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Outcomes of Coaxial Micro-incision Phacoemulsification in Nanophthalmic Eyes: Report of Retrospective Case Series

Eye Science 2015年第3期30卷 94-100页

作者： zi Ye Zhaohui Li Shouzhi He Bing chen Xiaojuan Xing Chunyan Ren Department of Ophthalmology the PLA General Hospital

Purpose: The surgical risk and complication rate after cataract surgery are extremely high in patients with *** study is designed to compare the visual and refractive outcomes before and after coaxial micro-incision phacoemulsification and evaluate postoperative ***:.Fifty nine patients(89 eyes) with axial length(AL)< 21 mm diagnosed with nanophthalmos were enrolled in this retrospective study. All patients underwent coaxial micro-incision phacoemulsification and IOL implantation..The main outcome measures included anterior chamber depth(ACD),anterior chamber volume(ACV), anterior chamber angle(A CA), intraocular pressure(IOP) and best corrected visual acuity(BCVA). Wilcoxon signed rank test or Mann-Whitney test,and Chi-square test and logistic regression analysis were performed for statistical tests as ***:.The median AL was 19.63 mm...Sixty-six eyes(74.16%) had a history of surgical intervention. Postoperative ACD, ACV and ACA were increased significantly(all P<0.001),whereas postoperative IOP was decreased significantly.(P <0.001) after surgery. Previous surgical intervention was related to a reduction in the postoperative ACD and ACA(P<0.01),and both preoperative and postoperative IOP.(P <0.001).Postoperative BCVA was improved in 94.38% of the *** complications mainly included iridoschisis(6eyes, 6.74%). Early postoperative complications included temporary corneal edema(TCE)(23 eyes, 25.84%), anterior inflammatory response(AIR)(19 eyes, 21.35%), cystoid macular edema(CME)(14 eyes, 15.73%), and uveal effusion(4 eyes, 4.49%). Late postoperative complications included CME(8 eyes, 8.99%), uveal effusion(8 eyes, 8.99%),malignant glaucoma(2 eyes, 2.25%) and posterior capsular opacification(PCO)(10 eyes, 11.24%). The majority of complications(80%) were successfully resolved by pharmacotherapy or operation. The risk of surgical complications was greater in patients with lower AL,ACD,ACV or ACA andhigher n

关键词：白内障手术超声乳化同轴切口 Logistic回归分析病例畸形小眼

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Ruthenium catalyzed amination cyclization of 1,2,4-butanetriol with primary amines:A borrowing hydrogen strategy for 3-pyrrolidinol synthesis

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Chinese Chemical Letters 2020年第1期31卷 103-106页

作者： qing-Song Xu chen Li Yong Xu Defeng Xu Mei-Hua Shen Hua-Dong Xu School of Pharmaceutical Engineering & Life Science Changzhou University

A ruthenium based catalytic system([Ru(p-cymene)Cl2]2/XantPhos with substoichiometric Cs2CO3)has been established to effectively achieve the first direct amination cyclization of 1,2,4-butanetriol with primary aromati... 详细信息

关键词： Amination cyclization N-Alkylation 1,2,4-Butanetriol 3-Pyrrolidinol Borrowing hydrogen Hydrogen autotransfer [Ru(p-cymene)Cl2]2

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Bacillus cereus X5 Enhanced Bio-Organic Fertilizers Effectively Control Root-Knot Nematodes(Meloidogyne sp.)

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Pedosphere 2013年第2期23卷 160-168页

作者： XIAO Tong-Jian chen Fang GAO Chao ZHAO qing-Yun SHEN Qi-Rong RAN Wei Jiangsu Provincial Key Lab for Solid Organic Waste Utilization Nanjing Agricultural University

