Deciphering glial scar after spinal cord injury
作者机构：Key Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Hospital of Chinese MedicineNanjing210000China Medical College of Nantong UniversityNantong226001China
出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)
年 卷 期：2021年第9卷第1期
页 面：109-122页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Key Basic Research Program of China,No.2017YFA0104701 The National Natural Science Foundation of China,No.81801281,81870975,81671230 The Natural Science Foundation of Jiangsu Province(BK20202013)
主 题：Spinal cord injury Glial scar Axon regeneration Therapeutic strategy
摘 要：Spinal cord injury(SCI)often leads to permanent disability,which is mainly caused by the loss of functional *** this review,we aimed to investigate why the healing process is *** of the reasons for this interruption is the formation of a glial scar around the severely damaged tissue,which is usually covered by reactive glia,macrophages and *** to clarify this issue,we summarize the latest research findings pertaining to scar formation,tissue repair,and the divergent roles of blood-derived monocytes/macrophages,ependymal cells,fibroblasts,microglia,oligodendrocyte progenitor cells(OPCs),neuron-glial antigen 2(NG2)and astrocytes during the process of scar formation,and further analyse the contribution of these cells to scar *** addition,we recapitulate the development of therapeutic treatments targeting glial scar ***,we aim to present a comprehensive decoding of the glial scar and explore potential therapeutic strategies for improving functional recovery after SCI.
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