检索结果-南通市图书馆

Spinal anesthesia alleviates dextran sodium sulfate-induced colitis by modulating the gut microbiota

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第12期28卷 1239-1256页

作者： Yu Hong Jie Zhao Ye-Ru Chen zi-hao huang Li-Dan Hou Bo Shen Yu Xin Department of General Surgery Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Department of Anaesthesiology Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina College of Medicine Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Biomedical Research Center Sir Run Run Shaw Hospital of Medical SchoolZhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Department of Anesthesiology Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)is a chronic disease with recurrent intestinal *** the exact etiology of IBD remains unknown,the accepted hypothesis of the pathogenesis to date is that abnormal immune responses to the gut microbiota are caused by environmental *** role of the gut microbiota,particularly the bidirectional interaction between the brain and gut microbiota,has gradually attracted more *** To investigate the potential effect of spinal anesthesia on dextran sodium sulfate(DSS)-induced colitis mice and to detect whether alterations in the gut microbiota would be crucial for *** A DSS-induced colitis mice model was *** anesthesia was administered on colitis mice in combination with the methods of cohousing and fecal microbiota transplantation(FMT)to explore the role of spinal anesthesia in IBD and identify the potential mechanisms *** We demonstrated that spinal anesthesia had protective effects against DSS-induced colitis by alleviating clinical symptoms,including reduced body weight loss,decreased disease activity index score,improved intestinal permeability and colonic morphology,decreased inflammatory response,and enhanced intestinal barrier ***,spinal anesthesia significantly increased the abundance of Bacteroidetes,which was suppressed in the gut microbiota of colitis ***,cohousing with spinal anesthetic mice and FMT from spinal anesthetic mice can also alleviate DSS-induced colitis by upregulating the abundance of *** further showed that spinal anesthesia can reduce the increase in noradrenaline levels induced by DSS,which might affect the gut *** These data suggest that microbiota dysbiosis may contribute to IBD and provide evidence supporting the protective effects of spinal anesthesia on IBD by modulating the gut microbiota,which highlights a novel approach for the treatment of IBD.

关键词： Spinal anesthesia Inflammatory bowel disease Gut microbiota Intestinal barrier Intestinal inflammation Intestinal immune

Enhancing electrocatalytic reduction of CO_(2)to C_(2+)products with high efficiency at Cu^(0)/Cu^(δ+)interfaces via iodine modification strategy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第11期43卷 5747-5756页

作者： Shao-Song Ding Xing-Pu Wang Ming-Wei Fang Rong Zhang zi-hao huang Ze-Wen Wang Mei-Ling Wang Ying Zhu Wen-Xiu Jiang Xiao-Chen Feng Ying Zhu Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology School of Chemistry Beihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100191China

Electrocatalytic CO_(2)reduction reaction(CO_(2)RR)to produce multicarbon(C_(2+))products over Cubased catalysts represents an ideal approach for renewable energy storage and carbon emissions *** Cu^(0)/Cu^(δ+)interfaces are widely recognized as crucial sites that promote C-C coupling and enhance the generation of C2+***,a major challenge arises from the tendency of Cu^(δ+)active sites within Cu^(0)/Cu^(δ+)interfaces to undergo reduction to Cu^(0)during the CO_(2)RR process,leading to a decline in catalytic ***,it is crucial to establish durable Cu^(0)/Cu^(δ+)interfaces to enhance the conversion of CO_(2)to C_(2+)*** this work,an iodine modification strategy is proposed to prepare a stable Cu@CuI composite catalyst with well-maintained Cu^(0)/Cu^(δ+)interfaces through a one-step redox reaction between iodine and *** optimized Cu@CuI-3composite catalyst demonstrates an excellent performance in CO_(2)RR,achieving a Faradaic efficiency of 75.7%for C^(2+)products and a partial current density of 288 mA·cm^(-2)at-1.57 V_(RHE)in a flow *** techniques reveal that a numerous persistent Cu^(δ+)species exist on the surface of the Cu@CuI-X composite catalyst even after CO_(2)RR due to the presence of adsorbed iodine ions,which prevent complete reduction of Cu^(δ+)species to Cu^(0)owing to their high *** functional theory calculations further verify that adsorbed iodine ions on the surface of Cu@CuI-X serve as charge regulators by adjusting local charge density,thereby facilitating the formation of*CHO intermediates from CO_(2)and lowering the energy barriers associated with coupling the*CHO and*CO intermediates during CO_(2)***,this phenomenon enhances the selectivity toward C_(2+)products during electrocatalytic CO_(2)reduction.