The efficacy of Bacillus cereus X5 as a potential biological control agent against root-knot nematodes was evaluated in vitro by examining second-stage juvenile mortality and egg hatching rate under addition of culture filtrate and in planta by application of bio-organic fertilizers enhanced with B. cereus X5, B. thuringiensis BTG, or Trichoderma harzianum SQR-T037 alone or together in greenhouse and field experiments. The biofumigation of the root-knot nematode-infested soil with organic materials (chicken manure, pig manure and rice straw) alone or in combination with B. cereus X5 was also conducted in greenhouse experiments. In laboratory, the filtrate of B. cereus X5 more effectively reduced egg hatching rates during the incubation period for 14 d and more effectively killed the second-stage juvenile during the incubation period of 24 h than that of B. thuringiensis BTG. The highest dry shoot weights for greenhouse tomatoes and field muskmelons were found in both the treatment consisting of the bio-organic fertilizer enhanced with the three biocontrol agents and the treatment consisting of the bio-organic fertilizer enhanced only with B. cereus X5. The two bio-organic fertilizers achieved better nematicidal effects than those enhanced only with B. thuringiensis BTG or T. harzianum SQR-T037. B. cereus X5 also enhanced effect of biofumigation, which resulted in increased plant biomass and reduced nematode counts in the roots and rhizosphere soil. Therefore, these results suggested that biological control of root-knot nematodes both in greenhouses and fields could be effectively achieved by using B. cereus X5 and agricultural wastes.

关键词： biofumigation biological control culture filtrate muskmelon rhizosphere soil

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Visible Light-Driven Catalyst-Free Amination of Indoles Initiated by Electron Donor-Acceptor Complexes

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Chinese Journal of Chemistry 2023年第12期41卷 1485-1490页

作者： Jiahong Sui Zhonglie Yang Shuangqiao Li Xueqin chen Xiaobin Zhang qing Shen Hezhong Jiang Jiahong Li School of Life Science and Engineering Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs Southwest Jiaotong University Chengdu Sichuan 610031 China Department of Pharmacy Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital/Personalized Drug Therapy Key Laboratory of Sichuan Province School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan 610072 China

The visible light-driven C2 or C3 amination of indoles without any additives was initiated via electron donor-acceptor (EDA) complex formed by indole and N-aminopyridinium *** method was compatible with a wide range of substrates and could proceed smoothly without the addition of any photocatalysts,transition-metal catalysts,or bases.A variety of studies were carried out to examine the presence of EDA complex.

关键词： Photochemistry Amination C-N bond formation Green chemistry N-Heterocycles Donor-acceptor systems

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Diazoxide attenuates ischemia/reperfusion injuryvia upregulation of heme oxygenase-1 after liver transplantation in rats

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World Journal of Gastroenterology 2012年第15期18卷 1765-1772页

作者： Zhong Zeng Han-Fei Huang Fei He Lin-Xi Wu Jie Lin Ming-qing chen Organ Transplantation Center the First Affili-ated Hospital of Kunming Medical CollegeKunming 650032Yunnan ProvinceChina

AIM:To evaluate the effects of diazoxide on ischemia/reperfusion(I/R)-injured hepatocytes and further elucidate its underlying ***:Male Sprague-Dawley rats were randomized(8 for donor and recipient per group)into five groups:I/R group(4 h of liver cold ischemia followed by 6 h of reperfusion);heme oxygenase-1(HO-1)small interfering RNA(siRNA)group(injection of siRNA via donor portal vein 48 h prior to harvest);diazoxide(DZ) group(injection of DZ via donor portal vein 10 min prior to harvest);HO-1 siRNA+DZ group;and siRNA control *** and liver samples were collected at 6 h after *** mRNA expressions and protein levels of HO-1 were determined by reverse transcription polymerase chain reaction and Western blotting,and tissue morphology was examined by light and transmission electron *** transaminases level and cytokines concentration were also ***:We observed that a significant reduction of HO-1 mRNA and protein levels in HO-1 siRNA and HO-1 siRNA+DZ group when compared with I/R group,while the increases were prominent in the DZ *** and transmission electron microscopy indicated severe disruption of tissue with lobular distortion and mitochondrial cristae damage in the HO-1 siRNA and HO-1 siRNA+DZ groups compared with DZ *** alanine aminotransferase,aspartate transaminase,tumor necrosis factor-αand interleukin-6 levels increased in the HO-1 siRNA and HO-1 siRNA+DZ groups,and decreased in the DZ ***:The protective effect of DZ may be induced by upregulation of *** inhibiting expression of HO-1,this protection pretreated with DZ was abolished.

