Application and prospect of adipose stem cell transplantation in treating lymphedema
作者机构：Department of Plastic and Reconstructive SurgeryPeking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2020年第12卷第7期
页 面：676-687页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Lymphedema Adipose-derived stem cells Animal model Clinical trial Vascular endothelial growth factor-C Lymphangiogenesis
摘 要：BACKGROUND Lymphedema is a chronic,debilitating and incurable disease that affects 0.13%-2%of the global *** evidence indicates that adipose-derived stem cells(ADSCs)might serve as suitable seed cells for lymphatic tissue engineering and lymphedema *** To summarize applications of ADSCs for treating lymphedema in both animal studies and clinical *** A systematic search was performed on four databases-PubMed,***,the evidence-based Cochrane Library,and OVID-using the following search string:(“lymphedemaor“lymphoedemaor“lymphangiogenesis)and(“adipose-derived stem cellsor“adipose-derived stromal cellsor“adipose-derived regenerative cells).A manual search was performed by skimming the references of relevant *** studies and clinical trials using adipose-derived cells for the treatment of any kind of lymphedema were *** A total of eight research articles published before November 2019 were included for this *** articles focused on animal studies and another three focused on clinical *** transplantation therapy was demonstrated to be effective against lymphedema in all *** animal studies found that coadministration of ADSCs and controlled-release vascular endothelial growth factor-C or platelet-rich plasma could improve the effectiveness of ADSC *** sequential clinical trials were conducted on breast cancer-related lymphedema patients,and all showed favorable *** ADSC-based therapy is a promising option for treating ***-scale,multicenter randomized controlled trials are needed to develop more effective and durable therapeutic strategies.
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