关键词： CO_(2)electroreduction Cu^(0)/Cu^(δ+)interfaces Multicarbon products

The role of axon guidance molecules in the pathogenesis of epilepsy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du hao You Junfeng huang Mudong Tu Hua Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao hao zi-Jian Wang Xiu-Liang Xu Jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

Plasmon-induced local electric field improved hydrogen evolution reaction on Ag/Mo_(2)C nanosheets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 270-277页

作者： huangJingWei Li Xin zi Jun Wu Xinli Wang Li Zhu Qiyou Wang Jianfu Han Junwei Fu Hongmei Li Kai huang Yu Chen Min Liu School of Physics State Key Laboratory of Powder MetallurgyHunan Joint International Research Center for Carbon Dioxide Resource UtilizationCentral South UniversityChangsha 410083China School of Metallurgy and Environment Central South UniversityChangsha 410083China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Nano-Institute Munich Faculty of PhysicsLudwig-Maxilimians-Universität MünchenMünchen 80539Germany Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

Electrocatalytic water splitting offers a promising way for hydrogen production with near-zero ***,such as molybdenum carbides(Mo_(2)C),are promising materials for hydrogen evolution reaction(HER)but still suffer from poor intrinsic water activation ***,we developed a plasmon-induced local electric field(PILEF)strategy to solve this ***(Ag)nanoparticles decorated Mo_(2)C nanosheets(Ag/Mo_(2)C)were successfully prepared by electrostatic *** visible light excited the PILEF on Ag/Mo_(2)C remarkably reducing the activation energy by 92.7 kJ·mol^(-1)from 147.3 kJ·mol^(-1)of Mo_(2)C to 54.6 kJ·mol^(-1).As a result,the plasmonic Ag/Mo_(2)C significantly enhances~2.3-fold of the current density from 2.8 mA·cm^(-2)of Mo_(2)C to 6.5 mA·cm^(-2)at-3 V *** and reduces the overpotential by 104 mV from 403 mV of dark state to 299 mV of light state at the current density of 10 mA·cm^(-2),achieving better performance than reported *** research demonstrates that PILEF enhances HER activities,offering a potential strategy for boosting the intrinsic activities of catalysts.

关键词： sliver particles plasmon effect field effect hydrogen evolution reaction(HER) electrocatalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

硅基光互连网络的研究

光通信技术 2016年第10期40卷 4-7页

作者：梁梓豪黄红斌陈舜儿刘伟平暨南大学信息科技学院电子工程系广州510632

分析了硅基光互连技术的特点与其优势,归纳了几种用于硅基光互连的主要器件和相关性能参数。对硅基光互连网络的网络结构和交换机制进行研究分析后,指出了目前技术的主要问题,并提出了未来硅基光互连的研究应集中在光源集成、减小噪声... 详细信息

分析了硅基光互连技术的特点与其优势,归纳了几种用于硅基光互连的主要器件和相关性能参数。对硅基光互连网络的网络结构和交换机制进行研究分析后,指出了目前技术的主要问题,并提出了未来硅基光互连的研究应集中在光源集成、减小噪声串扰和优化网络结构等方面。

关键词：硅基光互连片上光互连网络多核数据通信光交换

A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie zi-Meng Han hao-Cheng Liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

Recent Progresses in Liquid-Free Soft Ionic Conductive Elastomers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第7期41卷 835-860页

作者： Chuan Luo Zhenkai huang zi-hao Guo Kan Yue South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhouGuangdong510640 China School of Materials Science and Hydrogen Energy Foshan UniversityFoshanGuangdong528000 China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhouGuangdong510640 China

Comprehensive Summary With the rapid growth of soft electronic and ionotronic devices such as artificial tissues,soft luminescent devices,soft robotics,and human-machine interfaces,there is a demanding need to accelerate the development of soft ionic conductive *** date,the first-generation ionotronic devices are mainly based on hydrogels or ***,due to their intrinsic drawbacks,such as freezing or volatilization at extreme temperatures,and the leakage problem under external mechanical forces,the reliability of ionotronic devices under harsh conditions remains a great *** advent of liquid-free ionic conductive elastomers(ICEs)has the potentials to solve the issues related to the gel-type soft conductive *** free ions shuttling within the ion-dissolvable polymer network enable liquid-free ICEs to exhibit unparalleled ionic conductivity and ***,by tuning the composition and structure of the polymeric network,it is also feasible to integrate other desirable properties,such as self-healing ability,transparency,biocompatibility,and stimulus responsiveness,into liquid-free ICE *** this review,we summarize the design strategies of recently reported liquid-free ICEs,and further explore the methods to introduce multifunctionality,which originate from the rational molecular design and/or the synergy with other ***,we highlight the representative applications of liquid-free ICEs in soft *** is believed that liquid-free ICEs might provide a unique material platform for the next-generation ionotronics.

关键词： Liquid-free Elastomer lonic conductorSoft materials lonotronics