关键词： Ischemia/reperfusion injury Diazoxide Heme oxygenase-1 Liver transplantation Rat

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Detecting dopaminergic neuronal degeneration using diffusion tensor imaging in a rotenone-induced rat model of Parkinson's disease: fractional anisotropy and mean diffusivity values

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Neural Regeneration Research 2017年第9期12卷 1485-1491页

作者： Lan-xiang Liu Dan Du Tao Zheng Yuan Fang Yan-sheng chen Hui-ling Yi qing-yuan He Da-wei Gao qing-lei Shi Department of Magnetic Resonance Imaging First Hospital of Qinhuangdao Department of Radiology Peking University Third Hospital College of Environmental and Chemical Engineering Yanshan University Scientific Clinical Specialist Siemens Ltd.

Dopamine content in the basal ganglia is strongly associated with the degree of dopaminergic neuron loss in the substantia nigra pars com- pacta. Symptoms of Parkinson＇s disease might not arise until more than 50% of the substantia nigra pars compacta is lost and the dopamine content in the basal ganglia is reduced by more than 80%. Greater diagnostic sensitivity and specificity would allow earlier detection of Parkinson＇s disease. Diffusion tensor imaging is a recently developed magnetic resonance imaging technique that measures mean diffusiv- ity and fractional anisotropy, and responds to changes in brain microstructure. When the microscopic barrier （including cell membranes, microtubules and other structures that interfere with the free diffusion of water） is destroyed and extracellular fluid volume accumulates, the mean diffusivity value increases; when the integrity of the microstructure （such as myelin） is destroyed, fractional anisotropy value decreases. However, there is no consensus as to whether these changes can reflect the early pathological alterations in Parkinson＇s disease. Here, we established a rat model of Parkinson＇s disease by injecting rotenone （or sunflower oil in controls） into the right suhstantia nigra. Diffusion tensor imaging results revealed that in the stages of disease, at 1, 2, 4, and 6 weeks after rotenone injection, fiactional anisotropy value decreased, but mean diffusivity values increased in the right substantia nigra in the experimental group. Fractional anisotropy values were lower at 4 weeks than at 6 weeks in the right substantia nigra of rats from the experimental group. Mean diffusivity values were mark- edly greater at 1 week than at 6 weeks in the right corpus striatum of rats from the experimental group. These findings suggest that mean diffusivity and fractional anisotropy values in the brain of rat models of Parkinson＇s disease 4 weeks after model establishment can reflect early degeneration of dopaminergic neurons. ＇Th

关键词： nerve regeneration diffusion tensor imaging fractional anisotropy mean diffusivity magnetic resonance imaging Parkinson's disease rotenone neurodegenerative disease biomarkers substantia nigra tyrosine hydroxylase neural regeneration

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Synthesis and characterization of HPMA copolymer-5-FU conjugates

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Chinese Chemical Letters 2008年第2期19卷 137-140页

作者： Fang Yuan Fu chen qing Yu Xiang Xuan Qin Zhi Rong Zhang Yuan Huang Key Laboratory of Drug Targeting of Ministry of Education West China School of Pharmacy Sichuan University Chengdu 610041 China

N-（2-Hydroxypropyl） methacrylamide copolymer-5-fluorouracil （PHPMA-FU） conjugates were synthesized by a novel and simplified synthetic route, and characterized by UV, FTIR and HPLC analyses. The conjugated content of 5-fluorouracil （5-FU） was 3.41 ± 0.07 wt%. The stabilities of PHPMA-FU conjugates under different conditions were studied. The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU.

关键词： HPMA copolymer 5-Fluorouracil Conjugates Characterization Stability

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Hot Working of High Nitrogen Austenitic Stainless Steel

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Journal of Iron and Steel Research International 2010年第10期17卷 45-49,67页

作者： LANG Yu-ping ZHOU Yong RONG Fan chen Hai-tao WENG Yu-qing SU Jie Institute for Structural Materials Central Iron and Steel Research Institute Beijing 100081 China School of Materials Science and Engineering Beihang University Beijing 100191 China Chinese Society for Metals Beijing 100711 China

