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Application and prospect of adipose stem cell transplantation in treating lymphedema

World Journal of Stem Cells 2020年第7期12卷 676-687页

作者： zhu-jun li Elan Yang Yun-zhu li Zheng-Yun liang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Lymphedema is a chronic,debilitating and incurable disease that affects 0.13%-2%of the global *** evidence indicates that adipose-derived stem cells(ADSCs)might serve as suitable seed cells for lymphatic tissue engineering and lymphedema *** To summarize applications of ADSCs for treating lymphedema in both animal studies and clinical *** A systematic search was performed on four databases-PubMed,***,the evidence-based Cochrane library,and OVID-using the following search string:(“lymphedema”or“lymphoedema”or“lymphangiogenesis”)and(“adipose-derived stem cells”or“adipose-derived stromal cells”or“adipose-derived regenerative cells”).A manual search was performed by skimming the references of relevant *** studies and clinical trials using adipose-derived cells for the treatment of any kind of lymphedema were *** A total of eight research articles published before November 2019 were included for this *** articles focused on animal studies and another three focused on clinical *** transplantation therapy was demonstrated to be effective against lymphedema in all *** animal studies found that coadministration of ADSCs and controlled-release vascular endothelial growth factor-C or platelet-rich plasma could improve the effectiveness of ADSC *** sequential clinical trials were conducted on breast cancer-related lymphedema patients,and all showed favorable *** ADSC-based therapy is a promising option for treating ***-scale,multicenter randomized controlled trials are needed to develop more effective and durable therapeutic strategies.

关键词： Lymphedema Adipose-derived stem cells Animal model Clinical trial Vascular endothelial growth factor-C Lymphangiogenesis

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Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 677-682页

作者： Wei-feng SHAN Bing-quan CHEN Shao-jun zhu li JIANG Yan-feng ZHOU Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Decreased glucose tolerance and diabetes are frequently observed in advanced liver cirrhosis patients and may be related to insulin *** transporter-4 (GLUT4),one of the most important glucose transporters,plays a key role in the development of type 2 *** order to study the mechanism of insulin resistance in liver cirrhosis patients,we measured the insulin sensitivity index and determined the GLUT4 protein and mRNA contents of skeletal muscle by Western blotting and reverse transcription-polymerase chain reaction (RT-PCR),respectively,in normal people and liver cirrhosis *** results showed that the levels of glucose,insulin,and C-peptide in two liver cirrhosis groups were higher and the insulin sensitivity index lower than those of the normal control *** sensitivity of insulin may decrease with the decline of liver ***,the contents of GLUT4 protein and mRNA in patients with advanced liver cirrhosis were similar to those of normal *** conclusion,insulin resistance is observed in patients with advanced liver cirrhosis but may not be correlated with the skeletal contents of GLUT4 protein and mRNA.

关键词： Glucose transporter-4 (GLUT4) liver cirrhosis Insulin resistance Skeletal muscle

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Portal vein embolization induces compensatory hypertrophy of remnant liver

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World Journal of Gastroenterology 2006年第3期12卷 408-414页

作者： Jing-Yao Huang Wei-zhu Yang Jian-jun li Na Jiang Qu-Bin Zheng Department of Intcrvcntional Radiology TheAffiliated Union Hospital of Fujian Medical University Fuzhou350001 Fujian Province China

AIM： To evaluate the effectiveness and safety of different portal vein branch embolization agents in inducing compensatory hypertrophy of the remnant liver and to offer a theoretic basis for clinical portal vein branch embolization. METHODS： Forty-one adult dogs were included in the experiment and divided into four groups. Five dogs served as a control group, 12 as a gelfoam group, 12 as a coil-gelfoam group and 12 as an absolute ethanol group. Left portal vein embolization was performed in each group. The results from the embolization in each group using different embolic agents were compared. The safety of portal vein embolization （PVE） was evaluated by liver function test, computed tomography （CT） and digital subtraction angiography （DSA） of liver and portal veins. Statistical test of variance was performed to analyze the results. RESULTS： Gelfoam used for PVE was inefficient in recanalization of portal vein branch 4 wk after the procedure. The liver volume in groups of coil-gelfoam and absolute ethanol increased 25.1% and 33.18%, respectively. There was no evidence of recanalization of embolized portal vein, hepatic dysfunction, and portal hypertension in coil-gelfoam group and absolute ethanol group. CONCOUSION： Portal vein branch embolization using absolute ethanol and coil-gelfoam could induce atrophy of the embolized lobes and compensatory hypertrophy of the remnant liver. Gelfoam is an inefficient agent.

