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Efficiency and safety of Tripterygium Wilfordii Hook F for IgA nephropathy: an update systematic review and meta-analysis

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Pharmacology Discovery 2024年第2期4卷 24-31页

作者： zi-yi he Hui-Chuan Tian Yan Zhao Rui-Yu Mou Hong-Wei Yuan Department of Cardiology The Second Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300150China Department of Oncology The First Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300110China Department of Oncology National Clinical Research Center of Chinese Acupuncture and MoxibustionTianjin 301617China Department of Chinese Medicine Macao University of Science and TechnologyMacao 999078China

Background:Immunoglobulin A Nephropathy(IgAN)currently stands as the most prevalent primary chronic glomerular disease *** latest guidelines recommend the application of renin-angiotensin system inhibitors(RASi)in conjunction with corticosteroids for the treatment of IgAN patients exhibiting persistent proteinuria of≥1 g/***,numerous randomized controlled trials(RCTs)have revealed a heightened risk of adverse events associated with corticosteroid ***-glycoside of Tripterygium wilfordii Hook.f.(GTW),a traditional Chinese medicine(TCM),has been employed in the treatment of Chronic Kidney Disease(CKD)for an extensive *** years have witnessed an increasing number of RCTs providing evidence supporting the effectiveness of GTW therapy in *** this,there remains a paucity of systematic reviews on the application of GTW therapy for ***,this study undertakes a systematic review to assess the clinical efficacy and safety of GTW therapy,aiming to elucidate the role of GTW therapy in the treatment of ***:To collect relative information of randomized controlled trials(RCTs)of GTW in the treatment of IgAN,we searched for theses and dissertations publicized before April 10,2023,in PubMed,Embase,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Data knowledge service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and Clinical *** language limitation is English and ***,two reviewers performed literature screening,data extraction,and quality evaluation,and the meta-analysis was carried out with RevMan 5.4 and StataSE 15.0 ***:21 RCTs involving 1,405 Chinese patients were *** to ACEI/ARB alone or in combination,GTW with RASi or alone reduced 24 h-Upro,ALB,Scr,GFR,BUN,CD4+,VEGF,ET-1,and improved clinical ***,no associations were found for TC,Ccr,and adverse events due to limited ***:This study hi

关键词： Tripterygium IgA nephropathy systematic review meta-analysis

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Hardy Spaces Associated with Ball Quasi-Banach Function Spaces on Spaces of Homogeneous Type:Littlewood–Paley Characterizations with Applications to Boundedness of Calderón–Zygmund Operators

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Acta Mathematica Sinica,English Series 2022年第7期38卷 1133-1184页

作者： Xian Jie YAN zi yi he Da Chun YANG Wen YUAN Laboratory of Mathematics and Complex Systems(Ministry of Education of China) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China

Let(X,ρ,μ)be a space of homogeneous type in the sense of Coifman and Weiss,and Y(X)a ball quasi-Banach function space on X,which supports both a Fefferman–Stein vector-valued maximal inequality and the boundedness of the powered Hardy–Littlewood maximal operator on its associate *** authors first introduce the Hardy space H_(Y)(X)associated with Y(X),via the Lusin-area function,and then establish its various equivalent characterizations,respectively,in terms of atoms,molecules,and Littlewood–Paley g-functions and g_(λ)^(*)-*** an application,the authors obtain the boundedness of Calderón–Zygmund operators from H_(Y)(X)to Y(X),or to H_(Y)(X)via first establishing a boundedness criterion of linear operators on H_(Y)(X).All these results have a wide range of generality and,particularly,even when they are applied to variable Hardy spaces,the obtained results are also *** major novelties of this article exist in that,to escape the reverse doubling condition ofμand the triangle inequality ofρ,the authors subtly use the wavelet reproducing formula,originally establish an admissible molecular characterization of H_(Y)(X),and fully apply the geometrical properties of X expressed by dyadic reference points or dyadic cubes.

