）, SK＆F96365, econazole and miconazole, on Isoc in isolated rat Kupffer cells after hepatic I/R injury.METHODS： The model of rat hepatic I/R injury was established. Whole-cell patch-clamp techniques were performed to investigate the effects of 2-APB, SK＆F96365, econazole and miconazole on Isoc in isolated rat Kupffer cells after hepatic I/R injury.RESULTS： I/R injury significantly increased Isoc from -80.4±25.2pA to -159.5±34.5pA （^bp 〈 0.01, n = 30）. 2-APB （20, 40, 60, 80, 100 pmol/L）, SK＆F96365 （5, 10, 20, 40, 50 pmol/L）, econazole （0.1, 0.3, 1, 3, 10 μmol/L） and miconazole （0.1, 0.3, 1, 3, 10 μmol/L） inhibited Isoc in a concentration-dependent manner with IC50 of 37.41 μmol/L （n = 8）, 5.89 μmol/L （n = 11）, 0.21 μmol/L （n = 13）, and 0.28 μmol/L （n = 10）. The peak value of Isoc in the I-V relationship was decreased by the blockers in different concentrations, but the reverse potential of Isoc was not transformed. CONCLUSION： SOC is the main channel for the influx of Ca^2＋ during hepatic I/R injuries. Calcium channel blockers, 2-APB, SK＆F96365, econazole and miconazole,have obviously protective effects on I/R injury, probably by inhibiting Isoc in Kupffer cells and preventing the activation of Kupffer cells.

关键词： Kupffer cell Ischemia/reperfusion Storeoperated calcium channel currents 2-aminoethoxydiphenylborate SK&F96365 Econazole Miconazole

Therapeutic options for intermediate-advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第13期17卷 1685-1689页

作者： Zong-Ming zhang Jin-Xing Guo zi-chao zhang Nan ]iang Zhen-Ya zhang Li-Jie Pan Department of General Surgery Digestive Medical Center The First Affiliated Hospital Schoolof Medicine Tsinghua University Beijing 100016 China

Hepatocellular carcinoma (HCC) is one of the most common malignancies, ranking the sixth in the world, with 55% of cases occurring in China. Usually, patients with HCC did not present until the late stage of the disease, thus limiting their therapeutic options. Although surgical resection is a potentially curative modality for HCC, most patients with intermediate-advanced HCC are not suitable candidates. The current therapeutic modalities for intermediate-advanced HCC include: (1) surgical procedures, such as radical resection, palliative resection, intraoperative radiofrequency ablation or cryosurgical ablation, intraoperative hepatic artery and portal vein chemotherapeutic pump placement, two-stage hepatectomy and liver transplantation; (2) interventional treatment, such as transcatheter arterial chemoembolization, portal vein embolization and image-guided locoregional therapies; and (3) molecularly targeted therapies. So far, how to choose the therapeutic modalities remains controversial. Surgeons are faced with the challenge of providing the most appropriate treatment for patients with intermediate-advanced HCC. This review focuses on the optional therapeutic modalities for intermediateadvanced HCC.

关键词： Hepatocellular carcinoma Intermediateadvanced Surgical procedure Interventional treatment Molecularly targeted therapy

Grid-Connected/Islanded Switching Control Strategy for Photovoltaic Storage Hybrid Inverters Based on Modified Chimpanzee Optimization Algorithm

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Energy Engineering 2025年第1期122卷 265-284页

作者： chao Zhou NarisuWang Fuyin Ni Wenchao zhang School of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001China Jiangsu Key Laboratory of Power Transmission&Distribution Equipment Technology Jiangsu University of TechnologyChangzhou213001China

Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island *** response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization *** proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop ***,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control *** pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid ***,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee *** operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load *** strategy effectively mitigated transient voltage and current surges during mode ***,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid *** enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability.

关键词： Photovoltaic storage hybrid inverters modified chimpanzee optimization algorithm droop control seamless switching

钙池操纵的Ca^(2+)通道的激活机制研究进展

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世界华人消化杂志 2007年第17期15卷 1873-1880页

作者：张子超张宗明同济大学附属同济医院普外一科上海市200065 清华大学第一附属医院消化中心普外科北京市100016

钙池操纵的Ca^(2+)通道(store-operated Ca^(2+) channels,SOC)是非兴奋细胞Ca^(2+)内流的主要通道之一,参与多种病理和生理过程,在钙信号通路的研究中,SOC的激活机制一直是人们关注的焦点之一,迄今为止,钙内流因子模型(Ca^(2+) innux f... 详细信息

钙池操纵的Ca^(2+)通道(store-operated Ca^(2+) channels,SOC)是非兴奋细胞Ca^(2+)内流的主要通道之一,参与多种病理和生理过程,在钙信号通路的研究中,SOC的激活机制一直是人们关注的焦点之一,迄今为止,钙内流因子模型(Ca^(2+) innux factor model,CIF model)和构象耦联模型fconformational coupling model)受到广泛关注.部分学者已经从很多不同类型的细胞中提取出CIF,并证实钙非依赖性的磷脂酶A_2(Ca^(2+)-independent phospholipase A_2,iPLA_2)作为CIF的底物,在某些类型细胞的SOC激活过程中发挥重要作用,并进一步提出了ER- CIF-iPLA_2-CaM-LysoPLs-SOC通路模型.瞬时受体电位(transient receptor potential,TRP)通道蛋白与1.4,5-磷酸肌醇受体(inositol 1,4,5 trisphosphate receptor,IP_3R)的结构连接作为构象耦联模型的基础已被广泛证实,随着对IP_3R,Ryanodine受体、肌动蛋白等在钙信号通路中所发挥作用的深入研究,构象耦联模型将得到不断补充和完善.SOC激活机制的破解,将对进一步完善非兴奋细胞的钙通道特性及其调节机制理论带来重大突破.

关键词：钙池操纵的Ca^2+通道钙内流因子模型构象耦联模型

The EST Analysis of A Suppressive Subtraction cDNA Library of Chinese Wild Vitis pseudoreticulata Inoculated with Uncinula necator

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Agricultural Sciences in China 2010年第2期9卷 233-241页

作者： SHI Jiang-li, WANG Yue-jin, ZHU zi-guo and zhang chao-hong Key Laboratory of Horticultural Plant Germplasm Utilization in Northwest China, Ministry of Agriculture/Shaanxi Key Laboratory of Molecular Biology for Agriculture/College of Horticulture, Northwest A&F University, Yangling 712100, P.R.China [a] Key Laboratory of Horticultural Plant Germplasm Utilization in Northwest China Ministry of Agriculture/Shaanxi Key Laboratory of Molecular Biology for Agriculture/College of Horticulture Northwest A&F University Yangling 712100 P.R. China

Uncinula necator is a worldwide serious fungus disease causing annual heavy lost on grapevine production. In order to get more informations on defense related EST sequences and help breeding program, we constructed and characterized a suppression subtractive hybridization cDNA library with artificially inoculated leaves and control Chinese wild Vitis pseudoreticulata clone Baihe-35-1, which is highly resistant to powdery mildew. In the library, the length of 58 EST fragments known as putative functions varied from 130 to 800 bp, and 60% of the ESTs exhibited high similarity to known sequences in database of GenBank with BLASTX analysis. These genes were involved in stress/defense response, detoxification, signal transduction, disease defense, and etc., and 14 ESTs remained unknown or hypothetical proteins, which may be new genes. The experiment provided an important basis for studying the disease-resistance mechanism and obtaining the genes for the aim of improving grapevine powdery mildew resistance.

关键词： Chinese wild Vitis pseudoreticulata disease resistance SSH cDNA library EST sequence