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Frontiers of Medicine 2007年第2期1卷 130-135页

作者： wang zhonggao Vascular Institute&Xuan Wu Hospital Capital Medical UniversityBeijing 100053China

The Budd-Chiari syndrome(BCS)used to be a very rare disorder and lacked a means of ***,various shuntings and radical procedures have emerged in the last three decades with quite encouraging *** minimally invasive therapies,such as stenting of the inferior vena cava(IVC),are simple and easy to ***,it has been realized that the IVC stent may compromise the hepatic veins and cause catastrophic consequences,thus the indication for IVC stenting should be reevaluated and especially not to be ***,it should be applied by percutaneous transangiography(PTA)only,which may be repeated when *** BCS in China predominantly belongs to the IVC type rather than the intrahepatic type in Western;the outcome from its conventional therapy,at least for the moment,is better than that of liver *** is thus suggested that,before liver transplantation is decided,the conventional means for managing BCS be *** final suggestion is to restrict the indication both for stenting of the IVC and liver *** this paper,ten examples are given with figures.

关键词： Budd-Chiari syndrome stenting shunting liver transplantation inferior vena cava ascites hematemesis PTA

Not asthma, but GERD: case report

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Frontiers of Medicine 2007年第1期1卷 115-119页

作者： wang zhonggao Center for GERD Second Artillery General HospitalClinical Research CollegeBeijing Normal UniversityBeijing 100086China Department of Surgery Xuan Wu HospitalCapital Medical UniversityBeijing 100053China

Asthma is a disorder of the lungs characterized by increased responsiveness of the airways,as manifested by episodes of wheezing and increased resistance to expiratory airflow because of varying degrees of smooth muscle contraction,edema of the mucosa,and mucus in the lumen of the bronchi and *** stimuli vary widely and include antigens,infection,air pollutants,respiratory tract irritants,exercise,and emotional *** condition is completely different from distress breathing because of laryngotracheal *** of its causes is the gastric content reflux through the pharynx to the larynx because of gastroesophageal reflux disease(GERD),in addition to the typical human avian flu that may cause immediate suffocation by laryngospasm owing to acute larygotrachitis.A patient suffered from GERD without esophageal symptoms,which was diagnosed and treated as bronchial asthma during his five emergency *** admissions were because of episodic attacks of severe air hunger owing to an extreme throat *** patient was being treated for as long as two *** the correct diagnosis was made and treatment of laporascopic fundaplication was performed,the longstanding“bronchial asthma”,after all,completely *** concept of“not asthma,but GERD”seems undervalued,unappreciated,even misunderstood among patients with intractable ***,such a case is reported in detail,similar cases are mentioned briefly as well,and a mechanism responsible for GERD-originated larryngo-or laryngotracho-spasm is proposed.

关键词： gastroesophageal reflux disease asthma cough laryngospasm laporoscopy fundaplicaton PPI radiofrequency

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门静脉海绵样变性的诊治进展

中华血管外科杂志 2024年第2期9卷 122-128页

作者：薛文豪化召辉李震汪忠镐郑州大学第一附属医院腔内血管外科郑州450052 首都医科大学宣武医院血管外科北京100053

门静脉海绵样变性(CTPV)是指门静脉由于原发或继发因素导致门静脉回流受阻,门静脉为增加入肝血量及降低门静脉压力而产生的代偿性变化,表现为主干消失,代之形成大量侧支循环。近年来随着介入技术和器械的发展,对于CTPV的诊治产生了新的... 详细信息

门静脉海绵样变性(CTPV)是指门静脉由于原发或继发因素导致门静脉回流受阻,门静脉为增加入肝血量及降低门静脉压力而产生的代偿性变化,表现为主干消失,代之形成大量侧支循环。近年来随着介入技术和器械的发展,对于CTPV的诊治产生了新的认识和观点,本综述主要针对门静脉血栓形成所导致的CTPV进行讨论,并对不同类型CTPV的治疗进行分析。

关键词：门静脉海绵样变性肝硬化门静脉高压经颈静脉肝内门体分流术介入

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A belated revelation:from gastroesophageal reflux derived asthma to laryngotracheal irritation even spasm

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Frontiers of Medicine 2008年第2期2卷 127-129页

作者： zhonggao wang Center for GER Second Artillery General HospitalClinical Research CollegeBeijing Normal UniversityBeijing 100086China Department of Cardiothoracic Vascular Surgery China Center for GERXuanwu HospitalCapital Medical UniversityBeijing 100053China

