Quantitative Analysis of the Effectiveness of Antigen-and Polymerase Chain Reaction-Based Combination Strategies for Containing COVID-19 Transmission in a Simulated Community

作     者：Qiangru Huang Yanxia Sun Mengmeng Jia Ting Zhang Fangyuan Chen Mingyue Jiang Qing Wang Luzhao Feng Weizhong Yang Qiangru Huang;Yanxia Sun;Mengmeng Jia;Ting Zhang;Fangyuan Chen;Mingyue Jiang;Qing Wang;Luzhao Feng;Weizhong Yang

作者机构：School of Population Medicine and Public HealthChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China School of Arts and SciencesBeijing Institute of Fashion TechnologyBeijing 100105China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2023年第28卷第9期

页      面：234-242页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0711[理学-系统科学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 100401[医学-流行病与卫生统计学] 0811[工学-控制科学与工程] 10[医学] 

基　　金：supported by grants from the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2020-I2M-1-001 and 2021-I2M-1-044) 

主　　题：COVID-19 Antigen testing PCR testing Testing strategies 

摘      要：The number of coronavirus disease 2019(COVID-19)cases continues to surge,overwhelming healthcare systems and causing excess mortality in many *** of infectious populations remains a key strategy to contain the COVID-19 outbreak,delay the exponential spread of the disease,and flatten the epidemic *** the Omicron variant outbreak as a background,this study aimed to evaluate the effectiveness of testing strategies with different test combinations and frequencies,analyze the factors associated with testing effectiveness,and optimize testing strategies based on these influencing *** developed a stochastic,agent-based,discrete-time susceptible–latent–infectious–recovered model simulating a community to estimate the association between three levels of testing strategies and COVID-19 *** testing and its combination strategies were more efficient than polymerase chain reaction(PCR)-related *** testing also showed better performance in reducing the demand for hospital beds and intensive care unit *** delay in the turnaround time of test results had a more significant impact on the efficiency of the testing strategy compared to the detection limit of viral load and detection-related *** main advantage of antigen testing strategies is the short turnaround time,which is also a critical factor to be optimized to improve PCR *** modifying the turnaround time,the strategies with less frequent testing were comparable to daily *** choice of testing strategy requires consideration of containment goals,test efficacy,community prevalence,and economic *** study provides evidence for the selection and optimization of testing strategies in the post-pandemic era and provides guidance for optimizing healthcare resources.