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OXIDATIVE　DEHYDROGENATION　OF　ETHANE（ODE）　OVER　LaOF　CATALYST　PROMOTED　WITH　BaF_2

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Chinese Chemical Letters 1995年第4期6卷 347-348页

作者： zhou, xp Chao, ZS Wan, HL Tsai, KR Xiamen Univ Dept Chem Xiamen 361005 Peoples R China

The addition of BaF2 into LaOF catalyst significantly improves the catalytic properties of LaOF for the ODE reaction.

关键词： ODE ETHANE OVER LaOF DEHYDROGENATION BaF2 CATALYST

Cloning and expression of MXR7 gene in human HCC tissue

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World Journal of Gastroenterology 2000年第1期6卷 57-60页

作者： zhou xp Wang HY Yang GS Chen ZJ Li BA Wu MC The International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Hospitalthe Second Military Medical UniversityShanghai 200438China

AIM To clone and identify the whole cDNA ofMXR7 gene and to find out its expression inhuman HCC,and normal *** The DNA primers were designed andsynthesized according to the whole cDNAsequence of MXR? *** cDNA of humanHCC was taken as the template while the cDNA ofMXR7 gene was synthesized by polymerasechain reaction（PCR）.Recombinant DNAconforming to reading frame was constructed byconnecting purified PCR product of the cDNA ofMXR? gene with expression vector pGEX-5X-1 offusion *** plasmid MXRT/pGEX-5X-1was identified by *** 32p labeledMXR? cDNA as probe,MXR7 mRNA expressionwas detected by Northern blot analysis in 12different human normal tissues,7 preoperativelyuntreated non-liver tumor tissues,30preoperatively untreated HCC,theparacancerous liver tissues and 12 normal livertissues *** Restriction enzyme and sequenceanalysis confirmed that the insertion sequence invector pGEX-5X-1 was the same as the cDNAsequence of MXR7 *** blot analysisshowed no expression of MXR? mRNA in 12 kindsof normal human tissues including liver,7 tumortissues in other sites and 12 normal livertissues,the frequencies of MXR7 mRNA expression in HCC and paracancerous livertissues were 76.6% and 13.3%,*** frequency of MXR7 mRNA expression in HCCwithout elevation of serum AFP and in HCCxpressedin human HCC,which is specific and occurs at anearly stage of HCC,suggesting MXR7 mRNA canbe a tumor biomarker for *** detection ofMXR7 mRNA expression in the biopsied livertissue is helpful in discovering early subclinicalliver cancer in those with negative serum AFP.

关键词： Subject headings human HCC tissues MXR7 gene gene expression cDNA mRNA

Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 427-432页

作者： Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, zhou xp and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) Department of Radiology West China Hospital Sichuan University Chengdu 610041 China.

Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation.

关键词： animal-model hepatocellular carcinoma Sprague-Dawley rat magnetic resonance imaging

自制椎板钩分散椎弓根螺钉系统应力作用的有限元分析

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中国组织工程研究与临床康复 2007年第22期11卷 4292-4295页

作者：汪宇潘滔刘先银周希平东莞市人民医院骨科广东省东莞市523018 中山大学附属第一医院骨科广东省广州市510080 华南理工大学交通学院力学实验中心广东省广州市510641

目的:观察加用自制椎板钩对分散椎弓根螺钉系统应力的作用。方法:实验于2005-10-20在华南理工大学交通学院力学实验中心完成。①建立自行设计的新型椎板钩钉系统有限元模型:椎弓根螺钉长度为40mm,圆棒长度120mm,二者直径均为6mm,椎板钩... 详细信息

目的:观察加用自制椎板钩对分散椎弓根螺钉系统应力的作用。方法:实验于2005-10-20在华南理工大学交通学院力学实验中心完成。①建立自行设计的新型椎板钩钉系统有限元模型:椎弓根螺钉长度为40mm,圆棒长度120mm,二者直径均为6mm,椎板钩高度为9mm,长度为22mm。②有限元模型建立:根据以上参数,应用ANSYS8.0软件,按实际大小和结构以二维线梁单元BEAM188建立新型椎板钩钉系统有限元模型,约束尾侧椎弓根螺钉和尾侧椎板钩内表面,垂直于头侧椎弓根螺钉进行加载。③应力测量:前屈扭矩5N·m状态下,对椎弓根螺钉系统不加与加用椎板钩时,整个系统各处的应力变化进行评估。结果:加钩后整个系统受力点增加,受力更加均匀。临床上容易发生断钉的部位应力显著降低。头、尾侧椎弓根钉根部加钩后轴向应力显著降低,以尾侧钉为著,降低37.08%。头、尾侧钉棒连接处加钩后剪切应力下降明显,头侧下降44.02%,尾侧下降60.71%。结论:椎板钩使得椎弓根螺钉系统应力分散,以尾侧椎弓根钉根部及钉棒连接处为著,从而减少椎弓根螺钉断钉的发生。

关键词：椎弓根螺钉椎板钩有限元分析

血卟啉衍生物光动力效应对体外培养人鼻咽癌细胞株的杀伤作用

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中国组织工程研究与临床康复 2007年第9期11卷 1707-1709页