The author has been inspired by the Global Evidence-Based Consensus for gastroesophageal reflux(GER),which put forward four extra-esophageal syn-dromes:reflux cough syndrome,reflux laryngitis syn-drome,reflux dental erosion syndrome and the reflux asthma *** author himself happened to receive five emergency rescue treatments following appar-ent“bronchial asthma”,which was to be diagnosed as GER at his own *** resulted in some *** being rescued again from suffocation,he had a fun-daplication,which was performed at the Englewood Hospital&Medical Center,Englewood,USA in March *** procedure immediately cleared up his“asthma”.A month later he brought forth a Center for GER in an army hospital in Beijing,*** to now,601 patients with mainly respiratory distress(84%)were treated by Stretta Radiofrequency,58 by surgery and more by *** GER Center is now complete with a *** patients with respiratory distresses turned out to fare better than those with acid regurgitation.A nozzle-shaped pharynx was found in patients with the *** study revealed that the refluxate entered into tra-chea and even *** a hypothesis of a gastro-oesophago-laryngo-tracheal reflux took *** modest effort to treat GER-derived respiratory distresses has got off to an encouraging start amid relative shortage of experience and *** would like to share two thoughts with scholars and experts at home and abroad:*** GER-derived asthma is not asthma,but GER pure and simple;*** pathogenesis of“asthma”is not asthma,but laryngotracheal irritation/spasm and its sequence.

关键词： gastroesophageal reflux asthma laryngotracheal spasm brachiectasis tracheotomy

Effect of laparoscopic angle of His reconstruction in the treatment of patients with gastroesophageal reflux disease and hiatal hernia

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Chinese Medical Journal 2022年第14期135卷 1750-1752页

作者： Rui Zhang Zhitong Li Chunxia Li Feng Ji Xinwei Han zhonggao wang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan 450052China Department of Intervention The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan 450052China

Gastroesophageal reflux disease(GERD)is caused by esophageal dysfunction resulting in reflux of gastric and duodenal contents into the esophagus,which leads to a series of symptoms.[1]The incidence of GERD in East Asia ranges from 2.5%to 7.8%.[2]Hiatal hernia(HH)refers to the upper part of the stomach protruding into the chest through the esophageal *** is closely related to GERD and can play a role in the development and increased incidence of GERD.[3]The surgical treatment of patients with GERD and HH includes HH repair and Nissen,Toupet,or Dor fundoplication(DF).However,post-operative complications have been associated with fundoplication,including dysphagia and abdominal distension,which reduce the benefit of fundoplication.

关键词： hernia esophageal patients

Outcome of Stretta radiofrequency and fundoplication for GERD- related severe asthmatic symptoms

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Frontiers of Medicine 2015年第4期9卷 437-443页

作者： Zhiwei Hu Jimin Wu zhonggao wang Yu Zhang Weitao Liang Chao Yan Department of Gastroesophageal Reflux Disease the Second Artillery General Hospital PLA Beijing 100088 China

This study aimed to investigate the outcome of treatment with Stretta radiofrequency （SRF） or laparoscopic Nissen fundoplication （LNF）. A total of 137 gastroesophageal reflux disease （GERD） patients with severe asthmatic symptoms who responded inadequately to medical treatment for asthma were investigated. The patients were followed up 1 year and 5 years after SRF （n = 82） or LNF （n = 55） treatment. A questionnaire covering 29 related symptoms and medication use was employed. Digestive, respiratory, and ear-nose-throat （ENT） symptom scores significantly decreased after antireflux treatment. Symptom scores respectively changed from 17.2 ± 10.1, 31.9 ± 6.6, and 21.1± 11.8 to 5.0 ±6.2, 11.5 ±10.2, and 6.3± 6.8 at 1 year and to 5.6 ± 6.5, 13.1± 10.1, and 7.8 ± 7.2 at 5 years （P 〈 0.001）. The outcome of LNF was significantly better than that of SRF in terms of digestive （P 〈 0.001, P = 0.001）, respiratory （P = 0.006, P = 0.001）, and ENT symptoms （P = 0.006, P = 0.003） at both 1 year and 5 years. SRF and LNF were both effective against the digestive symptoms of GERD as well as GERD-related severe asthmatic and ENT symptoms, with better outcomes exhibited by the LNF group. Severe asthmatic symptoms and GERD were closely associated, and this finding warrants further study.

