检索结果-南通市图书馆

Numerical Simulation and Experimental Study of Heat-fluid-solid Coupling of Double Flapper-nozzle Servo Valve

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2015年第5期28卷 1030-1038页

作者： ZHAO Jianhua zhou songlin LU Xianghui GAO Dianrong Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Yanshan University Hebei Vocational & Technical College of Building Materials

The double flapper-nozzle servo valve is widely used to launch and guide the equipment. Due to the large instantaneous flow rate of servo valve working under specific operating conditions, the temperature of servo valve would reach 120℃ and the valve core and valve sleeve deform in a short amount of time. So the control precision of servo valve significantly decreases and the clamping stagnation phenomenon of valve core appears. In order to solve the problem of degraded control accuracy and clamping stagnation of servo valve under large temperature difference circumstance, the numerical simulation of heat-fluid-solid coupling by using finite element method is done. The simulation result shows that zero position leakage of servo valve is basically impacted by oil temperature and change of fit clearance. The clamping stagnation is caused by warpage-deformation and fit clearance reduction of the valve core and valve sleeve. The distribution roles of the temperature and thermal-deformation of shell, valve core and valve sleeve and the pressure, velocity and temperature field of flow channel are also analyzed. Zero position leakage and electromagnet＇s current when valve core moves in full-stroke are tested using Electro-hydraulic Servo-valve Characteristic Test-bed of an aerospace sciences and technology corporation. The experimental results show that the change law of experimental current at different oil temperatures is roughly identical to simulation current. The current curve of the electromagnet is smooth when oil temperature is below 80℃, but the amplitude of current significantly increases and the hairy appears when oil temperature is above 80℃. The current becomes smooth again after the warped valve core and valve sleeve are reground. It indicates that clamping stagnation is caused by warpage-deformation and fit clearance reduction of valve core and valve sleeve. This paper simulates and tests the heat-fluid-solid coupling of double flapper-nozzle servo valve, an

关键词： double flapper-nozzle servo valve heat-fluid-solid coupling numerical simulation warpage-deformation clamping stagnation zero position leakage

Role of CD36 in central nervous system diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第3期19卷 512-518页

作者： Min Feng Qiang zhou Huimin Xie Chang Liu Mengru Zheng Shuyu Zhang songlin zhou Jian Zhao School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Department of Orthopedic Oncology Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina

CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic ***36 was recently found to be widely expressed in various cell types in the nervous system,including endothelial cells,pericytes,astrocytes,and ***36 mediates a number of regulatory processes,such as endothelial dysfunction,oxidative stress,mitochondrial dysfunction,and inflammatory responses,which are involved in many central nervous system diseases,such as stroke,Alzheimer’s disease,Parkinson’s disease,and spinal cord ***36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand,thereby achieving inhibition of CD36-mediated pathways or ***,we reviewed the mechanisms of action of CD36 antagonists,such as Salvianolic acid B,tanshinone IIA,curcumin,sulfosuccinimidyl oleate,antioxidants,and small-molecule ***,we predicted the structures of binding sites between CD36 and *** sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases.

关键词： animal experiments antagonists CD36 antagonist central nervous system diseases clinical trial curcumin microRNA salvianolic acid B small-molecule drugs sulfosuccinimidyl oleate

Research on valve core’s clamping stagnation of double flapper-nozzle servo valve

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 2019年第1期25卷 65-73页

作者： Zhao Jianhua Zhang Bin Chen Tao Wang Qiang zhou songlin Gao Dianrong Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Yanshan University

Due to great changing of instantaneous temperature of hydraulic oil of double flapper-nozzle servo valve, thermal deformation between valve core and valve sleeve may result in catching phenomenon of valve core, and then the reliability of servo valve could be affected seriously. The work focuses on a particular model of double flapper-nozzle servo valve and establishes three dimension couple models of liquid-solid-thermal under extreme operating condition. The transmission route and dissipative mechanism of heat is revealed and thermal deformation behavior of valve core and valve sleeve is researched. A change law of the key fit clearance under the effect of thermal expansion and warp deformation is explored, the source of catching phenomenon of valve core is identified, and then preventive measure and improvement can be proposed. In order to verify the correctness of theoretical analysis, the moving smoothness of deformed valve core and reground valve core under the circumstance of high-temperature hydraulic oil on electrohydraulic servo valve static characteristics test table is compared and tested. The results show that as oil temperature rises, relative deformations between valve core and valve sleeve in different direction at a same cross-section are not equal, and then the key fit clearance is less than the initial value. Relative deformations in the same direction at different axial position are not equal, the deformations of middle and two ends are maximum and minimum values respectively, and then warp deformation of valve core occurs. When oil temperature is higher, the relative deformations between valve core and valve sleeve is larger, the moving smoothness of valve core gets worse, and the catching phenomenon of valve core occurs. Axial deformation of valve sleeve and valve core at different axial position is different, and the opening coefficient and stability of servo valve could be affected, especially the operation circumstance of small opening. The

