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机械制造企业大客户服务营销管理策略研究

市场周刊 2024年第17期37卷 84-87页

作者：周东升中航富士达科技股份有限公司陕西西安710076

在全球经济增长放缓、贸易保护主义抬头的大环境下,传统经济逐步向服务经济蜕变,服务正成为经济发展的助推器,也是企业竞争力的源泉。对身处其中的企业而言,既有不确定性、模糊性带来的无限机遇,也面临复杂、易变环境下的严峻挑战。如... 详细信息

在全球经济增长放缓、贸易保护主义抬头的大环境下,传统经济逐步向服务经济蜕变,服务正成为经济发展的助推器,也是企业竞争力的源泉。对身处其中的企业而言,既有不确定性、模糊性带来的无限机遇,也面临复杂、易变环境下的严峻挑战。如不更新服务营销理念,构建完善的服务营销体系,就会影响企业的发展。据此,企业应注重大客户服务营销,以增加用户的认知和忠诚度。基于此,文章以机械制造企业为例,审视了服务营销的内涵与特征,分析了大客户服务营销管理存在的问题,立足更新服务营销理念,打造营销管理文化氛围,提供个性化、精准化服务,注重先进技术手段的使用等层面,提出服务营销管理的具体策略,以期帮助企业进一步提升核心竞争力,助推我国经济高质量发展。

关键词：企业大客户服务营销营销策略

Formation and regulation of Yersinia biofilms

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Protein & Cell 2011年第3期2卷 173-179页

作者： dongsheng zhou Ruifu Yang State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China

Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor ***,a mild pathogen transmitted via the food-borne *** synthesizes biofilms in the flea gut,which is important for fleaborne *** biofilms are bacterial colonies surrounded by extracellular matrix primarily containing a homopolymer of N-acetyl-D-glucosamine that are synthesized by a set of specific *** biofilm production is tightly regulated at both transcriptional and post-transcriptional *** the known structural genes responsible for biofilm production are harbored in both *** and ***,but *** has evolved changes in the regulation of biofilm development,thereby acquiring efficient arthropod-borne transmission.

关键词： Yersinia pestis Y.pseudotuberculosis biofilm flea-borne transmission

ER-Net:Efficient Recalibration Network for Multi-ViewMulti-Person 3D Pose Estimation

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 2093-2109页

作者： Mi zhou Rui Liu Pengfei Yi dongsheng zhou National and Local Joint Engineering Laboratory of Computer Aided Design School of Software EngineeringDalian UniversityDalian116622China School of Computer Science and Technology Dalian University of TechnologyDalian116024China

Multi-view multi-person 3D human pose estimation is a hot topic in the field of human pose estimation due to its wide range of application *** the introduction of end-to-end direct regression methods,the field has entered a new stage of ***,the regression results of joints that are more heavily influenced by external factors are not accurate enough even for the optimal *** this paper,we propose an effective feature recalibration module based on the channel attention mechanism and a relative optimal calibration strategy,which is applied to themulti-viewmulti-person 3D human pose estimation task to achieve improved detection accuracy for joints that are more severely affected by external ***,it achieves relative optimal weight adjustment of joint feature information through the recalibration module and strategy,which enables the model to learn the dependencies between joints and the dependencies between people and their corresponding *** call this method as the Efficient Recalibration Network(ER-Net).Finally,experiments were conducted on two benchmark datasets for this task,Campus and Shelf,in which the PCP reached 97.3% and 98.3%,respectively.

关键词： Multi-view multi-person pose estimation attention mechanism computer vision

3D Human Pose Estimation Using Two-Stream Architecture with Joint Training

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 607-629页

作者： Jian Kang Wanshu Fan Yijing Li Rui Liu dongsheng zhou National and Local Joint Engineering Laboratory of Computer Aided Design School of Software EngineeringDalian UniversityDalian116622China Dalian Maritime University Dalian116023China

With the advancement of image sensing technology, estimating 3Dhuman pose frommonocular video has becomea hot research topic in computer vision. 3D human pose estimation is an essential prerequisite for subsequentaction analysis and understanding. It empowers a wide spectrum of potential applications in various areas, suchas intelligent transportation, human-computer interaction, and medical rehabilitation. Currently, some methodsfor 3D human pose estimation in monocular video employ temporal convolutional network (TCN) to extractinter-frame feature relationships, but the majority of them suffer from insufficient inter-frame feature relationshipextractions. In this paper, we decompose the 3D joint location regression into the bone direction and length, wepropose the TCG, a temporal convolutional network incorporating Gaussian error linear units (GELU), to solvebone direction. It enablesmore inter-frame features to be captured andmakes the utmost of the feature relationshipsbetween data. Furthermore, we adopt kinematic structural information to solve bone length enhancing the use ofintra-frame joint features. Finally, we design a loss function for joint training of the bone direction estimationnetwork with the bone length estimation network. The proposed method has extensively experimented on thepublic benchmark dataset Human3.6M. Both quantitative and qualitative experimental results showed that theproposed method can achieve more accurate 3D human pose estimations.

关键词： 3D human pose improved TCN GELU kinematic structure

PTGS2 identified as a biomarker of glucocorticoid-induced osteonecrosis of the femoral head and an enhancer of osteogenesis

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Genes & Diseases 2023年第1期10卷 14-17页

作者： Qingyu Zhang Shun Lu dongsheng zhou Jun Dong Fanxiao Liu Department of Orthopaedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250021China

Due to the use of more adjuvant therapies and the increasing prevalence of associated diseases,nontraumatic osteonecrosis of the femoral head(ONFH)has become a substantial worldwide health issue;while glucocorticoid administration was the highest-ranked risk factor,with a proportion ranging from 26.35 to 55.75%.1 Albeit with similar radiological features,glucocorticoid-induced ONFH(GONFH)manifested a greater probability for advance-tolate-stage(post-collapse)lesions in comparison with its non-glucocorticoid-induced counterparts.i1 Therefore,an accurate and timely diagnosis of osteonecrosis following glucocorticoid therapy is of great significance to initiate nonoperative treatment regimens or joint-preserving procedures,slow disease progression,and defer or avert joint arthroplasty.

关键词： glucocorticoid diagnosis operative

铜绿假单胞菌成孔毒素ExlA编码基因无痕缺失突变株的构建及其基本特性研究

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军事医学 2024年第2期48卷 108-114页

作者：张再青周媛媛胡凌飞金秀玉周冬生高波杨慧盈军事科学院军事医学研究院微生物流行病研究所病原微生物生物安全全国重点实验室北京100071 中部战区疾病预防控制中心北京100042 军事科学院军事医学研究院军事认知与脑科学研究所北京100850

目的构建铜绿假单胞菌NY8755 exlA基因无痕缺失突变株(NY8755ΔexlA),研究成孔毒素ExlA的基本特性。方法利用二次同源重组的方法构建铜绿假单胞菌exlA基因无痕缺失突变株。选取6~8周龄雌性C57BL/6J小鼠,经气溶胶肺递送途径分别感染铜绿... 详细信息

目的构建铜绿假单胞菌NY8755 exlA基因无痕缺失突变株(NY8755ΔexlA),研究成孔毒素ExlA的基本特性。方法利用二次同源重组的方法构建铜绿假单胞菌exlA基因无痕缺失突变株。选取6~8周龄雌性C57BL/6J小鼠,经气溶胶肺递送途径分别感染铜绿假单胞菌NY8755和NY8755ΔexlA,记录感染后7 d小鼠的生存状况和体重变化,检测小鼠肺泡灌洗液中的促炎因子。结果经过测序验证,成功构建铜绿假单胞菌成孔毒素ExlA编码基因无痕缺失突变株。利用气溶胶肺递送途径感染小鼠(1×107 CFU)后,野生株组小鼠48 h内全部死亡,突变株组48 h后开始死亡且7 d后仍有40%存活;突变株组存活小鼠体重先下降,后逐渐恢复;感染12 h后野生株组小鼠肺泡灌洗液明显比突变株组血性渗出物更多(颜色更红),肺泡灌洗液中促炎因子白细胞介素-1β(IL-1β)和白细胞介素-17A(IL-17A)含量有显著差异。结论铜绿假单胞菌成孔毒素ExlA是exlA阳性的新型铜绿假单胞菌的关键毒力因子,可显著影响小鼠的生存状况,引起小鼠体内明显的炎症反应。当前关于外毒素ExlA的致病机制研究较少,所构建的NY8755ΔexlA突变株及野生株和突变株肺炎小鼠模型,可为进一步探索exlA阳性的铜绿假单胞菌致病机制提供研究基础。

关键词：铜绿假单胞菌基因敲除成孔毒素动物模型

高毒力肺炎克雷伯菌两种金黄地鼠呼吸道感染模型比较研究

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军事医学 2024年第1期48卷 30-35页

作者：张之珺张丽丽吕蒙周冬生杨文慧高波军事科学院军事医学研究院微生物流行病研究所病原微生物生物安全国家重点实验室北京100071 军事科学院军事医学研究院军事认知与脑科学研究所北京100850

目的建立高毒力肺炎克雷伯菌经气溶胶肺递送和滴鼻感染金黄地鼠动物模型,并对比两种模型的构建效果。方法选取4~5周龄雄性金黄地鼠,经气溶胶肺递送和滴鼻两种途径攻毒高毒力肺炎克雷伯菌NTUHK2044,记录金黄地鼠攻毒后14 d的生存状况,计... 详细信息

目的建立高毒力肺炎克雷伯菌经气溶胶肺递送和滴鼻感染金黄地鼠动物模型,并对比两种模型的构建效果。方法选取4~5周龄雄性金黄地鼠,经气溶胶肺递送和滴鼻两种途径攻毒高毒力肺炎克雷伯菌NTUHK2044,记录金黄地鼠攻毒后14 d的生存状况,计算两种途径的半数致死量、存活率,并对呼吸道沉积分布、肺部细菌载量及组织病理进行检测。结果气溶胶肺递送途径攻毒引起金黄地鼠半数死亡剂量(3×10^(4)CFU)低于滴鼻途径(7×10^(5)CFU)。4×10^(6)CFU高毒力肺炎克雷伯菌以气溶胶肺递送途径感染金黄地鼠后,96.46%沉积在肺部并成功定植,主要引起大叶性肺炎,4 d内动物全部死亡;而同等剂量菌液滴鼻后95.62%沉积在口鼻部,随后下移至气管定植,主要引起支气管肺炎,病变程度相对较轻,细菌更易被机体清除,14 d存活率为70%。结论细菌呼吸道感染造模效果受攻毒途径影响,高毒力肺炎克雷伯菌经气溶胶肺递送攻毒主要引起病变严重的大叶性肺炎,滴鼻则主要引起病变较轻的支气管肺炎。上述两种动物模型的成功建立可为肺炎克雷伯菌致病机制研究和药效评价提供关键支撑。

关键词：高毒力肺炎克雷伯菌气溶胶金黄地鼠动物模型

饲料中添加过氧化氢酶对日本沼虾生长性能、抗氧化能力、免疫性能和肠道菌群结构的影响

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动物营养学报 2024年第1期36卷 464-477页

作者：李姗姗王俊保简永慧宋嘉欣周东生郑金仙孔有琴丁志丽湖州师范学院生命学院中国水产科学研究院水生动物繁育与营养重点实验室浙江省水生生物资源养护与开发技术研究重点实验室湖州313000

本试验旨在研究饲料中添加不同水平过氧化氢酶(CAT)对日本沼虾生长性能、抗氧能力、免疫性能和肠道菌群结构的影响。试验共配制6种饲料,分别在基础饲料中添加0(CAT1,对照组)、75(CAT2组)、150(CAT3组)、300(CAT4组)、600(CAT5组)和1200 ... 详细信息

本试验旨在研究饲料中添加不同水平过氧化氢酶(CAT)对日本沼虾生长性能、抗氧能力、免疫性能和肠道菌群结构的影响。试验共配制6种饲料,分别在基础饲料中添加0(CAT1,对照组)、75(CAT2组)、150(CAT3组)、300(CAT4组)、600(CAT5组)和1200 U/kg(CAT6组)的CAT,饲喂1080只初始体重为(0.10±0.03)g的日本沼虾,每组3个重复,每个重复60只虾。试验期为8周。结果显示:1)各试验组日本沼虾的存活率未受到饲料CAT添加水平的显著影响(P>0.05),但当饲料添加150 U/kg CAT时,日本沼虾的增重率显著高于对照组(P0.05);CAT2、CAT3和CAT4组肝胰腺丙二醛(MDA)含量显著低于其余各组(P0.05)。对日本沼虾肠道菌群进行β多样性分析发现,在门水平上,日本沼虾肠道菌群优势菌门为变形菌门、厚壁菌门和蓝藻菌门,CAT3和CAT4组中变形菌门的相对丰度显著低于对照组(P<0.05),而厚壁菌门相对丰度显著高于对照组(P<0.05);在属水平上,日本沼虾肠道菌群优势菌属为Tyzzerella、气单胞菌属和不动杆菌属,CAT4组中Tyzzerella相对丰度显著高于对照组(P<0.05),而CAT3、CAT4和CAT5组中气单胞菌属相对丰度显著低于对照组(P<0.05)。综上所述,饲料中添加150~300 U/kg的CAT可提高日本沼虾生长性能、抗氧化能力和免疫性能,增加肠道有益菌群的丰度,促进日本沼虾的健康养殖。

关键词：过氧化氢酶日本沼虾肠道菌群抗氧化

Multi-objective Optimization of Integrated Energy Systems Considering Ladder-type Carbon Emission Trading and Refined Load Demand Response

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 828-839页

作者： Yanhong Luo Haowei Hao dongsheng Yang Bowen zhou the Department of Electric Engineering Northeastern UniversityShenyang 110004China

In this paper,a novel multi-objective optimization model of integrated energy systems(IESs)is proposed based on the ladder-type carbon emission trading mechanism and refined load demand response ***,the carbon emission trading mechanism is introduced into the optimal scheduling of IESs,and a ladder-type carbon emission cost calculation model based on rewards and penalties is established to strictly control the carbon emissions of the ***,according to different response characteristics of electric load and heating load,a refined load demand response model is built based on the price elasticity matrix and substitutability of energy supply *** these basis,a multi-objective optimization model of IESs is established,which aims to minimize the total operating cost and the renewable energy source(RES)***,based on typical case studies,the simulation results show that the proposed model can effectively improve the economic benefits of IESs and the utilization efficiency of RESs.

关键词： Integrated energy system carbon emission trading load demand response renewable energy source