关键词： asthma gastroesophageal reflux Stretta radiofrequency laparoscopic Nissen fundoplication

Improved control of hypertension following laparoscopic fundoplication for gastroesophageal reflux disease

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Frontiers of Medicine 2017年第1期11卷 68-73页

作者： Zhiwei Hu Meiping Chen Jimin Wu Qing Song Chao Yan Xing Du zhonggao wang Department of Gastroesophageal Reflux Disease PLA Rocket Force General Hospital Beijing 100088 China Department of Vascular Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

This study aims to determine whether successful laparoscopic fundoplication for gastroesophageal reflux disease （GERD） can improve the control of hypertension. We conducted an observational study of GERD patients with hypertension. The esophageal and gastroesophageal symptoms of these patients were successfully treated with laparoscopic fundoplication, as measured by the reduced GERD symptoms and proton pump inhibitor consumption. A hypertension control scale was used to classify the use of antihypertensive medications and the quality of blood pressure control before and after anti-reflux surgery. Wilcoxon signed-ranks test was used for the statistical analyses. Seventy GERD patients were included in the analysis and followed up for a mean period of 3.5± 1.4 years. Prior to surgery, all participating patients were taking at least one class of antihypertensive medication, and 56 patients （80%） had intermittently high blood pressure. After surgery, the mean number of antihypertensive medication classes per patient was significantly reduced from 1.61 ± 0.77 pre-procedure to 1.27 ± 0.88 post-procedure （P 〈 0.001）. The blood pressure of 48 of the 56 cases （86±） with preoperative intermittent high blood pressure returned to normal post procedure. A total of 50 patients （71%） recorded improvements on the hypertension control scale, with the overall mean score decreasing from 3.1 ± 1.0 pre- procedure to 1.4 ± 1.0 post-procedure （P 〈 0.001）. Therefore, successful laparoscopic fundoplication may result in better blood pressure control in some hypertensive GERD patients. This result suggests a possible connection between gastroesophageal reflux and hypertension.

关键词： gastroesophageal reflux disease hypertension blood pressure laparoscopic fundoplication

Insult of gastroesophageal reflux on airway： clinical significance of pharyngeal nozzle

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Frontiers of Medicine 2015年第1期9卷 117-122页

作者： zhonggao wang Zhiwei Hu Jimin Wu Feng Ji Hongtao wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu Center for GER the Second Artillery General Hospital of PLA Beijing 100088 China Xuanwu Hospital Capital Medical University Beijing 100053 China Center for GER the First Ajfiliated Hospital of Zhengzhou University Zhengzhou 450052 China Center for GER the Fourth Affiliated Hospital of Zhengzhou University Zhengzhou 450044 China

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux （GER） insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. zhonggao wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. zhonggao wang and his team＇s work and would call attention to the public so as to recognize this relatively unknown entity -- a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

关键词： gastroesophageal reflux airway pharyngeal nozzle micro-aspiration asthma

Analysis of operation-related complications of totally laparoscopic aortoiliac surgery

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Chinese Medical Journal 2014年第7期127卷 1218-1221页

作者： Qi Lixing Gu Yongquan Guo Lianrui Li Xuefeng Wu Yingfeng Cui Shijun Tong Zhu Wu Xin Guo Jianming Zhang Jian wang zhonggao Department of Vascular Surgery Xuanwu Hospital Institute of Vascular Surgery Capital Medical University Beijing 100053 China

Background Totally laparoscopic aortoiliac surgery has been newly developed in *** is known as the most complex laparoscopic technique to learn because of its high-risk *** of the operation-related complications of this surgery is supposed to be helpful for the early success of this *** Twelve male patients （56-70 years old） with aortoiliac occlusive disease underwent totally laparoscopic aortoiliac bypass surgery （TLABS） in our *** data and operation-related complications were retrospectively *** Of the 12 patients,TLABS succeeded in nine and conversion to open surgery occurred in *** of the converted patients finally died of pulmonary ***-related complications included bleeding from arterial injury,perforation from colonic injury,graft embolism,residual aortic stenosis,and *** in two patients and colonic perforation in one patient resulted in three conversions to open *** graft embolectomy and postoperative aortic stenting were performed to resolve the thrombus/embolus-referring *** hydronephrosis,which was thought to result from intraoperative injury and treated with ureteric intubation drainage,recovered 6 months after *** Good understanding and avoidance of operation-related complications are important to guarantee the technical success of *** conversion to open surgery is necessary for saving the patient＇s life in case of lifethreatening complications.

关键词： totally laparoscopic aortoiliac surgery complication operation-related

Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3457-3475页

作者： Manqing Tang Zhijie Zhang Ping wang Feng Zhao Lin Miao Yuming wang Yingpeng Li Yunfei Li zhonggao Gao College of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic *** tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly contribute to this process by demonstrating remarkable *** survive shear stress,resist anoikis,evade immune surveillance,and thwart *** comprehensive review aims to elucidate the intricate landscape of CTC formation,metastatic mechanisms,and the myriad factors influencing their *** signaling pathways,such as integrin-related signaling,cellular autophagy,epithelial-mesenchymal transition,and interactions with platelets,are examined in ***,we explore the realm of precision nanomedicine design,with a specific emphasis on the anoikis‒platelet *** innovative approach strategically targets CTC survival mechanisms,offering promising avenues for combatting metastatic cancer with unprecedented precision and *** review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.

关键词： CTCs Anoikis Platelet Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting Nanomedicines