关键词： double flapper-nozzle servo valve flow-solid-thermal coupling numerical simulation catching phenomenon thermal deformation mechanism smooth movement

Deciphering glial scar after spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Burns & Trauma 2021年第1期9卷 109-122页

作者： Yu Zhang Shuhai Yang Chang Liu Xiaoxiao Han Xiaosong Gu songlin zhou Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Hospital of Chinese Medicine Nanjing210000China Medical College of Nantong University Nantong226001China

Spinal cord injury(SCI)often leads to permanent disability,which is mainly caused by the loss of functional *** this review,we aimed to investigate why the healing process is *** of the reasons for this interruption is the formation of a glial scar around the severely damaged tissue,which is usually covered by reactive glia,macrophages and *** to clarify this issue,we summarize the latest research findings pertaining to scar formation,tissue repair,and the divergent roles of blood-derived monocytes/macrophages,ependymal cells,fibroblasts,microglia,oligodendrocyte progenitor cells(OPCs),neuron-glial antigen 2(NG2)and astrocytes during the process of scar formation,and further analyse the contribution of these cells to scar *** addition,we recapitulate the development of therapeutic treatments targeting glial scar ***,we aim to present a comprehensive decoding of the glial scar and explore potential therapeutic strategies for improving functional recovery after SCI.

关键词： Spinal cord injury Glial scar Axon regeneration Therapeutic strategy

RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第8期19卷 1812-1821页

作者： Xinyang zhou Yehua Lv Huimin Xie Yan Li Chang Liu Mengru Zheng Ronghua Wu songlin zhou Xiaosong Gu Jingjing Li Daguo Mi Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Orthopedic Nantong Traditional Chinese Medicine HospitalNantongJiangsu ProvinceChina Nantong Stomatological Hospital Affiliated to Nantong University NantongJiangsu ProvinceChina Department of General Practice Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after *** non-coding RNAs(IncRNAs)have been reported to play a crucial role in axonal *** r,the role of the IncRNA-microRNAmessenger RNA(mRNA)-competitive endogenous RNA(ceRNA)network in exosome-mediated axonal regeneration remains *** this study,we performed RNA transcriptome sequencing analysis to assess mRNA expression patterns in exosomes produced by cultured fibroblasts(FC-EXOs)and Schwann cells(SCEXOs).Diffe rential gene expression analysis,Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,and protein-protein intera ction network analysis were used to explo re the functions and related pathways of RNAs isolated from FC-EXOs and *** found that the ribosome-related central gene Rps5 was enriched in FC-EXOs and SC-EXOs,which suggests that it may promote axonal *** addition,using the miRWalk and Starbase prediction databases,we constructed a regulatory network of ceRNAs targeting Rps5,including 27 microRNAs and five *** ceRNA regulatory network,which included Ftx and Miat,revealed that exsosome-derived Rps5 inhibits scar formation and promotes axonal regeneration and functional recovery after nerve *** findings suggest that exosomes derived from fibro blast and Schwann cells could be used to treat injuries of peripheral nervous system.

关键词： ceRNA network exosomes fibroblast cells Gene Ontology(GO) Kyoto Encyclopedia of Genes and Genomes(KEGG) protein-protein interaction(PPI)networks RNA-seq Schwann cells

Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in Control of Myelination Identity

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第7期38卷 720-740页

作者： Bin Zhang Wenfeng Su Junxia Hu Jinghui Xu Parizat Askar Shuangxi Bao songlin zhou Gang Chen Yun Gu Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairNMPAKey Laboratory for ResearchEvaluation of Tissue Engineering Technology ProductsNantong UniversityNantong 226001China

Enhancing remyelination after injury is of utmost importance for optimizing the recovery of nerve *** the formation of myelin by Schwann cells(SCs)is critical for the function of the peripheral nervous system,the temporal dynamics and regulatory mechanisms that control the progress of the s lineage through myelination require further ***,using in vitro co-culture models,gene expression profiling of laser capture-microdissected SCs at various stages of myelination,and multilevel bioinformatic analysis,we demonstrated that SCs exhibit three distinct transcriptional characteristics duringmyelination:the immature,promyelinating,and myelinating *** showed that suppressor interacting 3a(Sin3A)and 16 other transcription factors and chromatin regulators play important roles in the progress of ***3A knockdown in the sciatic nerve or specifically in SCs reduced or delayed the myelination of regenerating axons in a rat crushed sciatic nerve model,while overexpression of Sin3A greatly promoted the remyelination of ***,in vitro experiments revealed that Sin3A silencing inhibited SC migration and differentiation at the promyelination stage and promoted SC proliferation at the immature *** addition,SC differentiation and maturation may be regulated by the Sin3A/histone deacetylase2(HDAC2)complex functionally cooperating with Sox10,as demonstrated by rescue ***,these results complement the recent genome and proteome analyses of SCs during peripheral nerve myelin *** results also reveal a key role of Sin3A-dependent chromatin organization in promoting myelinogenic programs and SC differentiation to control peripheral myelination and *** findings may inform new treatments for enhancing remyelination and nerveregeneration.

