Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration

作     者：Songlin Zhou Fei Ding Xiaosong Gu 

作者机构：Jiangsu Key Laboratory of NeuroregenerationCo-innovation Center of NeuroregenerationNantong University 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2016年第32卷第3期

页      面：253-264页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Basic Research Development Program (973 Program) of China (2014CB542202) the National High-Technology Research Development Program (863 Program) of China (2012AA020502) the Natural Science Foundation of Jiangsu Province,China (BK20151270) the National Natural Science Foundation of China (31200799 and 81571198) the Priority Academic Program Development of Jiangsu Higher Education Institutions 

主　　题：ncRNA miRNA lncRNA Nerve injury Regeneration 

摘      要：Non-coding RNAs（ncRNAs） are a large cluster of RNAs that do not encode proteins,but have multiple functions in diverse cellular *** evidence indicates the involvement of nc RNAs in the physiology and pathophysiology of the central and peripheral nervous *** has been shown that numerous ncRNAs,especially micro RNAs and long non-coding RNAs,are differentially expressed after insults such as acquired brain injury,spinal cord injury,and peripheral nerve *** ncRNAs affect neuronal survival,neurite regrowth,and glial phenotype primarily by targeting specific mRNAs,resulting in translation repression or degradation of the *** increasing number of studies have investigated the regulatory roles of micro RNAs and long non-coding RNAs in neural injury and regeneration,and thus a new research field is *** this review,we highlight current progress in the field in an attempt to provide further insight into post-transcriptional changes occurring after neural injury,and to facilitate the potential use of ncRNAs for improving neural *** also suggest potential directions for future studies.