With hot rolling in laboratory and Gleeble thermal simulator, the hot working of a high nitrogen austenitic stainless steel （HNASS） was researched. The results showed that dynamic recovery （DRV） and dynamic recrystalli- zation （DRX） in HNASS occurred during hot working, and both of them had well-defined stress peaks in flow curves under different conditions. During hot rolling experiment at temperature from 950 to 1 050 ℃, recrystallization phe- nomenon does not take place in test material until the deformation ratio is up to 40%. Recrystallization influences remarkably the strength and ductility of material, and the test HNASS possesses better combination of strength with ductility. According to the curve of θ--α （strain hardening rate-steady state stress）, the DRX critical strain of test material was determined. Also, the activation energy of hot working was calculated to be 746.5 kJ/mol and the equation of hot working was obtained.

关键词： HNASS hot working DRX: DRX critical strain

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Effect of quaternary basicity on softening-melting behavior of primary slag based on magnesium flux pellet

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Journal of Iron and Steel Research International 2022年第8期29卷 1185-1193页

作者： Kai-kai Bai Hai-bin Zuo Wen-guo Liu Jing-song Wang Jian-sheng chen qing-guo Xue State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

It is generally accepted that the softening-melting properties of ferrous burden play a vital role in optimizing the shape and position of cohesive *** effect of quaternary basicity and atmosphere on softening,melting and permeation temperatures of primary slag based on magnesium flux pellet was investigated by visualization *** mechanisms were analyzed utilizing thermodynamic calculation,X-ray diffraction analysis and electron probe *** results indicated that the softening and melting temperatures of oxide samples increased by approximately 120℃with increasing quaternary basicity from 0.3 to 1.2 owing to the formation of slag phases with high melting point and solid ***,the difference between softening and melting temperatures decreased from 21 to 11℃.The permeation temperature was not affected by the quaternary basicity and fluctuated around a level of 1250 C,given that the permeation temperature depends on the wettability between slag and coke *** the other hand,as the ratios of CO/CO_(2) varied from 3/7 to 7/3,there were no significant differences in either the softening or melting temperatures,whereas the permeation temperature was increased from 1239 to 1271℃ since the reduction of FeO-bearing phases to solid Fe could decrease the wettability between slag and coke bed.

关键词： Magnesium flux pellet Primary slag Quaternary basicity CO/CO_(2)ratio Cohesive zone Softening-melting Behavior

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Quantitative Analysis of the Effectiveness of Antigen-and Polymerase Chain Reaction-Based Combination Strategies for Containing COVID-19 Transmission in a Simulated Community

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Engineering 2023年第9期28卷 234-242页

作者： Qiangru Huang Yanxia Sun Mengmeng Jia Ting Zhang Fangyuan chen Mingyue Jiang qing Wang Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China School of Arts and Sciences Beijing Institute of Fashion TechnologyBeijing 100105China

The number of coronavirus disease 2019(COVID-19)cases continues to surge,overwhelming healthcare systems and causing excess mortality in many *** of infectious populations remains a key strategy to contain the COVID-19 outbreak,delay the exponential spread of the disease,and flatten the epidemic *** the Omicron variant outbreak as a background,this study aimed to evaluate the effectiveness of testing strategies with different test combinations and frequencies,analyze the factors associated with testing effectiveness,and optimize testing strategies based on these influencing *** developed a stochastic,agent-based,discrete-time susceptible–latent–infectious–recovered model simulating a community to estimate the association between three levels of testing strategies and COVID-19 *** testing and its combination strategies were more efficient than polymerase chain reaction(PCR)-related *** testing also showed better performance in reducing the demand for hospital beds and intensive care unit *** delay in the turnaround time of test results had a more significant impact on the efficiency of the testing strategy compared to the detection limit of viral load and detection-related *** main advantage of antigen testing strategies is the short turnaround time,which is also a critical factor to be optimized to improve PCR *** modifying the turnaround time,the strategies with less frequent testing were comparable to daily *** choice of testing strategy requires consideration of containment goals,test efficacy,community prevalence,and economic *** study provides evidence for the selection and optimization of testing strategies in the post-pandemic era and provides guidance for optimizing healthcare resources.

关键词： COVID-19 Antigen testing PCR testing Testing strategies

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