Design and synthesis of unique thiazoloisoquinolinium thiolates and derivatives

作     者：Wasim Ahmed Zi-Hao Huang Zi-Ning Cui Ri-Yuan Tang Wasim Ahmed;Zi-Hao Huang;Zi-Ning Cui;Ri-Yuan Tang

作者机构：Department of Applied ChemistryCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642China State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesIntegrative Microbiology Research CentreGuangdong Province Key Laboratory of Microbial Signals and Disease ControlSouth China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern AgricultureGuangzhou 510642China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第10期

页      面：3211-3214页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：financially supported by Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (Nos.2019B151502052, 2021B1515020107) the programs of National Natural Science Foundation of China (No.32072450) the International Science and Technology Cooperation Program in Guangdong (No.2020A0505100048) the Program of Science and Technology of Guangzhou (No.202002030295) the open Project of the State Key Laboratory of Crop Stress Biology for Arid Areas (No.CSBAAKF2021009) 

主　　题：Isoquinoline Heterocycle Zewitterionic Elemental sulfur Cycloaddition 

摘      要：Natural isoquinolinium alkaloids possess a wide range of biological *** design and synthesis of mesoionic isoquinoliniums is of great *** paper reports the synthesis of unique mesoionic thiazoloisoquinolinium thiolates stabilized by aromatization and 1,*** compounds can be synthesized via the three component [2 + 2 + 1] cycloaddition reaction of isoquinolines with ethyl propionate and elemental sulfur in the absence of any metal catalyst and ***,thiazoloisoquinolinium thiolates can be transformed to thioether-containing thiazoloisoquinolinium halides.A selective [4 + 2] cycloaddition can also be used to form S-bridged fused tetracyclic compounds with a thiothiamide ring unit and two quarternary carbon *** I-1 shows good bioactivity against the chlorophyll of duckweed(Lemna minor) with inhibition rate of 51.5 mg/mL.