Spinal anesthesia alleviates dextran sodium sulfate-induced colitis by modulating the gut microbiota
作者机构：Department of General SurgerySir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Department of AnaesthesiologySir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina College of MedicineZhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Biomedical Research CenterSir Run Run Shaw Hospital of Medical SchoolZhejiang UniversityHangzhou 310012Zhejiang ProvinceChina Department of AnesthesiologySir Run Run Shaw Hospital of Zhejiang UniversityHangzhou 310012Zhejiang ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第12期
页 面：1239-1256页
核心收录：
学科分类：1002[医学-临床医学] 100217[医学-麻醉学] 10[医学]
基 金：Supported by the Zhejiang Provincial Natural Science Foundation,No.LY19H030011,No.LQ20C010005,and No.LQ19H030009 Key Project of Province and Ministry Foundation,No.WKJZJ2124
主 题：Spinal anesthesia Inflammatory bowel disease Gut microbiota Intestinal barrier Intestinal inflammation Intestinal immune
摘 要：BACKGROUND Inflammatory bowel disease(IBD)is a chronic disease with recurrent intestinal *** the exact etiology of IBD remains unknown,the accepted hypothesis of the pathogenesis to date is that abnormal immune responses to the gut microbiota are caused by environmental *** role of the gut microbiota,particularly the bidirectional interaction between the brain and gut microbiota,has gradually attracted more *** To investigate the potential effect of spinal anesthesia on dextran sodium sulfate(DSS)-induced colitis mice and to detect whether alterations in the gut microbiota would be crucial for *** A DSS-induced colitis mice model was *** anesthesia was administered on colitis mice in combination with the methods of cohousing and fecal microbiota transplantation(FMT)to explore the role of spinal anesthesia in IBD and identify the potential mechanisms *** We demonstrated that spinal anesthesia had protective effects against DSS-induced colitis by alleviating clinical symptoms,including reduced body weight loss,decreased disease activity index score,improved intestinal permeability and colonic morphology,decreased inflammatory response,and enhanced intestinal barrier ***,spinal anesthesia significantly increased the abundance of Bacteroidetes,which was suppressed in the gut microbiota of colitis ***,cohousing with spinal anesthetic mice and FMT from spinal anesthetic mice can also alleviate DSS-induced colitis by upregulating the abundance of *** further showed that spinal anesthesia can reduce the increase in noradrenaline levels induced by DSS,which might affect the gut *** These data suggest that microbiota dysbiosis may contribute to IBD and provide evidence supporting the protective effects of spinal anesthesia on IBD by modulating the gut microbiota,which highlights a novel approach for the treatment of IBD.
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