作者：杨小民罗荣城李黎波丁雪梅严晓吕成伟周晓平南方医科大学南方医院肿瘤治疗中心广东省广州市510515

目的:通过探讨血卟啉衍生物光动力学效应对人鼻咽癌细胞株CNE2的生物作用,为光动力治疗放、化疗效果较差的鼻咽癌提供理论依据。方法:实验于2005-10/2006-06在南方医科大学南方医院肿瘤生物治疗中心实验室完成。对体外培养的人鼻咽癌细... 详细信息

目的:通过探讨血卟啉衍生物光动力学效应对人鼻咽癌细胞株CNE2的生物作用,为光动力治疗放、化疗效果较差的鼻咽癌提供理论依据。方法:实验于2005-10/2006-06在南方医科大学南方医院肿瘤生物治疗中心实验室完成。对体外培养的人鼻咽癌细胞株CNE2分为光处理和无光处理各8个实验组及各分别设对照组和空白对照组,实验组分别加入0.5,1.0,1.5,2.0,2.5,3.0,3.5,4.0mg/L血卟啉衍生物100μL,每组设7个复孔;孵育4h,对照组除不加光敏剂外其他与实验组相同,空白对照组只加培养基不加细胞和光敏剂。光处理实验组给予波长为630nm的半导体激光进行照射,照射的功率密度为20mW/cm2,照射能量密度分别为20,10,5,2J/cm2,继续孵育24h,用四唑盐(MTT)比色法测定细胞存活率。细胞存活率(%)=(实验组A值-空白对照组A值)/(对照组A值-空白对照组A值)×100%。每次实验重复3次,取平均值。结果:①血卟啉衍生物与CNE2细胞共同孵育后,采用630nm的半导体激光照射可对其产生杀伤作用,杀伤作用大小与血卟啉衍生物的浓度和激光剂量成正相关(P0.05)。结论:血卟啉衍生物介导的光动力在体外可以对CNE2细胞产生杀伤效应,在一定范围内杀伤作用大小与血卟啉衍生物的浓度和激光剂量成正相关。

关键词：鼻咽肿瘤血卟啉衍生物光化学疗法血卟啉光照疗法

X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

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World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-Hua Yang Jin-zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-Hua Pan Wan-Qing Liao Tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of Dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(xp)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,xp combines various medicinal ***-performance liquid chromatography(HPLC)identified xp’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether xp participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between xp-treated and control *** docking clarified xp’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** xp notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following xp *** identified 21 primary xp components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** xp significantly promotes wound healing in STZ-induced diabetic *** xp’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

The Friedel-Crafts Acylation of Substituted Benzene with 2 - Phenylfuran-3, 4-dicarboxylic Acid Anhydride

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Chinese Chemical Letters 1998年第2期9卷 125-129页

作者： Nie, xp Ye, XL Peking Univ Dept Chem Beijing 100871 Peoples R China

2-Phenylfuran-3,4-dicarboxylic acid anhydride reacted with seven aromatic compounds, of which five gave keto acids in yields of 94%-63%. The structure of the keto acid was elucidated by reducing it to hydroxy acid and... 详细信息

关键词： Friedel-Crafts acylation 2-phenylfuran-3,4-dicarboxylic acid anhydride structure elucidation

IDENTIFICATION OF STIFFNESS COEFFICIENTS OF LAMINATED COMPOSITE PLATES

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中国有色金属学会会刊：英文版 1997年第3期7卷 46-50页

作者： Wang, XC Shen, xp Yuichiro, M Xu, BY N CHINA UNIV TECHNOL BEIJING 100041PEOPLES R CHINA TSING HUA UNIV DEPT MECH ENGNBEIJING 100084PEOPLES R CHINA IBARAKI UNIV DEPT ENGNHITACHIIBARAKI 316JAPAN

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ＩＤＥＮＴＩＦＩＣＡＴＩＯＮＯＦＳＴＩＦＦＮＥＳＳＣＯＥＦＦＩＣＩＥＮＴＳＯＦＬＡＭＩＮＡＴＥＤＣＯＭＰＯＳＩＴＥＰＬＡＴＥＳ①ＷａｎｇＸｉａｏｃｈｕｎ，ＳｈｅｎＸｉｎｐｕ，ＭａｓｕｄａＹｕｉｃｈｉｒｏ，ＸｕＢｉｎｇｙｅＮｏｒｔｈＣｈｉｎａＵｎｉｖｅ...

关键词： inverse analysis composite laminated plate stiffness coefficient

UVARIGRANIN:A NEW ACETOGENIN FROM UVARIA GRANDIFLORA ROXB

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Chinese Chemical Letters 1995年第6期6卷 473-476页

作者： Pan, xp Yu, DQ Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Beijing Union Med Coll Beijing 100050 Peoples R China

A new Annonaceous acetogenin, named uvarigranin(I),was isolated from the ethanol extract of the roots of Uvaria grandiflora Roxb, together with the known isodesacetyluvaricin (II) Their plane structures and relative configurations were established on the basis of NMR and MS spectroscopic methods. Compound I belongs to a mono(-1)-trahydrofuran (THF) type acetogenin with an unusual acetoxy group at the adjacent carbon on the THF ring.

关键词：