关键词： Portal vein embolization Interventional therapy liver Dog

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Deposition of thin TiO_(2)films on fluorophlogopite particle surface by CVD in fluidized bed reactor to prepare silver pearlescent pigments

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Particuology 2024年第6期89卷 88-98页

作者： Ming liu Guoqiang Shao Pengpeng Lv jun li Qingshan zhu State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Two critical parameters:Glossiness and chromaticity space of pearlescent pigments were evaluated based on crystallinity and grain *** the roughness and the vertical distance evolution along the surface of deposited TiO_(2)film are affected by the *** optimal crystallinity of TiO_(2)was deposited at the temperature of 350℃.The TiCl4 concentration effectively changed the grain ***,the high flow rate of fluidizing gas and optimal gas–solid ratio(ling the film thickness based on TiO_(2)***,the silver pearlescent pigment with high glossiness was prepared by chemical vapor deposition method in a fluidized bed reactor.

关键词： Fluidized bed chemical vapor deposition TiO_(2)film deposition Pearlescent pigment Free powder restrain Crystal growth

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Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： li-hua zhu Yu-pei liang lian Yang Feng zhu li-jun Jia He-gen li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis

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Day-ahead P2P Energy Sharing Strategy Among Energy Hubs Considering Flexibility of Energy Storage and Loads

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1105-1118页

作者： Penghua li Wanxing Sheng Qing Duan jun liang Cunhao zhu China Electric Power Research Institute Beijing 100192China School of Engineering Cardiff UniversityUK IEEE

Multi-energy systems are one of the key technologies to tackle energy crisis and environmental *** energy hub(EH)is a minimum multi-energy *** of multiple EHs through energy routers(ERs)can realize mutual energy *** paper proposes a peer-to-peer(P2P)energy sharing strategy between EHs including ERs in an interconnected system,which is divided into two *** the lower level,a method of determining the charging/discharging constraints of energy storage devices is *** on the Lyapunov optimization method,virtual queues are used to model the energy storage devices and flexible loads in the *** objective is to minimize the overall operating cost of the interconnected *** the upper level,a non-cooperative game model is introduced to minimize the cost of purchasing power from other EHs for each EH.A best response-based method is adapted to find the Nash *** simulation outcomes demonstrate that application of the proposed strategy can reduce operating costs of an interconnected system and each *** basis of a real-world dataset of interconnected EHs,both analytical and numerical results show the effectiveness of the proposed strategy.

关键词： Energy hub energy router Lyapunov optimization non-cooperative game peer to peer virtual queue

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The Effects of the Geometry of a Current Collector with an Equal Open Ratio on Output Power of a Direct Methanol Fuel Cell

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Energy Engineering 2024年第5期121卷 1161-1172页

作者： Yingli zhu Jiachi Xie Mingwei zhu jun Zhang Miaomiao li Tianjin Key Laboratory of Integrated Design and On-line Monitoring for light Industry&Food Machinery and Equipment School of Mechanical EngineeringTianjin University of Science&TechnologyTianjin300222China Tianjin College University of Science and Technology BeijingTianjin301830China Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjing210016China

The open ratio of a current collector has a great impact on direct methanol fuel cell(DMFC)*** a number of studies have investigated the influence of the open ratio of DMFC current collectors,far too little attention has been given to how geometry(including the shape and feature size of the flow field)affects a current collector with an equal open *** this paper,perforated and parallel current collectors with an equal open ratio of 50%and different feature sizes are designed,and the corresponding experimental results are shown to explain the geometry effects on the output power of the *** results indicate that the optimal feature sizes are between 2 and 2.5 mm for both perforated and parallel flow field in the current collectors with an equal open ratio of 50%.This means that for passive methanol fuel cells,to achieve the highest output power,the optimal feature size of the flow field in both anode and cathode current collectors is between 2 and 2.5 mm under the operating mode of this *** effects of rib and channel position are also investigated,and the results indicate that the optimum pattern depends on the feature sizes of the flow field.