关键词： ball quasi-Banach function space Hardy space space of homogeneous type Littlewood-Paley function Calderón-Zygmund operator

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More than just aligning the teeth:Clear aligners with multifunctional prowess

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Nano Research 2024年第8期17卷 7665-7674页

作者： Yang Chen Lei-Ming Cao Nian-Nian Zhong zi-Zhan Li Lin-Lin Bu Fang-yi Huo Hong he State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral and Maxillofacial-head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Zhuankou Clinical Branches School and Hospital of StomatologyWuhan UniversityWuhan 430000China Department of Orthodontics School and Hospital of StomatologyWuhan UniversityWuhan 430079China

With the increasing demand for beauty and health,clear aligners(CAs)have been widely applied among patients with ***,patients treated with CAs also face some potential complications,such as demineralization,dental caries,and periodontal *** addition,some patients have additional needs to improve their quality of life,such as bleaching *** order to prevent or solve these problems,the modification of CAs is a promising method because their extensive long-term contact with tooth surfaces makes them ideal devices for implementing adjuvant medical *** this review,we discuss various advanced CAs with medical functions based on the clinical needs of *** far as we know,the additional functions of CAs mainly include antibacterial,remineralization,whitening,and accelerating tooth *** functions are achieved by two major pathways,the combination of CAs with drugs/biomaterials and increasing the capacity or affinity of *** addition,we discuss the current limitations of in vitro experiments which are designed to explore the effectiveness and properties of novel CAs,and the challenges of bringing a multifunctional appliance from proposal to clinical *** the end of this review,we provide insights into the broader prospects for the improvement of CAs.

关键词： advanced clear aligners medical device modification drug delivery system personalized medicine

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Reliable calculations of nuclear binding energies by the Gaussian process of machine learning

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Nuclear Science and Techniques 2024年第6期35卷 130-144页

作者： zi-yi Yuan Dong Bai Zhen Wang Zhong-Zhou Ren School of Physics Science and Engineering Tongji UniversityShanghai 200092China College of Science Hohai UniversityNanjing 211100China Key Laboratory of Advanced Micro-Structure Materials Ministry of EducationShanghai 200092China

Reliable calculations of nuclear binding energies are crucial for advancing the research of nuclear physics. Machine learning provides an innovative approach to exploring complex physical problems. In this study, the nuclear binding energies are modeled directly using a machine-learning method called the Gaussian process. First, the binding energies for 2238 nuclei with Z > 20 and N > 20 are calculated using the Gaussian process in a physically motivated feature space, yielding an average deviation of 0.046 MeV and a standard deviation of 0.066 MeV. The results show the good learning ability of the Gaussian process in the studies of binding energies. Then, the predictive power of the Gaussian process is studied by calculating the binding energies for 108 nuclei newly included in AME2020. The theoretical results are in good agreement with the experimental data, reflecting the good predictive power of the Gaussian process. Moreover, the α-decay energies for 1169 nuclei with 50 ≤ Z ≤ 110 are derived from the theoretical binding energies calculated using the Gaussian process. The average deviation and the standard deviation are, respectively, 0.047 MeV and 0.070 MeV. Noticeably, the calculated α-decay energies for the two new isotopes ^ (204 )Ac(Huang et al. Phys Lett B 834, 137484(2022)) and ^ (207) Th(Yang et al. Phys Rev C 105, L051302(2022)) agree well with the latest experimental data. These results demonstrate that the Gaussian process is reliable for the calculations of nuclear binding energies. Finally, the α-decay properties of some unknown actinide nuclei are predicted using the Gaussian process. The predicted results can be useful guides for future research on binding energies and α-decay properties.

关键词： Nuclear binding energies decay Machine learning Gaussian process

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DNA hypermethylation of COL4A1 in ultraviolet-Binduced age-related cataract models in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1791-1799页

作者： Li Wang Dan Zhu Yang Yang Yuan he Jing Sun yi-Ming Li zi-Jing Wang Peng Li Department of Optometry Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Xi’an Medical UniversityXi’an 710038Shaanxi ProvinceChina Department of Ophthalmology Xijing 986 HospitalFourth Military Medical UniversityXi’an 710054Shaanxi ProvinceChina