关键词： (Re)myelination Schwann cells Sin3A Transcriptome Peripheral nerve injury

Chitosan/PLGA-based tissue engineered nerve grafts with SKP-SC-EVs enhance sciatic nerve regeneration in dogs through miR-30b-5p-mediated regulation of axon growth

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第10期40卷 378-395页

作者： Miaomei Yu Mi Shen Daiyue Chen Yan Li Qiang zhou Chunyan Deng Xinyang zhou Qi Zhang Qianru He Hongkui Wang Meng Cong Haiyan Shi Xiaosong Gu songlin zhou Fei Ding Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu226001China Clinical Medical Research Center The Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu213003China Department of Pathophysiology School of MedicineNantong UniversityNantongJiangsu226001China

Extracellular vesicles from skin-derived precursor Schwann cells(SKP-SC-EVs)promote neurite outgrowth in culture and enhance peripheral nerve regeneration in *** study aimed at expanding the application of SKPSC-EVs in nerve grafting by creating a chitosan/PLGA-based,SKP-SC-EVs-containing tissue engineered nerve graft(TENG)to bridge a 40-mm long sciatic nerve defect in ***-SC-EVs contained in TENGs significantly accelerated the recovery of hind limb motor and electrophysiological functions,supported the outgrowth and myelination of regenerated axons,and alleviated the denervation-induced atrophy of target muscles in *** clarify the underlying molecular mechanism,we observed that SKP-SC-EVs were rich in a variety of miRNAs linked to the axon growth of neurons,and miR-30b-5p was the most important among *** further noted that miR-30b-5p contained within SKP-SC-EVs exerted nerve regeneration-promoting effects by targeting the Sin3a/HDAC complex and activating the phosphorylation of ERK,STAT3 or *** findings suggested that SKP-SC-EVs-incorporating TENGs represent a novel type of bioactive material with potential application for peripheral nerve repair in the clinic.

关键词： Peripheral nerve regeneration Skin-derived precursor Schwann cells Extracellular vesicles Tissue engineered nerve graft miR-30b-5p Sin3a/HDAC complex

KIAA1199 induces advanced biological behavior and development of ovarian cancer through activation of the IL-6/STAT3 pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第3期46卷 689-697页

作者： SHUTING GU JINGYI QIN SAINAN GAO ZHEN WANG QI MENG YAN LI BING LU songlin zhou YUNZHAO XU Department of Obstetrics and Gynecology Affiliated Hospital of Nantong UniversityNantong226001China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantong226001China Key Laboratory for Nano-Bio Interface Research Nano-Bio-Chem CentreSuzhou Institute of Nano-Techand Nano-BionicsChinese Academy of SciencesSuzhou215123China Department of Obstetrics and Gynecology Dalian Medical UniversityDalian116044China Department of Clinical Biobank Affiliated Hospital of Nantong UniversityNantong226001China Department of Obstetrics and Gynecology School of MedicineNantong UniversityNantong226001China

Recently,abnormal expression of KIAA1199 has been detected in Epithelial Ovarian Cancer(EOC).However,the underlined anti-ovarian cancer mechanism of KIAA1199 remains to be *** our study,we performed to elucidate the effects of KIAA1199 on the advanced biological behavior of EOC cells through activation of the IL-6/STAT3 *** by immunohistochemistry,KIAA1199 was highly expressed in ovarian borderline and malignant epithelial tumors.A retrospective analysis found that EOC patients with low expression of KIAA1199 had a significantly higher 5-year survival rate than those with high ***,IL-6 was used to stimulate EOC cells,and the expression of KIAA1199,STAT3 and p-STAT3 increased after IL-6 *** results could show that KIAA1199 is transcriptionally activated by IL6/STAT3 pathway,thereby accelerating the deterioration of ***1199 could also be used as a poor prognosis factor and potential target in treatment.

关键词： Epithelial Ovarian Cancer(EOC) KIAA1199 IL-6/STAT3 pathway Prognosis

miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2021年第4期37卷 569-574页

作者： Lili Zhao Leilei Gong Ping Li Jing Qin Lingchi Xu Qiyao Wei Huimin Xie Susu Mao Bin Yu Xiaosong Gu songlin zhou Model Animal Research Center and Ministry of Education Key Laboratory of Animal Models of Disease Nanjing UniversityNanjing210000China Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantong226001China Pathological Anatomy Department Medical CollegeNantong UniversityNantong226001China School of Life Sciences East China Normal UniversityShanghai200241China Medical College Nantong UniversityNantong226001China

Dear Editor,The peripheral nervous system(PNS)regenerates more easily after injury than the central nervous system(CNS)[1].Sensory neurons in the L4–L6 dorsal root ganglia(DRGs)extend axons to form the sciatic nerve ... 详细信息

关键词： Regeneration exceptional injury