关键词： Direct methanol fuel cell geometry open ratio current collector position

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Energy Harvesting in the Wake of An Inverted C-Shaped Bluff Body

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China Ocean Engineering 2024年第1期38卷 68-80页

作者： WANG jun-lei li Shen-fang Md.Mahbub ALAM zhu Hong-jun HU Guo-biao School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou 450000China Center for Turbulence Control Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China Internet of Things Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China

This paper proposes a novel wake-induced vibration(WIV)-based energy harvesting system consisting of two bluff *** inverted C-shaped bluff body is stationary installed at the upstream position to generate an interference wake street,and a cylinder bluff body equipped with a transducer is elastically suspended at the downstream position to harness WIV *** hydrodynamics and energy harvesting(EH)performance of the proposed system are investigated via experimental *** reduced velocity(U*)ranging from 2 to 14(the corresponding Reynolds number ranging from 15100 to 106200)is considered in the present *** is found that the wake generated by the inverted C-shaped bluff body significantly affects the EH *** the opening angle(α)of the C-shaped bluff body increases the vibration amplitude of the downstream cylinder,thereby increasing the harvested *** the spacing(L)between two bluff bodies is two times the cylinder diameter(D),the wake-induced vibration(WIV)mode is observed,while the combined WIV and wake galloping(WG)mode occurs whenαis 150°,and L equals 3D or *** average drag coefficient becomes negative when L is 2D,3D,or *** carefully configuring a C-shaped bluff body,the wake generated by it can bring an augmenting effect on the vibration of the downstream EH *** example,the RMS power output of the proposed EH system reaches a maximum of 0.31 W at U*=8 and L=4D,which is 300%greater than that of its traditional ***,after a number of case stud-ies,it is identified that the proposed EH system can achieve the best performance whenαis 150°and L=2D.

关键词： wake-induced vibration vortex-induced vibration galloping energy harvesting bluff body

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Unraveling the role of iron on Ni-Fe alloy nanoparticles during the electrocatalytic ethanol-to-acetate process

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Nano Research 2024年第4期17卷 2328-2336页

作者： junshan li Luming li Xinyu Ma jun Wang jun Zhao Yu Zhang Ren He Yaoyue Yang Andreu Cabot Yongfa zhu Institute for Advanced Study Chengdu University610106 ChengduChina State Key Laboratory of Environmental-Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China College of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Chemistry and Environment Southwest Minzu UniversityChengdu 610041China Hebei Key Laboratory of Photoelectric Control on Surface and Interface College of ScienceHebei University of Science and TechnologyShijiazhuang 050018China Catalonia Institute for Energy Research-IREC Sant Adriàde BesòsBarcelona 08930CataloniaSpain ICREA Pg.Lluís Companys 23Barcelona 08010CataloniaSpain Department of Chemistry Tsinghua UniversityBeijing 100084China

The anodic electrooxidation of ethanol to value-added acetate is an excellent example of replacing the oxygen evolution reaction to promote the cathodic hydrogen evolution reaction and save ***,we present a colloidal strategy to produce Ni-Fe bimetallic alloy nanoparticles(NPs)as efficient electrocatalysts for the electrooxidation of ethanol in alkaline ***-Fe alloy NPs deliver a current density of 100 mA·cm^(-2) in a 1.0 M KOH solution containing 1.0 M ethanol merely at 1.5 V *** hydrogen electrode(RHE),well above the performance of other electrocatalysts in a similar *** continuous 10 h testing at this external potential,this electrode is able to produce an average of 0.49 mmol·cm^(-2)·h^(-1) of acetate with an ethanol-to-acetate Faradaic efficiency of 80%.A series of spectroscopy techniques are used to probe the electrocatalytic process and analyze the ***,density functional theory(DFT)calculations demonstrate that the iron in the alloy NPs significantly enhances the electroconductivity and electron transfer,shifts the rate-limiting step,and lowers the energy barrier during the ethanol-to-acetate reaction pathway.

关键词： electrocatalysis ethanol oxidation reaction alloy nanoparticle acetate biorefinery

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BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

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Genes & Diseases 2024年第1期11卷 19-22页

作者： Zhenhai li Wenchao Xu Feng Chen jun Zhang Wei-Guo zhu Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.

关键词： etoposide damage cancer

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