Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells

作     者：Manqing Tang Zhijie Zhang Ping Wang Feng Zhao Lin Miao Yuming Wang Yingpeng Li Yunfei Li Zhonggao Gao 

作者机构：College of Chinese Materia MedicaTianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2024年第14卷第8期

页      面：3457-3475页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by Tianjin University of Traditional Chinese Medicine Startup Funding to Yunfei Li,and supported by Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University(No.2023CCG13,China) funded by National Natural Science Foundation of China(No.82074030) 

主　　题：CTCs Anoikis Platelet Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting Nanomedicines 

摘      要：Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic *** tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly contribute to this process by demonstrating remarkable *** survive shear stress,resist anoikis,evade immune surveillance,and thwart *** comprehensive review aims to elucidate the intricate landscape of CTC formation,metastatic mechanisms,and the myriad factors influencing their *** signaling pathways,such as integrin-related signaling,cellular autophagy,epithelial-mesenchymal transition,and interactions with platelets,are examined in ***,we explore the realm of precision nanomedicine design,with a specific emphasis on the anoikis‒platelet *** innovative approach strategically targets CTC survival mechanisms,offering promising avenues for combatting metastatic cancer with unprecedented precision and *** review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.