AIM:To explore the DNA methylation of COL4A1 in ultraviolet-B(UVB)-induced age-related cataract(ARC)models in vitro and in ***:Human lens epithelium B3(HLEB3)cells and Sprague Dawley rats were exposure to UVB *** MTT assay was utilized to evaluate cell *** cytometry was employed for analysis of cell apoptosis and cell ***4A1 expression in HLEB3 cells and anterior lens capsules were assessed using Western blot and reverse transcription-polymerase chain reaction(RTPCR).The localization of COL4A1 in HLEB3 cells was determined by *** methylation status of CpG islands located in COL4A1 promoter was verified using bisulfite-sequencing PCR(BSP).DNMTs and TETs mRNA levels was examined by ***:UVB exposure decreased HLEB3 cells proliferation,while increased the apoptosis rate and cells were arrested in G0/G1 ***4A1 expression was markedly inhibited in UVB treated cells compared to the *** status was detected in the CpG islands within COL4A1 promoter in HLEB3 cells subjected to UVB *** of DNMTs including DNMT1/2/3 were elevated in UVB treated HLEB3 cells compared to that in the controls,while expressions of TETs including TET1/2/3 showed the opposite *** from the UVB treated rat model further confirmed the decreased expression of COL4A1,hypermethylation status of the CpG islands at promoter of COL4A1 and abnormal expression of DNMT1/2/3 and TET1/2/in UVB exposure ***:DNA hypermethylation of COL4A1 promoter CpG islands is correlated with decreased COL4A1 expression in UVB induced HLEB3 cells and anterior lens capsules of rats.

关键词： human lens epithelium cells age-related cataract COL4A1 hypermethylation ultraviolet-B rat

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Multivariable analysis of factors associated with hospital readmission following pancreaticoduodenectomy for malignant diseases

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Chinese Medical Journal 2011年第7期124卷 1022-1025页

作者： ZHU zi-yi he Ji-kai WANG yi-fan LIANG Xiao YU Hong WANG Xian-fa CAI Xiu-jun Institute of Micro-Invasive Surgery of Zhejiang University Department of General Surgery Sir Run Run Shaw HospitalCollege of Medicine Zhejiang University Hangzhou Zhejiang310016 China

Background Readmission rates after pancreaticoduodenectomy （PD） for malignant diseases have a significant impact on survival rate. Identification of risk factors for readmission may improve discharge plans and postoperative care. Data exist on the morbidity and mortality of patients undergoing PD, but there are few reports about hospital readmissions after this procedure. Our aims were to evaluate the proportion and reasons for readmissions after PD for malignant diseases, the factors influencina readmissions, and to analyze the. r~.latinn^hin hAtwAAn r^dmi^inn r^fa ~nrl ~lln/i~,~l r^t~

关键词： pancreaticoduodenectomy readmission complications survival rate

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Hot Compression Behavior and Tensile Property of a Novel Ni-Co-Based Superalloy Prepared by Electron Beam Smelting Layered Solidification Technology

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 283-292页

作者： Yong-Chao Gai Rui Zhang Chuan-Yong Cui zi-Jian Zhou yi Tan yi-Zhou Zhou Xiao-Feng Sun Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The hot compression behavior and tensile strength after compression of a new Ni-Co-based superalloy produced using electron beam smelting layered(EBSL)solidification technology were *** compression tests were performed at temperatures of 1120℃and 1150℃,with strain rates of 1 s^(-1) and 0.01 s^(-1),reaching a true strain of *** strength was evaluated at room *** results revealed that this EBSL technology accelerates dynamic recrystallization(DRX),without compromising the strength of alloy.A significant correlation between the volume fraction of DRX and the strain rate was observed,with higher fractions at lower strain rates,leading to higher tensile ***,at the same strain rate,the specimens compressed at 1120℃exhibited higher tensile strength due to undissolvedγ′*** solution and aging heat treatment,the alloy maintained high tensile *** results suggested that the EBSL Ni-Co-based superalloy offers excellent prospects for practical applications.

关键词： Ni-Co-based superalloy Hot deformation Electron beam smelting Tensile strength

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Engineering CuMn Prussian blue analog-shelled nanobox for efficient electrochemical reduction of nitrate to ammonia

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Tungsten 2024年第4期6卷 833-844页

作者： zi-yi Yang Yu-Dong Li Dan Liu Mao-Sen Song Yang Gao Qing-Ping Wu En-Shan Han Yan-Zhen he Xiao-Hui Yang School of Chemical Engineering and Technology Hebei University of Technology Key Laboratory of Bio-Based Material Science and Technology Northeast Forestry University Institute of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

Electrocatalytic nitrate reduction reaction（ENRR） for ammonia synthesis is a promising strategy to relieve nitration contamination,as well as an alternative to the Haber-Bosch *** blue analogs（PBAs） are expected to be an electrocatalytic material with superior performance owing to their abundant active sites and open channel ***,most reported PBA materials possess low nitrate conversion and ammonia yield rates,which has led to a hindrance in their research of ***,CuMn-PBA-shelled nanoboxes（CuMn-PBA SNBs） synthesized through tannic acid etching and cation exchange approaches are demonstrated for efficient ammonia *** optimal CuMn-PBA SNBs electrode achieves a high nitrate conversion of 91.33% and ammonia selectivity of 98.87% in a 0.2 mol·L-1Na2SO4solution with100×10-6NO3--N at-1.4 V ***,the CuMn-PBA SNB s electrode exhibits exceptional stability throughout a 30 h electrocatalytic *** outstanding electrochemical performance is attributed to the unique hollow nanobox structure with abundant active sites and high-throughput transport pathways for ions' aspects.

关键词： Acid etching Ammonia synthesis Cation exchange Electrocatalytic nitrate reduction Nanobox Prussian blue analogs

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P_(c)(4457)Interpreted as a J^(P)=1/2+State byD^(0)∧_(c)^(+)(2595)-π^(0)P_(c)(4312)Interaction

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Chinese Physics Letters 2024年第9期41卷 23-27页

作者： Jin-zi Wu Jin-yi Pang Jia-Jun Wu School of Physics Sciences University of Chinese Academy of SciencesBeijing 100049China Columbian College of Arts&Sciences George Washington University80122nd St.NW Washington DC 20052USA College of Science University of Shanghai for Science and TechnologyShanghai 200093China Southern Center for Nuclear-Science Theory Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

P_(c)(4457)has been discovered over five years,but the parity of this particle remains *** propose a new interpretation for P_(c)(4457),which is the state generated from the coupled-channel D^(0)Ac+(2595)andπ^(0)P_(c)(4312)since they can exchange an almost on-shell∑_(c)^(+).In this scenario,the parity of P_(c)(4457)will be positive,which is different from the candidate of the bound state of D*∑_(c).The main decay channel of P_(c)(4457)in this model is Pc(4312)π.We propose three processes∧_(b)^(0)→J/ψKapπ^(-),∧_(b)^(0)→J/ψK-pπ^(0),and∧_(b)^(0)→J/ψpπ^(-)π^(+)k^(-)to verify Pc(4457)→Pc(4312)π.

关键词： (0 parity verify

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Correlation between longitudinal crack occurrence and mold heat transfer in continuous casting based on process data mining

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Journal of Iron and Steel Research International 2024年第5期31卷 1139-1152页

作者： Zhi-qiang Peng zi-bing Hou Kai yi Kun-hui Guo Dong-wei Guo Guang-hua Wen College of Materials Science and Engineering Chongqing UniversityChongqing400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing400044China

The correlation between the longitudinal crack occurrence and integrated heat transfer of the mold with data mining methods was ***,three kinds of support vector machine models based on principal component analysis with different input features were established to explore the effect of integrated heat transfer on the accuracy of the prediction model for the longitudinal *** results show that the accuracy was improved while features including mean and standard deviation of integrated heat transfer were ***,the difference in integrated heat transfer between defect and normal samples under the same process parameters was quantitatively *** with normal samples,the temperature difference of cooling water for defect samples decreased by 0.65%,and the temperature difference fluctuation increased by 31.1%.Finally,the literature data were used to provide support for the quantitative correlation according to defect formation mechanism.A new criterion for the prediction of longitudinal crack and a discovering method for correlation between product quality and process parameters in the manufacturing industry have been provided.

关键词： Continuous casting slab Longitudinal surface crack heat transfer Data mining Quantitative correlation

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