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Synthesis, Structural Characterization and Antibacterial Activities of Series of Chalcone Derivatives

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Synthesis, Structural Characterization and Antibacterial Act...

中国化学会第九届全国有机化学学术会议

作者： Zhi-Peng Ni zhong-cheng song Chun-Lei Fan Miao-Miao Qin Xiao-Kang song Xiao-Chang Mei School of Life Science Zhejiang Chinese Medical University

Series of chalcone derivatives were synthesized. Their structures were characterized by NMR spectrum. The results showed that trans-structure were the main products, which exhibited the C=C double bond was on the both sides of the aromatic rings in all compounds. The antibacterial activities were tested against gram positive bacteria and gram negative bacteria by MTT method. The results showed that these compounds had a certain antibacterial effect. Also according to anti-biological activities results, the inhibitory effects of these compounds were different, as for, the different substitution group on the both sides of the aromatic ring in the same location and the same substitution group on the both sides of the aromatic ring in the different location.

关键词： Synthesis Structural characterization Chalcone

Synthesis, Structural Characterization and Antibacterial Activities of Series of（Z）-4-oxo-4-（arylamino）but-2-enoic Acid Derivatives

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Synthesis, Structural Characterization and Antibacterial Act...

中国化学会第九届全国有机化学学术会议

作者： Meng-Chao Yao zhong-cheng song Chun-Lei Fan Miao-Miao Qin Xiao Ye Qiao-Ye Ding School of Life Science Zhejiang Chinese Medical University

Series of（Z）-4-oxo-4-（arylamino）but-2-enoic acid derivatives were synthesized. Their structures were characterized by NMR spectrum. The results showed that cis-structure were the main products, which exhibited the C=C double bond was on the both sides of carbonyl groups in all compounds. The anti-biological activities were tested against gram positive bacteria and gram negative bacteria by MTT method. The results showed that these compounds had a certain antibacterial effect. Also according to anti-biological activities results, the inhibitory effects of these compounds were different, as for, the different substitution group on the aromatic ring in the same location and the same substitution group on the aromatic ring in the different location.

关键词： Synthesis Structural characterization (Z)-4-oxo-4-(arylamino)but-2-enoic Acid

Synthesis, Structural Characterization and Antibacterial Activities of N-halogen-Substituted Benzylidene Aromatic Amine

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Synthesis, Structural Characterization and Antibacterial Act...

中国化学会第九届全国有机化学学术会议

作者： Miao-Miao Qin zhong-cheng song Chun-Lei Fan Zhi-Peng Ni Yuan-Yuan Fang Meng-Chao Yao School of Life Science Zhejiang Chinese Medical University

Series of N-halogen-substituted benzylidene aromatic amine were synthesized. Their structures were characterized by NMR spectrum. Some crystal structures were refined through the SHELXL97 software processing. The results showed that trans-structure were the main products, which exhibited the C=N double bond was on the both sides of the aromatic rings in all compounds. The antibacterial activities were tested against gram positive bacteria and gram negative bacteria by MTT method. The results showed that these compounds had a certain antibacterial effect. Also according to anti-biological activities results, the inhibitory effects of these compounds were different, as for, the different substitution group on the both sides of the aromatic ring in the same location and the same substitution group on the both sides of the aromatic ring in the different location.

关键词： Synthesis Structural characterization Benzylidene aromatic amine

The Effects of Tankyrase1、hTERT Transfection on Corpus Cavernosum Smooth Muscle Cell

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The Effects of Tankyrase1、hTERT Transfection on Corpus Cave...

中华医学会第八次全国男科学学术会议

作者： WU Xiao-jun XIN zhong-cheng song Wei-dong TIAN Long WU Yi-guang LIU Bao-xing(Andrology Center,Peking University First Hospital,Peking University,Beijing 100009,China)

Objective:According to our previous research findings and other studies showed that aging and ED accompanied with loss of smooth muscle cell,accumulation of collagen due to insufficient supply of blood for Corpus Cavernosum as well as decreased compliance of e- rectile tissue in penis which might be strongly related to telomerase and human telomerase reverse transcriptse(hTERT).Recently rec- ognized Tankyrase 1 is another enzyme concerning cell senescence,however,few reports on the relationship between Tankyrase l,

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圆柱分层介质中格林函数的完整求解Ⅱ:混合位格林函数

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微波学报 2009年第4期25卷 11-15页

作者：胡梦中尹成友宋铮解放军电子工程学院合肥230037

在PartⅠ的基础之上,详细、完整地推导出有关z、φ和ρ方向电偶极子圆柱分层介质的3种不同形式的混合位格林函数。分析了这3种格林函数的特点,从而为利用混合位积分方程(MPIE)准确分析圆柱共形微带天线提供了理论基础。通过与文献[2]、... 详细信息

在PartⅠ的基础之上,详细、完整地推导出有关z、φ和ρ方向电偶极子圆柱分层介质的3种不同形式的混合位格林函数。分析了这3种格林函数的特点,从而为利用混合位积分方程(MPIE)准确分析圆柱共形微带天线提供了理论基础。通过与文献[2]、[3]给出的混合位格林函数的比较,说明了本文公式的正确性,最后,通过Mat-lab仿真,成功计算了文献[8]中的圆柱分层介质的第一类混合位格林函数。

关键词：圆柱分层介质混合位积分方程混合位格林函数广义函数束法

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li chengcheng Gai Danqing Xin Yijing Zhao Yan song Yahong cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： song Jiang Congwen Zhu Ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

Achieving both high reversible and stable Zn anode by a practical glucose electrolyte additive toward highperformance Zn-ion batteries

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Rare Metals 2022年第2期41卷 356-360页

作者： Ming song cheng-Lin zhong College Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou 221018China College of Chemistry and Chemical Engineering Linyi UniversityLinyi 276000China

Aqueous Zn-ion batteries(ZIBs)featuring safety,affordability and high energy density may provide a promising solution to the demand for better energy storage *** with high electrochemical performances rely on a stable and reversible Zn metal negative *** side reactions such as the hydrogen evolution reaction(HER)at the anode-electrolyte interface are responsible for the low reversibility,and uneven Zn deposition/dissolution gives rise to the instability of Zn ***,a facile and scalable method of regulating electrolytes has been proposed by Chao and his co-works through adding a lowcost,safe and environmentally-friendly electrolyte additive:*** calculations and experimental studies reveal that the glucose not only suppresses side reactions by modulating the solvated shell of Zn^(2+)but also homogenizes Zn deposition/dissolution through forming a special local absorption *** bi-functional electrolyte additive endows the Zn anode with both high reversibility and stability,which efficiently improves the performances of *** work explores a promising electrolyte strategy for realizing the large-scale application of ZIBs.

关键词： electrolyte additive anode

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes